Marchf8 (membrane associated ring-CH-type finger 8) - Rat Genome Database

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Gene: Marchf8 (membrane associated ring-CH-type finger 8) Rattus norvegicus
Analyze
Symbol: Marchf8
Name: membrane associated ring-CH-type finger 8
RGD ID: 1309339
Description: Predicted to enable MHC class II protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including antigen processing and presentation of peptide antigen via MHC class II; negative regulation of MHC class II biosynthetic process; and protein polyubiquitination. Predicted to be located in endosome. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Orthologous to human MARCHF8 (membrane associated ring-CH-type finger 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-mir, cellular modulator of immune recognition; E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCHF8; LOC312656; March8; membrane-associated ring finger (C3HC4) 8; membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase; Mir
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84151,086,076 - 151,203,205 (+)NCBIGRCr8
mRatBN7.24149,415,642 - 149,530,771 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4149,416,071 - 149,530,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4155,645,156 - 155,762,684 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04151,429,191 - 151,546,718 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04150,052,095 - 150,169,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04148,285,467 - 148,398,148 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,286,853 - 148,398,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,232,430 - 214,345,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,494,801 - 152,609,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,786,633 - 152,851,226 (+)NCBI
Celera4138,301,019 - 138,414,819 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14722266   PMID:16785530   PMID:19117940  


Genomics

Comparative Map Data
Marchf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84151,086,076 - 151,203,205 (+)NCBIGRCr8
mRatBN7.24149,415,642 - 149,530,771 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4149,416,071 - 149,530,770 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4155,645,156 - 155,762,684 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04151,429,191 - 151,546,718 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04150,052,095 - 150,169,616 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04148,285,467 - 148,398,148 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,286,853 - 148,398,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,232,430 - 214,345,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,494,801 - 152,609,538 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,786,633 - 152,851,226 (+)NCBI
Celera4138,301,019 - 138,414,819 (+)NCBICelera
Cytogenetic Map4q42NCBI
MARCHF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,454,585 - 45,594,907 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1045,454,585 - 45,594,906 (-)EnsemblGRCh38hg38GRCh38
GRCh371045,950,033 - 46,090,355 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,272,823 - 45,410,360 (-)NCBINCBI36Build 36hg18NCBI36
Build 341045,272,822 - 45,410,360NCBI
Celera1041,950,772 - 42,088,280 (-)NCBICelera
Cytogenetic Map10q11.21-q11.22NCBI
HuRef1042,478,465 - 42,614,172 (-)NCBIHuRef
CHM1_11045,992,033 - 46,129,577 (-)NCBICHM1_1
T2T-CHM13v2.01046,335,573 - 46,475,913 (-)NCBIT2T-CHM13v2.0
Marchf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,312,546 - 116,386,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6116,314,985 - 116,386,501 (+)EnsemblGRCm39 Ensembl
GRCm386116,337,599 - 116,409,540 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,338,024 - 116,409,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv376116,288,141 - 116,359,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366116,303,742 - 116,375,159 (+)NCBIMGSCv36mm8
Celera6118,176,248 - 118,247,139 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.78NCBI
Marchf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555462,558,027 - 2,641,108 (-)NCBIChiLan1.0ChiLan1.0
MARCHF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,279,383 - 58,418,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,284,712 - 58,423,857 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01042,539,079 - 42,677,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11045,718,172 - 45,856,328 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1045,718,172 - 45,796,771 (-)Ensemblpanpan1.1panPan2
MARCHF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,006,923 - 2,165,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,072,181 - 2,161,981 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,240,660 - 2,399,732 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,184,859 - 2,344,207 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,185,150 - 2,344,204 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,981,227 - 2,141,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,019,033 - 2,178,318 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0282,150,933 - 2,310,134 (+)NCBIUU_Cfam_GSD_1.0
Marchf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721378,824,923 - 78,952,602 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493672827,658 - 32,174 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCHF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,725,574 - 90,854,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,725,550 - 90,854,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,768,503 - 98,901,744 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MARCHF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,157,445 - 41,294,277 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048836,596 - 978,252 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marchf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624966225,855 - 318,633 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Marchf8
575 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:437
Count of miRNA genes:237
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000017294
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat

Markers in Region
D4Mgh9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24149,491,524 - 149,491,645 (+)MAPPERmRatBN7.2
Rnor_6.04148,360,954 - 148,361,074NCBIRnor6.0
Rnor_5.04214,306,934 - 214,307,054UniSTSRnor5.0
RGSC_v3.44152,570,244 - 152,570,365RGDRGSC3.4
RGSC_v3.44152,570,245 - 152,570,365UniSTSRGSC3.4
RGSC_v3.14152,815,085 - 152,815,206RGD
Celera4138,376,277 - 138,376,397UniSTS
RH 3.4 Map4966.3UniSTS
RH 3.4 Map4966.3RGD
Cytogenetic Map4q42UniSTS
D4Rat199  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,745,964 - 122,746,032 (-)MAPPERmRatBN7.2
mRatBN7.24149,425,650 - 149,425,853 (+)MAPPERmRatBN7.2
Rnor_6.04148,296,425 - 148,296,629NCBIRnor6.0
Rnor_5.04214,242,405 - 214,242,609UniSTSRnor5.0
RGSC_v3.44152,504,371 - 152,504,576RGDRGSC3.4
RGSC_v3.44152,504,372 - 152,504,576UniSTSRGSC3.4
RGSC_v3.14152,749,162 - 152,749,540RGD
Celera4138,310,589 - 138,310,793UniSTS
SHRSP x BN Map472.4899UniSTS
SHRSP x BN Map472.4899RGD
Cytogenetic Map4q42UniSTS
RH128931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24149,530,503 - 149,530,707 (+)MAPPERmRatBN7.2
Rnor_6.04148,397,881 - 148,398,084NCBIRnor6.0
Rnor_5.04214,345,139 - 214,345,342UniSTSRnor5.0
RGSC_v3.44152,609,272 - 152,609,475UniSTSRGSC3.4
Celera4138,414,553 - 138,414,756UniSTS
RH 3.4 Map21098.7UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 57 41 19 41 7 7 74 35 39 11 7
Low 3 1 4 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001401674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000017294   ⟹   ENSRNOP00000017294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4149,416,071 - 149,530,770 (+)Ensembl
Rnor_6.0 Ensembl4148,286,858 - 148,398,144 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092294   ⟹   ENSRNOP00000075920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4149,416,071 - 149,530,770 (+)Ensembl
Rnor_6.0 Ensembl4148,286,879 - 148,398,146 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4148,287,172 - 148,333,031 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092477   ⟹   ENSRNOP00000075886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4148,286,938 - 148,398,148 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4148,286,853 - 148,332,469 (+)Ensembl
RefSeq Acc Id: NM_001107882   ⟹   NP_001101352
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,088,506 - 151,203,205 (+)NCBI
mRatBN7.24149,416,059 - 149,530,771 (+)NCBI
Rnor_6.04148,286,854 - 148,398,147 (+)NCBI
Rnor_5.04214,232,430 - 214,345,406 (+)NCBI
RGSC_v3.44152,494,801 - 152,609,538 (+)RGD
Celera4138,301,019 - 138,414,819 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401666   ⟹   NP_001388595
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,088,506 - 151,203,205 (+)NCBI
mRatBN7.24149,416,059 - 149,530,771 (+)NCBI
RefSeq Acc Id: NM_001401674   ⟹   NP_001388603
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,088,506 - 151,203,205 (+)NCBI
mRatBN7.24149,416,059 - 149,530,771 (+)NCBI
RefSeq Acc Id: XM_017592645   ⟹   XP_017448134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,131,558 - 151,203,205 (+)NCBI
mRatBN7.24149,459,643 - 149,530,771 (+)NCBI
Rnor_6.04148,328,829 - 148,398,144 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592647   ⟹   XP_017448136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,086,076 - 151,203,205 (+)NCBI
mRatBN7.24149,415,642 - 149,530,771 (+)NCBI
Rnor_6.04148,287,042 - 148,398,144 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107644   ⟹   XP_038963572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,086,076 - 151,203,205 (+)NCBI
mRatBN7.24149,415,673 - 149,530,771 (+)NCBI
RefSeq Acc Id: XM_039107645   ⟹   XP_038963573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,086,076 - 151,203,205 (+)NCBI
mRatBN7.24149,415,674 - 149,530,771 (+)NCBI
