Far2 (fatty acyl CoA reductase 2) - Rat Genome Database

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Gene: Far2 (fatty acyl CoA reductase 2) Mus musculus
Analyze
Symbol: Far2
Name: fatty acyl CoA reductase 2
RGD ID: 1556953
MGI Page MGI
Description: Enables alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to act upstream of or within wax biosynthetic process. Located in peroxisome. Is expressed in alveolar sulcus; anterior naris; brain; ovary; and skin. Used to study alopecia and dry eye syndrome. Orthologous to human FAR2 (fatty acyl-CoA reductase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A230046P18; AW048109; BC055759; fatty acyl-CoA reductase 2; male sterility domain containing 1; male sterility domain-containing protein 1; MGC67167; Mlst; Mlstd1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396147,948,914 - 148,084,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6147,948,757 - 148,084,256 (+)EnsemblGRCm39 Ensembl
GRCm386148,047,416 - 148,182,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6148,047,259 - 148,182,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv376147,995,938 - 148,131,282 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366148,004,586 - 148,139,930 (+)NCBIMGSCv36mm8
Celera6151,079,635 - 151,214,866 (+)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:15220348   PMID:15220349   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17130451  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:24009241   PMID:24194600   PMID:24952961   PMID:25556833   PMID:27208706   PMID:27626380   PMID:28700664   PMID:29652635   PMID:30256126  
PMID:30372477   PMID:31220455   PMID:35238077   PMID:37660780  


Genomics

Comparative Map Data
Far2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396147,948,914 - 148,084,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6147,948,757 - 148,084,256 (+)EnsemblGRCm39 Ensembl
GRCm386148,047,416 - 148,182,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6148,047,259 - 148,182,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv376147,995,938 - 148,131,282 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366148,004,586 - 148,139,930 (+)NCBIMGSCv36mm8
Celera6151,079,635 - 151,214,866 (+)NCBICelera
Cytogenetic Map6G3NCBI
cM Map678.49NCBI
FAR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381229,149,278 - 29,335,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1229,149,016 - 29,341,121 (+)EnsemblGRCh38hg38GRCh38
GRCh371229,302,211 - 29,488,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,267,865 - 29,378,273 (+)NCBINCBI36Build 36hg18NCBI36
Build 341229,267,864 - 29,378,272NCBI
Celera1234,522,215 - 34,632,754 (+)NCBICelera
Cytogenetic Map12p11.22NCBI
HuRef1229,070,510 - 29,257,494 (+)NCBIHuRef
CHM1_11229,267,516 - 29,454,137 (+)NCBICHM1_1
T2T-CHM13v2.01229,021,810 - 29,208,149 (+)NCBIT2T-CHM13v2.0
Far2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84182,705,499 - 182,819,290 (+)NCBIGRCr8
mRatBN7.24180,973,968 - 181,087,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4181,007,622 - 181,087,255 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.04182,446,400 - 182,563,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4182,483,194 - 182,565,436 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04246,589,572 - 246,698,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44185,758,904 - 185,791,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4169,455,254 - 169,577,917 (+)NCBICelera
Cytogenetic Map4q44NCBI
Far2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555055,585,846 - 5,663,895 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555055,585,846 - 5,724,234 (-)NCBIChiLan1.0ChiLan1.0
FAR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21067,478,866 - 67,668,709 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11267,475,260 - 67,665,013 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01256,975,589 - 57,165,923 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11259,599,063 - 59,785,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1259,599,063 - 59,676,543 (-)Ensemblpanpan1.1panPan2
FAR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12718,659,688 - 18,791,757 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2718,661,449 - 18,792,253 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2727,618,455 - 27,750,457 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02718,851,338 - 18,983,048 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2718,852,272 - 18,983,051 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12718,661,033 - 18,792,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02718,685,805 - 18,817,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02727,773,948 - 27,905,644 (+)NCBIUU_Cfam_GSD_1.0
Far2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494580,529,346 - 80,667,427 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367601,362,364 - 1,409,418 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367601,265,803 - 1,406,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl544,381,129 - 44,559,374 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1544,386,808 - 44,559,506 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2547,705,595 - 47,904,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11128,869,987 - 29,049,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1128,987,566 - 29,046,448 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660695,985,117 - 6,176,706 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Far2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247786,456,008 - 6,493,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247786,456,396 - 6,642,551 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Far2
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:964
Count of miRNA genes:566
Interacting mature miRNAs:679
Transcripts:ENSMUST00000032443, ENSMUST00000111607
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128601582149588044Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128601582149588044Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128601582149588044Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129330484149588044Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129330484149588044Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129330484149588044Mouse
1301620Insq8_minsulin QTL 8 (mouse)Not determined6129534979149588044Mouse
1558959Eamcd2_mexperimental autoimmune myocarditis 2 (mouse)Not determined6129953954149588044Mouse
14746990Manh61_mmandible shape 61 (mouse)6130156355149588044Mouse
14746999Mancz6_mmandible centroid size 6 (mouse)6130156355149588044Mouse

