Far2 (fatty acyl CoA reductase 2)

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Gene: Far2 (fatty acyl CoA reductase 2) Rattus norvegicus

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Symbol:

Far2

Name:

fatty acyl CoA reductase 2

RGD ID:

1565966

Description:

Predicted to enable alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be located in peroxisomal membrane. Predicted to be active in peroxisome. Orthologous to human FAR2 (fatty acyl-CoA reductase 2); INTERACTS WITH atrazine; benzo[a]pyrene; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

fatty acyl-CoA reductase 2; LOC500368; male sterility domain containing 1; Mlstd1; RGD1565966; similar to male sterility domain containing 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FAR2 (fatty acyl-CoA reductase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Far2 (fatty acyl CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Far2 (fatty acyl-CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FAR2 (fatty acyl-CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FAR2 (fatty acyl-CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Far2 (fatty acyl-CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FAR2 (fatty acyl-CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FAR2 (fatty acyl-CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Far2 (fatty acyl-CoA reductase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AKT2 (AKT serine/threonine kinase 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	FAR2 (fatty acyl-CoA reductase 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Far2 (fatty acyl CoA reductase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-97m3.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG12268	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	fard-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1441	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG14893	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG5065	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	wat	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG10096	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG17560	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG17562	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG10097	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Sgp	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	182,705,499 - 182,819,290 (+)	NCBI		GRCr8
mRatBN7.2	4	180,973,968 - 181,087,862 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	181,007,622 - 181,087,255 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	182,446,400 - 182,563,485 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	182,483,194 - 182,565,436 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	246,589,572 - 246,698,456 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	185,758,904 - 185,791,596 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	169,455,254 - 169,577,917 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alopecia (ISS)

dry eye syndrome (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

belinostat (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

genistein (ISO)

glyphosate (EXP)

indole-3-methanol (EXP)

indometacin (ISO)

isotretinoin (ISO)

levonorgestrel (ISO)

lipopolysaccharide (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

methylparaben (ISO)

N-nitrosodiethylamine (EXP)

NADP zwitterion (ISO)

NADP(+) (ISO)

nickel atom (ISO)

ozone (EXP)

potassium chromate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

testosterone (ISO)

testosterone undecanoate (ISO)

titanium dioxide (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

long-chain fatty-acyl-CoA metabolic process (IBA,ISO)

Cellular Component

peroxisomal membrane (ISO)

peroxisome (IBA,ISO)

Molecular Function

alcohol-forming long-chain fatty acyl-CoA reductase activity (IEA)

alcohol-forming very long-chain fatty acyl-CoA reductase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15220348	PMID:24108123

Genomics

Comparative Map Data

Far2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	182,705,499 - 182,819,290 (+)	NCBI		GRCr8
mRatBN7.2	4	180,973,968 - 181,087,862 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	181,007,622 - 181,087,255 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	182,446,400 - 182,563,485 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	182,483,194 - 182,565,436 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	246,589,572 - 246,698,456 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	185,758,904 - 185,791,596 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	169,455,254 - 169,577,917 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

FAR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	29,149,278 - 29,335,616 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	29,149,016 - 29,341,121 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	29,302,211 - 29,488,549 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	29,267,865 - 29,378,273 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	29,267,864 - 29,378,272	NCBI
Celera	12	34,522,215 - 34,632,754 (+)	NCBI		Celera
Cytogenetic Map	12	p11.22	NCBI
HuRef	12	29,070,510 - 29,257,494 (+)	NCBI		HuRef
CHM1_1	12	29,267,516 - 29,454,137 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	29,021,810 - 29,208,149 (+)	NCBI		T2T-CHM13v2.0

Far2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	147,948,914 - 148,084,256 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	147,948,757 - 148,084,256 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	148,047,416 - 148,182,758 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	148,047,259 - 148,182,758 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	147,995,938 - 148,131,282 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	148,004,586 - 148,139,930 (+)	NCBI		MGSCv36	mm8
Celera	6	151,079,635 - 151,214,866 (+)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	78.49	NCBI

Far2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955505	5,585,846 - 5,663,895 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955505	5,585,846 - 5,724,234 (-)	NCBI	ChiLan1.0	ChiLan1.0

FAR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	67,478,866 - 67,668,709 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	67,475,260 - 67,665,013 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	56,975,589 - 57,165,923 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	59,599,063 - 59,785,139 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	59,599,063 - 59,676,543 (-)	Ensembl	panpan1.1		panPan2

