MAP2K4 (mitogen-activated protein kinase kinase 4) - Rat Genome Database

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Gene: MAP2K4 (mitogen-activated protein kinase kinase 4) Sus scrofa
Analyze
Symbol: MAP2K4
Name: mitogen-activated protein kinase kinase 4
RGD ID: 14242097
Description: ENCODES a protein that exhibits JUN kinase kinase activity (ortholog); MAP kinase kinase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN cell growth involved in cardiac muscle cell development (ortholog); cellular response to sorbitol (ortholog); JNK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Brain Death (ortholog); Breast Neoplasms (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); perikaryon (ortholog); INTERACTS WITH hydrogen peroxide; oleanolic acid
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity mitogen-activated protein kinase kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,402,075 - 56,516,238 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,402,029 - 56,516,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21259,330,511 - 59,409,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAP2K4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,402,075 - 56,516,238 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,402,029 - 56,516,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21259,330,511 - 59,409,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,020,877 - 12,143,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1712,020,829 - 12,143,830 (+)EnsemblGRCh38hg38GRCh38
GRCh371711,924,194 - 12,047,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361711,864,860 - 11,987,776 (+)NCBINCBI36Build 36hg18NCBI36
Build 341711,864,859 - 11,987,775NCBI
Celera1711,954,698 - 12,077,624 (+)NCBICelera
Cytogenetic Map17p12ENTREZGENE
HuRef1711,825,033 - 11,947,931 (+)NCBIHuRef
CHM1_11711,933,251 - 12,056,267 (+)NCBICHM1_1
T2T-CHM13v2.01711,928,859 - 12,051,837 (+)NCBIT2T-CHM13v2.0
Map2k4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,579,070 - 65,679,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,579,069 - 65,679,123 (-)EnsemblGRCm39 Ensembl
GRCm381165,688,244 - 65,788,359 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,688,243 - 65,788,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv371165,501,746 - 65,601,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361165,504,439 - 65,604,492 (-)NCBIMGSCv36mm8
Celera1172,623,125 - 72,726,188 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.53NCBI
Map2k4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,842,348 - 50,947,063 (-)NCBIGRCr8
mRatBN7.21050,343,227 - 50,447,956 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1050,344,915 - 50,447,993 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1055,014,269 - 55,116,147 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01054,504,259 - 54,606,140 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01050,012,148 - 50,114,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01052,196,121 - 52,301,887 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1052,196,124 - 52,290,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,951,707 - 52,054,098 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41052,009,149 - 52,041,599 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11052,020,408 - 52,055,249 (-)NCBI
Celera1049,553,065 - 49,624,419 (-)NCBICelera
Cytogenetic Map10q24NCBI
Map2k4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554675,187,356 - 5,307,692 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554675,188,036 - 5,295,570 (-)NCBIChiLan1.0ChiLan1.0
MAP2K4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21961,596,659 - 61,721,974 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11766,403,318 - 66,528,369 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01739,497,105 - 39,622,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11744,246,301 - 44,359,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1744,248,857 - 44,359,909 (-)Ensemblpanpan1.1panPan2
MAP2K4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,142,610 - 36,243,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,118,388 - 36,241,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha536,246,628 - 36,382,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0536,216,260 - 36,351,866 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl536,216,250 - 36,351,818 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1536,183,407 - 36,318,935 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0536,137,113 - 36,272,679 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0536,321,228 - 36,456,796 (+)NCBIUU_Cfam_GSD_1.0
Map2k4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,288,135 - 51,356,168 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365954,727,108 - 4,830,662 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365954,762,327 - 4,828,433 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11611,366,610 - 11,485,411 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1611,366,751 - 11,486,125 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660599,768,762 - 9,889,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478614,457,452 - 14,597,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478614,457,382 - 14,597,027 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP2K4
