Kcne5 (potassium voltage-gated channel subfamily E regulatory subunit 5) - Rat Genome Database

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Gene: Kcne5 (potassium voltage-gated channel subfamily E regulatory subunit 5) Rattus norvegicus
Analyze
Symbol: Kcne5
Name: potassium voltage-gated channel subfamily E regulatory subunit 5
RGD ID: 1583501
Description: Predicted to enable potassium channel regulator activity and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including cardiac muscle cell action potential involved in contraction; regulation of cardiac muscle cell membrane repolarization; and regulation of potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNE5 (potassium voltage-gated channel subfamily E regulatory subunit 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: KCNE1-like; Kcne1l; LOC681190; potassium channel, voltage gated subfamily E regulatory beta subunit 5; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 5; potassium voltage-gated channel subfamily E member 1-like protein; potassium voltage-gated channel subfamily E regulatory beta subunit 5; potassium voltage-gated channel, Isk-related family, member 1-like; similar to potassium voltage-gated channel, Isk-related family, member 1-like; voltage-gated potassium channel accessory subunit 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,727,234 - 110,727,849 (-)NCBIGRCr8
mRatBN7.2X105,930,398 - 105,931,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,930,398 - 105,931,013 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX108,068,193 - 108,068,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,567,368 - 111,567,983 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X109,133,664 - 109,134,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,583,844 - 113,584,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,583,844 - 113,584,459 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X112,033,789 - 112,034,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,243,961 - 36,244,576 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX105,344,535 - 105,345,150 (-)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12324418   PMID:18313602   PMID:20533308   PMID:21493962  


Genomics

Comparative Map Data
Kcne5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X110,727,234 - 110,727,849 (-)NCBIGRCr8
mRatBN7.2X105,930,398 - 105,931,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX105,930,398 - 105,931,013 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX108,068,193 - 108,068,808 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X111,567,368 - 111,567,983 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X109,133,664 - 109,134,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X113,583,844 - 113,584,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX113,583,844 - 113,584,459 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X112,033,789 - 112,034,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X36,243,961 - 36,244,576 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX105,344,535 - 105,345,150 (-)NCBICelera
Cytogenetic MapXq33NCBI
KCNE5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X109,623,700 - 109,625,172 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX109,623,700 - 109,625,172 (-)EnsemblGRCh38hg38GRCh38
GRCh37X108,866,929 - 108,868,401 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X108,753,585 - 108,755,049 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X108,673,073 - 108,674,538NCBI
CeleraX109,346,567 - 109,348,031 (-)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX98,489,930 - 98,491,217 (-)NCBIHuRef
CHM1_1X108,778,194 - 108,779,658 (-)NCBICHM1_1
T2T-CHM13v2.0X108,071,490 - 108,072,962 (-)NCBIT2T-CHM13v2.0
Kcne5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X141,087,749 - 141,089,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX141,087,748 - 141,089,290 (-)EnsemblGRCm39 Ensembl
GRCm38X142,304,753 - 142,306,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX142,304,752 - 142,306,294 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X138,739,296 - 138,740,741 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X137,551,121 - 137,552,566 (-)NCBIMGSCv36mm8
CeleraX126,300,230 - 126,301,675 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX63.11NCBI
Kcne5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554906,242,197 - 6,243,627 (+)NCBIChiLan1.0ChiLan1.0
KCNE5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X109,114,032 - 109,115,971 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X109,117,636 - 109,119,108 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X98,731,109 - 98,732,575 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X109,201,428 - 109,202,890 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX109,202,320 - 109,202,748 (-)Ensemblpanpan1.1panPan2
KCNE5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,844,188 - 82,845,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX82,845,064 - 82,846,083 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX68,922,748 - 68,924,125 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,494,588 - 84,496,047 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX84,495,468 - 84,495,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X81,971,600 - 81,973,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,665,901 - 83,667,358 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,494,598 - 83,495,963 (-)NCBIUU_Cfam_GSD_1.0
Kcne5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X82,099,472 - 82,100,922 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364995,557,202 - 5,557,627 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364995,557,076 - 5,558,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX89,741,190 - 89,742,672 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X89,741,187 - 89,742,732 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X105,356,199 - 105,357,717 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X97,477,667 - 97,485,376 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX97,478,562 - 97,478,987 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606522,673,085 - 22,676,609 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcne5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248036,385,405 - 6,385,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcne5
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:41
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000025923
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 34 6 15 2
Low 3 30 27 21 15 21 4 7 40 25 15 11 4
Below cutoff 13 28 19 4 19 1 1 4 6 1

Sequence


RefSeq Acc Id: ENSRNOT00000025923   ⟹   ENSRNOP00000067483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX105,930,398 - 105,931,013 (-)Ensembl
Rnor_6.0 EnsemblX113,583,844 - 113,584,459 (-)Ensembl
RefSeq Acc Id: NM_001101003   ⟹   NP_001094473
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X110,727,234 - 110,727,849 (-)NCBI
mRatBN7.2X105,930,398 - 105,931,013 (-)NCBI
Rnor_6.0X113,583,844 - 113,584,459 (-)NCBI
Rnor_5.0X112,033,789 - 112,034,404 (-)NCBI
RGSC_v3.4X36,243,961 - 36,244,576 (+)RGD
CeleraX105,344,535 - 105,345,150 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094473 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABQ08565 (Get FASTA)   NCBI Sequence Viewer  
  EDL85209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067483
  ENSRNOP00000067483.1
RefSeq Acc Id: NP_001094473   ⟸   NM_001101003
- UniProtKB: A5HKJ1 (UniProtKB/TrEMBL),   M0RCZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067483   ⟸   ENSRNOT00000025923

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A5HKJ1-F1-model_v2 AlphaFold A5HKJ1 1-143 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701962
Promoter ID:EPDNEW_R12486
Type:initiation region
Name:Kcne5_1
Description:potassium voltage-gated channel subfamily E regulatory subunit5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X113,584,543 - 113,584,603EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583501 AgrOrtholog
BioCyc Gene G2FUF-1516 BioCyc
Ensembl Genes ENSRNOG00000019176 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025923 ENTREZGENE
  ENSRNOT00000025923.7 UniProtKB/TrEMBL
InterPro K_chnl_volt-dep_bsu_KCNE UniProtKB/TrEMBL
KEGG Report rno:681190 UniProtKB/TrEMBL
NCBI Gene 681190 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E REGULATORY BETA SUBUNIT 5 UniProtKB/TrEMBL
  PTHR15282 UniProtKB/TrEMBL
Pfam ISK_Channel UniProtKB/TrEMBL
PhenoGen Kcne5 PhenoGen
RatGTEx ENSRNOG00000019176 RatGTEx
UniProt A5HKJ1 ENTREZGENE, UniProtKB/TrEMBL
  M0RCZ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcne5  potassium voltage-gated channel subfamily E regulatory subunit 5  Kcne5  potassium channel, voltage gated subfamily E regulatory beta subunit 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Kcne5  potassium channel, voltage gated subfamily E regulatory beta subunit 5  Kcne5  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcne5  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 5  Kcne1l  KCNE1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-17 Kcne1l  KCNE1-like  Kcne1l  potassium voltage-gated channel, Isk-related family, member 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Kcne1l  potassium voltage-gated channel, Isk-related family, member 1-like  LOC681190  similar to potassium voltage-gated channel, Isk-related family, member 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681190  similar to potassium voltage-gated channel, Isk-related family, member 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL