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Gene: LOC100513484 (transmembrane protease serine 11B) Sus scrofa

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Symbol:

LOC100513484 (Ensembl: TMPRSS11B)

Name:

transmembrane protease serine 11B (Ensembl:transmembrane serine protease 11B)

RGD ID:

14054701

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH Breast Cancer, Familial (ortholog); FOUND IN extracellular region (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

TMPRSS11B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	65,882,623 - 65,902,436 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	8	65,881,985 - 65,898,898 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	70,305,132 - 70,321,065 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Cancer, Familial (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein processing (IBA)

proteolysis (IEA)

Cellular Component

extracellular region (IEA)

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IBA,IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

LOC100513484
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	65,882,623 - 65,902,436 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	8	65,881,985 - 65,898,898 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	70,305,132 - 70,321,065 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMPRSS11B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	68,226,653 - 68,245,694 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	68,226,653 - 68,245,694 (-)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	4	69,092,371 - 69,111,412 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	68,774,966 - 68,794,004 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	66,551,717 - 66,570,749 (-)	NCBI		Celera
Cytogenetic Map	4	q13.2	NCBI
HuRef	4	65,004,927 - 65,023,958 (-)	NCBI		HuRef
CHM1_1	4	69,129,015 - 69,148,054 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	71,666,935 - 71,685,995 (-)	NCBI		T2T-CHM13v2.0

Tmprss11b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	86,806,326 - 86,824,221 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	86,805,490 - 86,824,221 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	86,659,522 - 86,676,298 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	86,657,631 - 86,676,362 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	5	87,088,547 - 87,105,323 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	87,732,998 - 87,750,911 (-)	NCBI		MGSCv36	mm8
Celera	5	83,879,850 - 83,896,603 (-)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	43.56	NCBI

Tmprss11b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	21,738,760 - 21,763,896 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	21,738,760 - 21,762,107 (+)	Ensembl				GRCr8
mRatBN7.2	14	21,383,936 - 21,407,283 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	21,383,862 - 21,408,817 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	21,740,535 - 21,760,392 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	23,059,465 - 23,079,322 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	21,590,547 - 21,610,408 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	14	22,034,154 - 22,057,900 (+)	NCBI
Lyon_Normotensive	14	22,139,247 - 22,162,993 (+)	NCBI
Lyon_Hypertensive	14	22,147,125 - 22,170,871 (+)	NCBI
F344_StmMcwi	14	22,124,155 - 22,147,893 (+)	NCBI
Rnor_6.0	14	24,103,768 - 24,125,260 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	24,103,954 - 24,123,253 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	14	23,940,743 - 23,960,116 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	23,009,055 - 23,029,587 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	20,876,772 - 20,895,405 (+)	NCBI		Celera
RGSC_v3.1	14	23,009,054 - 23,029,587 (+)	NCBI
Cytogenetic Map	14	p21	NCBI

TMPRSS11B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	61,648,353 - 61,670,960 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	61,858,476 - 61,881,030 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	55,802,811 - 55,825,366 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	62,200,252 - 62,219,386 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	62,200,414 - 62,218,523 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

LOC482175
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	58,648,662 - 58,656,588 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	58,577,447 - 58,587,987 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	59,350,520 - 59,361,072 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
UMICH_Zoey_3.1	13	58,998,034 - 59,010,354 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	58,481,818 - 58,495,882 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	59,501,056 - 59,513,565 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101971243
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	9	50,872,363 - 50,887,347 (-)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405285	17,751,893 - 17,770,648 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936582	314,997 - 333,837 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936582	315,088 - 333,814 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC103235709
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	7	1,133,244 - 1,151,751 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666066	819,735 - 838,550 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	7	734,885 - 748,755 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	734,900 - 748,477 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Tmprss11b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	279,966 - 293,486 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in LOC100513484
273 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
1	1	1	1	1	1	2	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021101398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_084973774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	FP236685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JBREVY020000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000009780 ⟹ ENSSSCP00000009527

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	65,882,623 - 65,902,436 (-)	Ensembl

RefSeq Acc Id:

XM_021101398 ⟹ XP_020957057

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	8	65,881,985 - 65,898,898 (-)	NCBI