FAR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	18,659,688 - 18,791,757 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	18,661,449 - 18,792,253 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	27,618,455 - 27,750,457 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	18,851,338 - 18,983,048 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	18,852,272 - 18,983,051 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	18,661,033 - 18,792,581 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	18,685,805 - 18,817,601 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	27,773,948 - 27,905,644 (+)	NCBI		UU_Cfam_GSD_1.0

Far2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	80,529,346 - 80,667,427 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936760	1,362,364 - 1,409,418 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936760	1,265,803 - 1,406,405 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FAR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	44,381,129 - 44,559,374 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	44,386,808 - 44,559,506 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	47,705,595 - 47,904,904 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FAR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	28,869,987 - 29,049,421 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	28,987,566 - 29,046,448 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	5,985,117 - 6,176,706 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Far2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	6,456,008 - 6,493,697 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	6,456,396 - 6,642,551 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Far2
497 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	154
Count of miRNA genes:	111
Interacting mature miRNAs:	123
Transcripts:	ENSRNOT00000002528, ENSRNOT00000067367
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157710145	182687754	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat

Markers in Region

RH143722

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	181,092,430 - 181,092,675 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	182,569,492 - 182,569,736	NCBI	Rnor6.0
Rnor_5.0	4	246,703,926 - 246,704,170	UniSTS	Rnor5.0
RGSC_v3.4	4	185,797,571 - 185,797,815	UniSTS	RGSC3.4
Celera	4	169,583,868 - 169,584,112	UniSTS
RH 3.4 Map	4	1120.7	UniSTS
Cytogenetic Map	4	q44	UniSTS

RH140381

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	181,090,987 - 181,091,120 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	182,568,049 - 182,568,181	NCBI	Rnor6.0
Rnor_5.0	4	246,702,483 - 246,702,615	UniSTS	Rnor5.0
RGSC_v3.4	4	185,796,128 - 185,796,260	UniSTS	RGSC3.4
Celera	4	169,582,425 - 169,582,557	UniSTS
RH 3.4 Map	4	1116.7	UniSTS
Cytogenetic Map	4	q44	UniSTS

AA892242

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	181,092,430 - 181,092,675 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	182,569,492 - 182,569,736	NCBI	Rnor6.0
Rnor_5.0	4	246,703,926 - 246,704,170	UniSTS	Rnor5.0
RGSC_v3.4	4	185,797,571 - 185,797,815	UniSTS	RGSC3.4
Celera	4	169,583,868 - 169,584,112	UniSTS
RH 3.4 Map	4	1120.9	UniSTS
Cytogenetic Map	4	q44	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	47	113	84	83	52	25	52	6	205	95	93	41	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001074438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006225134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017593068	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002528 ⟹ ENSRNOP00000002528

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	181,007,622 - 181,087,255 (+)	Ensembl
Rnor_6.0 Ensembl	4	182,483,194 - 182,565,436 (+)	Ensembl

RefSeq Acc Id:

NM_001427803 ⟹ NP_001414732

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	182,705,499 - 182,819,290 (+)	NCBI

RefSeq Acc Id:

XM_006237697 ⟹ XP_006237759

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	182,763,426 - 182,819,290 (+)	NCBI
mRatBN7.2	4	181,031,915 - 181,087,862 (+)	NCBI
Rnor_6.0	4	182,506,908 - 182,563,485 (+)	NCBI
Rnor_5.0	4	246,589,572 - 246,698,456 (+)	NCBI

Sequence:

