FAR2 (fatty acyl-CoA reductase 2) - Rat Genome Database

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Gene: FAR2 (fatty acyl-CoA reductase 2) Homo sapiens
Analyze
Symbol: FAR2
Name: fatty acyl-CoA reductase 2
RGD ID: 1344680
HGNC Page HGNC
Description: Enables fatty-acyl-CoA reductase (alcohol-forming) activity. Involved in long-chain fatty-acyl-CoA metabolic process. Is integral component of peroxisomal membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: epididymis secretory protein Li 81; fatty acyl CoA reductase 2; FLJ10462; HEL-S-81; male sterility domain containing 1; male sterility domain-containing protein 1; MLSTD1; SDR10E2; short chain dehydrogenase/reductase family 10E, member 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC073869.7   FAR2P1   FAR2P2   FAR2P3   FAR2P4   LOC100420171   LOC100420172   LOC100420175  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1229,149,016 - 29,341,121 (+)EnsemblGRCh38hg38GRCh38
GRCh381229,149,101 - 29,335,617 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371229,302,211 - 29,488,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,267,865 - 29,378,273 (+)NCBINCBI36hg18NCBI36
Build 341229,267,864 - 29,378,272NCBI
Celera1234,522,215 - 34,632,754 (+)NCBI
Cytogenetic Map12p11.22NCBI
HuRef1229,070,510 - 29,257,494 (+)NCBIHuRef
CHM1_11229,267,516 - 29,454,137 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alopecia  (ISS)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:11230166   PMID:14702039   PMID:15220348   PMID:15220349   PMID:15489334   PMID:16344560   PMID:16756494   PMID:19027726   PMID:20379614   PMID:21873635   PMID:22139419   PMID:24108123  
PMID:26186194   PMID:28514442   PMID:29652635   PMID:31741433   PMID:32694731   PMID:33961781   PMID:34079125  


Genomics

Comparative Map Data
FAR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1229,149,016 - 29,341,121 (+)EnsemblGRCh38hg38GRCh38
GRCh381229,149,101 - 29,335,617 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371229,302,211 - 29,488,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,267,865 - 29,378,273 (+)NCBINCBI36hg18NCBI36
Build 341229,267,864 - 29,378,272NCBI
Celera1234,522,215 - 34,632,754 (+)NCBI
Cytogenetic Map12p11.22NCBI
HuRef1229,070,510 - 29,257,494 (+)NCBIHuRef
CHM1_11229,267,516 - 29,454,137 (+)NCBICHM1_1
Far2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396147,948,914 - 148,084,256 (+)NCBIGRCm39mm39
GRCm39 Ensembl6147,948,757 - 148,084,256 (+)Ensembl
GRCm386148,047,416 - 148,182,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6148,047,259 - 148,182,758 (+)EnsemblGRCm38mm10GRCm38
MGSCv376147,995,938 - 148,131,282 (+)NCBIGRCm37mm9NCBIm37
MGSCv366148,004,586 - 148,139,930 (+)NCBImm8
Celera6151,079,635 - 151,214,866 (+)NCBICelera
Cytogenetic Map6G3NCBI
Far2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24180,973,968 - 181,087,862 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4181,007,622 - 181,087,255 (+)Ensembl
Rnor_6.04182,446,400 - 182,563,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4182,483,194 - 182,565,436 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04246,589,572 - 246,698,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44185,758,904 - 185,791,596 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4169,455,254 - 169,577,917 (+)NCBICelera
Cytogenetic Map4q44NCBI
Far2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555055,585,846 - 5,663,895 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555055,585,846 - 5,724,234 (-)NCBIChiLan1.0ChiLan1.0
FAR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11259,599,063 - 59,785,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1259,599,063 - 59,676,543 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01256,975,589 - 57,165,923 (-)NCBIMhudiblu_PPA_v0panPan3
FAR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12718,659,688 - 18,791,757 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2718,661,449 - 18,792,253 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2727,618,455 - 27,750,457 (+)NCBI
ROS_Cfam_1.02718,851,338 - 18,983,048 (-)NCBI
UMICH_Zoey_3.12718,661,033 - 18,792,581 (-)NCBI
UNSW_CanFamBas_1.02718,685,805 - 18,817,601 (-)NCBI
UU_Cfam_GSD_1.02727,773,948 - 27,905,644 (+)NCBI
Far2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494580,529,346 - 80,667,427 (-)NCBI
