Timm8a2 (translocase of inner mitochondrial membrane 8A2) - Rat Genome Database

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Gene: Timm8a2 (translocase of inner mitochondrial membrane 8A2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Timm8a2
Name: translocase of inner mitochondrial membrane 8A2
RGD ID: 1588172
Description: Predicted to be involved in protein transport. Predicted to be located in mitochondrial inner membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC680794; similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog); translocase of inner mitochondrial membrane 8 homolog a2; translocase of inner mitochondrial membrane 8 homolog a2 (yeast)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815105,529,725 - 105,537,745 (+)NCBIGRCr8
mRatBN7.21599,123,374 - 99,131,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1599,127,384 - 99,131,155 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15103,060,193 - 103,063,884 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015104,152,345 - 104,156,008 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015101,080,171 - 101,083,834 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015108,448,351 - 108,456,834 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,453,147 - 108,456,808 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015111,840,703 - 111,844,364 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415107,145,036 - 107,148,697 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1597,899,949 - 97,903,743 (+)NCBICelera
Cytogenetic Map15q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Variants

.
Variants in Timm8a2
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:56
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000018486
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 5 18 90 34 42 16 25 16 4 122 52 83 45 56 26

Sequence


Ensembl Acc Id: ENSRNOT00000018486   ⟹   ENSRNOP00000018486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1599,127,410 - 99,131,071 (+)Ensembl
Rnor_6.0 Ensembl15108,453,147 - 108,456,808 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107031   ⟹   ENSRNOP00000078149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1599,127,384 - 99,131,155 (+)Ensembl
RefSeq Acc Id: NM_001109429   ⟹   NP_001102899
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815105,534,058 - 105,537,719 (+)NCBI
mRatBN7.21599,127,410 - 99,131,071 (+)NCBI
Rnor_6.015108,453,147 - 108,456,808 (+)NCBI
Rnor_5.015111,840,703 - 111,844,364 (+)NCBI
RGSC_v3.415107,145,036 - 107,148,697 (+)RGD
Celera1597,899,949 - 97,903,743 (+)RGD
Sequence:
RefSeq Acc Id: XM_063274627   ⟹   XP_063130697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815105,530,465 - 105,537,745 (+)NCBI
RefSeq Acc Id: XM_063274628   ⟹   XP_063130698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815105,529,725 - 105,537,745 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102899 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130697 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130698 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02573 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018486.3
  ENSRNOP00000078149.1
RefSeq Acc Id: NP_001102899   ⟸   NM_001109429
- UniProtKB: D3ZV76 (UniProtKB/TrEMBL),   A6HUL0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018486   ⟸   ENSRNOT00000018486
Ensembl Acc Id: ENSRNOP00000078149   ⟸   ENSRNOT00000107031
RefSeq Acc Id: XP_063130698   ⟸   XM_063274628
- Peptide Label: isoform X1
- UniProtKB: A6HUL0 (UniProtKB/TrEMBL),   D3ZV76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130697   ⟸   XM_063274627
- Peptide Label: isoform X1
- UniProtKB: A6HUL0 (UniProtKB/TrEMBL),   D3ZV76 (UniProtKB/TrEMBL)
Protein Domains
Tim10-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZV76-F1-model_v2 AlphaFold D3ZV76 1-97 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588172 AgrOrtholog
BioCyc Gene G2FUF-12360 BioCyc
Ensembl Genes ENSRNOG00000013835 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018486.4 UniProtKB/TrEMBL
  ENSRNOT00000107031.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.810 UniProtKB/TrEMBL
InterPro Tim10/FAM136A-like_domain UniProtKB/TrEMBL
  Tim8/9/10/13_Znf-like UniProtKB/TrEMBL
KEGG Report rno:680794 UniProtKB/TrEMBL
NCBI Gene 680794 ENTREZGENE
Pfam zf-Tim10_DDP UniProtKB/TrEMBL
PhenoGen Timm8a2 PhenoGen
RatGTEx ENSRNOG00000013835 RatGTEx
Superfamily-SCOP SSF144122 UniProtKB/TrEMBL
UniProt A6HUL0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZV76 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-21 Timm8a2  translocase of inner mitochondrial membrane 8A2  Timm8a2  translocase of inner mitochondrial membrane 8 homolog a2 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Timm8a2  translocase of inner mitochondrial membrane 8 homolog a2 (yeast)  LOC680794  similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680794  similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)  LOC687531  similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)  Data merged from RGD:1584234 1643240 APPROVED
2006-11-19 LOC680794  similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687531  similar to Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1 homolog)      Symbol and Name status set to provisional 70820 PROVISIONAL