Spink4 (serine peptidase inhibitor, Kazal type 4) - Rat Genome Database

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Gene: Spink4 (serine peptidase inhibitor, Kazal type 4) Mus musculus
Analyze
Symbol: Spink4
Name: serine peptidase inhibitor, Kazal type 4
RGD ID: 1553095
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in brain ventricular layer; ganglia; liver lobe; and olfactory epithelium. Orthologous to human SPINK4 (serine peptidase inhibitor Kazal type 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MPGC6; MPGC60; peptide PEC-60 homolog; serine protease inhibitor Kazal-type 4; serine protease inhibitor, Kazal type 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,920,056 - 40,931,395 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,920,052 - 40,931,395 (+)EnsemblGRCm39 Ensembl
GRCm38440,920,056 - 40,931,395 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,920,052 - 40,931,395 (+)EnsemblGRCm38mm10GRCm38
MGSCv37440,867,089 - 40,878,428 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,095,937 - 41,143,924 (+)NCBIMGSCv36mm8
Celera440,580,572 - 40,591,997 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9810707   PMID:12477932   PMID:14610273   PMID:16602821   PMID:17062627   PMID:18554416   PMID:19549527   PMID:20562862   PMID:21267068   PMID:37013514   PMID:38997284  


Genomics

Comparative Map Data
Spink4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,920,056 - 40,931,395 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,920,052 - 40,931,395 (+)EnsemblGRCm39 Ensembl
GRCm38440,920,056 - 40,931,395 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,920,052 - 40,931,395 (+)EnsemblGRCm38mm10GRCm38
MGSCv37440,867,089 - 40,878,428 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,095,937 - 41,143,924 (+)NCBIMGSCv36mm8
Celera440,580,572 - 40,591,997 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.64NCBI
SPINK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38933,240,167 - 33,248,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl933,218,365 - 33,248,567 (+)EnsemblGRCh38hg38GRCh38
GRCh37933,240,165 - 33,248,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36933,230,196 - 33,238,565 (+)NCBINCBI36Build 36hg18NCBI36
Build 34933,230,195 - 33,238,564NCBI
Celera933,170,395 - 33,178,768 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef933,197,153 - 33,205,532 (+)NCBIHuRef
CHM1_1933,239,128 - 33,247,497 (+)NCBICHM1_1
T2T-CHM13v2.0933,258,882 - 33,267,284 (+)NCBIT2T-CHM13v2.0
Spink4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,811,899 - 60,860,823 (+)NCBIGRCr8
mRatBN7.2556,043,936 - 56,064,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,981,624 - 56,064,795 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,010,977 - 58,031,900 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,830,126 - 59,851,051 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,824,235 - 59,845,122 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,238,221 - 57,252,654 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,239,086 - 57,250,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0561,770,297 - 61,782,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4558,314,305 - 58,325,973 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1558,314,483 - 58,326,152 (+)NCBI
Celera554,664,999 - 54,676,599 (+)NCBICelera
Cytogenetic Map5q22NCBI
Spink4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554722,406,279 - 2,415,668 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554722,406,279 - 2,415,668 (-)NCBIChiLan1.0ChiLan1.0
SPINK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,353,771 - 91,358,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1991,359,713 - 91,364,695 (-)NCBINHGRI_mPanPan1
SPINK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,340,068 - 50,345,777 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,340,145 - 50,345,777 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1148,967,880 - 48,975,762 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01151,277,984 - 51,285,866 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,278,074 - 51,285,866 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,942,377 - 49,950,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,809,310 - 49,817,196 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,574,406 - 50,582,288 (+)NCBIUU_Cfam_GSD_1.0
Spink4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,237,296 - 165,243,461 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,785,415 - 1,790,954 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,784,805 - 1,789,464 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,246,247 - 33,255,688 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11033,246,260 - 33,255,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21037,503,380 - 37,512,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Spink4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473637,998,891 - 38,008,535 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473637,988,002 - 38,010,277 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink4
394 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:338
Count of miRNA genes:260
Interacting mature miRNAs:286
Transcripts:ENSMUST00000030122, ENSMUST00000132943
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
4142290Ssrq9_mstress response QTL 9 (mouse)Not determined3439516046332776Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse

Markers in Region
D4Mit195  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38440,937,840 - 40,937,943UniSTSGRCm38
MGSCv37440,884,873 - 40,884,976UniSTSGRCm37
Celera440,598,514 - 40,598,621UniSTS
Cytogenetic Map4AUniSTS
Cytogenetic Map4B1UniSTS
cM Map412.1UniSTS
Whitehead Genetic416.4UniSTS
Whitehead_YAC4 UniSTS
Bag1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38440,936,446 - 40,936,651UniSTSGRCm38
MGSCv37440,883,479 - 40,883,684UniSTSGRCm37
Celera440,597,120 - 40,597,325UniSTS
Cytogenetic Map4AUniSTS
Cytogenetic Map4B1UniSTS
cM MapUN UniSTS
cM Map4 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000030122   ⟹   ENSMUSP00000030122
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl440,920,052 - 40,931,395 (+)Ensembl
GRCm38.p6 Ensembl440,920,052 - 40,931,395 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132943
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl440,920,054 - 40,925,044 (+)Ensembl
GRCm38.p6 Ensembl440,920,054 - 40,925,044 (+)Ensembl
RefSeq Acc Id: NM_011463   ⟹   NP_035593
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39440,920,056 - 40,931,395 (+)NCBI
GRCm38440,920,056 - 40,931,395 (+)ENTREZGENE
MGSCv37440,867,089 - 40,878,428 (+)RGD
Celera440,580,572 - 40,591,997 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_035593 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI17049 (Get FASTA)   NCBI Sequence Viewer  
  AAI17051 (Get FASTA)   NCBI Sequence Viewer  
  CAA72282 (Get FASTA)   NCBI Sequence Viewer  
  EDL05424 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000030122
  ENSMUSP00000030122.5
GenBank Protein O35679 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035593   ⟸   NM_011463
- Peptide Label: precursor
- UniProtKB: Q149Z4 (UniProtKB/Swiss-Prot),   O35679 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000030122   ⟸   ENSMUST00000030122
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35679-F1-model_v2 AlphaFold O35679 1-86 view protein structure

Promoters
RGD ID:6883066
Promoter ID:EPDNEW_M4984
Type:multiple initiation site
Name:Spink4_1
Description:Mus musculus serine peptidase inhibitor, Kazal type 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38440,920,056 - 40,920,116EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341848 AgrOrtholog
Ensembl Genes ENSMUSG00000028415 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000030122 ENTREZGENE
  ENSMUST00000030122.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
InterPro Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Spink4-like UniProtKB/Swiss-Prot
KEGG Report mmu:20731 UniProtKB/Swiss-Prot
MGD MGI:1341848 ENTREZGENE
NCBI Gene 20731 ENTREZGENE
PANTHER PTHR21179 UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 4 UniProtKB/Swiss-Prot
Pfam Kazal_1 UniProtKB/Swiss-Prot
PharmGKB SPINK4 RGD
PhenoGen Spink4 PhenoGen
PROSITE KAZAL_1 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
SMART KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
UniProt ISK4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q149Z4 ENTREZGENE
UniProt Secondary Q149Z4 UniProtKB/Swiss-Prot