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Gene: UROS (uroporphyrinogen III synthase) Homo sapiens
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Symbol: UROS
Name: uroporphyrinogen III synthase
Description: Exhibits uroporphyrinogen-III synthase activity. Involved in heme biosynthetic process and uroporphyrinogen III biosynthetic process. Predicted to localize to the mitochondrion. Implicated in cutaneous porphyria.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hydroxymethylbilane hydrolyase; UROIIIS; uroporphyrinogen-III cosynthase; uroporphyrinogen-III synthase
Orthologs:
Mus musculus (house mouse) : Uros (uroporphyrinogen III synthase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Uros (uroporphyrinogen III synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uros (uroporphyrinogen III synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : UROS (uroporphyrinogen III synthase)
Canis lupus familiaris (dog) : UROS (uroporphyrinogen III synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uros (uroporphyrinogen III synthase)
Sus scrofa (pig) : UROS (uroporphyrinogen III synthase)
Chlorocebus sabaeus (green monkey) : UROS (uroporphyrinogen III synthase)
Heterocephalus glaber (naked mole-rat) : Uros (uroporphyrinogen III synthase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl10125,784,980 - 125,823,258 (-)Ensembl
GRCh3810125,784,980 - 125,823,280 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710127,474,091 - 127,511,837 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610127,467,142 - 127,501,757 (-)NCBINCBI36hg18NCBI36
Build 3410127,467,141 - 127,501,757NCBI
Celera10121,252,582 - 121,287,272 (-)NCBI
Cytogenetic Map10q26.2NCBI
HuRef10121,166,434 - 121,201,129 (-)NCBIHuRef
CHM1_110127,755,284 - 127,793,568 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on UROS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321278
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.