4413 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000019611   ⟹   ENSSSCP00000019092
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1256,402,075 - 56,516,238 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000052657   ⟹   ENSSSCP00000051354
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1256,402,075 - 56,516,238 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000088197   ⟹   ENSSSCP00000070388
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1256,402,085 - 56,516,238 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000089384   ⟹   ENSSSCP00000064592
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1256,455,857 - 56,516,214 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000103791   ⟹   ENSSSCP00000076058
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1256,437,938 - 56,516,238 (+)Ensembl
RefSeq Acc Id: XM_003132006   ⟹   XP_003132054
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11256,451,429 - 56,516,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021067890   ⟹   XP_020923549
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11256,402,029 - 56,516,217 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020923549   ⟸   XM_021067890
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SMU6 (UniProtKB/TrEMBL),   F1SS51 (UniProtKB/TrEMBL),   A0A4X1SNA9 (UniProtKB/TrEMBL),   A0A5G2QZR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003132054   ⟸   XM_003132006
- Peptide Label: isoform X2
- UniProtKB: A0A8D1CWD0 (UniProtKB/TrEMBL),   A0A5G2QJE6 (UniProtKB/TrEMBL),   A0A8D0NQH6 (UniProtKB/TrEMBL),   A0A8D0NMI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000070388   ⟸   ENSSSCT00000088197
Ensembl Acc Id: ENSSSCP00000019092   ⟸   ENSSSCT00000019611
Ensembl Acc Id: ENSSSCP00000064592   ⟸   ENSSSCT00000089384
Ensembl Acc Id: ENSSSCP00000051354   ⟸   ENSSSCT00000052657
Ensembl Acc Id: ENSSSCP00000076058   ⟸   ENSSSCT00000103791
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000018016 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005043432 UniProtKB/TrEMBL
  ENSSSCG00015038473 UniProtKB/TrEMBL
  ENSSSCG00025049528 UniProtKB/TrEMBL
  ENSSSCG00030049224 UniProtKB/TrEMBL
  ENSSSCG00035046914 UniProtKB/TrEMBL
  ENSSSCG00040009066 UniProtKB/TrEMBL
  ENSSSCG00045025832 UniProtKB/TrEMBL
  ENSSSCG00055021340 UniProtKB/TrEMBL
  ENSSSCG00060024932 UniProtKB/TrEMBL
  ENSSSCG00065034329 UniProtKB/TrEMBL
  ENSSSCG00070002484 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019611 ENTREZGENE
  ENSSSCT00000019611.5 UniProtKB/TrEMBL
  ENSSSCT00000052657.3 UniProtKB/TrEMBL
  ENSSSCT00000088197.2 UniProtKB/TrEMBL
  ENSSSCT00000089384 ENTREZGENE
  ENSSSCT00000089384.1 UniProtKB/TrEMBL
  ENSSSCT00000103791.1 UniProtKB/TrEMBL
  ENSSSCT00005069765.1 UniProtKB/TrEMBL
  ENSSSCT00005069772.1 UniProtKB/TrEMBL
  ENSSSCT00005069787.1 UniProtKB/TrEMBL
  ENSSSCT00005069812.1 UniProtKB/TrEMBL
  ENSSSCT00015051180.1 UniProtKB/TrEMBL
  ENSSSCT00015051238.1 UniProtKB/TrEMBL
  ENSSSCT00025067570.1 UniProtKB/TrEMBL
  ENSSSCT00025067684.1 UniProtKB/TrEMBL
  ENSSSCT00025067821.1 UniProtKB/TrEMBL
  ENSSSCT00025067999.1 UniProtKB/TrEMBL
  ENSSSCT00030068710.1 UniProtKB/TrEMBL
  ENSSSCT00030068723.1 UniProtKB/TrEMBL
  ENSSSCT00030068739.1 UniProtKB/TrEMBL
  ENSSSCT00030068773.1 UniProtKB/TrEMBL
  ENSSSCT00035062449.1 UniProtKB/TrEMBL
  ENSSSCT00035062458.1 UniProtKB/TrEMBL
  ENSSSCT00035062467.1 UniProtKB/TrEMBL
  ENSSSCT00035062487.1 UniProtKB/TrEMBL
  ENSSSCT00035062498.1 UniProtKB/TrEMBL
  ENSSSCT00040011802.1 UniProtKB/TrEMBL
  ENSSSCT00040011813.1 UniProtKB/TrEMBL
  ENSSSCT00040011827.1 UniProtKB/TrEMBL
  ENSSSCT00040011849.1 UniProtKB/TrEMBL
  ENSSSCT00045044178.1 UniProtKB/TrEMBL
  ENSSSCT00045044300.1 UniProtKB/TrEMBL
  ENSSSCT00045044418.1 UniProtKB/TrEMBL
  ENSSSCT00045044571.1 UniProtKB/TrEMBL
  ENSSSCT00055042101.1 UniProtKB/TrEMBL
  ENSSSCT00055042206.1 UniProtKB/TrEMBL
  ENSSSCT00055042326.1 UniProtKB/TrEMBL
  ENSSSCT00055042478.1 UniProtKB/TrEMBL
  ENSSSCT00060033804.1 UniProtKB/TrEMBL
  ENSSSCT00060033809.1 UniProtKB/TrEMBL
  ENSSSCT00060033812.1 UniProtKB/TrEMBL
  ENSSSCT00060033830.1 UniProtKB/TrEMBL
  ENSSSCT00065046722.1 UniProtKB/TrEMBL
  ENSSSCT00065046726.1 UniProtKB/TrEMBL
  ENSSSCT00065046733.1 UniProtKB/TrEMBL
  ENSSSCT00065046741.1 UniProtKB/TrEMBL
  ENSSSCT00070004684.1 UniProtKB/TrEMBL
  ENSSSCT00070004695.1 UniProtKB/TrEMBL
  ENSSSCT00070004700.1 UniProtKB/TrEMBL
  ENSSSCT00070004711.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100520100 UniProtKB/TrEMBL
NCBI Gene MAP2K4 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287B4Y9_PIG UniProtKB/TrEMBL
  A0A4X1SMR4_PIG UniProtKB/TrEMBL
  A0A4X1SMU6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SNA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SNB9_PIG UniProtKB/TrEMBL
  A0A5G2QJE6 ENTREZGENE
  A0A5G2QZR5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0M193_PIG UniProtKB/TrEMBL
  A0A8D0M194_PIG UniProtKB/TrEMBL
  A0A8D0NMI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NQH6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0TPM5_PIG UniProtKB/TrEMBL
  A0A8D1A8F4_PIG UniProtKB/TrEMBL
  A0A8D1CWD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4F9Q5_PIG UniProtKB/TrEMBL
  F1SS51 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A5G2QJE6 UniProtKB/TrEMBL
VGNC ID VGNC:98101 ENTREZGENE