Markers in Region
BB378162  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386148,176,039 - 148,176,125UniSTSGRCm38
MGSCv376148,124,561 - 148,124,647UniSTSGRCm37
Celera6151,208,145 - 151,208,231UniSTS
Cytogenetic Map6G3UniSTS
Whitehead/MRC_RH61491.31UniSTS
RH124714  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386148,181,380 - 148,181,478UniSTSGRCm38
MGSCv376148,129,902 - 148,130,000UniSTSGRCm37
Celera6151,213,486 - 151,213,584UniSTS
Cytogenetic Map6G3UniSTS
Mlstd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6G3UniSTS
cM Map6 UniSTS
UniSTS:235576  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386148,113,785 - 148,114,037UniSTSGRCm38
MGSCv376148,062,307 - 148,062,559UniSTSGRCm37
Celera6151,145,916 - 151,146,168UniSTS
Cytogenetic Map6G3UniSTS
UniSTS:235580  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386148,175,926 - 148,176,125UniSTSGRCm38
MGSCv376148,124,448 - 148,124,647UniSTSGRCm37
Celera6151,208,032 - 151,208,231UniSTS
Cytogenetic Map6G3UniSTS
AW048109  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386148,176,722 - 148,176,820UniSTSGRCm38
MGSCv376148,125,244 - 148,125,342UniSTSGRCm37
Celera6151,208,828 - 151,208,926UniSTS
Cytogenetic Map6G3UniSTS
Whitehead/MRC_RH61490.58UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032443   ⟹   ENSMUSP00000032443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6147,948,757 - 148,078,347 (+)Ensembl
GRCm38.p6 Ensembl6148,047,259 - 148,176,849 (+)Ensembl
RefSeq Acc Id: ENSMUST00000111607   ⟹   ENSMUSP00000107234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6147,948,914 - 148,084,256 (+)Ensembl
GRCm38.p6 Ensembl6148,047,416 - 148,182,758 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6147,948,913 - 147,951,070 (+)Ensembl
GRCm38.p6 Ensembl6148,047,415 - 148,049,572 (+)Ensembl
RefSeq Acc Id: NM_001347516   ⟹   NP_001334445
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396147,948,914 - 148,078,347 (+)NCBI
GRCm386148,047,416 - 148,176,849 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178797   ⟹   NP_848912
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396147,948,914 - 148,084,256 (+)NCBI
GRCm386148,047,416 - 148,182,758 (+)NCBI
MGSCv376147,995,938 - 148,131,282 (+)RGD
Celera6151,079,635 - 151,214,866 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006507070   ⟹   XP_006507133
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,010,903 - 148,078,347 (+)NCBI
GRCm386148,109,386 - 148,176,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036166257   ⟹   XP_036022150
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396148,018,183 - 148,078,347 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_848912   ⟸   NM_178797
- Peptide Label: isoform 2
- UniProtKB: Q7TNT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006507133   ⟸   XM_006507070
- Peptide Label: isoform X1
- UniProtKB: Q8BH72 (UniProtKB/Swiss-Prot),   Q3TTT7 (UniProtKB/Swiss-Prot),   B2KFC6 (UniProtKB/Swiss-Prot),   Q8CAK7 (UniProtKB/Swiss-Prot),   Q7TNT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001334445   ⟸   NM_001347516
- Peptide Label: isoform 1
- UniProtKB: Q8BH72 (UniProtKB/Swiss-Prot),   Q3TTT7 (UniProtKB/Swiss-Prot),   B2KFC6 (UniProtKB/Swiss-Prot),   Q8CAK7 (UniProtKB/Swiss-Prot),   Q7TNT2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000107234   ⟸   ENSMUST00000111607
RefSeq Acc Id: ENSMUSP00000032443   ⟸   ENSMUST00000032443
RefSeq Acc Id: XP_036022150   ⟸   XM_036166257
- Peptide Label: isoform X1
- UniProtKB: Q8BH72 (UniProtKB/Swiss-Prot),   Q7TNT2 (UniProtKB/Swiss-Prot),   Q3TTT7 (UniProtKB/Swiss-Prot),   B2KFC6 (UniProtKB/Swiss-Prot),   Q8CAK7 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNT2-F1-model_v2 AlphaFold Q7TNT2 1-515 view protein structure

Promoters
RGD ID:6891554
Promoter ID:EPDNEW_M9228
Type:multiple initiation site
Name:Far2_1
Description:Mus musculus fatty acyl CoA reductase 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9229  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386148,047,417 - 148,047,477EPDNEW
RGD ID:6891556
Promoter ID:EPDNEW_M9229
Type:multiple initiation site
Name:Far2_2
Description:Mus musculus fatty acyl CoA reductase 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9228  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386148,109,510 - 148,109,570EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2687035 AgrOrtholog
Ensembl Genes ENSMUSG00000030303 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032443 ENTREZGENE
  ENSMUST00000032443.14 UniProtKB/Swiss-Prot
  ENSMUST00000111607 ENTREZGENE
  ENSMUST00000111607.4 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro FAR UniProtKB/Swiss-Prot
  FAR_C UniProtKB/Swiss-Prot
  Male_sterile_NAD-bd UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:330450 UniProtKB/Swiss-Prot
MGD MGI:2687035 ENTREZGENE
NCBI Gene 330450 ENTREZGENE
PANTHER FATTY ACYL-COA REDUCTASE 2 UniProtKB/Swiss-Prot
  PTHR11011 UniProtKB/Swiss-Prot
Pfam NAD_binding_4 UniProtKB/Swiss-Prot
  Sterile UniProtKB/Swiss-Prot
PhenoGen Far2 PhenoGen
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt B2KFC6 ENTREZGENE
  FACR2_MOUSE UniProtKB/Swiss-Prot
  Q3TTT7 ENTREZGENE
  Q7TNT2 ENTREZGENE
  Q8BH72 ENTREZGENE
  Q8CAK7 ENTREZGENE
UniProt Secondary B2KFC6 UniProtKB/Swiss-Prot
  Q3TTT7 UniProtKB/Swiss-Prot
  Q8BH72 UniProtKB/Swiss-Prot
  Q8CAK7 UniProtKB/Swiss-Prot