show sequence

TGCACCTGCATGCACACACTCACCCAGAGAACGTAAGAGGTGTTACACTCATTTTTCATAAACT
CTACAAAAGCCAGGAGGCAAGAAGCAAGGTTGGATCTCTGTGAGTTCAAGTCCAGGCTAATCTA
CATAGTGAATTCTAGGCCAGCTAAGGCTAAATACATAGACCCTGTATCAGATTAATTAAATAGA
TAGATAGACAGACAGACAGACAGACAGACAGACAGACAGACAGACAGACAGATGCAAACTCTGG
AATAGGAACTTCCTCTTTGTTTTATGCTATTATAGAGGACTGTCACCTGCTGAGCTCCTCTGAA
TGAAATCCTTTAGTAGAATCCCACACATAAACTTCAGCAGACGGCAAACACACTTAAATATCGA
TAGTGTACTAATTATTTGCTGCCTCCTGCCCTAATCCATTTCTGGAAATCGACCCCTTTGATCT
TTGCAGAGAATTCACATAGAGGAACTCTATTACCTCCATTTTAGGATTACAGGAGGCTGAAGCA
CACAGCTATTACAAACCCTGTTCAAAATTAAAATCGCAGCACATCAGGATGTGAGTGACTCTCA
GACCCTAGTGATTGAGAGAGCTCTCAGGTAATGTGCTGGTGTGAGTGTGTGAAATGTGTCCTTT
TCCCCAGTAAACACACAGGACATGGAGTGGAGAATGGTTTGCAAATTTGGATGTCTATATATTT
TGGCACATTTGGAACTCCTTATCTACAAAGTGTGGTGTGTGATAGAGGGCCAGTTATCAGTCCT
TCCTTATATTAGCTGAATGCCTGGTTGATTAAGTTAACAAGATGAGTGCATATTCTGTTCCTGA
TCTCTAAAAAAGATATAAAGTCCGTGTTTCTCAAACCTGGGTATGCTGAGGGCTGCAATGGCAA
CACTCTAGGACCAGAAGGCATTGTCTGTGTGTCACAATACAGAGAGGATTGCAGGTGTCAGTGG
CAAGCCCAGCCCACAGAACCTTCCAAGCTCAACTGGTAAAGACCTAGAACTCAGGCAGGGGATA
TAATGGTGCAATGAGCTGTTCTTCTGGAGCCTTGTGGTGAAAGCTGCTGTTCCTGGGATGCTGA
GAGAGGCTCTTTGGAGGTGATTTCAATTCAACCGTGTTCTCTACCCAGCCTTACCCACACCTAC
TGGTCTCAGAGAAACACAAGCCAGAGCGGGAAAAAGGCAGACAGGACTCTTTTCCCAGAACCGT
ACAAGAAGAACAGAGGAATCATGTCCATGATCGCCGCTTTCTACAGCAACAAGTCTATCCTCAT
CACAGGGGCCACAGGCTTCCTGGGCAAGGTGCTCATGGAGAAGTTATTCCGTACCAGCCCCCAC
TTGAAAGTCATTTACATCCTCGTGAGACCCAAGTCTGGACAGACACTGCAGGAGAGGGTTTTCC
AGATCCTCAACAGTAAGCTGTTCGAGAGAGTCAAGGAAGTCTGTCCAAATGTGCACGAGAAGAT
CAGACCCATCTCTGCAGACCTCAACCAGCGTGACTTCGCCATCAGCAAGGAAGATATGCAAGAA
CTTCTGTCCTGCACCAACATCGTCTTCCACTGTGCAGCCACAGTGCGCTTTGATGCACATCTGA
GAGAAGCTGTGCAGCTGAACGTCACCGCCACCCAGCAGCTCCTGCTCATGGCCAGCGAGATGCC
AAAGCTGGAAGCCTTCATCCACATCTCCACTGCCTTTTCTAACTGCAACCTGAGCCACATCGAT
GAGGTCATCTACCCGTGCCCCGTGGAGCCGAGAAAGATCATTGACTCCATGGAGTGGTTAGATG
ACTCTATCATTGAAGAGATCACTCCCAAGCTAATTGGGGACCGGCCCAATACCTACACCTACAC
CAAAGCCTTGGGAGAGGTAGTTGTGCAGCAAGAGAGCGGAAACTTGAATGTGGCTATCGTCAGG
CCATCCATAGTGGGAGCAACCTGGCAGGAGCCTTTCCCGGGTTGGGTTGATAATCTAAATGGAC
CCAGTGGACTCATTATTGCGACTGGGAAAGGATTTCTTCGGTCCATAAAAGCAACACCCATGGC
AGTGGCAGATCTGATTCCAGTTGACACAGTTGTTAACCTCACCATAGCAGTAGGATGGTATACT
GCCGTTCATAGACCTAAGTCAACGTTAATCTACCATTCCACATCTGGCAATCTCAATCCCTGTA
ACTGGTACGAAATGGGATTACAGGTCTTGGCGACCGTCGAAAAGATCCCATTTGAGAGTGCTTT
CAGAAGGCCAAATGCTGACTTCACCACCAACAATTTCACTACCCAGTATTGGAACACCGTCAGC
CACTGGGCTCCGGCCATCATCTATGACTTCTATCTGAGGCTTACTGGAAGGAAACCCAGGATGC
TGAAGCTCATGAACCGGCTGCTAAAAACCATTTCCATGCTGGAGTATTTCATCAACCACAGCTG
GGAATGGAGCACAAACAACACTGAGATGCTTCTGTCAGAGCTCAGTCCTGAAGACCAGAGAGTA
TTCAACTTTGATGTGCGTCAGTTGAACTGGCTTGAATACATTGAGAATTATGTTTTGGGGGTTA
AGAAGTATCTACTGAAAGAGGATCTGGCTGGTATCCCCAAAGCAAAGCAACACCTAAAAAGGCT
CCGGAATATTCACTACCTCTTCAACACTGCCCTGTTTCTTATCATCTGGCGCCTCCTCATTGCA
AGGTCTCAGATGGCTCGGAACATCTGGTTCTTCATTGTGAGCTTCTGTTACAAGTTCATCTCCT
ACTTCCGGGCCTCCAGCACACTCAAGGTCTAAGAACATTATACCAGCCCATCATCTGGGACCTC
AGATACCTCTAAGGCAGTAAACTGGGTCTTAAGCTAGAAAGTAACAAGCAGCACACCAAGCTTC
CAGTCGAAGTTGCCATTCCATCTTCTTCCCTATTCTTGAGAGAGAGGGAGAGAGGGAGAGTATT
TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT

