Marchf8 (membrane associated ring-CH-type finger 8) - Rat Genome Database

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Gene: Marchf8 (membrane associated ring-CH-type finger 8) Mus musculus
Analyze
Symbol: Marchf8
Name: membrane associated ring-CH-type finger 8
RGD ID: 1551233
MGI Page MGI
Description: Enables MHC class II protein binding activity and ubiquitin protein ligase activity. Involved in antigen processing and presentation of peptide antigen via MHC class II; negative regulation of MHC class II biosynthetic process; and protein ubiquitination. Predicted to be located in endosome. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Orthologous to human MARCHF8 (membrane associated ring-CH-type finger 8).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 1300017E09Rik; c-mir, cellular modulator of immune recognition; cellular modulator of immune recognition; E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCHF8; M; Marc; MARCH-VIII; March8; membrane-associated ring finger (C3HC4) 8; membrane-associated RING finger protein 8; membrane-associated RING-CH protein VIII; Mir; RING-type E3 ubiquitin transferase MARCH8; RING-type E3 ubiquitin transferase MARCHF8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,312,546 - 116,386,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6116,314,985 - 116,386,501 (+)EnsemblGRCm39 Ensembl
GRCm386116,337,599 - 116,409,540 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,338,024 - 116,409,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv376116,288,141 - 116,359,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366116,303,742 - 116,375,159 (+)NCBIMGSCv36mm8
Celera6118,176,248 - 118,247,139 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16785530  
PMID:17967808   PMID:18799693   PMID:21393633   PMID:21873635   PMID:27503069   PMID:27503071   PMID:30104731   PMID:34285233   PMID:35411049   PMID:35503863   PMID:37747937  


Genomics

Comparative Map Data
Marchf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,312,546 - 116,386,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6116,314,985 - 116,386,501 (+)EnsemblGRCm39 Ensembl
GRCm386116,337,599 - 116,409,540 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,338,024 - 116,409,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv376116,288,141 - 116,359,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366116,303,742 - 116,375,159 (+)NCBIMGSCv36mm8
Celera6118,176,248 - 118,247,139 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.78NCBI
MARCHF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,454,585 - 45,594,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1045,454,585 - 45,594,906 (-)EnsemblGRCh38hg38GRCh38
GRCh371045,950,033 - 46,090,355 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,272,823 - 45,410,360 (-)NCBINCBI36Build 36hg18NCBI36
Build 341045,272,822 - 45,410,360NCBI
Celera1041,950,772 - 42,088,280 (-)NCBICelera
Cytogenetic Map10q11.21-q11.22NCBI
HuRef1042,478,465 - 42,614,172 (-)NCBIHuRef
CHM1_11045,992,033 - 46,129,577 (-)NCBICHM1_1
T2T-CHM13v2.01046,335,573 - 46,475,913 (-)NCBIT2T-CHM13v2.0
Marchf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84151,086,076 - 151,203,205 (+)NCBIGRCr8
mRatBN7.24149,415,642 - 149,530,771 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4149,416,071 - 149,530,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4155,645,156 - 155,762,684 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04151,429,191 - 151,546,718 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04150,052,095 - 150,169,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04148,285,467 - 148,398,148 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,286,853 - 148,398,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,232,430 - 214,345,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,494,801 - 152,609,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,786,633 - 152,851,226 (+)NCBI
Celera4138,301,019 - 138,414,819 (+)NCBICelera
Cytogenetic Map4q42NCBI
Marchf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555462,558,027 - 2,641,108 (-)NCBIChiLan1.0ChiLan1.0
MARCHF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,279,383 - 58,418,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,284,712 - 58,423,857 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01042,539,079 - 42,677,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11045,718,172 - 45,856,328 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1045,718,172 - 45,796,771 (-)Ensemblpanpan1.1panPan2
MARCHF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,006,923 - 2,165,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,072,181 - 2,161,981 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,240,660 - 2,399,732 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,184,859 - 2,344,207 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,185,150 - 2,344,204 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,981,227 - 2,141,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,019,033 - 2,178,318 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0282,150,933 - 2,310,134 (+)NCBIUU_Cfam_GSD_1.0
Marchf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721378,824,923 - 78,952,602 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493672827,658 - 32,174 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCHF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,725,574 - 90,854,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,725,550 - 90,854,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,768,503 - 98,901,744 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MARCHF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,157,445 - 41,294,277 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048836,596 - 978,252 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marchf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624966225,855 - 318,633 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Marchf8
2381 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3660
Count of miRNA genes:812
Interacting mature miRNAs:1102
Transcripts:ENSMUST00000079012, ENSMUST00000101032, ENSMUST00000123246, ENSMUST00000123405, ENSMUST00000126376, ENSMUST00000127992, ENSMUST00000129170, ENSMUST00000130445, ENSMUST00000135901, ENSMUST00000140884, ENSMUST00000156014
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
8552704Cia43_mcollagen induced arthritis QTL 43 (mouse)Not determined6114159241119737532Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse

Markers in Region
UniSTS:235531  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386116,409,229 - 116,409,491UniSTSGRCm38
MGSCv376116,359,247 - 116,359,509UniSTSGRCm37
Celera6118,246,828 - 118,247,090UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001302383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_027920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ770041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000079012   ⟹   ENSMUSP00000078024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,314,985 - 116,386,501 (+)Ensembl
GRCm38.p6 Ensembl6116,338,024 - 116,409,540 (+)Ensembl
RefSeq Acc Id: ENSMUST00000101032   ⟹   ENSMUSP00000098594
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,314,994 - 116,386,501 (+)Ensembl
GRCm38.p6 Ensembl6116,338,033 - 116,409,540 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123246
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,363,211 - 116,383,095 (+)Ensembl
GRCm38.p6 Ensembl6116,386,250 - 116,406,134 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123405   ⟹   ENSMUSP00000144936
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,314,995 - 116,383,317 (+)Ensembl
GRCm38.p6 Ensembl6116,338,034 - 116,406,356 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126376   ⟹   ENSMUSP00000145270
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,315,025 - 116,353,763 (+)Ensembl
GRCm38.p6 Ensembl6116,338,064 - 116,376,802 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127992
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,369,485 - 116,378,818 (+)Ensembl
GRCm38.p6 Ensembl6116,392,524 - 116,401,857 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129170   ⟹   ENSMUSP00000145054
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,327,894 - 116,353,824 (+)Ensembl
GRCm38.p6 Ensembl6116,350,933 - 116,376,863 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130445
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,353,654 - 116,378,392 (+)Ensembl
GRCm38.p6 Ensembl6116,376,693 - 116,401,431 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135901   ⟹   ENSMUSP00000115510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,363,185 - 116,383,185 (+)Ensembl
GRCm38.p6 Ensembl6116,386,224 - 116,406,224 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140884   ⟹   ENSMUSP00000145060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,327,853 - 116,380,389 (+)Ensembl
GRCm38.p6 Ensembl6116,350,892 - 116,403,428 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,379,953 - 116,382,743 (+)Ensembl
GRCm38.p6 Ensembl6116,402,992 - 116,405,782 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203116   ⟹   ENSMUSP00000145237
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,315,014 - 116,382,702 (+)Ensembl
GRCm38.p6 Ensembl6116,338,053 - 116,405,741 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203193   ⟹   ENSMUSP00000145137
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,315,017 - 116,386,499 (+)Ensembl
GRCm38.p6 Ensembl6116,338,056 - 116,409,538 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204657   ⟹   ENSMUSP00000145351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,315,005 - 116,382,714 (+)Ensembl
GRCm38.p6 Ensembl6116,338,044 - 116,405,753 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,382,138 - 116,383,266 (+)Ensembl
GRCm38.p6 Ensembl6116,405,177 - 116,406,305 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6116,327,346 - 116,330,452 (+)Ensembl
GRCm38.p6 Ensembl6116,350,385 - 116,353,491 (+)Ensembl
RefSeq Acc Id: NM_001302383   ⟹   NP_001289312
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
GRCm386116,338,022 - 116,409,540 (+)NCBI
Celera6118,176,147 - 118,247,139 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302384   ⟹   NP_001289313
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
GRCm386116,338,022 - 116,409,540 (+)NCBI
Celera6118,176,147 - 118,247,139 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302385   ⟹   NP_001289314
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
GRCm386116,338,022 - 116,409,540 (+)NCBI
Celera6118,176,147 - 118,247,139 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001401668   ⟹   NP_001388597
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
RefSeq Acc Id: NM_001401669   ⟹   NP_001388598
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,362,967 - 116,386,501 (+)NCBI
RefSeq Acc Id: NM_001401670   ⟹   NP_001388599
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
RefSeq Acc Id: NM_001401671   ⟹   NP_001388600
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
RefSeq Acc Id: NM_001401672   ⟹   NP_001388601
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,362,967 - 116,386,501 (+)NCBI
RefSeq Acc Id: NM_001401673   ⟹   NP_001388602
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
RefSeq Acc Id: NM_027920   ⟹   NP_082196
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,314,983 - 116,386,501 (+)NCBI
GRCm386116,338,022 - 116,409,540 (+)NCBI
MGSCv376116,288,141 - 116,359,558 (+)RGD
Celera6118,176,147 - 118,247,139 (+)NCBI
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506641   ⟹   XP_006506704
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,320,666 - 116,386,501 (+)NCBI
GRCm386116,349,603 - 116,409,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006506642   ⟹   XP_006506705
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,353,102 - 116,386,501 (+)NCBI
GRCm386116,376,152 - 116,409,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011241469   ⟹   XP_011239771
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,312,546 - 116,386,501 (+)NCBI
GRCm386116,337,599 - 116,409,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036152311   ⟹   XP_036008204
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396116,327,351 - 116,386,501 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001289312 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289313 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289314 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388597 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388598 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388599 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388600 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388601 (Get FASTA)   NCBI Sequence Viewer  
  NP_001388602 (Get FASTA)   NCBI Sequence Viewer  
  NP_082196 (Get FASTA)   NCBI Sequence Viewer  
  XP_006506704 (Get FASTA)   NCBI Sequence Viewer  
  XP_006506705 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239771 (Get FASTA)   NCBI Sequence Viewer  
  XP_036008204 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH50908 (Get FASTA)   NCBI Sequence Viewer  
  AAH53090 (Get FASTA)   NCBI Sequence Viewer  
  BAB23759 (Get FASTA)   NCBI Sequence Viewer  
  BAE31321 (Get FASTA)   NCBI Sequence Viewer  
  BAE32966 (Get FASTA)   NCBI Sequence Viewer  
  EDK99558 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000078024
  ENSMUSP00000078024.7
  ENSMUSP00000098594
  ENSMUSP00000098594.4
  ENSMUSP00000115510
  ENSMUSP00000115510.3
  ENSMUSP00000144936
  ENSMUSP00000144936.2
  ENSMUSP00000145054.2
  ENSMUSP00000145060.2
  ENSMUSP00000145137
  ENSMUSP00000145137.2
  ENSMUSP00000145237.2
  ENSMUSP00000145270.2
  ENSMUSP00000145351.2
GenBank Protein Q9DBD2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_082196   ⟸   NM_027920
- Peptide Label: isoform 1
- UniProtKB: Q9DBD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506704   ⟸   XM_006506641
- Peptide Label: isoform X1
- UniProtKB: A0A0N4SV35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506705   ⟸   XM_006506642
- Peptide Label: isoform X1
- UniProtKB: A0A0N4SV35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289312   ⟸   NM_001302383
- Peptide Label: isoform 1
- UniProtKB: Q9DBD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001289314   ⟸   NM_001302385
- Peptide Label: isoform 2
- UniProtKB: A0A0N4SVK0 (UniProtKB/TrEMBL),   F6THH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289313   ⟸   NM_001302384
