Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | KLHL22 | Human | 17beta-estradiol | multiple interactions | ISO | Klhl22 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of KLHL22 mRNA | CTD | PMID:26496021 | KLHL22 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Klhl22 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLHL22 mRNA | CTD | PMID:21570461 | KLHL22 | Human | 2,4-dinitrotoluene | affects expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of KLHL22 mRNA | CTD | PMID:21346803 | KLHL22 | Human | 2,6-dinitrotoluene | affects expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of KLHL22 mRNA | CTD | PMID:21346803 | KLHL22 | Human | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KLHL22 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL22 mRNA | CTD | PMID:28628672 | KLHL22 | Human | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Klhl22 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of KLHL22 mRNA | CTD | PMID:18648102 | KLHL22 | Human | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL22 mRNA | CTD | PMID:28628672 | KLHL22 | Human | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Klhl22 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of KLHL22 promoter | CTD | PMID:33297965 | KLHL22 | Human | 6-propyl-2-thiouracil | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of KLHL22 mRNA | CTD | PMID:30047161 | KLHL22 | Human | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of KLHL22 intron | CTD | PMID:30157460 | KLHL22 | Human | amitrole | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of KLHL22 mRNA | CTD | PMID:30047161 | KLHL22 | Human | amphetamine | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of KLHL22 mRNA | CTD | PMID:30779732 | KLHL22 | Human | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of KLHL22 mRNA | CTD | PMID:24449571 | KLHL22 | Human | bisphenol A | multiple interactions | ISO | Klhl22 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of KLHL22 mRNA | CTD | PMID:26496021 | KLHL22 | Human | bisphenol A | affects expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of KLHL22 mRNA | CTD | PMID:25181051 | KLHL22 | Human | bisphenol A | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of KLHL22 mRNA | CTD | PMID:26982218 | KLHL22 | Human | bisphenol F | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KLHL22 mRNA | CTD | PMID:28628672 | KLHL22 | Human | C60 fullerene | increases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | fullerene C60 results in increased expression of KLHL22 mRNA | CTD | PMID:19167457 | KLHL22 | Human | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of KLHL22 mRNA | CTD | PMID:38568856 | KLHL22 | Human | caffeine | increases phosphorylation | EXP | | 6480464 | Caffeine results in increased phosphorylation of KLHL22 protein | CTD | PMID:35688186 | KLHL22 | Human | carbamazepine | affects expression | EXP | | 6480464 | Carbamazepine affects the expression of KLHL22 mRNA | CTD | PMID:25979313 | KLHL22 | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KLHL22 gene] | CTD | PMID:28238834 | KLHL22 | Human | ciguatoxin CTX1B | affects expression | ISO | Klhl22 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of KLHL22 mRNA | CTD | PMID:18353800 | KLHL22 | Human | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of KLHL22 mRNA | CTD | PMID:27594783 | KLHL22 | Human | copper atom | multiple interactions | EXP | | 6480464 | [Disulfiram binds to Copper] which results in increased expression of KLHL22 mRNA | CTD | PMID:24690739 | KLHL22 | Human | copper(0) | multiple interactions | EXP | | 6480464 | [Disulfiram binds to Copper] which results in increased expression of KLHL22 mRNA | CTD | PMID:24690739 | KLHL22 | Human | dexamethasone | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KLHL22 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL22 mRNA | CTD | PMID:28628672 | KLHL22 | Human | diazinon | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Diazinon results in decreased expression of KLHL22 mRNA | CTD | PMID:29108742 | KLHL22 | Human | Dibutyl phosphate | affects expression | EXP | | 6480464 | di-n-butylphosphoric acid affects the expression of KLHL22 mRNA | CTD | PMID:37042841 | KLHL22 | Human | dibutyl phthalate | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in decreased expression of KLHL22 mRNA | CTD | PMID:21266533 | KLHL22 | Human | disulfiram | multiple interactions | EXP | | 6480464 | [Disulfiram binds to Copper] which results in increased expression of KLHL22 mRNA | CTD | PMID:24690739 | KLHL22 | Human | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of KLHL22 mRNA | CTD | PMID:29803840 | KLHL22 | Human | finasteride | increases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Finasteride results in increased expression of KLHL22 mRNA | CTD | PMID:24136188 | KLHL22 | Human | flutamide | increases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of KLHL22 mRNA | CTD | PMID:24136188 | KLHL22 | Human | indometacin | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KLHL22 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of KLHL22 mRNA | CTD | PMID:28628672 | KLHL22 | Human | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of KLHL22 protein | CTD | PMID:32959892 | KLHL22 | Human | methamphetamine | increases expression | ISO | Klhl22 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of KLHL22 mRNA | CTD | PMID:26307267 | KLHL22 | Human | methimazole | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of KLHL22 mRNA | CTD | PMID:30047161 | KLHL22 | Human | N-methyl-N-nitrosourea | increases expression | ISO | Klhl22 (Mus musculus) | 6480464 | Methylnitrosourea results in increased expression of KLHL22 mRNA | CTD | PMID:25270620 | KLHL22 | Human | paracetamol | affects expression | ISO | Klhl22 (Mus musculus) | 6480464 | Acetaminophen affects the expression of KLHL22 mRNA | CTD | PMID:17562736 | KLHL22 | Human | paracetamol | increases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of KLHL22 mRNA | CTD | PMID:33387578 | KLHL22 | Human | pirinixic acid | increases expression | ISO | Klhl22 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of KLHL22 mRNA | CTD | PMID:25270620 | KLHL22 | Human | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of KLHL22 mRNA | CTD | PMID:30047161 | KLHL22 | Human | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of KLHL22 mRNA | CTD | PMID:34032870 | KLHL22 | Human | sulfadimethoxine | decreases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of KLHL22 mRNA | CTD | PMID:30047161 | KLHL22 | Human | titanium dioxide | increases expression | ISO | Klhl22 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of KLHL22 mRNA | CTD | PMID:29264374 | KLHL22 | Human | trichloroethene | increases expression | ISO | Klhl22 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of KLHL22 mRNA | CTD | PMID:33387578 | KLHL22 | Human | triptonide | increases expression | ISO | Klhl22 (Mus musculus) | 6480464 | triptonide results in increased expression of KLHL22 mRNA | CTD | PMID:33045310 | KLHL22 | Human | urethane | decreases expression | EXP | | 6480464 | Urethane results in decreased expression of KLHL22 mRNA | CTD | PMID:28818685 | KLHL22 | Human | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of KLHL22 gene | CTD | PMID:29154799 | KLHL22 | Human | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of KLHL22 mRNA | CTD | PMID:23179753 and PMID:28001369 | |