SDHD (succinate dehydrogenase complex subunit D) - Rat Genome Database

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Gene: SDHD (succinate dehydrogenase complex subunit D) Sus scrofa
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Symbol: SDHD
Name: succinate dehydrogenase complex subunit D
RGD ID: 14109857
Description: ENCODES a protein that exhibits heme binding; ubiquinone binding; INVOLVED IN cellular response to hypoxia (ortholog); regulation of catecholamine secretion (ortholog); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; electron transport chain pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN mitochondrial inner membrane; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CII-4; CybS; QPs3; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex, subunit D, integral membrane protein; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,790,595 - 39,803,950 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,790,654 - 39,803,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,632,268 - 44,645,249 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:14681463   PMID:15989954   PMID:17145712   PMID:17480203   PMID:17550355   PMID:17651329   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SDHD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,790,595 - 39,803,950 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,790,654 - 39,803,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,632,268 - 44,645,249 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SDHD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,086,873 - 112,095,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,086,824 - 112,120,016 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,957,597 - 111,966,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,462,832 - 111,471,727 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,462,831 - 111,471,727NCBI
Celera11109,110,763 - 109,119,710 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,881,580 - 107,890,557 (+)NCBIHuRef
CHM1_111111,840,726 - 111,849,704 (+)NCBICHM1_1
T2T-CHM13v2.011112,097,127 - 112,106,049 (+)NCBIT2T-CHM13v2.0
Sdhd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,507,640 - 50,515,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,507,657 - 50,515,112 (-)EnsemblGRCm39 Ensembl
GRCm38950,596,340 - 50,603,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,596,357 - 50,603,812 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,404,445 - 50,411,954 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,348,576 - 50,356,047 (-)NCBIMGSCv36mm8
Celera947,891,569 - 47,899,078 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Sdhd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,841,090 - 59,850,641 (-)NCBIGRCr8
mRatBN7.2850,944,702 - 50,954,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,944,704 - 50,954,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,450,402 - 56,459,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,729,300 - 54,738,844 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,593,576 - 52,603,120 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,028,125 - 55,037,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,028,125 - 55,037,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,625,447 - 53,634,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,955,067 - 53,964,547 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,974,120 - 53,983,601 (-)NCBI
Celera850,493,184 - 50,502,624 (-)NCBICelera
Cytogenetic Map8q23NCBI
Sdhd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,768,501 - 13,778,932 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,768,501 - 13,778,944 (+)NCBIChiLan1.0ChiLan1.0
SDHD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,030,295 - 21,041,125 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,952,816 - 20,963,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,053,488 - 21,064,559 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,053,492 - 21,064,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,115,095 - 21,126,173 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,015,331 - 21,026,183 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,063,761 - 21,074,834 (-)NCBIUU_Cfam_GSD_1.0
Sdhd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,336,365 - 94,348,330 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366122,357,336 - 2,369,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,443,666 - 103,452,681 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604322,530,988 - 22,540,558 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,241,836 - 7,251,916 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,241,770 - 7,252,016 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SDHD
424 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000016399   ⟹   ENSSSCP00000015958
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,790,595 - 39,803,950 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069328   ⟹   ENSSSCP00000073219
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,790,561 - 39,803,143 (+)Ensembl
RefSeq Acc Id: NM_001097516   ⟹   NP_001090985
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1939,790,654 - 39,803,602 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001090985   ⟸   NM_001097516
- UniProtKB: A7E1T8 (UniProtKB/Swiss-Prot),   A7E1T4 (UniProtKB/Swiss-Prot),   A5GZW8 (UniProtKB/Swiss-Prot),   A0A8D1GMP5 (UniProtKB/TrEMBL),   A0A4X1TEU3 (UniProtKB/TrEMBL),   A0A8D0PUA3 (UniProtKB/TrEMBL),   A0A8D1WDJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000015958   ⟸   ENSSSCT00000016399
RefSeq Acc Id: ENSSSCP00000073219   ⟸   ENSSSCT00000069328


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015034 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015065867 UniProtKB/TrEMBL
  ENSSSCG00025044948 UniProtKB/TrEMBL
  ENSSSCG00035066314 UniProtKB/TrEMBL
  ENSSSCG00040062773 UniProtKB/TrEMBL
  ENSSSCG00045005817 UniProtKB/TrEMBL
  ENSSSCG00050019733 UniProtKB/TrEMBL
  ENSSSCG00055012746 UniProtKB/TrEMBL
  ENSSSCG00060064751 UniProtKB/TrEMBL
  ENSSSCG00065075599 UniProtKB/TrEMBL
  ENSSSCG00070008322 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016399 ENTREZGENE
  ENSSSCT00000016399.5 UniProtKB/TrEMBL
  ENSSSCT00015088615.1 UniProtKB/TrEMBL
  ENSSSCT00025061039.1 UniProtKB/TrEMBL
  ENSSSCT00035089328.1 UniProtKB/TrEMBL
  ENSSSCT00040085573.1 UniProtKB/TrEMBL
  ENSSSCT00045009668.1 UniProtKB/TrEMBL
  ENSSSCT00050026644.1 UniProtKB/TrEMBL
  ENSSSCT00055025188.1 UniProtKB/TrEMBL
  ENSSSCT00060088383.1 UniProtKB/TrEMBL
  ENSSSCT00065104365.1 UniProtKB/TrEMBL
  ENSSSCT00070016047.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CybS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SQR/QFR_C/D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100048954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene SDHD ENTREZGENE
PANTHER PTHR13337 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CybS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81343 UniProtKB/TrEMBL
UniProt A0A4X1TEU3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0PUA3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GMP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1WDJ5 ENTREZGENE, UniProtKB/TrEMBL
  A5GZW8 ENTREZGENE
  A7E1T4 ENTREZGENE
  A7E1T8 ENTREZGENE
  DHSD_PIG UniProtKB/Swiss-Prot
  F1SMA9_PIG UniProtKB/TrEMBL
UniProt Secondary A7E1T4 UniProtKB/Swiss-Prot
  A7E1T8 UniProtKB/Swiss-Prot
VGNC ID VGNC:110220 ENTREZGENE