RefSeq Acc Id: XM_063286103   ⟹   XP_063142173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,086,076 - 151,203,205 (+)NCBI
RefSeq Acc Id: XM_063286104   ⟹   XP_063142174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,089,351 - 151,203,205 (+)NCBI
RefSeq Acc Id: XM_063286105   ⟹   XP_063142175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,086,076 - 151,203,205 (+)NCBI
RefSeq Acc Id: XM_063286106   ⟹   XP_063142176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,086,076 - 151,203,205 (+)NCBI
RefSeq Acc Id: XM_063286107   ⟹   XP_063142177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,132,999 - 151,203,205 (+)NCBI
RefSeq Acc Id: XM_063286108   ⟹   XP_063142178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84151,098,615 - 151,203,205 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001101352   ⟸   NM_001107882
- Peptide Label: isoform 1
- UniProtKB: D3ZG81 (UniProtKB/TrEMBL),   A6IL15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448136   ⟸   XM_017592647
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017448134   ⟸   XM_017592645
- Peptide Label: isoform X1
- UniProtKB: A0A0U1RS36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075920   ⟸   ENSRNOT00000092294
RefSeq Acc Id: ENSRNOP00000075886   ⟸   ENSRNOT00000092477
RefSeq Acc Id: ENSRNOP00000017294   ⟸   ENSRNOT00000017294
RefSeq Acc Id: XP_038963572   ⟸   XM_039107644
- Peptide Label: isoform X1
- UniProtKB: A0A0U1RS36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963573   ⟸   XM_039107645
- Peptide Label: isoform X1
- UniProtKB: A0A0U1RS36 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388595   ⟸   NM_001401666
- Peptide Label: isoform 1
- UniProtKB: D3ZG81 (UniProtKB/TrEMBL),   A6IL15 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388603   ⟸   NM_001401674
- Peptide Label: isoform 2
- UniProtKB: A0A0U1RS36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142176   ⟸   XM_063286106
- Peptide Label: isoform X3
- UniProtKB: A6IL15 (UniProtKB/TrEMBL),   D3ZG81 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142173   ⟸   XM_063286103
- Peptide Label: isoform X1
- UniProtKB: A0A0U1RS36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142175   ⟸   XM_063286105
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142174   ⟸   XM_063286104
- Peptide Label: isoform X1
- UniProtKB: A0A0U1RS36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142178   ⟸   XM_063286108
- Peptide Label: isoform X3
- UniProtKB: A6IL15 (UniProtKB/TrEMBL),   D3ZG81 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142177   ⟸   XM_063286107
- Peptide Label: isoform X3
- UniProtKB: A6IL15 (UniProtKB/TrEMBL),   D3ZG81 (UniProtKB/TrEMBL)
Protein Domains
RING-CH-type   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG81-F1-model_v2 AlphaFold D3ZG81 1-286 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693333
Promoter ID:EPDNEW_R3857
Type:initiation region
Name:March8_1
Description:membrane associated ring-CH-type finger 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04148,286,842 - 148,286,902EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309339 AgrOrtholog
BioCyc Gene G2FUF-43299 BioCyc
Ensembl Genes ENSRNOG00000012297 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017294 ENTREZGENE
  ENSRNOT00000017294.5 UniProtKB/TrEMBL
  ENSRNOT00000092294 ENTREZGENE
  ENSRNOT00000092294.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Znf_RING UniProtKB/TrEMBL
  Znf_RING-CH UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:312656 UniProtKB/TrEMBL
NCBI Gene 312656 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MARCHF8 UniProtKB/TrEMBL
  LD02310P UniProtKB/TrEMBL
Pfam RINGv UniProtKB/TrEMBL
PhenoGen Marchf8 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
  ZF_RING_CH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012297 RatGTEx
SMART RINGv UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A0U1RS36 ENTREZGENE, UniProtKB/TrEMBL
  A6IL15 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG81 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Marchf8  membrane associated ring-CH-type finger 8  March8  membrane associated ring-CH-type finger 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 March8  membrane associated ring-CH-type finger 8  March8  membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 March8  membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase  March8  membrane-associated ring finger (C3HC4) 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 March8  membrane-associated ring finger (C3HC4) 8   March8_predicted  membrane-associated ring finger (C3HC4) 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 March8_predicted  membrane-associated ring finger (C3HC4) 8 (predicted)  Mir_predicted  c-mir, cellular modulator of immune recognition (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Mir_predicted  c-mir, cellular modulator of immune recognition (predicted)      Symbol and Name status set to approved 70820 APPROVED