PAK6 (p21 (RAC1) activated kinase 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: PAK6 (p21 (RAC1) activated kinase 6) Sus scrofa
Analyze
Symbol: PAK6
Name: p21 (RAC1) activated kinase 6
RGD ID: 14011578
Description: ENCODES a protein that exhibits 3-phosphoinositide-dependent protein kinase activity (inferred); AMP-activated protein kinase activity (inferred); ATP binding (inferred); INVOLVED IN learning (ortholog); locomotory behavior (ortholog); memory (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); clear cell renal cell carcinoma (ortholog); colorectal cancer (ortholog); FOUND IN postsynaptic density (ortholog); INTERACTS WITH deoxynivalenol; zearalenone
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase PAK 6; serine/threonine-protein kinase PAK 6-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,039,318 - 131,076,631 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,039,313 - 131,077,420 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,145,830 - 146,151,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PAK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,039,318 - 131,076,631 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,039,313 - 131,077,420 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,145,830 - 146,151,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,239,063 - 40,277,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,217,428 - 40,277,487 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,531,264 - 40,569,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,319,368 - 38,356,979 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,319,367 - 38,356,979NCBI
Celera1517,275,604 - 17,335,680 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,352,605 - 17,412,646 (+)NCBIHuRef
CHM1_11540,629,582 - 40,689,654 (+)NCBICHM1_1
T2T-CHM13v2.01538,045,955 - 38,084,404 (+)NCBIT2T-CHM13v2.0
Pak6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,493,531 - 118,528,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,493,784 - 118,528,501 (+)EnsemblGRCm39 Ensembl
GRCm382118,663,045 - 118,698,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,663,303 - 118,698,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,489,313 - 118,523,756 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,354,744 - 118,388,677 (+)NCBIMGSCv36mm8
Celera2119,818,133 - 119,852,648 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.41NCBI
Pak6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,092,576 - 126,128,320 (+)NCBIGRCr8
mRatBN7.23105,638,248 - 105,674,399 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,638,653 - 105,672,975 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,312,014 - 109,345,868 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,907,575 - 117,941,432 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,567,941 - 115,601,794 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,442,175 - 110,486,317 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,442,637 - 110,487,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,987,226 - 117,027,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,141,150 - 105,191,676 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,080,467 - 105,088,577 (+)NCBI
Celera3104,554,473 - 104,587,411 (+)NCBICelera
Cytogenetic Map3q35NCBI
Pak6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,178,524 - 7,212,053 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,190,584 - 7,211,705 (+)NCBIChiLan1.0ChiLan1.0
PAK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,473,050 - 29,511,489 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,624,528 - 33,662,919 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,173,171 - 19,211,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,441,567 - 37,466,520 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,453,802 - 37,465,119 (+)Ensemblpanpan1.1panPan2
PAK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,424,410 - 7,462,265 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,425,948 - 7,461,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,478,897 - 7,516,220 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,553,994 - 7,588,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,577,691 - 7,588,086 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,475,297 - 7,512,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,581,248 - 7,618,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,709,827 - 7,747,189 (+)NCBIUU_Cfam_GSD_1.0
Pak6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,863,845 - 85,899,290 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,713,406 - 3,747,356 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,692,058 - 3,747,355 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,737,848 - 42,798,960 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,737,613 - 42,750,248 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,187,124 - 98,226,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,549,630 - 7,584,567 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,549,847 - 7,583,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PAK6
675 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 2 23 3 2 5 10 6 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000005280   ⟹   ENSSSCP00000005152
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1131,039,705 - 131,076,631 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000047256   ⟹   ENSSSCP00000031673
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1131,039,318 - 131,076,631 (-)Ensembl
RefSeq Acc Id: XM_021097786   ⟹   XP_020953445
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11131,039,313 - 131,077,420 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021097791   ⟹   XP_020953450
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11131,039,313 - 131,077,420 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021097802   ⟹   XP_020953461
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11131,039,313 - 131,077,420 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020953445 (Get FASTA)   NCBI Sequence Viewer  
  XP_020953450 (Get FASTA)   NCBI Sequence Viewer  
  XP_020953461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000005152.5
  ENSSSCP00000031673
  ENSSSCP00000031673.1
  ENSSSCP00025007544.1
RefSeq Acc Id: XP_020953445   ⟸   XM_021097786
- UniProtKB: A0A286ZJP1 (UniProtKB/TrEMBL),   A0A8D0QVT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953450   ⟸   XM_021097791
- UniProtKB: A0A286ZJP1 (UniProtKB/TrEMBL),   A0A8D0QVT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020953461   ⟸   XM_021097802
- UniProtKB: A0A286ZJP1 (UniProtKB/TrEMBL),   A0A8D0QVT2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000005152   ⟸   ENSSSCT00000005280
Ensembl Acc Id: ENSSSCP00000031673   ⟸   ENSSSCT00000047256
Protein Domains
CRIB   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025013965 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005280.5 UniProtKB/TrEMBL
  ENSSSCT00000047256 ENTREZGENE
  ENSSSCT00000047256.1 UniProtKB/TrEMBL
  ENSSSCT00025018681.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.810.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PAK6 UniProtKB/TrEMBL
  PAK_BD UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  STE20_Ser/Thr_kinase UniProtKB/TrEMBL
NCBI Gene PAK6 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PAK 6 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TAO UniProtKB/TrEMBL
Pfam PBD UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE CRIB UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART PBD UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A286ZJP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0QVT2 ENTREZGENE, UniProtKB/TrEMBL
  F1SS32_PIG UniProtKB/TrEMBL
VGNC ID VGNC:103144 ENTREZGENE