Spink4 (serine peptidase inhibitor Kazal type 4)

Gene: Spink4 (serine peptidase inhibitor Kazal type 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Spink4

Name:

serine peptidase inhibitor Kazal type 4 (Ensembl:serine peptidase inhibitor, Kazal type 4)

RGD ID:

12611522

Description:

ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN response to xenobiotic stimulus (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); distal arthrogryposis type 1A (ortholog); frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ortholog); FOUND IN extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine peptidase inhibitor, Kazal type 4; serine protease inhibitor Kazal-type 4

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	165,237,296 - 165,243,461 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	1,785,415 - 1,790,954 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	1,784,805 - 1,789,464 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

genetic disease (ISO)

primary ciliary dyskinesia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

response to xenobiotic stimulus (ISO)

Cellular Component

extracellular region (IEA)

Molecular Function

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Spink4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	165,237,296 - 165,243,461 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	1,785,415 - 1,790,954 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	1,784,805 - 1,789,464 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	33,240,167 - 33,248,567 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	33,218,365 - 33,248,567 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	33,240,165 - 33,248,565 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	33,230,196 - 33,238,565 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	33,230,195 - 33,238,564	NCBI
Celera	9	33,170,395 - 33,178,768 (+)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	33,197,153 - 33,205,532 (+)	NCBI		HuRef
CHM1_1	9	33,239,128 - 33,247,497 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	33,258,882 - 33,267,284 (+)	NCBI		T2T-CHM13v2.0

Spink4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	40,920,056 - 40,931,395 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	40,920,052 - 40,931,395 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	40,920,056 - 40,931,395 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	40,920,052 - 40,931,395 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	40,867,089 - 40,878,428 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	41,095,937 - 41,143,924 (+)	NCBI		MGSCv36	mm8
Celera	4	40,580,572 - 40,591,997 (+)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	20.64	NCBI

Spink4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	60,811,899 - 60,860,823 (+)	NCBI		GRCr8
mRatBN7.2	5	56,043,936 - 56,064,841 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	55,981,624 - 56,064,795 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	58,010,977 - 58,031,900 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	59,830,126 - 59,851,051 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	59,824,235 - 59,845,122 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	57,238,221 - 57,252,654 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	57,239,086 - 57,250,662 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	61,770,297 - 61,782,009 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	58,314,305 - 58,325,973 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	58,314,483 - 58,326,152 (+)	NCBI
Celera	5	54,664,999 - 54,676,599 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Spink4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	2,406,279 - 2,415,668 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	2,406,279 - 2,415,668 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPINK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	91,353,771 - 91,358,753 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	91,359,713 - 91,364,695 (-)	NCBI		NHGRI_mPanPan1

SPINK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	50,340,068 - 50,345,777 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	50,340,145 - 50,345,777 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	48,967,880 - 48,975,762 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	51,277,984 - 51,285,866 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	51,278,074 - 51,285,866 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	49,942,377 - 49,950,251 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	49,809,310 - 49,817,196 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	50,574,406 - 50,582,288 (+)	NCBI		UU_Cfam_GSD_1.0

SPINK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	33,246,247 - 33,255,688 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	33,246,260 - 33,255,617 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	37,503,380 - 37,512,763 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Spink4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	37,998,891 - 38,008,535 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	37,988,002 - 38,010,277 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021726923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006961 ⟹ ENSSTOP00000006222

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936524	1,785,415 - 1,790,954 (+)	Ensembl

RefSeq Acc Id:

XM_021726923 ⟹ XP_021582598

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	165,237,296 - 165,243,461 (+)	NCBI
SpeTri2.0	NW_004936524	1,784,805 - 1,789,464 (+)	NCBI

Sequence:

show sequence

TTTATCTGCTGGTCATGCCCACTTCATGGCACCAAAAAATAAGTAAAAAGAATCAGTTTTGTTT
ATATTTCTCTCACTGCATACTTAACAAATGTTTCCCATCTGCTCTCACCAATCCAGTTTCACAG
CTCTTCTGGGAGAGAGGCTGAGTCAGCATTATCATCTCTTGTTTTGTGCACAGAAAAACTGAGG
CCCAGTTAAGAAAAATGGCTTTCCTAAGTCACAGGGAAGTACTGACAAAGGTATCCATGACTCC
AGCCCCCTTTCTCTGCCTCCTCCTACTTGCTGTTTTTTCTGTTCTTTCTCTTCCCTTTTCTTTT
TAATTCAACTACCCTGTCCTTGCTCCAATCTACTTTGCAAGTTATCCAAACATTTGCTCCCTCC
AGAAATCTGCCATTCTCATAGCCACAGCTCCATGTCACCAGAAACTCAGAATATTTACCTTGAA
CCAGCCCTTTCCTGGTTCCAGGATGCAGGGATTAACTTGAGGTGACGCTCTTGTCTCCAACTGG
TCCCAGATAAGGGTGGGGATCAGCACTATAAACACGTTTCCATCCTTCCTTGCCACCCAGGCCC
CAGTTAGCTTGGGCCACACCAGCTCAGGATCAGCATGGCCTTCCGTCTATGGGTGGTCACCCTG
GCCTTGGTTGCCCTCCTCGCTCTGGACACGGAGGTTCCAGTGTCAGCAAGAAAGCGCATTTTCT
CAAGAATGCCCATCTGTGAGCACATGACAGAGCCTCCAAATTGTTCCCAGACACCAAACCTCGT
CTGTGGCACTGATGGGGTCACATACAACAGTGAATGTCATCTCTGCTTGACCCGAATGTAAGAC
CTCCCAACTCAGCTTGCTTGGGTAGGCCCCATCTTGGCTGCACACAAATCTGAAAAGAGAAAAG
AATTGACCTCCTTCTTCCTTCACACATGCTTGGCCTGAGGAATAGTGACATTTACTCTTAACAT
AATAAGCCAAAATATAATTGAAAGAGGGGGCATGATTCCAAGCAGAAATCCAGAAGCTGGTGGG
GGTGGAGGAGAGGGGCCAGAAACCCTGG

hide sequence

Protein Sequences


Protein RefSeqs	XP_021582598	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006222.2
GenBank Protein	KAG3287377	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_021582598 ⟸ XM_021726923
- UniProtKB:	I3M8V3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFRLWVVTLALVALLALDTEVPVSARKRIFSRMPICEHMTEPPNCSQTPNLVCGTDGVTYNSE CHLCLTRM hide sequence

RefSeq Acc Id:

ENSSTOP00000006222 ⟸ ENSSTOT00000006961

Protein Domains

Kazal-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006971	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006961.3	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.30	UniProtKB/TrEMBL
InterPro	Kazal_dom	UniProtKB/TrEMBL
	Kazal_dom_sf	UniProtKB/TrEMBL
	Spink4-like	UniProtKB/TrEMBL
NCBI Gene	Spink4	ENTREZGENE
PANTHER	PTHR21179	UniProtKB/TrEMBL
	SERINE PROTEASE INHIBITOR KAZAL-TYPE 4	UniProtKB/TrEMBL
Pfam	Kazal_1	UniProtKB/TrEMBL
PROSITE	KAZAL_1	UniProtKB/TrEMBL
	KAZAL_2	UniProtKB/TrEMBL
SMART	KAZAL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF100895	UniProtKB/TrEMBL
UniProt	I3M8V3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-10-08	Spink4	serine peptidase inhibitor Kazal type 4	Spink4	serine peptidase inhibitor, Kazal type 4	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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