SpeTri2.0NW_0049367601,265,803 - 1,406,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl544,381,009 - 44,558,744 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1544,386,808 - 44,559,506 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2547,705,595 - 47,904,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11128,869,987 - 29,049,421 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1128,987,566 - 29,046,448 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660695,985,117 - 6,176,706 (-)NCBIVero_WHO_p1.0
Far2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247786,456,396 - 6,642,551 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
WI-13845  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371229,453,244 - 29,453,343UniSTSGRCh37
Build 361229,344,511 - 29,344,610RGDNCBI36
Celera1234,598,985 - 34,599,084RGD
Cytogenetic Map12p11.22UniSTS
HuRef1229,222,199 - 29,222,298UniSTS
GeneMap99-GB4 RH Map12109.31UniSTS
Whitehead-RH Map12187.3UniSTS
NCBI RH Map12304.3UniSTS
SHGC-35864  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371229,484,387 - 29,484,512UniSTSGRCh37
Build 361229,375,654 - 29,375,779RGDNCBI36
Celera1234,630,135 - 34,630,260RGD
Cytogenetic Map12p11.22UniSTS
HuRef1229,253,332 - 29,253,457UniSTS
Stanford-G3 RH Map121373.0UniSTS
GeneMap99-GB4 RH Map12109.31UniSTS
Whitehead-RH Map12187.3UniSTS
NCBI RH Map12304.3UniSTS
GeneMap99-G3 RH Map121373.0UniSTS
RH94141  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371229,486,594 - 29,486,723UniSTSGRCh37
Build 361229,377,861 - 29,377,990RGDNCBI36
Celera1234,632,342 - 34,632,471RGD
Cytogenetic Map12p11.22UniSTS
HuRef1229,255,539 - 29,255,668UniSTS
GeneMap99-GB4 RH Map12111.38UniSTS
G62239  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371229,379,343 - 29,379,439UniSTSGRCh37
Build 361229,270,610 - 29,270,706RGDNCBI36
Celera1234,524,960 - 34,525,056RGD
Cytogenetic Map12p11.22UniSTS
HuRef1229,147,897 - 29,147,993UniSTS
STS-AA005136  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371229,434,554 - 29,434,789UniSTSGRCh37
Build 361229,325,821 - 29,326,056RGDNCBI36
Celera1234,580,297 - 34,580,531RGD
Cytogenetic Map12p11.22UniSTS
HuRef1229,203,564 - 29,203,798UniSTS
GeneMap99-GB4 RH Map12107.31UniSTS
WI-14934  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371229,488,399 - 29,488,523UniSTSGRCh37
Build 361229,379,666 - 29,379,790RGDNCBI36
Celera1234,634,147 - 34,634,271RGD
Cytogenetic Map12p11.22UniSTS
HuRef1229,257,344 - 29,257,468UniSTS
GeneMap99-GB4 RH Map12108.99UniSTS
Whitehead-RH Map12187.9UniSTS
NCBI RH Map12303.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1610
Count of miRNA genes:828
Interacting mature miRNAs:949
Transcripts:ENST00000182377, ENST00000536681, ENST00000547116, ENST00000547411, ENST00000547759, ENST00000549080, ENST00000550541, ENST00000551193, ENST00000551451, ENST00000552137
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 435 329 7 6 602 6 423 42 240 58 88 111 2 30 37 2
Low 1984 2579 1514 424 1295 264 3791 1945 3408 344 1325 1459 169 1174 2612 3
Below cutoff 8 76 199 191 25 192 141 204 60 9 29 25 1 1 139

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC012150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB217408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA068892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA848036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ472211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000182377   ⟹   ENSP00000182377
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,223,665 - 29,334,073 (+)Ensembl
RefSeq Acc Id: ENST00000536681   ⟹   ENSP00000443291
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,149,278 - 29,335,616 (+)Ensembl
RefSeq Acc Id: ENST00000547116   ⟹   ENSP00000449349
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,223,745 - 29,334,072 (+)Ensembl
RefSeq Acc Id: ENST00000547411
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,149,253 - 29,297,196 (+)Ensembl
RefSeq Acc Id: ENST00000547759   ⟹   ENSP00000447467
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,332,688 - 29,334,072 (+)Ensembl
RefSeq Acc Id: ENST00000549080
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,149,210 - 29,172,050 (+)Ensembl
RefSeq Acc Id: ENST00000550541
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,149,320 - 29,151,874 (+)Ensembl
RefSeq Acc Id: ENST00000551193   ⟹   ENSP00000449187
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,321,904 - 29,340,980 (+)Ensembl
RefSeq Acc Id: ENST00000551451   ⟹   ENSP00000450117
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,149,103 - 29,297,078 (+)Ensembl
RefSeq Acc Id: ENST00000552137   ⟹   ENSP00000449436
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1229,270,449 - 29,307,835 (+)Ensembl
