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Gene: Lrrd1 (leucine-rich repeats and death domain containing 1) Rattus norvegicus

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Symbol:

Lrrd1

Name:

leucine-rich repeats and death domain containing 1

RGD ID:

1562785

Description:

Predicted to be involved in inflammatory response; innate immune response; and intracellular signal transduction. Orthologous to human LRRD1 (leucine rich repeats and death domain containing 1); INTERACTS WITH bisphenol A; methoxychlor; rotenone.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

leucine-rich repeat and death domain-containing protein 1; LOC296836; RGD1562785; similar to hypothetical protein 4932412H11

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	31,219,573 - 31,247,702 (-)	NCBI		GRCr8
mRatBN7.2	4	30,263,147 - 30,293,119 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	30,264,862 - 30,293,173 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	27,403,299 - 27,432,649 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	27,404,663 - 27,426,179 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	27,307,882 - 27,335,975 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	26,980,658 - 27,001,991 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	25,688,786 - 25,718,209 (-)	NCBI		Celera
Cytogenetic Map	4	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrd1	Rat	cerebral cavernous malformation		ISO	LRRD1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Cerebral cavernous malformation	ClinVar	PMID:10508515 more ...
Lrrd1	Rat	long QT syndrome		ISO	LRRD1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Long QT syndrome	ClinVar	PMID:28492532
Lrrd1	Rat	pleomorphic xanthoastrocytoma		ISO	LRRD1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma	ClinVar	PMID:28299358

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrd1	Rat	(-)-epigallocatechin 3-gallate	increases expression	ISO	LRRD1 (Homo sapiens)	6480464	epigallocatechin gallate results in increased expression of LRRD1 mRNA	CTD	PMID:32512070
Lrrd1	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	Lrrd1 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of LRRD1 mRNA	CTD	PMID:36331819
Lrrd1	Rat	2-palmitoylglycerol	increases expression	ISO	LRRD1 (Homo sapiens)	6480464	2-palmitoylglycerol results in increased expression of LRRD1 mRNA	CTD	PMID:37199045
Lrrd1	Rat	benzo[a]pyrene	increases methylation	ISO	LRRD1 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of LRRD1 exon and Benzo(a)pyrene results in increased methylation of LRRD1 promoter	CTD	PMID:27901495
Lrrd1	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Lrrd1 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of LRRD1 mRNA	CTD	PMID:34319233
Lrrd1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of LRRD1 mRNA	CTD	PMID:25181051
Lrrd1	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with tributyltin] results in increased expression of LRRD1 mRNA	CTD	PMID:31129395
Lrrd1	Rat	bisphenol F	decreases expression	ISO	Lrrd1 (Mus musculus)	6480464	bisphenol F results in decreased expression of LRRD1 mRNA	CTD	PMID:38685157
Lrrd1	Rat	cadmium dichloride	decreases expression	ISO	LRRD1 (Homo sapiens)	6480464	Cadmium Chloride results in decreased expression of LRRD1 mRNA	CTD	PMID:38382870
Lrrd1	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of LRRD1 gene	CTD	PMID:35440735
Lrrd1	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	Lrrd1 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of LRRD1 mRNA	CTD	PMID:36331819
Lrrd1	Rat	rotenone	increases expression	EXP		6480464	Rotenone results in increased expression of LRRD1 mRNA	CTD	PMID:28374803
Lrrd1	Rat	sodium arsenite	increases expression	ISO	LRRD1 (Homo sapiens)	6480464	sodium arsenite results in increased expression of LRRD1 mRNA	CTD	PMID:38568856
Lrrd1	Rat	tributylstannane	multiple interactions	EXP		6480464	[bisphenol A co-treated with tributyltin] results in increased expression of LRRD1 mRNA	CTD	PMID:31129395
Lrrd1	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of LRRD1 mRNA	CTD	PMID:33387578
Lrrd1	Rat	valproic acid	decreases expression	EXP		6480464	Valproic Acid results in decreased expression of LRRD1 mRNA	CTD	PMID:35594946

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Lrrd1	Rat	inflammatory response	involved_in	IBA	MGI:1098644 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lrrd1	Rat	innate immune response	involved_in	IBA	MGI:1098644 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Lrrd1	Rat	intracellular signal transduction	involved_in	IBA	MGI:103040 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Lrrd1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	31,219,573 - 31,247,702 (-)	NCBI		GRCr8
mRatBN7.2	4	30,263,147 - 30,293,119 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	30,264,862 - 30,293,173 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	4	27,403,299 - 27,432,649 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	27,404,663 - 27,426,179 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	27,307,882 - 27,335,975 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	26,980,658 - 27,001,991 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	25,688,786 - 25,718,209 (-)	NCBI		Celera
Cytogenetic Map	4	q13	NCBI