hide sequence

RefSeq Acc Id:

XM_039108896 ⟹ XP_038964824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	182,738,945 - 182,819,290 (+)	NCBI
mRatBN7.2	4	181,007,459 - 181,087,862 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414732	(Get FASTA)	NCBI Sequence Viewer
	XP_006237759	(Get FASTA)	NCBI Sequence Viewer
	XP_038964824	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01389	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002528.5

RefSeq Acc Id:	XP_006237759 ⟸ XM_006237697
- Peptide Label:	isoform X1
- UniProtKB:	D4A9Z0 (UniProtKB/TrEMBL), A6IN50 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSMIAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILVRPKSGQTLQERVFQILNSKL FERVKEVCPNVHEKIRPISADLNQRDFAISKEDMQELLSCTNIVFHCAATVRFDAHLREAVQLN VTATQQLLLMASEMPKLEAFIHISTAFSNCNLSHIDEVIYPCPVEPRKIIDSMEWLDDSIIEEI TPKLIGDRPNTYTYTKALGEVVVQQESGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIA TGKGFLRSIKATPMAVADLIPVDTVVNLTIAVGWYTAVHRPKSTLIYHSTSGNLNPCNWYEMGL QVLATVEKIPFESAFRRPNADFTTNNFTTQYWNTVSHWAPAIIYDFYLRLTGRKPRMLKLMNRL LKTISMLEYFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKE DLAGIPKAKQHLKRLRNIHYLFNTALFLIIWRLLIARSQMARNIWFFIVSFCYKFISYFRASST LKV hide sequence

Ensembl Acc Id:

ENSRNOP00000002528 ⟸ ENSRNOT00000002528

RefSeq Acc Id:	XP_038964824 ⟸ XM_039108896
- Peptide Label:	isoform X1
- UniProtKB:	D4A9Z0 (UniProtKB/TrEMBL), A6IN50 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001414732 ⟸ NM_001427803
- UniProtKB:	A6IN50 (UniProtKB/TrEMBL), D4A9Z0 (UniProtKB/TrEMBL)

Protein Domains

Fatty acyl-CoA reductase C-terminal Thioester reductase (TE)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A9Z0-F1-model_v2	AlphaFold	D4A9Z0	1-515	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565966	AgrOrtholog
BioCyc Gene	G2FUF-42409	BioCyc
Ensembl Genes	ENSRNOG00000001851	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002528.7	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	FAR	UniProtKB/TrEMBL
	FAR_C	UniProtKB/TrEMBL
	Male_sterile_NAD-bd	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:500368	UniProtKB/TrEMBL
NCBI Gene	500368	ENTREZGENE
PANTHER	FATTY ACYL-COA REDUCTASE 2	UniProtKB/TrEMBL
	PTHR11011	UniProtKB/TrEMBL
Pfam	NAD_binding_4	UniProtKB/TrEMBL
	Sterile	UniProtKB/TrEMBL
PhenoGen	Far2	PhenoGen
RatGTEx	ENSRNOG00000001851	RatGTEx
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A6IN50	ENTREZGENE, UniProtKB/TrEMBL
	D4A9Z0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-23	Far2	fatty acyl CoA reductase 2	Mlstd1	male sterility domain containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Mlstd1	male sterility domain containing 1	RGD1565966_predicted	similar to male sterility domain containing 1 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565966_predicted	similar to male sterility domain containing 1 (predicted)	LOC500368	similar to male sterility domain containing 1	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500368	similar to male sterility domain containing 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI