PTPRU (protein tyrosine phosphatase receptor type U) - Rat Genome Database

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Gene: PTPRU (protein tyrosine phosphatase receptor type U) Sus scrofa
Analyze
Symbol: PTPRU
Name: protein tyrosine phosphatase receptor type U
RGD ID: 14040853
Description: ENCODES a protein that exhibits beta-catenin binding (inferred); hydrolase activity (inferred); protein tyrosine phosphatase activity (inferred); INVOLVED IN animal organ regeneration (ortholog); homotypic cell-cell adhesion (ortholog); protein dephosphorylation (ortholog); ASSOCIATED WITH cervical cancer (ortholog); clear cell renal cell carcinoma (ortholog); colon adenocarcinoma (ortholog); FOUND IN anchoring junction (inferred); cell-cell junction (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol; graphene oxide
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-type tyrosine-protein phosphatase U
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl686,137,737 - 86,228,145 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1686,137,743 - 86,228,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2680,024,234 - 80,106,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
PTPRU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl686,137,737 - 86,228,145 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1686,137,743 - 86,228,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2680,024,234 - 80,106,252 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,236,522 - 29,326,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,236,500 - 29,326,813 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37129,563,034 - 29,653,312 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,435,634 - 29,525,903 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34129,383,643 - 29,473,927NCBI
Celera127,959,180 - 28,049,910 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,814,346 - 27,905,164 (+)NCBIHuRef
CHM1_1129,678,424 - 29,768,677 (+)NCBICHM1_1
T2T-CHM13v2.0129,079,179 - 29,169,454 (+)NCBIT2T-CHM13v2.0
Ptpru
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394131,495,768 - 131,565,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,495,696 - 131,565,650 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384131,768,457 - 131,838,306 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4131,768,457 - 131,838,288 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv374131,324,372 - 131,394,193 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364131,040,533 - 131,110,354 (-)NCBIMGSCv36mm8
Celera4129,928,568 - 129,998,810 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.5NCBI
Ptpru
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,234,624 - 149,308,857 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5149,234,624 - 149,308,833 (-)EnsemblGRCr8
mRatBN7.25143,950,542 - 144,024,791 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5143,950,965 - 144,024,768 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5146,656,411 - 146,730,321 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,426,261 - 148,500,169 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,413,833 - 148,488,044 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5148,857,656 - 148,932,272 (-)NCBI
Lyon_Normotensive5150,852,892 - 150,927,520 (-)NCBI
Lyon_Hypertensive5150,022,582 - 150,097,190 (-)NCBI
F344_StmMcwi5143,602,680 - 143,676,765 (-)NCBI
Rnor_6.05149,922,374 - 149,996,352 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5149,922,352 - 149,996,334 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.05153,601,160 - 153,675,514 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45150,612,095 - 150,695,183 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5142,397,414 - 142,468,771 (-)NCBICelera
RGSC_v3.15150,660,034 - 150,668,570 (-)NCBI
Cytogenetic Map5q36NCBI
Ptpru
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554528,223,692 - 8,296,769 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554528,223,773 - 8,296,769 (+)NCBIChiLan1.0ChiLan1.0
PTPRU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21197,516,640 - 197,606,767 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,635,952 - 196,726,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,507,078 - 28,597,154 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,556,675 - 29,623,247 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,551,912 - 29,622,104 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
PTPRU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,284,979 - 71,363,253 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,285,851 - 71,363,691 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha267,861,226 - 67,939,839 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0271,844,918 - 71,923,499 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,844,933 - 71,923,492 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,673,740 - 68,752,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,681,824 - 69,760,389 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0270,679,504 - 70,758,203 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptpru
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11120,014,560 - 20,184,733 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440505847,268,246 - 47,438,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647413,197,786 - 13,263,362 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647413,197,786 - 13,263,187 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap120107,748,623 - 107,837,306 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603312,943,572 - 13,032,266 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.120103,497,681 - 103,586,494 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20103,498,839 - 103,586,348 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Ptpru
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476412,994,562 - 13,072,723 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462476412,994,521 - 13,073,251 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl721,356,750 - 21,439,699 (-)Ensembl
Ptpru
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1126,416,223 - 26,490,319 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in PTPRU
2961 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 5 14 12 23 3 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021095724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021095732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_084963512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_084963513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_084963514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_084963515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_084963516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_084963517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002344956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002344957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_014807360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_014807361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_014807362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_014807363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_014807364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_014807365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK238104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK238384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU638838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01121309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JBREVY020000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000003985   ⟹   ENSSSCP00000003894
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl686,137,737 - 86,228,145 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000056743   ⟹   ENSSSCP00000057253
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl686,137,737 - 86,228,145 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000065587   ⟹   ENSSSCP00000035599
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl686,137,737 - 86,228,146 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000066021   ⟹   ENSSSCP00000051375
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl686,137,737 - 86,228,146 (+)Ensembl
RefSeq Acc Id: XM_021095724   ⟹   XP_020951383
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,806 - 86,228,148 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095725   ⟹   XP_020951384
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,805 - 86,228,145 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095727   ⟹   XP_020951386
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,145,027 - 86,228,145 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095728   ⟹   XP_020951387
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,806 - 86,228,145 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095729   ⟹   XP_020951388
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,805 - 86,228,145 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095730   ⟹   XP_020951389
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,807 - 86,228,145 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095731   ⟹   XP_020951390
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,743 - 86,228,148 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095732   ⟹   XP_020951391
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,764 - 86,228,146 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002344956
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,804 - 86,228,148 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002344957
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1686,137,803 - 86,228,145 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020951390   ⟸   XM_021095731
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_020951391   ⟸   XM_021095732
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_020951384   ⟸   XM_021095725
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020951388   ⟸   XM_021095729
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020951383   ⟸   XM_021095724
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020951387   ⟸   XM_021095728
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020951389   ⟸   XM_021095730
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_020951386   ⟸   XM_021095727
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSSSCP00000035599   ⟸   ENSSSCT00000065587
Ensembl Acc Id: ENSSSCP00000003894   ⟸   ENSSSCT00000003985
Ensembl Acc Id: ENSSSCP00000051375   ⟸   ENSSSCT00000066021
Ensembl Acc Id: ENSSSCP00000057253   ⟸   ENSSSCT00000056743
Protein Domains
Fibronectin type-III   MAM   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003590 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003985.5 UniProtKB/TrEMBL
  ENSSSCT00000056743.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  Fn3_PTPRU UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  R-tyr_protein_phosphatases UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene PTPRU ENTREZGENE
PANTHER PROTEIN-TYROSINE-PHOSPHATASE-RELATED UniProtKB/TrEMBL
  SUSHI DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  Fn3_PTPRU UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS MAMDOMAIN UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  MAM_1 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A287BL62_PIG UniProtKB/TrEMBL
  F1STL3_PIG UniProtKB/TrEMBL
UniProt Secondary A0A286ZVW3 UniProtKB/TrEMBL
VGNC ID VGNC:91995 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPRU  protein tyrosine phosphatase receptor type U    protein tyrosine phosphatase, receptor type U  Symbol and/or name change 5135510 APPROVED