LRRD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	92,141,643 - 92,179,142 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	92,141,643 - 92,179,531 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	91,770,957 - 91,808,456 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Celera	7	86,478,757 - 86,499,146 (-)	NCBI		Celera
Cytogenetic Map	7	q21.2	NCBI
HuRef	7	86,381,635 - 86,401,962 (-)	NCBI		HuRef
CHM1_1	7	91,704,265 - 91,724,657 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	93,382,921 - 93,420,430 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	91,103,440 - 91,123,828 (-)	NCBI

Lrrd1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	3,895,173 - 3,916,596 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	3,895,173 - 3,916,596 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	3,845,173 - 3,866,596 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	3,845,173 - 3,866,596 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	3,845,173 - 3,866,596 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	3,851,179 - 3,872,602 (+)	NCBI		MGSCv36	mm8
Celera	5	3,781,462 - 3,802,885 (+)	NCBI		Celera
Cytogenetic Map	5	A1	NCBI
cM Map	5	2.26	NCBI

Lrrd1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	9,132,229 - 9,163,965 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	9,132,229 - 9,166,690 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRRD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	110,029,761 - 110,064,604 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	158,294,403 - 158,329,246 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	84,142,698 - 84,176,943 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	97,738,076 - 97,774,329 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	97,738,096 - 97,774,111 (-)	Ensembl	panpan1.1		panPan2

LRRD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	17,781,791 - 17,811,408 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	17,781,934 - 17,809,825 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	17,343,238 - 17,384,482 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	17,588,970 - 17,629,674 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	17,589,112 - 17,616,772 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	17,749,948 - 17,790,351 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	17,461,396 - 17,502,455 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	17,735,405 - 17,776,064 (-)	NCBI		UU_Cfam_GSD_1.0

Lrrd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	31,204,645 - 31,230,183 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936621	2,143,287 - 2,164,010 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	72,094,065 - 72,140,882 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	72,094,221 - 72,142,939 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LRRD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	56,834,845 - 56,856,287 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	56,835,305 - 56,856,108 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	47,409,335 - 47,430,673 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrd1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624809	1,052,811 - 1,067,622 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624809	1,052,787 - 1,067,770 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Lrrd1
97 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	128
Count of miRNA genes:	110
Interacting mature miRNAs:	115
Transcripts:	ENSRNOT00000032529
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
2303585	Bw86	Body weight QTL 86	4		body mass (VT:0001259)	body weight (CMO:0000012)	4	14678065	59678065	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	26775591	168368347	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
70222	Eae2	Experimental allergic encephalomyelitis QTL 2	4.3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	4	21333343	39505420	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	10814170	91360527	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
2313401	Anxrr27	Anxiety related response QTL 27			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	4	17933508	62933508	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	9940885	44463908	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	22710685	34430484	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	26907285	75585128	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
61412	Pia2	Pristane induced arthritis QTL 2	3.9		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	4	21333343	62278020	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	29494195	81006281	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
7387227	Uae40	Urinary albumin excretion QTL 40	2.9	0.0052	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	17946999	62946999	Rat
6909122	Insul22	Insulin level QTL 22	4.63		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	4	26907285	75585128	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
1354665	Stl10	Serum triglyceride level QTL 10	3.57		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	21333343	44463908	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10024901	39524530	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
4	3	45	87	24	27	3	14	3	3	85	67	76	8	42	24


RefSeq Transcripts	NM_001431710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001068373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_216085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC079990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000032529 ⟹ ENSRNOP00000038387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	30,264,862 - 30,293,173 (-)	Ensembl
Rnor_6.0 Ensembl	4	27,404,663 - 27,426,179 (-)	Ensembl

RefSeq Acc Id:

XM_039108581 ⟹ XP_038964509

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	31,219,573 - 31,232,824 (-)	NCBI
mRatBN7.2	4	30,263,147 - 30,277,912 (-)	NCBI

RefSeq Acc Id:

XM_216085 ⟹ XP_216085

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	31,219,573 - 31,247,702 (-)	NCBI
mRatBN7.2	4	30,263,147 - 30,293,119 (-)	NCBI
Rnor_6.0	4	27,403,299 - 27,432,649 (-)	NCBI
Rnor_5.0	4	27,307,882 - 27,335,975 (-)	NCBI
RGSC_v3.4	4	26,980,658 - 27,001,991 (-)	RGD

