MAP2K4 (mitogen-activated protein kinase kinase 4) - Rat Genome Database

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Gene: MAP2K4 (mitogen-activated protein kinase kinase 4) Pan paniscus
Analyze
Symbol: MAP2K4
Name: mitogen-activated protein kinase kinase 4
RGD ID: 11919080
Description: ENCODES a protein that exhibits JUN kinase kinase activity (ortholog); MAP kinase kinase activity (ortholog); INVOLVED IN cell growth involved in cardiac muscle cell development (ortholog); cellular response to mechanical stimulus (ortholog); cellular response to sorbitol (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Brain Death (ortholog); Breast Neoplasms (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity mitogen-activated protein kinase kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11744,246,301 - 44,359,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1744,248,857 - 44,359,909 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01739,497,105 - 39,622,331 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Genomics

Comparative Map Data
MAP2K4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11744,246,301 - 44,359,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1744,248,857 - 44,359,909 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01739,497,105 - 39,622,331 (-)NCBIMhudiblu_PPA_v0panPan3
MAP2K4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,020,877 - 12,143,828 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1712,020,829 - 12,143,830 (+)EnsemblGRCh38hg38GRCh38
GRCh371711,924,194 - 12,047,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361711,864,860 - 11,987,776 (+)NCBINCBI36hg18NCBI36
Build 341711,864,859 - 11,987,775NCBI
Celera1711,954,698 - 12,077,624 (+)NCBI
Cytogenetic Map17p12ENTREZGENE
HuRef1711,825,033 - 11,947,931 (+)NCBIHuRef
CHM1_11711,933,251 - 12,056,267 (+)NCBICHM1_1
Map2k4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,579,070 - 65,679,185 (-)NCBIGRCm39mm39
GRCm39 Ensembl1165,579,069 - 65,679,123 (-)Ensembl
GRCm381165,688,244 - 65,788,359 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,688,243 - 65,788,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv371165,501,746 - 65,601,799 (-)NCBIGRCm37mm9NCBIm37
MGSCv361165,504,439 - 65,604,492 (-)NCBImm8
Celera1172,623,125 - 72,726,188 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.53NCBI
Map2k4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21050,343,227 - 50,447,956 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1050,344,915 - 50,447,993 (-)Ensembl
Rnor_6.01052,196,121 - 52,301,887 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1052,196,124 - 52,290,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,951,707 - 52,054,098 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41052,009,149 - 52,041,599 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11052,020,408 - 52,055,249 (-)NCBI
Celera1049,553,065 - 49,624,419 (-)NCBICelera
Cytogenetic Map10q24NCBI
Map2k4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554675,187,356 - 5,307,692 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554675,188,036 - 5,295,570 (-)NCBIChiLan1.0ChiLan1.0
MAP2K4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,142,610 - 36,243,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,118,388 - 36,241,296 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha536,246,628 - 36,382,182 (+)NCBI
ROS_Cfam_1.0536,216,260 - 36,351,866 (+)NCBI
ROS_Cfam_1.0 Ensembl536,216,250 - 36,351,818 (+)Ensembl
UMICH_Zoey_3.1536,183,407 - 36,318,935 (+)NCBI
UNSW_CanFamBas_1.0536,137,113 - 36,272,679 (+)NCBI
UU_Cfam_GSD_1.0536,321,228 - 36,456,796 (+)NCBI
Map2k4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,288,135 - 51,356,168 (+)NCBI
SpeTri2.0NW_0049365954,762,327 - 4,828,433 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,402,075 - 56,516,240 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,402,029 - 56,516,217 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21259,330,511 - 59,409,571 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11611,366,610 - 11,485,411 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1611,366,751 - 11,486,125 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660599,768,762 - 9,889,281 (-)NCBIVero_WHO_p1.0
Map2k4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478614,457,382 - 14,597,027 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032289   ⟹   ENSPPAP00000009646
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1744,248,857 - 44,359,909 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000032292   ⟹   ENSPPAP00000009649
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1744,248,857 - 44,338,228 (-)Ensembl
RefSeq Acc Id: XM_034942363   ⟹   XP_034798254
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01739,497,105 - 39,622,327 (-)NCBI
RefSeq Acc Id: XM_034942364   ⟹   XP_034798255
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01739,497,105 - 39,622,325 (-)NCBI
RefSeq Acc Id: XR_004667234
RefSeq Status:
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01739,499,697 - 39,622,331 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034798254 (Get FASTA)   NCBI Sequence Viewer  
  XP_034798255 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034798254   ⟸   XM_034942363
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034798255   ⟸   XM_034942364
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000009649   ⟸   ENSPPAT00000032292
RefSeq Acc Id: ENSPPAP00000009646   ⟸   ENSPPAT00000032289
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028045 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000009646 UniProtKB/TrEMBL
  ENSPPAP00000009649 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032289 UniProtKB/TrEMBL
  ENSPPAT00000032292 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene MAP2K4 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R8ZXE8_PANPA UniProtKB/TrEMBL
  A0A2R9A2Y6_PANPA UniProtKB/TrEMBL