SDHD (succinate dehydrogenase complex subunit D) - Rat Genome Database

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Gene: SDHD (succinate dehydrogenase complex subunit D) Sus scrofa
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Symbol: SDHD
Name: succinate dehydrogenase complex subunit D
RGD ID: 14109857
Description: ENCODES a protein that exhibits heme binding; protein-membrane adaptor activity; ubiquinone binding; INVOLVED IN cellular response to hypoxia (ortholog); regulation of catecholamine secretion (ortholog); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; electron transport chain pathway; ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN mitochondrial inner membrane; respiratory chain complex II (succinate dehydrogenase); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CII-4; CybS; malate dehydrogenase [quinone] cytochrome b small subunit; QPs3; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex, subunit D, integral membrane protein; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,790,595 - 39,803,950 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,790,654 - 39,803,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,632,268 - 44,645,249 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SDHDPigCOVID-19  ISOSDHD (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
1 to 20 of 33 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SDHDPigataxia telangiectasia  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571 more ...
SDHDPigBH4-deficient hyperphenylalaninemia A  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: BH4-deficient hyperphenylalaninemia AClinVarPMID:28492532
SDHDPigCarney-Stratakis syndrome  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10323245 more ...
SDHDPigchromosome 11 partial duplication syndrome  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Distal trisomy 11qClinVarPMID:25741868
SDHDPigcombined oxidative phosphorylation deficiency 8  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Fatal infantile mitochondrial cardiomyopathyClinVarPMID:26008905
SDHDPigdilated cardiomyopathy 1II  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Dilated cardiomyopathy 1IIClinVarPMID:28492532
SDHDPigGlomus Jugulare Tumor  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Glomus tumors familial 1ClinVarPMID:10323245 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10323245 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10323245 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10323245 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10323245 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10657297 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10657297 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10657297 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10657297 more ...
SDHDPigHereditary Neoplastic Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10323245 more ...
SDHDPigHereditary Paraganglioma-Pheochromocytoma Syndromes  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma SyndromesClinVarPMID:10323245 more ...
SDHDPigintellectual disability  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
SDHDPigIntestinal Carcinoid Tumors  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: Carcinoid tumors and intestinalClinVarPMID:12007193 more ...
SDHDPigIslet Cell Tumor Syndrome  ISOSDHD (Homo sapiens)8554872ClinVar Annotator: match by term: ChromaffinomaClinVarPMID:10323245 more ...
1 to 20 of 33 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SDHDPigmelanoma  ISOSDHD (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25261935


Biological Process

  

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SDHDPigmembrane located_inIEAInterPro:IPR007992 and InterPro:IPR034804150520179 InterProGO_REF:0000002
SDHDPigmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
SDHDPigmitochondrial envelope located_inIEAInterPro:IPR007992150520179 InterProGO_REF:0000002
SDHDPigmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-0999150520179 UniProtGO_REF:0000043
SDHDPigmitochondrial inner membrane located_inIDA 150520179 PMID:17480203UniProtPMID:17480203
SDHDPigmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-0168150520179 UniProtGO_REF:0000044
SDHDPigmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
SDHDPigmitochondrion is_active_inISOMGI:35265219068941 PMID:15572694MGIPMID:15572694
SDHDPigmitochondrion located_inIEAARBA:ARBA00026962150520179 UniProtGO_REF:0000117
SDHDPigrespiratory chain complex II (succinate dehydrogenase) part_ofIDA 150520179 PMID:15989954UniProtPMID:15989954
SDHDPigrespiratory chain complex II (succinate dehydrogenase) part_ofIEAARBA:ARBA00027643150520179 UniProtGO_REF:0000117
SDHDPigrespiratory chain complex II (succinate dehydrogenase) part_ofIBAMGI:1914175 more ...150520179 GO_CentralGO_REF:0000033
1 to 12 of 12 rows

Molecular Function

  

RGD Manual Annotations


  

Imported Annotations - SMPDB

PMID:14681463   PMID:15989954   PMID:17145712   PMID:17480203   PMID:17550355   PMID:17651329   PMID:22301074   PMID:30032202  