Sequence:

show sequence

ACCAGATCTCCAGAGCTGCAAGATCTCCCAAGGAGAGGACAGTCAACCAGCAAACTGCCCCACAGCTGACCAGAGATGGTTGCTGAGCGGTCGAATGACAGCAGGGCCCACCTAGTACCCCGCCTTGC
GACCAAAGCGAGCTCATAAACGCCAGAGGGAGGCGGGACACAACTGAGCCTGCGCAACCTCCATCGCCACAATCACGGACATTCGCCTCGCGGGCTCGCCTCCTGCAGGCTTCCGAGCGCCACAGGGA
GGCTCTGCGAGACTGATCTAAGGACTGCTAAGTTCTTTACTTGCCTCCATCCCCTCGCAGCACCAGCACCTTCACGCCCCCGGCCCACAGCTCCTAGTGTTTGCGTTCTGTCCCGTGCTGCTTTAGCC
GCCAAAGCTCAGCGATCTTCTCCCCACACCGGTCGAAGCAATTTGTTAATGTCACTAAAGTCTTGTAGTTACTTGGATGTCCACATCGTTCAGATAGGTTCAAAGGGGAAAAACACACGAAAAAGTAA
AGTTATAATCTGTTCGTACAAGAGTTACCCGTAAATAAGATGTCTGAAGATGGGAGTAATGTGGAGCCTGAAGGACTCACTAGATCTGAGTCACTGGAGGAGCCTGAATTTATTGATGAAATATCAGA
TCCCTCGAATGAAACCTCACCTCACTCTGGAAATACAGATTTCAACCAGATTTATGAATCAAATTCTTCAGAGAACACAGAACAGCCATCAGCTTCCTCCACAAGCCAGCTTAATGGAAATGAAGAGA
CAAACATAGAAATTCCATTTTCGGACACTAACATAGAAGAGGTCATCCCACTGTCAAACTCAGAAAGTCCGCAGAGCTCTGAGTCATCAGAGACTAACGAGGCTGAAGAATATCACCCAGTCAAATTC
CCAATTGGGAGGAAATTTAGAGGACGAACCTTTAATGGACACCACAAAGGATTTGACATGGAGTCTGATACCTTTACAGTTCATCTTGATGCCAAGGGTTTACAAGAATTCCCTGTAGACATTGTTAA
AGTCAAATATGTAAAATATTTATATTTAGATAAGAATCAAATAAAAACTTTCCAAGGGGCAGATCCAGGTGATCTGCTAGGACTTGAAACTCTGTCCTTGCAAGAAAATGGATTGTCATCGATTCCCC
AGGAAATTCAGTTGTTTCACAATTTAAAGGTACTAAATGCCAGTTACAACGAGATATCACATATCCCTAAAGAACTATTACAACTGGGGAATATGAGGCAACTCTTCTTAAATAGTAATCATATTGAA
TCTTTACCTTCTGGCTTAGAAAATCTTAGATATTTGGAAACTTTAAGTTTGGGTAAAAATAGGTTAACACATATACCAGACTCTTTGTGTGGTTTGAAAAATTTGAAAACTCTCAATCTGGAATATAA
CCAATTAACAATATTTTCTAAATCGCTATGCTTCCTTCCAAAACTCGTTTCCCTAAACCTTACTGGAAACATGATAGGCAGTTTGCCAAAAGAAGTTAGGGAACTGAAAAATTTAGAAAACCTTTTAA
TGAATCACAATAAACTTACTTTTTTGGCTGTGGAGATATTTCAGTTGCTCAAAATAAAAGAACTTCATCTAGCTGACAATAAATTGGAAGCCATTTCACCCAAAATTGAGAATTTCAAGGAACTCAGG
CTGCTCAACCTTGATAACAATTTATTGCAAAGCTTACCAAAGAAAATTTCCCACTGCGTAAACTTGGAATCTCTTACTCTCAGTGATAATAATTTAGAAGAACTTCCTAAGAAAATCCGAAAGCTTAA
AAATCTGAGACAACTCCATGCAAACAGAAATAAAATGATAAAAATGGCTGAAGAAATCTCACATCTTAGCAAGATACACAGCCTAGAGTTTTCAGGCAATCAAATCACACATGTTCCTATTGAAATAA
AAAACTGCAAAGAAATAACCAGAGTTGAATTGAATTATAACAACATAATGTATTTCCCAGTGGGGTTGTGTGCCTTACAGTCACTTGACTACTTGAGTTTTAATGGAAATTATATTTCAGAAATCCCT
GTGGATTTGTCATTCAGTAAGCAGCTGCTTCATTTAGAGTTGAATAAAAACAAGATCACCATATTTTCAGAACATTTATGTTCTCTCACTAATCTTGAATACCTGGATCTTGCTAAAAATCAAATAAG
GAAAATTCCTCACTGTATCTCTGCTATGTTATCACTCCATGTTCTCATTCTGTCTGATAATAAGTTCGAGATTTTCCCAAAGGAACTGTGTTCTTTAAAAAACTTGCAACTGCTTGATATTTCAGAAA