Sequence:

show sequence

AAGCAGATTTAGGATTATCCTGATTTACCACAAAGTTGTTTCTTGGGTGTACCTTTTAGGTGAC
CAATCCAAGATTGGGCTATTCTTTTTCTGAATACCAAGTCAAGGAGGTTTGTCATTCCCTGGAT
GACTCCTGTCTTGAAACCATAGAAATATGACAGTAATTAACACTAGCCAGACAAGTTTCATCTT
ATTTGTTCTCTACCCTCCACCAAGCCCATAAAAACCAACCAACCAACACTGGACATGGCACATA
AAGCTGTGAACCACTGATCATCTTAAAAGCTACACCAGGAGATCCTTATTTTTATTATTACTCT
CATCATTGTCATCATCGTCATCACTACCATTGTCCCTGATACCACCACAACCATCAGAATACTA
TGTACAGGTATGGCATATCTTCCCAGAGAAGATCTTGGCCTCTATGGATGACGATCCTTATTTT
TCTTGGAGTGATGCTGATCTTGGGAGTGATTATTGGTCTCCTGGTTCATTTTCTGGCAGTTGGA
AAAACTTACTATTACCAAGGTGATTTTCATATTTCTGGAGTCACTTACAATCACAGTTGTGAAA
AAGCAGTTTCACAAACCGGCACAGATCTAAGTAAAGCTATTGAAACTAAGATGTCAGATGCATT
TCAAAATTCTAGTGTATACAAAGAATATATCAATTCTCAGGTTATCAAATTTCTGCCTTATCCC
AATGGATCAAGGGTACAGTTTCAATTGACACTGAAGTTTCCACCAGCAAAGAAGAATAGCATGA
AAACTAAAATCGAAGGTATCTTACATCAAATGTTGAAGGACAACATGGCATCCTGGAATGCAGT
TCCCTCTTCCATTAAACTTACAGAAACCAGCAAGGCTAATGCTGAAATGCTCACTAACAACTGT
TGTGGAAGACAACTGGCCAACAGTATCATTGCAGGCAACCGAATTGTGAATGGGGAAAACGCCC
TGGTAGGGGCCTGGCCCTGGCAAGCAAGCATGCAATGGAAAGGCCGACACCACTGTGGTGCCTC
TCTGATTAGCAGCAAGTGGCTCCTATCTGCAGCTCACTGCTTTGCTCTGAAAAATAATTCAGAA
GACTGGACTATCAACTTTGGAACTCTAGTAAATAAACCATATATGAGGAGGAAAGTCCAAAACA
TTATTTTTCATGAAAATTATACCAAGGCCGGGGTCCATGATGATATTGCCCTCGTGCAGCTTGC
TGAAGACGTCTCTTTTACGAAGTATGTTCGTAAGATTTGTCTTCCTGAAGCCAAAATGAAGCTC
TCAGAAAATGACAGTGTTGTAGTTACAGGATGGGGAACACTTTATATGAATGGTCCTCTCCCAG
TAATACTTCAACAGGCTGTTTTGAAGATTATTGATAACGAAGTTTGCAATGCTCCCCATGCATT
ATCTGGCTTGGTGACTGACACAATGCTCTGTGCTGGATTTATGTCAGGAGAAGCTGATGCCTGT
CAGAATGATTCTGGTGGACCACTAGCTTATCCTGACTCTAGAAATATCTGGCACCTTGTTGGAA
TAGTAAGCTGGGGTGAGGGATGTGGTAAGAAGAATAAACCGGGTGTCTATACTCGCGTGTCTGC
TTACCGTGACTGGATTACCTCTAAGACTGGACTCTGAGAGAGAAGTCATTTTGGAAAGACACAA
AAGACAACCGTAGAGTATTCTTATCCATCGCTGCAGAATCTTTTTGATTAATGGTATACCAATC
GTTTCTTATGTACAAATGCATGAAGGTCTGGATTAATATTTTATCTAAAATTCTATCCATTCAT
TTATTTACCTATTTAACTCATATAAGAAATAGGAAGGAAAAAAAGAAAGGGTGGCCAAAATATT
TTCATGAATAGCCTAGTTTTGACATTATGTTCATAGTAGACCTTAATTTATTTTTCAGAATTAA
AAGAGATATACATTTTGGTAGCATGAGAACATATATGTTGGCTCTACCAAATAAATTATTTTTC
ATTCTATAAATTATAATTACATTTTGTTAAACTGGAATATGTAAGACAAATAATGTACATGCAC
TTTTATTTATATGGGAGATAGTTTGTGTACCTTGTAAGATATCAGAGCTTCAACTAGACCAAGT
CTCTTAACTTACAGATTGAGAAGCTAAAAACAATTCTTGCTTAAAGTCATTCTTCAGCCTCTCT
GAAAAGCTGTACCACTCACGTGAATTTTCACTCATAGAATTTAAATCCAAAATTAGTCCGGAAT
TTAAAAATGATTTTAAAGTTGCCATTCTTTATTTAGTATTTCCTTCCTATCCTTCTTCTGTTAT
TTGTCTGGACTCCTTTGCAGCAAAAAATACCATGAGGCCCTCAAGGGCGGAGAACTGTGTAGCA
TCTCATGTAGTAGCTCTCCTGACAGTGCATGTGCCAGTGTATGAAGGGCCAACTTTGTAATCTC
TGAAAATAGTTCACCTTTTGTAATTTCCTAAAATTAAAAAAGTAGTTTCAAATTTCATAAGCAG
CTGAAATAAAAAATTCTCTCCCTTCAATTGTGATGTTACTCTTTTATTTTCTCTTTATCATAAA
TTATGACTCAAATGACATGCATAATGACAAGAAGCCAGTCCATAACCAGGTGTGACAGGATGGC
GCTCTTGTCCTCCCCATACTTTTCTCAGGCATGGGACACACATTTATTGAACACCAGTGTGTTC
TAGGAACTGTCAGTATTGTCTTTCAAGGCTGCTGCATTTAGTGGATAAACATAGGCAGTAAACA
CATGAATAAGTTCGGATTGTGGTAAGTGTTATGAAGGAAAAAAAAAAGCAATGTGATAGAAAAT
AATGGGGCAGATGAGAAGTACTTGAGATCAGAGAGTCTGAACAACTTTTCAAGAGGGCAGCATT
TGAATTGGATCTAAATGATGAAGTGGCAAAATATACAAAACATCTGAGAGAAGAAAACTAATGG
GAACAATTGTAGAATCCTTGAGGGAGAATTACAAGTGAAGTGGATGTATGGGTAGAAAAAAAAG
AGCCAGTGGGACTTAAGCCTGGTGGGTAAGTGAAAGATGGTAGGGCAGAACTGGAACGAGGTAA
TTAAGGGCCAGGTCAGAGAAGGCTTTGTAAAGACCTTGATTGTATTCAACTACAGTGGGAGACC
CTTGAGTTTTCCAAGCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_084829900	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000009527.3