SDHD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,790,595 - 39,803,950 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,790,654 - 39,803,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,632,268 - 44,645,249 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SDHD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,086,873 - 112,095,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,086,824 - 112,120,016 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,957,597 - 111,966,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,462,832 - 111,471,727 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411111,462,831 - 111,471,727NCBI
Celera11109,110,763 - 109,119,710 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,881,580 - 107,890,557 (+)NCBIHuRef
CHM1_111111,840,726 - 111,849,704 (+)NCBICHM1_1
T2T-CHM13v2.011112,097,127 - 112,106,049 (+)NCBIT2T-CHM13v2.0
Sdhd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,507,640 - 50,515,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,507,657 - 50,515,112 (-)EnsemblGRCm39 Ensembl
GRCm38950,596,340 - 50,603,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,596,357 - 50,603,812 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,404,445 - 50,411,954 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,348,576 - 50,356,047 (-)NCBIMGSCv36mm8
Celera947,891,569 - 47,899,078 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Sdhd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,841,090 - 59,850,641 (-)NCBIGRCr8
mRatBN7.2850,944,702 - 50,954,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,944,704 - 50,954,238 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx856,450,402 - 56,459,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,729,300 - 54,738,844 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,593,576 - 52,603,120 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,028,125 - 55,037,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,028,125 - 55,037,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,625,447 - 53,634,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4853,955,067 - 53,964,547 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1853,974,120 - 53,983,601 (-)NCBI
Celera850,493,184 - 50,502,624 (-)NCBICelera
Cytogenetic Map8q23NCBI
Sdhd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,768,501 - 13,778,932 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,768,501 - 13,778,944 (+)NCBIChiLan1.0ChiLan1.0
SDHD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,030,295 - 21,041,125 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,952,816 - 20,963,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,053,488 - 21,064,559 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,053,492 - 21,064,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,115,095 - 21,126,173 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,015,331 - 21,026,183 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,063,761 - 21,074,834 (-)NCBIUU_Cfam_GSD_1.0
Sdhd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,336,365 - 94,348,330 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366122,357,336 - 2,369,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,443,666 - 103,452,681 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604322,530,988 - 22,540,558 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,241,836 - 7,251,916 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247847,241,770 - 7,252,016 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in SDHD
426 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3



Ensembl Acc Id: ENSSSCT00000016399   ⟹   ENSSSCP00000015958
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,790,595 - 39,803,950 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000069328   ⟹   ENSSSCP00000073219
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl939,790,561 - 39,803,143 (+)Ensembl
RefSeq Acc Id: NM_001097516   ⟹   NP_001090985
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1939,790,654 - 39,803,602 (+)NCBI
Sequence:
Protein RefSeqs NP_001090985 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A5GZW8 (Get FASTA)   NCBI Sequence Viewer  
  AAW29970 (Get FASTA)   NCBI Sequence Viewer  
  AAW30631 (Get FASTA)   NCBI Sequence Viewer  
  AAW30633 (Get FASTA)   NCBI Sequence Viewer  
  ABF29393 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000015958
RefSeq Acc Id: NP_001090985   ⟸   NM_001097516
- UniProtKB: A7E1T8 (UniProtKB/Swiss-Prot),   A7E1T4 (UniProtKB/Swiss-Prot),   A5GZW8 (UniProtKB/Swiss-Prot),   A0A8D1GMP5 (UniProtKB/TrEMBL),   A0A4X1TEU3 (UniProtKB/TrEMBL),   A0A8D0PUA3 (UniProtKB/TrEMBL),   A0A8D1WDJ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000015958   ⟸   ENSSSCT00000016399
Ensembl Acc Id: ENSSSCP00000073219   ⟸   ENSSSCT00000069328



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000015034 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000016399 ENTREZGENE
Gene3D-CATH 1.20.1300.10 UniProtKB/Swiss-Prot
InterPro CybS UniProtKB/Swiss-Prot
  SQR/QFR_C/D UniProtKB/Swiss-Prot
KEGG Report ssc:100048954 UniProtKB/Swiss-Prot
NCBI Gene SDHD ENTREZGENE
PANTHER PTHR13337 UniProtKB/Swiss-Prot
  SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam CybS UniProtKB/Swiss-Prot
UniProt A0A4X1TEU3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0PUA3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GMP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1WDJ5 ENTREZGENE, UniProtKB/TrEMBL
  A5GZW8 ENTREZGENE
  A7E1T4 ENTREZGENE
  A7E1T8 ENTREZGENE
  DHSD_PIG UniProtKB/Swiss-Prot
  F1SMA9_PIG UniProtKB/TrEMBL
UniProt Secondary A7E1T4 UniProtKB/Swiss-Prot
  A7E1T8 UniProtKB/Swiss-Prot
VGNC ID VGNC:110220 ENTREZGENE
1 to 22 of 22 rows