ATCAATTACATAAGATACCTTCAGAAATATCCAAACTGAAAAAGATCCAGAAGTTAAACTTGTCAAACAATAATTTCACACATTTTCCTGCTGAACTGTGCCAACTTCAAACTCTGGAGGACCTGAAT
ATAAGTCAGATAAGTGGGAAAAAGTTAACAAGACTTCCAGAAGAGGTGTCTCGTATGACTCAACTCAAAGCCCTCAATATTTCGAACAATGCAATCAAAGAGATTCCAAGAAATATAGGGGAGCTGAG
AAATCTCATTACTTTTCATGCAAGCAACAATCAAATAAATTCTCTTCCATCGTCCTTTCTGTCTTTAAACGTTCTACAGAGCCTAGATCTTGGAGGAAACAATCTGACAGATTTGCCCAGTGCTATCT
ACAAACTTTCATCTCTGAAAGAGATAAATTTTGATGACAATCCTTTGCTGAGACCTCCAATGGAAATCTGTAAAGGAAAACAGATGCATACAATCACTTGCTATCTCCAGAGAGCAGATGACAGAGAC
GAGAAAATCTTAGAGAAGATATTCCACATAGTTGCCAACAATATCACTGAAACAAAATTTGAATTTTTGCAACAAAAACTACACATGGCAAGGTCAGAAAACAGCGTCCCTGTAAAGACCACTACTCC
ATTAAATGAAGGAATCTACCAGGCATTACTTAAGTGGAAAACAGAGAAGAGGGTATCATTCACAGCTATTGCCTTAAAAGACCAACTTTTTCGGGCACTAAATATGATAGGTGCCTATGATATAATGG
ACAAGATCACAGCGTTGAACCTTTATACAAGCGCCATCAAACTGTAGCGTAAGGGATCTGAAATAGAAGCTGAAACCTTATCACACACTTACAGAATGGAAATCTGACCTCTGGGCTGTTTCATTTTT
GCTGATACAAGGAAATTATTTGCATATCCTCTCTCTATCTCTTTTGTTTCCTAGTAGTGTGTGGGTGTGTGGGTGTGCGTGCAAGGACGTGTGTGTGAGTGTGAATGTGACACAGTCGGCATGCGGAA
GTGAAAGGAAAACTTCCAGGTGTCAATGTTCTCCTTCCTTCCATCATGTGGTCCTGAGACTGAAGTGAGGTCATCAGGCTTAGCCTGCGTCATGTCTCTTTTTATTTATCGCTAAGAGATGCTGTCAA
TGTTTGTCTACCATTCTAGTTTTATCCAAACAAAAATATCACAGACATGGCTTCACATATTTTTTTGTTGCATTGGTAATGCTACTGAACTTGAAAACAATTCTATTAGGATTATTTTATTATAGTAC
TCTTACACGTCAAGATGTATGGGTAATAGGTTGGTGGTGATTTCCATTGAGTTGAGAAAGAAGAGAAGCTCCTGACTTATAATGAAAATGGTTTACCATCTCTGGTTCCCCTCATTTAGAAGTAGGAT
GTCTTCATTATCCATAAAATAGAGCCAGGGAGAGTATTACTTCAGCTTTGCGTCCTCATGGGTATGATGTCATAGGTAGCTTTTCCCTTCTGTCCTGTATTTTCCCTTTCTTCTGTTATCAGAAATTC
TCATTCATGAAGAATCTATTGCACATATTTTACACAGGTCTGTCCTTGTTGTATGTAACCTACTTTCCTCCTTTTTGAATCCACTAATGTTAAGGTCTGGTTGTCTTTGGCAATCCGTTTCAGTTAAG
TCATGTCAGTGAGTTTCCTTGGGATTTCCTGGAGTGCTTCCTGGGAAGGTGCACTCCTTTCATCGGGAGATTATGCATCTGGGAACATGCTGCCATCTACTCAGTGTTACATAGAGAAACTCAGAACC
CTAATTACATTGTTTGGACTTCAAATCCTAACATACCTGAAACTTACTGTGTTTCCAAACTCCCACTTTAACTCACTTAAATTGCCATGACTCGAATAGGGTTCTGTAACTTTGAATAAAAAGAGACC
AAATTTAGGTAATTAATAATATTGTAGACGCACTGCGGTTAAAATGTCATATGAGAACTAATTATAGAACAAATTTATCTTCCTGGTTAGAGTTTGTGTATATTTTTTCAGTTGTAAAATGTTTTCTA
AAATATTGGTTCAACAGAAAAAAACCTATATCTCTAATCTTAAAATATTTTTCCAATATTACTACCCTGCAAATATATTAACTTAGTGTCAGCTGCTGTTTCATATACCTCCTTGGAAGTGGGGATAT
TTTCACAGAATAGTAAAGTAAAAAGGACCTTGCCGAATTACCTATTGATTTCAGATCACCCTGCAACCTGAACAAAATTAGACCTAGAAATCATGAATGCTATGAGTGTGTGTGTG

