Vom2r59 (vomeronasal 2 receptor, 59) - Rat Genome Database

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Gene: Vom2r59 (vomeronasal 2 receptor, 59) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r59 (Ensembl: Vom2r60)
Name: vomeronasal 2 receptor, 59 (Ensembl:vomeronasal 2 receptor, 60)
RGD ID: 1566381
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane; INTERACTS WITH vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC288396; RGD1566381; similar to putative pheromone receptor (Go-VN5)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,811,768 - 7,875,115 (-)NCBIGRCr8
mRatBN7.2123,013,942 - 3,077,289 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,890,226 - 3,077,368 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,673,634 - 3,737,065 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0124,297,246 - 4,360,685 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,967,237 - 3,030,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0123,969,493 - 4,032,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl123,969,493 - 4,032,656 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0126,100,534 - 6,163,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,059,451 - 1,122,798 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera124,832,920 - 4,896,203 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vom2r59Ratvinclozolin decreases expressionEXP 6480464vinclozolin results in decreased expression of VOM2R59 mRNACTDPMID:23869203


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vom2r59RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Vom2r59RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000068 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Vom2r59Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vom2r59Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Vom2r59Ratmembrane located_inIEAInterPro:IPR000068 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Vom2r59Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Vom2r59Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Vom2r59RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Vom2r59RatG protein-coupled receptor activity enablesIEAInterPro:IPR000068 more ...1600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:17382427  



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Variants in Vom2r59
589 total Variants

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000042692
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 20 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

1 to 10 of 20 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 1 4 29 23 26 4 18 4 5 44 29 18 5 18 22


RefSeq Transcripts NM_001099466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041244   ⟹   ENSRNOP00000042646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,890,226 - 2,996,619 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000041532   ⟹   ENSRNOP00000050214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,890,226 - 3,077,368 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000042692   ⟹   ENSRNOP00000047784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl123,969,493 - 4,032,656 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113174   ⟹   ENSRNOP00000093105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl123,012,954 - 3,077,368 (-)Ensembl
RefSeq Acc Id: NM_001099466   ⟹   NP_001092936
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,811,768 - 7,875,115 (-)NCBI
mRatBN7.2123,013,942 - 3,077,289 (-)NCBI
Rnor_6.0123,969,493 - 4,032,641 (+)NCBI
Rnor_5.0126,100,534 - 6,163,682 (+)NCBI
RGSC_v3.4121,059,451 - 1,122,798 (+)RGD
Celera124,832,920 - 4,896,203 (-)RGD
Sequence:
Protein RefSeqs NP_001092936 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047784
  ENSRNOP00000050214.4
  ENSRNOP00000093105.1
RefSeq Acc Id: NP_001092936   ⟸   NM_001099466
- Peptide Label: precursor
- UniProtKB: A0A8I6AGM1 (UniProtKB/TrEMBL),   D3ZGY3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047784   ⟸   ENSRNOT00000042692
Ensembl Acc Id: ENSRNOP00000042646   ⟸   ENSRNOT00000041244
Ensembl Acc Id: ENSRNOP00000093105   ⟸   ENSRNOT00000113174
Ensembl Acc Id: ENSRNOP00000050214   ⟸   ENSRNOT00000041532
G-protein coupled receptors family 3 profile


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20334 BioCyc
Ensembl Genes ENSRNOG00000045674 Ensembl
  ENSRNOG00000066069 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000080353 ENTREZGENE
Ensembl Transcript ENSRNOT00000041532.4 UniProtKB/TrEMBL
  ENSRNOT00000042692 ENTREZGENE
  ENSRNOT00000113174.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
KEGG Report rno:288396 UniProtKB/TrEMBL
NCBI Gene 288396 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
  VOMERONASAL 2, RECEPTOR 10-RELATED UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r59 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
  VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045674 RatGTEx
  ENSRNOG00000066069 RatGTEx
  ENSRNOG00000080353 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A8I6AGM1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGY3 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-23 Vom2r59  vomeronasal 2 receptor, 59  RGD1566381  similar to putative pheromone receptor (Go-VN5)   Symbol and Name updated 1299863 APPROVED
2008-07-08 RGD1566381  similar to putative pheromone receptor (Go-VN5)   LOC683421  similar to putative pheromone receptor (Go-VN5)  Data merged from RGD:1586869 1643240 APPROVED
2008-04-30 RGD1566381  similar to putative pheromone receptor (Go-VN5)   RGD1566381_predicted  similar to putative pheromone receptor (Go-VN5) (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC683421  similar to putative pheromone receptor (Go-VN5)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1566381_predicted  similar to putative pheromone receptor (Go-VN5) (predicted)  LOC288396  similar to putative pheromone receptor (Go-VN5)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC288396  similar to putative pheromone receptor (Go-VN5)      Symbol and Name status set to provisional 70820 PROVISIONAL