ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase) - Rat Genome Database

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Gene: ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase) Sus scrofa
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Symbol: ALKBH3
Name: alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
RGD ID: 14028701
Description: ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (ortholog); cytosine C-5 DNA demethylase activity (ortholog); endonuclease activity (ortholog); INVOLVED IN biosynthetic process (inferred); cell population proliferation (inferred); DNA alkylation repair (inferred); ASSOCIATED WITH intellectual disability (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkB homolog 3, alpha-ketoglutaratedependent dioxygenase; alkB, alkylation repair homolog 3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl218,408,987 - 18,446,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1218,408,987 - 18,448,285 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2220,011,987 - 20,048,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALKBH3Pigintellectual disability  ISOALKBH3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALKBH3Pigbiosynthetic process involved_inIEAInterPro:IPR004839150520179 InterProGO_REF:0000002
ALKBH3Pigcell population proliferation involved_inIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3PigDNA alkylation repair involved_inIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3PigDNA alkylation repair involved_inIEAInterPro:IPR032854150520179 InterProGO_REF:0000002
ALKBH3PigDNA repair involved_inIEAInterPro:IPR032854150520179 InterProGO_REF:0000002
ALKBH3PigDNA repair involved_inIBAPANTHER:PTN001261013 and UniProtKB:Q96Q83150520179 GO_CentralGO_REF:0000033
ALKBH3Pignegative regulation of cytoplasmic translation involved_inIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALKBH3Pigcytosol located_inIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3Pigmitochondrion located_inIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3Pigmitochondrion is_active_inIBAPANTHER:PTN001261013 and UniProtKB:Q96Q83150520179 GO_CentralGO_REF:0000033
ALKBH3Pignucleoplasm located_inIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3Pignucleoplasm is_active_inIBAPANTHER:PTN001261013 and UniProtKB:Q96Q83150520179 GO_CentralGO_REF:0000033

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ALKBH3Pig2-oxoglutarate-dependent dioxygenase activity enablesISOAlkbh3 (Mus musculus)9068941 PMID:16174769MGIPMID:16174769
ALKBH3Pigbroad specificity oxidative DNA demethylase activity enablesIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3Pigcytosine C-5 DNA demethylase activity enablesISOAlkbh3 (Mus musculus)9068941 PMID:16174769MGIPMID:16174769
ALKBH3Pigdioxygenase activity enablesIEAInterPro:IPR032854150520179 InterProGO_REF:0000002
ALKBH3Pigdioxygenase activity enablesIEAUniProtKB-KW:KW-0223150520179 UniProtGO_REF:0000043
ALKBH3Pigendonuclease activity NOT|enablesISOAlkbh3 (Mus musculus)9068941 PMID:16174769MGIPMID:16174769
ALKBH3Pigexonuclease activity NOT|enablesISOAlkbh3 (Mus musculus)9068941 PMID:16174769MGIPMID:16174769
ALKBH3Pigferrous iron binding enablesIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3PigmRNA N1-methyladenosine dioxygenase activity enablesIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3Pigoxidative RNA demethylase activity enablesIEAUniProtKB:Q96Q83 and ensembl:ENSP00000302232150520179 EnsemblGO_REF:0000107
ALKBH3Pigprotein binding enablesISOUniProtKB:O75400-2 more ...9068941 PMID:32814053IntActPMID:32814053
ALKBH3Pigprotein binding enablesISOUniProtKB:O76003 more ...9068941 PMID:25416956IntActPMID:25416956
ALKBH3Pigprotein binding enablesISOUniProtKB:Q8N3C09068941 PMID:22055184UniProtPMID:22055184
ALKBH3Pigprotein binding enablesISOUniProtKB:Q08379 and UniProtKB:Q134229068941 PMID:29892012 and PMID:31515488IntActPMID:29892012 and PMID:31515488
ALKBH3Pigpyridoxal phosphate binding enablesIEAInterPro:IPR004839150520179 InterProGO_REF:0000002
1 to 15 of 15 rows

PMID:14681463   PMID:17145712   PMID:30032202  



ALKBH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl218,408,987 - 18,446,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1218,408,987 - 18,448,285 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2220,011,987 - 20,048,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALKBH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381143,880,831 - 43,920,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1143,880,811 - 43,920,274 (+)EnsemblGRCh38hg38GRCh38
GRCh371143,902,381 - 43,941,824 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361143,858,971 - 43,898,389 (+)NCBINCBI36Build 36hg18NCBI36
Celera1144,048,227 - 44,087,676 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1143,611,668 - 43,651,108 (+)NCBIHuRef
CHM1_11143,901,678 - 43,940,820 (+)NCBICHM1_1
T2T-CHM13v2.01144,036,210 - 44,075,625 (+)NCBIT2T-CHM13v2.0
Alkbh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39293,810,979 - 93,841,099 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl293,810,895 - 93,841,152 (-)EnsemblGRCm39 Ensembl
GRCm38293,980,624 - 94,010,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl293,980,550 - 94,010,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv37293,820,791 - 93,850,887 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36293,781,391 - 93,811,646 (-)NCBIMGSCv36mm8
Celera295,377,139 - 95,407,273 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map251.62NCBI
Alkbh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,394,942 - 100,429,466 (-)NCBIGRCr8
mRatBN7.2379,939,515 - 79,972,820 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl379,939,600 - 79,972,000 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,413,118 - 83,445,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0392,012,208 - 92,044,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0389,857,713 - 89,889,968 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0382,874,242 - 82,907,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl382,874,248 - 82,906,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,575,451 - 89,608,158 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4378,386,098 - 78,418,432 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1378,282,525 - 78,314,860 (-)NCBI
Celera379,141,033 - 79,172,722 (-)NCBICelera
Cytogenetic Map3q31NCBI
Alkbh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554223,657,765 - 3,695,409 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554223,660,504 - 3,695,352 (-)NCBIChiLan1.0ChiLan1.0
ALKBH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2946,095,666 - 46,135,186 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11146,101,637 - 46,141,224 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,841,083 - 43,880,608 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11144,336,655 - 44,376,058 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1144,336,655 - 44,376,057 (+)Ensemblpanpan1.1panPan2
ALKBH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,864,041 - 25,899,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,824,877 - 25,899,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,551,100 - 25,585,936 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,486,584 - 26,521,476 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1826,449,542 - 26,519,594 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,996,121 - 26,030,947 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,641,660 - 25,676,520 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,253,706 - 26,288,540 (-)NCBIUU_Cfam_GSD_1.0
Alkbh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494722,615,131 - 22,666,079 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365624,741,371 - 4,777,727 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365624,743,595 - 4,777,685 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALKBH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,463,744 - 21,505,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,462,516 - 21,505,934 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038118,701,961 - 118,743,776 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alkbh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247674,103,446 - 4,139,345 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247674,088,173 - 4,139,288 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in ALKBH3
1360 total Variants






RefSeq Acc Id: XM_003353890   ⟹   XP_003353938
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1218,408,989 - 18,448,285 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083167   ⟹   XP_020938826
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1218,408,987 - 18,448,281 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083168   ⟹   XP_020938827
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1218,408,987 - 18,448,089 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020938826   ⟸   XM_021083167
- UniProtKB: A0A287B3Y6 (UniProtKB/TrEMBL),   A0A8D0N0X7 (UniProtKB/TrEMBL),   A0A480SMH5 (UniProtKB/TrEMBL),   A0A4X1SIA3 (UniProtKB/TrEMBL),   A0A8D1XG30 (UniProtKB/TrEMBL),   A0A8D0ZPZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938827   ⟸   XM_021083168
- UniProtKB: A0A287B3Y6 (UniProtKB/TrEMBL),   A0A8D0N0X7 (UniProtKB/TrEMBL),   A0A480SMH5 (UniProtKB/TrEMBL),   A0A4X1SIA3 (UniProtKB/TrEMBL),   A0A8D1XG30 (UniProtKB/TrEMBL),   A0A8D0ZPZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003353938   ⟸   XM_003353890
- UniProtKB: A0A287B3Y6 (UniProtKB/TrEMBL),   A0A8D0N0X7 (UniProtKB/TrEMBL),   A0A480SMH5 (UniProtKB/TrEMBL),   A0A4X1SIA3 (UniProtKB/TrEMBL),   A0A8D1XG30 (UniProtKB/TrEMBL),   A0A8D0ZPZ0 (UniProtKB/TrEMBL)
- Sequence:


1 to 40 of 72 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000040937 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015022773 UniProtKB/TrEMBL
  ENSSSCG00025007546 UniProtKB/TrEMBL
  ENSSSCG00030041674 UniProtKB/TrEMBL
  ENSSSCG00035033877 UniProtKB/TrEMBL
  ENSSSCG00040062780 UniProtKB/TrEMBL
  ENSSSCG00045035085 UniProtKB/TrEMBL
  ENSSSCG00050002932 UniProtKB/TrEMBL
  ENSSSCG00055015758 UniProtKB/TrEMBL
  ENSSSCG00060010499 UniProtKB/TrEMBL
  ENSSSCG00065010246 UniProtKB/TrEMBL
  ENSSSCG00070000956 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000044385 ENTREZGENE
  ENSSSCT00000044385.3 UniProtKB/TrEMBL
  ENSSSCT00015030193.1 UniProtKB/TrEMBL
  ENSSSCT00015030269.1 UniProtKB/TrEMBL
  ENSSSCT00025010032.1 UniProtKB/TrEMBL
  ENSSSCT00030057942.1 UniProtKB/TrEMBL
  ENSSSCT00030057951.1 UniProtKB/TrEMBL
  ENSSSCT00035044906.1 UniProtKB/TrEMBL
  ENSSSCT00035044923.1 UniProtKB/TrEMBL
  ENSSSCT00040085653.1 UniProtKB/TrEMBL
  ENSSSCT00040085939.1 UniProtKB/TrEMBL
  ENSSSCT00040086065.1 UniProtKB/TrEMBL
  ENSSSCT00045060571.1 UniProtKB/TrEMBL
  ENSSSCT00045060664.1 UniProtKB/TrEMBL
  ENSSSCT00050003827.1 UniProtKB/TrEMBL
  ENSSSCT00055031020.1 UniProtKB/TrEMBL
  ENSSSCT00055031227.1 UniProtKB/TrEMBL
  ENSSSCT00060013644.1 UniProtKB/TrEMBL
  ENSSSCT00065013624.1 UniProtKB/TrEMBL
  ENSSSCT00070001855.1 UniProtKB/TrEMBL
  ENSSSCT00070001866.1 UniProtKB/TrEMBL
  ENSSSCT00070001876.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.590 UniProtKB/TrEMBL
  3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro AlkB-like UniProtKB/TrEMBL
  AlkB-like_sf UniProtKB/TrEMBL
  ALKBH3 UniProtKB/TrEMBL
1 to 40 of 72 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-21 ALKBH3  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase  ALKBH3  alkB homolog 3, alpha-ketoglutaratedependent dioxygenase  Symbol and/or name change 5135510 APPROVED