hide sequence


Protein RefSeqs	NP_001418639	(Get FASTA)	NCBI Sequence Viewer
	XP_038964509	(Get FASTA)	NCBI Sequence Viewer
	XP_216085	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL84357	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000038387
	ENSRNOP00000038387.5

RefSeq Acc Id:	XP_216085 ⟸ XM_216085
- Peptide Label:	isoform X1
- UniProtKB:	D4AD14 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEDGSNVEPEGLTRSESLEEPEFIDEISDPSNETSPHSGNTDFNQIYESNSSENTEQPSASSTSQLNGNEETNIEIPFSDTNIEEVIPLSNSESPQSSESSETNEAEEYHPVKFPIGRKFRGRTFNG HHKGFDMESDTFTVHLDAKGLQEFPVDIVKVKYVKYLYLDKNQIKTFQGADPGDLLGLETLSLQENGLSSIPQEIQLFHNLKVLNASYNEISHIPKELLQLGNMRQLFLNSNHIESLPSGLENLRYLE TLSLGKNRLTHIPDSLCGLKNLKTLNLEYNQLTIFSKSLCFLPKLVSLNLTGNMIGSLPKEVRELKNLENLLMNHNKLTFLAVEIFQLLKIKELHLADNKLEAISPKIENFKELRLLNLDNNLLQSLP KKISHCVNLESLTLSDNNLEELPKKIRKLKNLRQLHANRNKMIKMAEEISHLSKIHSLEFSGNQITHVPIEIKNCKEITRVELNYNNIMYFPVGLCALQSLDYLSFNGNYISEIPVDLSFSKQLLHLE LNKNKITIFSEHLCSLTNLEYLDLAKNQIRKIPHCISAMLSLHVLILSDNKFEIFPKELCSLKNLQLLDISENQLHKIPSEISKLKKIQKLNLSNNNFTHFPAELCQLQTLEDLNISQISGKKLTRLP EEVSRMTQLKALNISNNAIKEIPRNIGELRNLITFHASNNQINSLPSSFLSLNVLQSLDLGGNNLTDLPSAIYKLSSLKEINFDDNPLLRPPMEICKGKQMHTITCYLQRADDRDEKILEKIFHIVAN NITETKFEFLQQKLHMARSENSVPVKTTTPLNEGIYQALLKWKTEKRVSFTAIALKDQLFRALNMIGAYDIMDKITALNLYTSAIKL hide sequence

Ensembl Acc Id:

ENSRNOP00000038387 ⟸ ENSRNOT00000032529

RefSeq Acc Id:	XP_038964509 ⟸ XM_039108581
- Peptide Label:	isoform X2

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4AD14-F1-model_v2	AlphaFold	D4AD14	1-855	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-45770	BioCyc
Ensembl Genes	ENSRNOG00000026196	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000032529	ENTREZGENE
	ENSRNOT00000032529.7	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_domain-containing	UniProtKB/TrEMBL
NCBI Gene	296836	ENTREZGENE
PANTHER	NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE-RELATED	UniProtKB/TrEMBL
	PTHR48051	UniProtKB/TrEMBL
Pfam	LRR_1	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PhenoGen	Lrrd1	PhenoGen
PROSITE	LRR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000026196	RatGTEx
SMART	LRR_BAC	UniProtKB/TrEMBL
	LRR_SD22	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
UniProt	D4AD14	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-06-10	Lrrd1	leucine-rich repeats and death domain containing 1	RGD1562785	similar to hypothetical protein 4932412H11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1562785	similar to hypothetical protein 4932412H11	RGD1562785_predicted	similar to hypothetical protein 4932412H11 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1562785_predicted	similar to hypothetical protein 4932412H11 (predicted)	LOC296836	similar to hypothetical protein 4932412H11	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC296836	similar to hypothetical protein 4932412H11			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar