LIPT1 (lipoyltransferase 1) - Rat Genome Database

Name: LIPT1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: LIPT1 (lipoyltransferase 1) Sus scrofa

Analyze

Symbol:

LIPT1

Name:

lipoyltransferase 1

RGD ID:

14294554

Description:

ENCODES a protein that exhibits lipoate-protein ligase activity (inferred); lipoyltransferase activity (inferred); transferase activity (inferred); ASSOCIATED WITH Cardiovascular Abnormalities (ortholog); Failure to Thrive (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lipoyltransferase 1, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LIPT1 (lipoyltransferase 1)	HGNC	Ensembl, NCBI, OrthoDB
Mus musculus (house mouse):	Lipt1 (lipoyltransferase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lipt1 (lipoyltransferase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lipt1 (lipoyltransferase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LIPT1 (lipoyltransferase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C10H2orf15 (chromosome 10 C2orf15 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lipt1 (lipoyltransferase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LIPT1 (lipoyltransferase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lipt1 (lipoyltransferase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	55,176,387 - 55,177,508 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiovascular Abnormalities (ISO)

Failure to Thrive (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

Lipoyltransferase 1 Deficiency (ISO)

Muscle Hypotonia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

mitochondrion (IEA)

Molecular Function

lipoate-protein ligase activity (IEA)

lipoyltransferase activity (IEA)

protein binding (ISO)

transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LIPT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	55,176,387 - 55,177,508 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LIPT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	99,154,967 - 99,163,137 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	99,154,955 - 99,163,157 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	99,771,430 - 99,779,600 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	99,137,850 - 99,146,043 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	93,976,106 - 93,984,222 (+)	NCBI		Celera
Cytogenetic Map	2	q11.2	NCBI
HuRef	2	93,537,214 - 93,545,383 (+)	NCBI		HuRef
CHM1_1	2	99,776,369 - 99,784,525 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	99,613,838 - 99,622,016 (+)	NCBI		T2T-CHM13v2.0

Lipt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	37,910,819 - 37,915,309 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	37,910,819 - 37,915,309 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	37,871,738 - 37,876,228 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	37,871,738 - 37,876,228 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	37,929,051 - 37,933,143 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	37,816,752 - 37,821,933 (+)	NCBI		MGSCv36	mm8
Celera	1	37,653,124 - 37,657,217 (+)	NCBI		Celera
Cytogenetic Map	1	B	NCBI
cM Map	1	16.13	NCBI

Lipt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	47,603,972 - 47,609,365 (+)	NCBI		GRCr8
mRatBN7.2	9	40,107,938 - 40,118,268 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	40,098,615 - 40,113,565 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	48,604,043 - 48,609,412 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	53,726,798 - 53,732,167 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	52,008,904 - 52,014,263 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	44,466,627 - 44,471,986 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	44,466,627 - 44,471,986 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	44,164,007 - 44,169,366 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	36,822,120 - 36,827,479 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	36,825,135 - 36,827,380 (+)	NCBI
Celera	9	37,862,435 - 37,867,794 (+)	NCBI		Celera
Cytogenetic Map	9	q21	NCBI

Lipt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	5,480,279 - 5,492,250 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	5,480,279 - 5,492,259 (+)	NCBI	ChiLan1.0	ChiLan1.0

LIPT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	29,264,381 - 29,277,632 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	29,266,189 - 29,280,392 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	100,136,392 - 100,144,665 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	100,083,711 - 100,091,689 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

C10H2orf15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	43,545,023 - 43,556,215 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	43,468,490 - 43,480,004 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	44,417,127 - 44,428,643 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	10	44,127,161 - 44,138,669 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	44,410,705 - 44,421,962 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	44,595,142 - 44,606,656 (-)	NCBI		UU_Cfam_GSD_1.0

Lipt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	84,923,893 - 84,929,911 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	1,638,036 - 1,645,607 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936661	1,640,255 - 1,645,588 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LIPT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	2,865,856 - 2,887,132 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	2,885,887 - 2,886,987 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	170,458,562 - 170,489,721 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lipt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	4,155,943 - 4,163,642 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	4,155,827 - 4,163,648 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in LIPT1
7 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003362087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003362087 ⟹ XP_003362135

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	55,176,387 - 55,177,508 (-)	NCBI

Sequence:

