Tmprss11b (transmembrane serine protease 11B) - Rat Genome Database

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Gene: Tmprss11b (transmembrane serine protease 11B) Rattus norvegicus
Analyze
Symbol: Tmprss11b
Name: transmembrane serine protease 11B
RGD ID: 1303278
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Orthologous to human TMPRSS11B (transmembrane serine protease 11B); INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: airway trypsin-like 5; airway trypsin-like protease 5; Hatl5; Tmprss11bnl; transmembrane protease serine 11B; transmembrane protease, serine 11B
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,738,760 - 21,763,896 (+)NCBIGRCr8
mRatBN7.21421,383,936 - 21,407,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,383,862 - 21,408,817 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1421,740,535 - 21,760,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,059,465 - 23,079,322 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,590,547 - 21,610,408 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01424,103,768 - 24,125,260 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1424,103,954 - 24,123,253 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01423,940,743 - 23,960,116 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41423,009,055 - 23,029,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11423,009,054 - 23,029,587 (+)NCBI
Celera1420,876,772 - 20,895,405 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19199708   PMID:24498351  


Genomics

Comparative Map Data
Tmprss11b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,738,760 - 21,763,896 (+)NCBIGRCr8
mRatBN7.21421,383,936 - 21,407,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,383,862 - 21,408,817 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1421,740,535 - 21,760,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,059,465 - 23,079,322 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,590,547 - 21,610,408 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01424,103,768 - 24,125,260 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1424,103,954 - 24,123,253 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01423,940,743 - 23,960,116 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41423,009,055 - 23,029,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11423,009,054 - 23,029,587 (+)NCBI
Celera1420,876,772 - 20,895,405 (+)NCBICelera
Cytogenetic Map14p21NCBI
TMPRSS11B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38468,226,653 - 68,245,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl468,226,653 - 68,245,694 (-)EnsemblGRCh38hg38GRCh38
GRCh37469,092,371 - 69,111,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,774,966 - 68,794,004 (-)NCBINCBI36Build 36hg18NCBI36
Celera466,551,717 - 66,570,749 (-)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef465,004,927 - 65,023,958 (-)NCBIHuRef
CHM1_1469,129,015 - 69,148,054 (-)NCBICHM1_1
T2T-CHM13v2.0471,666,935 - 71,685,995 (-)NCBIT2T-CHM13v2.0
Tmprss11b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,806,326 - 86,824,221 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,805,490 - 86,824,221 (-)EnsemblGRCm39 Ensembl
GRCm38586,659,522 - 86,676,298 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,657,631 - 86,676,362 (-)EnsemblGRCm38mm10GRCm38
MGSCv37587,088,547 - 87,105,323 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36587,732,998 - 87,750,911 (-)NCBIMGSCv36mm8
Celera583,879,850 - 83,896,603 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
TMPRSS11B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2361,648,353 - 61,670,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1461,858,476 - 61,881,030 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0455,802,811 - 55,825,366 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1462,200,252 - 62,219,386 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl462,200,414 - 62,218,523 (+)Ensemblpanpan1.1panPan2
LOC482175
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,648,662 - 58,656,588 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1358,577,447 - 58,587,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01359,350,520 - 59,361,072 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11358,998,034 - 59,010,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01358,481,818 - 58,495,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01359,501,056 - 59,513,565 (-)NCBIUU_Cfam_GSD_1.0
Tmprss11b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528517,751,893 - 17,770,648 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936582315,088 - 333,814 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100513484
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl865,882,623 - 65,902,436 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1865,881,985 - 65,898,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,305,132 - 70,321,065 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235709
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17734,885 - 748,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7734,900 - 748,477 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666066819,735 - 838,550 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tmprss11b
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000002743
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 2 4 4 3 9
Below cutoff 4 8 4 4 4 1 1 8 6 16 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002743   ⟹   ENSRNOP00000002743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,388,181 - 21,408,817 (+)Ensembl
Rnor_6.0 Ensembl1424,103,954 - 24,123,253 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118946   ⟹   ENSRNOP00000085141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,383,862 - 21,408,817 (+)Ensembl
RefSeq Acc Id: NM_001412524   ⟹   NP_001399453
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,738,760 - 21,762,107 (+)NCBI
mRatBN7.21421,383,936 - 21,407,283 (+)NCBI
RefSeq Acc Id: XM_063273446   ⟹   XP_063129516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,740,748 - 21,763,896 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001399453 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129516 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51905 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002743.4
  ENSRNOP00000085141
  ENSRNOP00000085141.1
GenBank Protein Q6IE14 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000002743   ⟸   ENSRNOT00000002743
RefSeq Acc Id: ENSRNOP00000085141   ⟸   ENSRNOT00000118946
RefSeq Acc Id: NP_001399453   ⟸   NM_001412524
- UniProtKB: Q6IE14 (UniProtKB/Swiss-Prot),   A0A8I6A3C5 (UniProtKB/TrEMBL),   A0A8L2UHK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129516   ⟸   XM_063273446
- Peptide Label: isoform X1
Protein Domains
Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE14-F1-model_v2 AlphaFold Q6IE14 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303278 AgrOrtholog
BioCyc Gene G2FUF-16079 BioCyc
Ensembl Genes ENSRNOG00000002002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002743.4 UniProtKB/TrEMBL
  ENSRNOT00000118946 ENTREZGENE
  ENSRNOT00000118946.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Pept_S1A_HAT/DESC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:365265 UniProtKB/Swiss-Prot
NCBI Gene 365265 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE SERINE PROTEASE 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmprss11b PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002002 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A3C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UHK6 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE14 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss11b  transmembrane serine protease 11B  Tmprss11b  transmembrane protease, serine 11B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-13 Tmprss11b  transmembrane protease, serine 11B  Tmprss11bnl  transmembrane protease, serine 11B N terminal like  Name and Symbol changed 629549 APPROVED
2013-08-02 Tmprss11bnl  transmembrane protease, serine 11B N terminal like  Tmprss11bnl  TMPRSS11B N terminal-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-06 Tmprss11bnl  TMPRSS11B N terminal-like  Tmprss11bnl  transmembrane protease, serine 11b N terminal like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-04 Tmprss11bnl  transmembrane protease, serine 11b N terminal like  Tmprss11b  transmembrane protease, serine 11b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tmprss11b  transmembrane protease, serine 11b  Hatl5  airway trypsin-like 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Hatl5  airway trypsin-like 5      Symbol and Name status set to provisional 70820 PROVISIONAL