RefSeq Acc Id: NM_001271783   ⟹   NP_001258712
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,149,278 - 29,335,616 (+)NCBI
HuRef1229,070,510 - 29,257,494 (+)NCBI
CHM1_11229,267,516 - 29,454,137 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271784   ⟹   NP_001258713
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,223,666 - 29,335,616 (+)NCBI
GRCh371229,301,936 - 29,488,549 (+)NCBI
HuRef1229,070,510 - 29,257,494 (+)NCBI
CHM1_11229,342,132 - 29,454,137 (+)NCBI
Sequence:
RefSeq Acc Id: NM_018099   ⟹   NP_060569
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,223,666 - 29,335,616 (+)NCBI
GRCh371229,301,936 - 29,488,549 (+)NCBI
Build 361229,267,865 - 29,378,273 (+)NCBI Archive
Celera1234,522,215 - 34,632,754 (+)RGD
HuRef1229,070,510 - 29,257,494 (+)NCBI
CHM1_11229,342,132 - 29,454,137 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011520747   ⟹   XP_011519049
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,208,512 - 29,335,616 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011520748   ⟹   XP_011519050
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,208,172 - 29,335,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017019624   ⟹   XP_016875113
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,149,101 - 29,335,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017019625   ⟹   XP_016875114
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,149,103 - 29,335,616 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_060569   ⟸   NM_018099
- Peptide Label: isoform 1
- UniProtKB: Q96K12 (UniProtKB/Swiss-Prot),   A0A024RAW7 (UniProtKB/TrEMBL),   B2RBI0 (UniProtKB/TrEMBL),   Q9NUX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258712   ⟸   NM_001271783
- Peptide Label: isoform 1
- UniProtKB: Q96K12 (UniProtKB/Swiss-Prot),   A0A024RAW7 (UniProtKB/TrEMBL),   B2RBI0 (UniProtKB/TrEMBL),   Q9NUX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258713   ⟸   NM_001271784
- Peptide Label: isoform 2
- UniProtKB: Q9NUX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011519050   ⟸   XM_011520748
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011519049   ⟸   XM_011520747
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016875113   ⟸   XM_017019624
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016875114   ⟸   XM_017019625
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000447467   ⟸   ENST00000547759
RefSeq Acc Id: ENSP00000449349   ⟸   ENST00000547116
RefSeq Acc Id: ENSP00000443291   ⟸   ENST00000536681
RefSeq Acc Id: ENSP00000182377   ⟸   ENST00000182377
RefSeq Acc Id: ENSP00000449187   ⟸   ENST00000551193
RefSeq Acc Id: ENSP00000450117   ⟸   ENST00000551451
RefSeq Acc Id: ENSP00000449436   ⟸   ENST00000552137
Protein Domains
NAD_binding_4   Sterile

Promoters
RGD ID:7223527
Promoter ID:EPDNEW_H17509
Type:initiation region
Name:FAR2_3
Description:fatty acyl-CoA reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17510  EPDNEW_H17511  EPDNEW_H17512  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,149,118 - 29,149,178EPDNEW
RGD ID:7223529
Promoter ID:EPDNEW_H17510
Type:initiation region
Name:FAR2_1
Description:fatty acyl-CoA reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17509  EPDNEW_H17511  EPDNEW_H17512  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,149,302 - 29,149,362EPDNEW
RGD ID:7223531
Promoter ID:EPDNEW_H17511
Type:single initiation site
Name:FAR2_4
Description:fatty acyl-CoA reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17509  EPDNEW_H17510  EPDNEW_H17512  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,179,574 - 29,179,634EPDNEW
RGD ID:7223533
Promoter ID:EPDNEW_H17512
Type:initiation region
Name:FAR2_2
Description:fatty acyl-CoA reductase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17509  EPDNEW_H17510  EPDNEW_H17511  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381229,223,666 - 29,223,726EPDNEW
RGD ID:6790038
Promoter ID:HG_KWN:15269
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_018099,   UC009ZJM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361229,267,701 - 29,268,201 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p12.1-11.21(chr12:21771052-32222232)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052783]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052783]|See cases [RCV000052783] Chr12:21771052..32222232 [GRCh38]
Chr12:21923986..32375166 [GRCh37]
Chr12:21815253..32266433 [NCBI36]
Chr12:12p12.1-11.21
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p11.22(chr12:28856455-29343246)x3 copy number gain See cases [RCV000053562] Chr12:28856455..29343246 [GRCh38]
