Klhl22 (kelch like family member 22) - Rat Genome Database

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Gene: Klhl22 (kelch like family member 22) Heterocephalus glaber
Analyze
Symbol: Klhl22
Name: kelch like family member 22
RGD ID: 18919179
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to L-leucine (ortholog); mitotic sister chromatid segregation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); FOUND IN intercellular bridge (ortholog); intracellular membrane-bounded organelle (ortholog); microtubule cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Kelch-like protein 22
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945408,999 - 441,975 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945409,093 - 446,619 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Klhl22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945408,999 - 441,975 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945409,093 - 446,619 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
KLHL22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,441,519 - 20,495,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,441,519 - 20,495,844 (-)EnsemblGRCh38hg38GRCh38
GRCh372220,795,806 - 20,850,082 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,125,806 - 19,180,122 (-)NCBINCBI36Build 36hg18NCBI36
Celera224,282,529 - 4,336,886 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,059,895 - 4,107,538 (-)NCBIHuRef
CHM1_12220,796,082 - 20,850,455 (-)NCBICHM1_1
T2T-CHM13v2.02220,845,791 - 20,900,118 (-)NCBIT2T-CHM13v2.0
Klhl22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,577,485 - 17,611,246 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,577,482 - 17,611,246 (+)EnsemblGRCm39 Ensembl
GRCm381617,759,621 - 17,793,382 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,759,618 - 17,793,382 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,759,714 - 17,793,475 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,673,234 - 17,706,943 (+)NCBIMGSCv36mm8
Celera1618,332,703 - 18,366,464 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.01NCBI
Klhl22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,695,168 - 96,736,079 (-)NCBIGRCr8
mRatBN7.21183,190,891 - 83,231,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,190,891 - 83,231,770 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,919,784 - 91,960,680 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,580,927 - 84,621,830 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,634,547 - 83,675,443 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,646,489 - 87,718,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,677,966 - 87,718,826 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,699,112 - 90,771,253 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,179,262 - 85,220,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,219,855 - 85,260,693 (-)NCBI
Celera1181,962,736 - 82,003,585 (-)NCBICelera
Cytogenetic Map11q23NCBI
Klhl22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,009,155 - 19,051,393 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,010,971 - 19,051,300 (-)NCBIChiLan1.0ChiLan1.0
KLHL22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,062,468 - 30,116,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,609,513 - 32,664,017 (-)NCBINHGRI_mPanPan1
PanPan1.12219,126,658 - 19,174,839 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,122,875 - 19,174,842 (-)Ensemblpanpan1.1panPan2
KLHL22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,248,253 - 30,281,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,248,240 - 30,281,843 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,207,137 - 30,246,532 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02631,656,570 - 31,696,204 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,656,561 - 31,696,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,702,711 - 29,742,120 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,327,051 - 29,366,309 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,416,255 - 30,455,878 (-)NCBIUU_Cfam_GSD_1.0
Klhl22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,854,676 - 139,899,247 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,854,803 - 2,899,460 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,854,915 - 2,899,386 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,773,964 - 50,809,986 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,773,917 - 50,809,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,334,392 - 54,451,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,211,732 - 5,264,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl195,218,653 - 5,265,063 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660851,671,542 - 1,725,149 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004175   ⟹   ENSHGLP00000004117
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624945408,999 - 441,975 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000004176   ⟹   ENSHGLP00000004118
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624945422,155 - 441,975 (-)Ensembl
RefSeq Acc Id: XM_004874874   ⟹   XP_004874931
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624945409,093 - 446,618 (-)NCBI
RefSeq Acc Id: XM_004874875   ⟹   XP_004874932
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624945409,093 - 446,619 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004874931 (Get FASTA)   NCBI Sequence Viewer  
  XP_004874932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14906 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004117
GenBank Protein JAN98134 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004874932   ⟸   XM_004874875
- UniProtKB: G5C045 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004874931   ⟸   XM_004874874
- UniProtKB: G5C045 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004117   ⟸   ENSHGLT00000004175
Ensembl Acc Id: ENSHGLP00000004118   ⟸   ENSHGLT00000004176


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003024 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004175 ENTREZGENE
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL22 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
NCBI Gene Klhl22 ENTREZGENE
PANTHER LD33804P UniProtKB/TrEMBL
  PTHR45632:SF5 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  Kelch_3 UniProtKB/TrEMBL
  Kelch_6 UniProtKB/TrEMBL
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
  SSF54695 UniProtKB/TrEMBL
UniProt A0AAX6QIG9_HETGA UniProtKB/TrEMBL
  G5C045 ENTREZGENE, UniProtKB/TrEMBL