show sequence

ATGCTGATCCCATTTTCAAGGAAGAATGGCTTCCAGTTACTTTGTAACCTCAAGTTCCCAGCAG
TTGGCTTTAAAAACATAGTTCAAAGTGGGCTCATTTTGCAATCGATTTCCAATGATGTTTATCA
AAATCTGGCTGTAGAGGACTGGATCCATGACCACATGAATCTAGAAGGCAGGTCAGTTCTTTTC
TTCTGGAGGAATTCTCCCTCTGTAGTAATTGGTCGGCATCAGAACCCTTGGCAGGAGTGTAACC
TGAATCTGCTGAGAGAAGAAGGTATAAAACTGGCTCGCAGGAGAAGTGGAGGAGGGACTGTCTA
CCATGATATGGGTAACATCAACTTGACCTTCTTTACAACCAAAAAAAAGTATGATAGGATGAAA
AATCTAAAGTTAATTGTGAGAGGTCTGAACACTGTCCAGCCCCAACTGGATGTGCAGGCCACCA
GAAGATTTGACCTTTTACTGGATGGCCAGTTTAAAATCTCAGGGACCGCTTCCAAGATTGGTCG
GACTGCTGCTTATCACCATTGCACTTTATTATGCAGCACCAACAGGACCTTCCTGTCATCTTTG
CTCAAGAGTCCTTACCGAGGGATCAGGAGCACTGCCACTGCCAGCATACCTTCCTCGGTGAAAA
ACCTTGTGGAAAAAGATCCCACTCTGACCTGTGAAGTAGTGATCGATGCCATTGCTGCAGAGTA
TGCTGCTTTTCATCACATTGAGAATCACATTCACCTCATAAACCCAACAGATGAGACCCTGTTT
CCTGGAATTAACAGCAAAGCCAAAGAGCTACAGACCTGGGAGTGGATATATGGCAAAACGCCAA
AGTTTAGCATAAACACGTCCTTGAATGTGCTGCATGAACAGTCACCCTTGGAAATTAAAGTATT
CATAGACATAAAGAATGGAAGAATTGAAGTCTGTAACATCAAAGCCCCTGATCATTGGTTGCCG
CTGGAAATATGTGACAGATTAAACTCAGGTTTCATTGGTAGTAAGTTTTGCCCAACGGAAACGA
CTGTGCTGACAAGTACACTGCGTAGGACGTGTCCAGAAGATGATGGACTACACAGTAAATGGAA
TATTCTCTGTGAAAAAATTAAGGAAATAATGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003362135	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00005004100.1
	ENSSSCP00005004111.1
	ENSSSCP00015020000.1
	ENSSSCP00015020009.1
	ENSSSCP00025018511.1
	ENSSSCP00030002888.1
	ENSSSCP00035031445.1
	ENSSSCP00040000077.1
	ENSSSCP00045025206.1
	ENSSSCP00050007269.1
	ENSSSCP00055019590.1
	ENSSSCP00060039648.1
	ENSSSCP00065032659.1
	ENSSSCP00070048398.1

RefSeq Acc Id:

XP_003362135 ⟸ XM_003362087

- UniProtKB:

A0A480KFN1 (UniProtKB/TrEMBL), A0A4X1W4G2 (UniProtKB/TrEMBL), A0A8D1ZAQ1 (UniProtKB/TrEMBL), A0A8D0HZG6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLIPFSRKNGFQLLCNLKFPAVGFKNIVQSGLILQSISNDVYQNLAVEDWIHDHMNLEGRSVLF
FWRNSPSVVIGRHQNPWQECNLNLLREEGIKLARRRSGGGTVYHDMGNINLTFFTTKKKYDRMK
NLKLIVRGLNTVQPQLDVQATRRFDLLLDGQFKISGTASKIGRTAAYHHCTLLCSTNRTFLSSL
LKSPYRGIRSTATASIPSSVKNLVEKDPTLTCEVVIDAIAAEYAAFHHIENHIHLINPTDETLF
PGINSKAKELQTWEWIYGKTPKFSINTSLNVLHEQSPLEIKVFIDIKNGRIEVCNIKAPDHWLP
LEICDRLNSGFIGSKFCPTETTVLTSTLRRTCPEDDGLHSKWNILCEKIKEIM

hide sequence

Protein Domains

BPL/LPL catalytic

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00005004743	UniProtKB/TrEMBL
	ENSSSCG00015037667	UniProtKB/TrEMBL
	ENSSSCG00025032051	UniProtKB/TrEMBL
	ENSSSCG00030004869	UniProtKB/TrEMBL
	ENSSSCG00035057523	UniProtKB/TrEMBL
	ENSSSCG00040000268	UniProtKB/TrEMBL
	ENSSSCG00045021220	UniProtKB/TrEMBL
	ENSSSCG00050013035	UniProtKB/TrEMBL
	ENSSSCG00055012558	UniProtKB/TrEMBL
	ENSSSCG00060067270	UniProtKB/TrEMBL
	ENSSSCG00065054754	UniProtKB/TrEMBL
	ENSSSCG00070028406	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00005007038.1	UniProtKB/TrEMBL
	ENSSSCT00005007057.1	UniProtKB/TrEMBL
	ENSSSCT00015050124.1	UniProtKB/TrEMBL
	ENSSSCT00015050150.1	UniProtKB/TrEMBL
	ENSSSCT00025043548.1	UniProtKB/TrEMBL
	ENSSSCT00030006558.1	UniProtKB/TrEMBL
	ENSSSCT00035076930.1	UniProtKB/TrEMBL
	ENSSSCT00040000306.1	UniProtKB/TrEMBL
	ENSSSCT00045036235.1	UniProtKB/TrEMBL
	ENSSSCT00050017592.1	UniProtKB/TrEMBL
	ENSSSCT00055024684.1	UniProtKB/TrEMBL
	ENSSSCT00060091757.1	UniProtKB/TrEMBL
	ENSSSCT00065074987.1	UniProtKB/TrEMBL
	ENSSSCT00070056953.1	UniProtKB/TrEMBL
Gene3D-CATH	CO dehydrogenase flavoprotein, C-terminal domain	UniProtKB/TrEMBL
InterPro	aa-tRNA-synth_II/BPL/LPL	UniProtKB/TrEMBL
	BPL_LPL_catalytic	UniProtKB/TrEMBL
	LipoylTrfase_LipoateP_Ligase	UniProtKB/TrEMBL
NCBI Gene	LIPT1	ENTREZGENE
PANTHER	LIPOYLTRANSFERASE 1, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR12561	UniProtKB/TrEMBL
PROSITE	BPL_LPL_CATALYTIC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55681	UniProtKB/TrEMBL
UniProt	A0A480KFN1	ENTREZGENE
	A0A4X1W4G2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0HZG6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1ZAQ1	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A480KFN1	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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