Chr12:29009388..29496179 [GRCh37]
Chr12:28900655..29387446 [NCBI36]
Chr12:12p11.22
benign
NM_001271783.1(FAR2):c.189+10237T>C single nucleotide variant Lung cancer [RCV000110929] Chr12:29280875 [GRCh38]
Chr12:29433808 [GRCh37]
Chr12:12p11.22
uncertain significance
NM_001271783.1(FAR2):c.*345G>A single nucleotide variant Lung cancer [RCV000110930] Chr12:29334139 [GRCh38]
Chr12:29487072 [GRCh37]
Chr12:12p11.22
uncertain significance
GRCh38/hg38 12p12.1-11.1(chr12:25263833-34064528)x1 copy number loss See cases [RCV000133858] Chr12:25263833..34064528 [GRCh38]
Chr12:25416767..34217463 [GRCh37]
Chr12:25308034..34108730 [NCBI36]
Chr12:12p12.1-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12p11.22(chr12:28942339-29418625)x3 copy number gain See cases [RCV000141623] Chr12:28942339..29418625 [GRCh38]
Chr12:29095272..29571558 [GRCh37]
Chr12:28986539..29462825 [NCBI36]
Chr12:12p11.22
uncertain significance
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p11.22(chr12:29056626-29766989)x0 copy number loss See cases [RCV000449326] Chr12:29056626..29766989 [GRCh37]
Chr12:12p11.22
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p11.22-q12(chr12:29123400-40956186)x3 copy number gain See cases [RCV000512027] Chr12:29123400..40956186 [GRCh37]
Chr12:12p11.22-q12
likely pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1
likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p11.22(chr12:29426826-29630386)x3 copy number gain not provided [RCV000683401] Chr12:29426826..29630386 [GRCh37]
Chr12:12p11.22
uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11
pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21
pathogenic
GRCh37/hg19 12p11.22(chr12:29370200-29596365)x3 copy number gain not provided [RCV000750344] Chr12:29370200..29596365 [GRCh37]
Chr12:12p11.22
benign
NM_001271783.2(FAR2):c.1293G>A (p.Leu431=) single nucleotide variant not provided [RCV000920980] Chr12:29332635 [GRCh38]
Chr12:29485568 [GRCh37]
Chr12:12p11.22
benign
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p11.22(chr12:29274700-29458694)x1 copy number loss not provided [RCV000847700] Chr12:29274700..29458694 [GRCh37]
Chr12:12p11.22
uncertain significance
NM_001271783.2(FAR2):c.769-8C>T single nucleotide variant not provided [RCV000974472] Chr12:29311020 [GRCh38]
Chr12:29463953 [GRCh37]
Chr12:12p11.22
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25531 AgrOrtholog
COSMIC FAR2 COSMIC
Ensembl Genes ENSG00000064763 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000182377 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000443291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000447467 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000449187 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000449349 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000449436 UniProtKB/TrEMBL
  ENSP00000450117 UniProtKB/TrEMBL
Ensembl Transcript ENST00000182377 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000536681 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000547116 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000547759 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000551193 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000551451 UniProtKB/TrEMBL
  ENST00000552137 UniProtKB/TrEMBL
GTEx ENSG00000064763 GTEx
HGNC ID HGNC:25531 ENTREZGENE
Human Proteome Map FAR2 Human Proteome Map
InterPro FAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAR_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Male_sterile_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:55711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 55711 ENTREZGENE
OMIM 616156 OMIM
PANTHER PTHR11011 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NAD_binding_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sterile UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162388036 PharmGKB
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RAW7 ENTREZGENE, UniProtKB/TrEMBL
  B2RBI0 ENTREZGENE, UniProtKB/TrEMBL
  F8VPF2_HUMAN UniProtKB/TrEMBL
  F8VX60_HUMAN UniProtKB/TrEMBL
  FACR2_HUMAN UniProtKB/Swiss-Prot
  H0YHP1_HUMAN UniProtKB/TrEMBL
  H0YIE0_HUMAN UniProtKB/TrEMBL
  Q96K12 ENTREZGENE
  Q9NUX8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F8VV73 UniProtKB/Swiss-Prot
  Q9H0D5 UniProtKB/Swiss-Prot
  Q9NVW8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 FAR2  fatty acyl-CoA reductase 2    fatty acyl CoA reductase 2  Symbol and/or name change 5135510 APPROVED