RefSeq Acc Id:

XP_020957057 ⟸ XM_021101398

- Sequence:

show sequence

MYRYGISSQRRSWPLWMTILIFLGVMLILGVIIGLLVHFLAVGKTYYYQGDFHISGVTYNHSCE
KAVSQTGTDLSKAIETKMSDAFQNSSVYKEYINSQVIKFLPYPNGSRVQFQLTLKFPPAKKNSM
KTKIEGILHQMLKDNMASWNAVPSSIKLTETSKANAEMLTNNCCGRQLANSIIAGNRIVNGENA
LVGAWPWQASMQWKGRHHCGASLISSKWLLSAAHCFALKNNSEDWTINFGTLVNKPYMRRKVQN
IIFHENYTKAGVHDDIALVQLAEDVSFTKYVRKICLPEAKMKLSENDSVVVTGWGTLYMNGPLP
VILQQAVLKIIDNEVCNAPHALSGLVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVG
IVSWGEGCGKKNKPGVYTRVSAYRDWITSKTGL

hide sequence

Ensembl Acc Id:

ENSSSCP00000009527 ⟸ ENSSSCT00000009780

Protein Domains

Peptidase S1 SEA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000008932	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000009780.5	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	3.30.70.960	UniProtKB/TrEMBL
InterPro	Pept_S1A_HAT/DESC1	UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	SEA_dom	UniProtKB/TrEMBL
	SEA_dom_sf	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
NCBI Gene	LOC100513484	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/TrEMBL
	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED	UniProtKB/TrEMBL
Pfam	SEA	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PIRSF	TMPRSS11ABCDE	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	SEA	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
	SSF82671	UniProtKB/TrEMBL
UniProt	F1RUS1_PIG	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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