Iho1 (interactor of HORMAD1 1) - Rat Genome Database

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Gene: Iho1 (interactor of HORMAD1 1) Rattus norvegicus
Analyze
Symbol: Iho1
Name: interactor of HORMAD1 1
RGD ID: 1596869
Description: Predicted to be involved in several processes, including meiosis I cell cycle process; regulation of homologous chromosome segregation; and spermatogenesis. Predicted to be active in condensed nuclear chromosome. Orthologous to human IHO1 (interactor of HORMAD1 1); INTERACTS WITH bisphenol A; 4,4'-sulfonyldiphenol (ortholog); cadmium atom (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ccdc36; coiled-coil domain containing 36; coiled-coil domain-containing protein 36; hypothetical protein LOC680018; hypothetical protein LOC686631; interactor of HORMAD1 protein 1; LOC680018
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,091,134 - 109,126,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,092,758 - 109,125,434 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08117,182,484 - 117,215,390 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,183,343 - 117,211,170 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,531,078 - 116,559,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,394,590 - 108,425,677 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27723721  


Genomics

Comparative Map Data
Iho1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,091,134 - 109,126,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,092,758 - 109,125,434 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.08117,182,484 - 117,215,390 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,183,343 - 117,211,170 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,531,078 - 116,559,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,394,590 - 108,425,677 (-)NCBICelera
Cytogenetic Map8q32NCBI
IHO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,191,309 - 49,258,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,198,428 - 49,258,106 (+)EnsemblGRCh38hg38GRCh38
GRCh37349,235,861 - 49,295,539 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,210,865 - 49,270,160 (+)NCBINCBI36Build 36hg18NCBI36
Celera349,193,717 - 49,258,916 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,293,567 - 49,352,860 (+)NCBIHuRef
CHM1_1349,188,591 - 49,248,327 (+)NCBICHM1_1
T2T-CHM13v2.0349,219,377 - 49,286,187 (+)NCBIT2T-CHM13v2.0
Iho1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,280,691 - 108,309,040 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,280,810 - 108,305,683 (-)EnsemblGRCm39 Ensembl
GRCm389108,403,492 - 108,431,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,403,611 - 108,428,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv379108,305,952 - 108,330,813 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,261,591 - 108,294,188 (-)NCBIMGSCv36mm8
Celera9108,012,831 - 108,037,747 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.32NCBI
Iho1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555321,198,316 - 1,226,875 (+)NCBIChiLan1.0ChiLan1.0
IHO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1349,174,605 - 49,240,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,122,120 - 49,181,228 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,217,333 - 50,260,487 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,239,250 - 50,259,890 (+)Ensemblpanpan1.1panPan2
IHO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,964,629 - 40,006,726 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,965,480 - 39,990,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,882,962 - 39,925,161 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,321,654 - 40,363,853 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,321,646 - 40,350,915 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,688,399 - 39,730,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,092,252 - 40,134,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,371,900 - 40,414,505 (-)NCBIUU_Cfam_GSD_1.0
Iho1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,109,471 - 64,172,647 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529889,423 - 929,929 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529905,692 - 929,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IHO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,802,948 - 31,837,912 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,802,963 - 31,836,911 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,060,241 - 35,067,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IHO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,593,516 - 10,653,519 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041156,373,695 - 156,435,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iho1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,215,447 - 3,239,060 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,208,648 - 3,249,281 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iho1
184 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000071189
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 12 10 10 10 2 6 36 2
Below cutoff 1 26 22 8 14 8 6 7 46 24 4 9 6

Sequence


RefSeq Acc Id: ENSRNOT00000071189   ⟹   ENSRNOP00000065793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,092,758 - 109,125,434 (-)Ensembl
Rnor_6.0 Ensembl8117,183,343 - 117,211,170 (-)Ensembl
RefSeq Acc Id: XM_001055346   ⟹   XP_001055346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,091,134 - 109,126,386 (-)NCBI
Rnor_6.08117,182,484 - 117,215,390 (-)NCBI
Rnor_5.08116,531,078 - 116,559,700 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001055346 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77175 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065793
  ENSRNOP00000065793.1
RefSeq Acc Id: XP_001055346   ⟸   XM_001055346
- UniProtKB: M0R8J7 (UniProtKB/TrEMBL),   A6I352 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065793   ⟸   ENSRNOT00000071189

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8J7-F1-model_v2 AlphaFold M0R8J7 1-574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596869 AgrOrtholog
BioCyc Gene G2FUF-29144 BioCyc
Ensembl Genes ENSRNOG00000048919 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071189 ENTREZGENE
  ENSRNOT00000071189.2 UniProtKB/TrEMBL
InterPro DUF4700 UniProtKB/TrEMBL
KEGG Report rno:680018 UniProtKB/TrEMBL
NCBI Gene 680018 ENTREZGENE
PANTHER INTERACTOR OF HORMAD1 PROTEIN 1 UniProtKB/TrEMBL
  PTHR35662 UniProtKB/TrEMBL
Pfam DUF4700 UniProtKB/TrEMBL
PhenoGen Iho1 PhenoGen
RatGTEx ENSRNOG00000048919 RatGTEx
UniProt A6I352 ENTREZGENE, UniProtKB/TrEMBL
  M0R8J7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-28 Iho1  interactor of HORMAD1 1  Ccdc36  coiled-coil domain containing 36  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Ccdc36  coiled-coil domain containing 36  LOC686631  hypothetical protein LOC686631  Data merged from RGD:1595017 1643240 APPROVED
2008-03-05 Ccdc36  coiled-coil domain containing 36  LOC680018  hypothetical protein LOC680018  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680018  hypothetical protein LOC680018      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC686631  hypothetical protein LOC686631      Symbol and Name status set to provisional 70820 PROVISIONAL