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Gene: Flt3l (FMS-like tyrosine kinase 3 ligand) Mus musculus
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Symbol: Flt3l
Name: FMS-like tyrosine kinase 3 ligand
Description: Exhibits protein homodimerization activity and receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of macromolecule metabolic process. Localizes to the extracellular space and intrinsic component of external side of plasma membrane. Human ortholog(s) of this gene implicated in colon carcinoma; glioblastoma multiforme; and malignant glioma. Is expressed in several structures, including central nervous system; liver; retina; spleen; and yolk sac. Orthologous to human FLT3LG (fms related tyrosine kinase 3 ligand); INTERACTS WITH 3,4-methylenedioxymethamphetamine; acrolein; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: flt3 ligand; Flt3lg; fms-related tyrosine kinase 3 ligand; Ly72L; SL cytokine
Orthologs:
Homo sapiens (human) : FLT3LG (fms related tyrosine kinase 3 ligand)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flt3lg (fms-related tyrosine kinase 3 ligand)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt3lg (fms related tyrosine kinase 3 ligand)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT3LG (fms related tyrosine kinase 3 ligand)
Canis lupus familiaris (dog) : FLT3LG (fms related tyrosine kinase 3 ligand)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt3lg (fms related tyrosine kinase 3 ligand)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38745,131,183 - 45,136,490 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37752,386,559 - 52,391,802 (-)NCBIGRCm37mm9NCBIm37
MGSCv36744,999,456 - 45,004,327 (-)NCBImm8
Celera740,584,281 - 40,589,522 (-)NCBICelera
Cytogenetic Map7 B3NCBI
cM Map729.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Flt3l
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557069
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.