- Peptide Label: isoform 1
- UniProtKB: Q9DBD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011239771   ⟸   XM_011241469
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000145237   ⟸   ENSMUST00000203116
RefSeq Acc Id: ENSMUSP00000145137   ⟸   ENSMUST00000203193
RefSeq Acc Id: ENSMUSP00000078024   ⟸   ENSMUST00000079012
RefSeq Acc Id: ENSMUSP00000145351   ⟸   ENSMUST00000204657
RefSeq Acc Id: ENSMUSP00000145270   ⟸   ENSMUST00000126376
RefSeq Acc Id: ENSMUSP00000145060   ⟸   ENSMUST00000140884
RefSeq Acc Id: ENSMUSP00000115510   ⟸   ENSMUST00000135901
RefSeq Acc Id: ENSMUSP00000145054   ⟸   ENSMUST00000129170
RefSeq Acc Id: ENSMUSP00000098594   ⟸   ENSMUST00000101032
RefSeq Acc Id: ENSMUSP00000144936   ⟸   ENSMUST00000123405
RefSeq Acc Id: XP_036008204   ⟸   XM_036152311
- Peptide Label: isoform X4
- UniProtKB: Q9DBD2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001388597   ⟸   NM_001401668
- Peptide Label: isoform 3
- UniProtKB: A0A0N4SV35 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388600   ⟸   NM_001401671
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001388599   ⟸   NM_001401670
- Peptide Label: isoform 3
- UniProtKB: A0A0N4SV35 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388602   ⟸   NM_001401673
- Peptide Label: isoform 2
- UniProtKB: A0A0N4SVK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388598   ⟸   NM_001401669
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001388601   ⟸   NM_001401672
- Peptide Label: isoform 6
Protein Domains
RING-CH-type   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DBD2-F1-model_v2 AlphaFold Q9DBD2 1-286 view protein structure

Promoters
RGD ID:6839603
Promoter ID:MM_KWN:47287
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000040374,   OTTMUST00000040375,   OTTMUST00000040376,   OTTMUST00000040381,   UC009DKA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366116,288,024 - 116,288,524 (+)MPROMDB
RGD ID:6839605
Promoter ID:MM_KWN:47291
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Spleen
Transcripts:OTTMUST00000040379,   OTTMUST00000040380
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366116,335,911 - 116,336,411 (+)MPROMDB
RGD ID:6890758
Promoter ID:EPDNEW_M8830
Type:initiation region
Name:March8_1
Description:Mus musculus membrane-associated ring finger 8 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8831  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386116,338,022 - 116,338,082EPDNEW
RGD ID:6890760
Promoter ID:EPDNEW_M8831
Type:multiple initiation site
Name:March8_2
Description:Mus musculus membrane-associated ring finger 8 , transcript variant4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8830  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386116,350,930 - 116,350,990EPDNEW
RGD ID:6839604
Promoter ID:MM_KWN:47293
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000040384
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366116,352,596 - 116,353,096 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919029 AgrOrtholog
Ensembl Genes ENSMUSG00000025702 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079012 ENTREZGENE
  ENSMUST00000079012.13 UniProtKB/Swiss-Prot
  ENSMUST00000101032 ENTREZGENE
  ENSMUST00000101032.10 UniProtKB/Swiss-Prot
  ENSMUST00000123405 ENTREZGENE
  ENSMUST00000123405.8 UniProtKB/TrEMBL
  ENSMUST00000126376.8 UniProtKB/TrEMBL
  ENSMUST00000129170.8 UniProtKB/TrEMBL
  ENSMUST00000135901 ENTREZGENE
  ENSMUST00000135901.2 UniProtKB/TrEMBL
  ENSMUST00000140884.8 UniProtKB/TrEMBL
  ENSMUST00000203116.2 UniProtKB/TrEMBL
  ENSMUST00000203193 ENTREZGENE
  ENSMUST00000203193.3 UniProtKB/TrEMBL
  ENSMUST00000204657.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING-CH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71779 UniProtKB/Swiss-Prot
MGD MGI:1919029 ENTREZGENE
NCBI Gene 71779 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MARCHF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LD02310P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RINGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Marchf8 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
  ZF_RING_CH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RINGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SV35 ENTREZGENE, UniProtKB/TrEMBL
  A0A0N4SVD4_MOUSE UniProtKB/TrEMBL
  A0A0N4SVD9_MOUSE UniProtKB/TrEMBL
  A0A0N4SVK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0N4SVT6_MOUSE UniProtKB/TrEMBL
  A0A0N4SVW5_MOUSE UniProtKB/TrEMBL
  A0A0N4SW32_MOUSE UniProtKB/TrEMBL
  F6THH9 ENTREZGENE, UniProtKB/TrEMBL
  MARH8_MOUSE UniProtKB/Swiss-Prot
  Q3U7P8_MOUSE UniProtKB/TrEMBL
  Q9DBD2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-27 Marchf8  membrane associated ring-CH-type finger 8  March8  membrane-associated ring finger (C3HC4) 8  Symbol and/or name change 5135510 APPROVED