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Gene: Uba3-ps2 (ubiquitin-like modifier activating enzyme 3, pseudogene 2) Rattus norvegicus

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No known orthologs.

Symbol:

Uba3-ps2

Name:

ubiquitin-like modifier activating enzyme 3, pseudogene 2

RGD ID:

1584154

Description:

Predicted to enable ATP binding activity and NEDD8 activating enzyme activity. Predicted to be involved in protein neddylation.

Type:

pseudo (Ensembl: protein-coding)

RefSeq Status:

MODEL

Previously known as:

LOC688812; similar to ubiquitin-activating enzyme E1C

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	7,131,175 - 7,132,567 (-)	NCBI		GRCr8
mRatBN7.2	12	2,333,319 - 2,334,709 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	2,334,153 - 2,334,709 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	12	4,112,043 - 4,113,433 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	4,112,043 - 4,113,424 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	6,242,421 - 6,243,809 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	1,825,278 - 1,826,662 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	4,159,387 - 4,160,777 (-)	NCBI		Celera
Cytogenetic Map	12	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uba3-ps2	Rat	protein modification by small protein conjugation	involved_in	IEA	UniRule:UR001455778	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Uba3-ps2	Rat	protein neddylation	involved_in	IEA	UniPathway:UPA00885	1600115	GO_REF:0000041	UniProt	GO_REF:0000041
Uba3-ps2	Rat	protein neddylation	involved_in	IEA	UniRule:UR001455778	1600115	GO_REF:0000104	UniProt	GO_REF:0000104

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Uba3-ps2	Rat	ATP binding	enables	IEA	UniRule:UR001455778	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Uba3-ps2	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Uba3-ps2	Rat	ligase activity	enables	IEA	UniProtKB-KW:KW-0436	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Uba3-ps2	Rat	NEDD8 activating enzyme activity	enables	IEA	UniRule:UR001455778	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Uba3-ps2	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Uba3-ps2	Rat	ubiquitin-like modifier activating enzyme activity	enables	IEA	InterPro:IPR035985	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Variants in Uba3-ps2
12 total Variants

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	36247923	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	797729	8525593	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	9318387	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	3	9	26	29	29	10	13	10	6	65	37	14	9	26	19


RefSeq Transcripts	XR_085582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_085983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000084052

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	2,334,153 - 2,334,709 (-)	Ensembl
Rnor_6.0 Ensembl	12	4,112,043 - 4,113,424 (+)	Ensembl

RefSeq Acc Id:

XR_085983

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	2,333,319 - 2,334,709 (-)	NCBI
Rnor_6.0	12	4,112,043 - 4,113,433 (+)	NCBI
Rnor_5.0	12	6,242,421 - 6,243,809 (+)	NCBI
RGSC_v3.4	12	1,825,278 - 1,826,662 (+)	RGD

Sequence:

show sequence

ATGGCGGATGGCGAGGAGCTGGAGAAGAAAAGTAGGAGAATAGAGGAGCTGCTGGCTGAGAAAATGGCTGTTGATGGTGGGTGTGGGGACACTGGAGACTGGGAAGGTCGCTGGAACCATGTAAAGAA
GTTCCTTGAGTGGCCTGGACCCTTCATACACCCTGATTTCGAACCGAGCACTGAATCACTCCAGTTCTTGTTAGATACATGTAAAGTTCTAGTCATTGGAGCTGGTGGCTTAGGATGTGAGCTTCTGA
AAAATCTGGCATTGTCTGGTTTTAGACAGATTCATGTTATAGACATGGACACTATAGATGTTTCCAATTTAAATAGTCAGTTTTTATTTAGGCCTAAAGATGTTGGAAGACCCAAGGCTGAAGTTGCT
GCAGAATTCCTGAATGACAGAGTTCCTAACTGCAACGTGGTCCCACATTTCAACAAGATTCAAGACTTTAACGACACTTTCTACCTACAATTTCATATTATCGTATGTGGCCTGAACTCTATCATAGC
CAGGAGATGGATCAATGGAATGCTGATATCTCTTCTAAATTATGAAGATGGTGTGTTGGATCCAAGCTCCATTGTACCTTTGATAGATGGGGGGACAGAAAGCTTTAAAGGGAATGCCCGAATGATTT
TTGCCTGGAATGACCACTTGTATTGAGTGCACTCTGGAACTTTACCCACCACAGGTCAATTTCCCCATGTGTACCACTGCATCTATGTCCAGGCTCCCAGAGCACTGTATCGAGTATGTAAGGACGTT
GCAATGGCCTAAAGAGCAGCCTTTTGGAGATGGGGTTTCATTAGATGGAGATGACCCTGAACATAGTCAGTGGATTTTCCAAAAGTCTGTAGAGAGAGCATCACAATATAATATTAGAGGTGTTACCT
ACAGACTCTCTCAAGGGGTAGTAAAACGAATCATTCCTGCAGTAGCTTCTACAAATGCAGTCATTGCAGCTGTGTGTGCCACTGAGGTTTTCAAGATAGCTACAAGTGCGTACATCCCCCTTAATAAC
TACTTAGTATTCAATGATGTAGATGGACTGTACATTTACACATTTGAGCAGAGAGAAAGGAGAACTGTCCTGTGTGTAGCCAGCTTCCTCAAAACATCCAGTTCTCCCCAACAGCTAAACTGCAAGAG
GTCTTAGACTATCTAACCAACAGTGCTTCTCTGCAAATGAAGTCTCCAGCTATAACAGCCACATTAGAGGGAGAAAACAGGACACTTTACAGTCAGTAATGTCTATTGAAGAACGAACGAGACCGAAT
CTGTCCAAAACATTAAAAGAGCTGGGACTAGTTGATGGACAAGAACTGGCTGTTGCTGATGTCACCACACCACAAACTGTACTATTTAAACTTCATTTTACTTAAGGAAAA

hide sequence


Ensembl Protein	ENSRNOP00000080181.1

Protein Domains

THIF-type NAD/FAD binding fold

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-20364	BioCyc
Ensembl Genes	ENSRNOG00000054096	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000084052.2	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	ThiF/MoeB/HesA	UniProtKB/TrEMBL
	ThiF_NAD_FAD-bd	UniProtKB/TrEMBL
	Ubiquitin-activating_enz	UniProtKB/TrEMBL
NCBI Gene	688812	ENTREZGENE
PANTHER	PTHR10953	UniProtKB/TrEMBL
	PTHR10953:SF6	UniProtKB/TrEMBL
Pfam	ThiF	UniProtKB/TrEMBL
PhenoGen	Uba3-ps2	PhenoGen
RatGTEx	ENSRNOG00000054096	RatGTEx
Superfamily-SCOP	SSF69572	UniProtKB/TrEMBL
UniProt	A0A8I5ZSI2_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-10	Uba3-ps2	ubiquitin-like modifier activating enzyme 3, pseudogene 2	LOC688812	similar to ubiquitin-activating enzyme E1C	Symbol and Name Changed	1299863	APPROVED
2006-11-19	LOC688812	similar to ubiquitin-activating enzyme E1C			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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