Thap4 (THAP domain containing 4) - Rat Genome Database

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Pathways
Gene: Thap4 (THAP domain containing 4) Rattus norvegicus
Analyze
Symbol: Thap4
Name: THAP domain containing 4
RGD ID: 1359473
Description: Predicted to enable several functions, including heme binding activity; nitric oxide binding activity; and peroxynitrite isomerase activity. Predicted to be involved in nitrate metabolic process and tyrosine metabolic process. Predicted to be located in cytosol and nucleoplasm. Orthologous to human THAP4 (THAP domain containing 4); INTERACTS WITH (+)-schisandrin B; bisphenol A; diuron.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ferric nitrobindin; MGC93755; Nb(III); peroxynitrite isomerase THAP4; THAP domain-containing protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,689,935 - 101,729,656 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,689,936 - 101,729,441 (-)EnsemblGRCr8
mRatBN7.2994,242,581 - 94,282,312 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,242,581 - 94,282,306 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9102,678,061 - 102,717,571 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,813,709 - 107,853,217 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,169,811 - 106,209,318 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,848,597 - 100,888,107 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,848,598 - 100,888,107 (-)Ensemblrn6Rnor6.0
Rnor_5.09100,501,661 - 100,541,256 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4992,989,072 - 93,031,408 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,777,055 - 91,816,491 (-)NCBICelera
RGSC_v3.1993,193,841 - 93,236,177 (-)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. null JRS Domain-based curation
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:21387410   PMID:30524950   PMID:38658415  


Genomics

Comparative Map Data
Thap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,689,935 - 101,729,656 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,689,936 - 101,729,441 (-)EnsemblGRCr8
mRatBN7.2994,242,581 - 94,282,312 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,242,581 - 94,282,306 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9102,678,061 - 102,717,571 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,813,709 - 107,853,217 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,169,811 - 106,209,318 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,848,597 - 100,888,107 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,848,598 - 100,888,107 (-)Ensemblrn6Rnor6.0
Rnor_5.09100,501,661 - 100,541,256 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4992,989,072 - 93,031,408 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,777,055 - 91,816,491 (-)NCBICelera
RGSC_v3.1993,193,841 - 93,236,177 (-)NCBI
Cytogenetic Map9q36NCBI
THAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,584,405 - 241,637,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,584,405 - 241,637,158 (-)Ensemblhg38GRCh38
GRCh372242,523,820 - 242,576,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,172,493 - 242,225,328 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2236,191,554 - 236,248,451 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,277,652 - 234,329,989 (-)NCBIHuRef
CHM1_12242,529,419 - 242,582,861 (-)NCBICHM1_1
T2T-CHM13v2.02242,084,274 - 242,140,900 (-)NCBIT2T-CHM13v2.0
Thap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,633,113 - 93,682,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,629,657 - 93,682,586 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38193,705,391 - 93,754,838 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,701,935 - 93,754,864 (-)Ensemblmm10GRCm38
MGSCv37195,601,968 - 95,651,415 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36195,535,797 - 95,585,244 (-)NCBIMGSCv36mm8
MGSCv36194,158,268 - 94,207,849 (-)NCBIMGSCv36mm8
Celera196,650,530 - 96,699,008 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.29NCBI
Thap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542195,088 - 217,831 (+)Ensembl
ChiLan1.0NW_004955542192,888 - 217,985 (+)NCBIChiLan1.0ChiLan1.0
THAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,290,268 - 144,345,336 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,305,143 - 144,360,216 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,858,512 - 128,913,474 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,650,249 - 247,684,576 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,650,249 - 247,701,219 (-)EnsemblpanPan2panpan1.1
THAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,456,349 - 51,480,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,456,344 - 51,494,367 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2551,674,803 - 51,713,677 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02551,654,937 - 51,693,321 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,654,925 - 51,693,318 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,504,264 - 51,543,189 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,244,160 - 51,282,359 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,520,478 - 51,559,045 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Thap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,881,163 - 192,902,172 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745316,748 - 338,142 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936745324,988 - 338,257 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,185,682 - 140,223,477 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115140,190,198 - 140,223,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215154,825,625 - 154,838,103 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THAP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,643,567 - 127,689,582 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,643,102 - 127,689,377 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604071,633,005 - 71,678,844 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,578,001 - 5,605,423 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248475,579,521 - 5,605,447 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Thap4
215 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:145
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000024794
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
AA924144  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2994,242,657 - 94,242,852 (+)MAPPERmRatBN7.2
Rnor_6.09100,848,674 - 100,848,868NCBIRnor6.0
Rnor_5.09100,501,738 - 100,501,932UniSTSRnor5.0
RGSC_v3.4992,989,149 - 92,989,343UniSTSRGSC3.4
Celera991,777,132 - 91,777,326UniSTS
RH 3.4 Map9806.7UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024794   ⟹   ENSRNOP00000024794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,689,936 - 101,729,441 (-)Ensembl
mRatBN7.2 Ensembl994,242,581 - 94,282,125 (-)Ensembl
Rnor_6.0 Ensembl9100,848,598 - 100,888,107 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096279   ⟹   ENSRNOP00000088157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,242,605 - 94,282,111 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100100   ⟹   ENSRNOP00000094711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,242,581 - 94,282,306 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103287   ⟹   ENSRNOP00000077619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,689,936 - 101,722,608 (-)Ensembl
mRatBN7.2 Ensembl994,242,581 - 94,265,301 (-)Ensembl
RefSeq Acc Id: NM_001005564   ⟹   NP_001005564
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,689,935 - 101,729,441 (-)NCBI
mRatBN7.2994,242,581 - 94,282,090 (-)NCBI
Rnor_6.09100,848,597 - 100,888,107 (-)NCBI
Rnor_5.09100,501,661 - 100,541,256 (-)NCBI
RGSC_v3.4992,989,072 - 93,031,408 (-)RGD
Celera991,777,055 - 91,816,491 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767380   ⟹   XP_008765602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,689,935 - 101,720,079 (-)NCBI
mRatBN7.2994,242,581 - 94,265,160 (-)NCBI
Rnor_6.09100,848,597 - 100,872,100 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083932   ⟹   XP_038939860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,689,935 - 101,729,656 (-)NCBI
mRatBN7.2994,242,581 - 94,282,312 (-)NCBI
RefSeq Acc Id: NP_001005564   ⟸   NM_001005564
- UniProtKB: Q642B6 (UniProtKB/Swiss-Prot),   A6JR27 (UniProtKB/TrEMBL),   A0A8I6ANL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765602   ⟸   XM_008767380
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBX9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024794   ⟸   ENSRNOT00000024794
RefSeq Acc Id: XP_038939860   ⟸   XM_039083932
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANL8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094711   ⟸   ENSRNOT00000100100
Ensembl Acc Id: ENSRNOP00000077619   ⟸   ENSRNOT00000103287
Ensembl Acc Id: ENSRNOP00000088157   ⟸   ENSRNOT00000096279
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q642B6-F1-model_v2 AlphaFold Q642B6 1-569 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696881
Promoter ID:EPDNEW_R7405
Type:initiation region
Name:Thap4_1
Description:THAP domain containing 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,888,145 - 100,888,205EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359473 AgrOrtholog
BioCyc Gene G2FUF-26632 BioCyc
Ensembl Genes ENSRNOG00000018351 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024794 ENTREZGENE
  ENSRNOT00000024794.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
  6.20.210.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108379 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/Swiss-Prot
  DUF1794 UniProtKB/Swiss-Prot
  THAP4-like UniProtKB/Swiss-Prot
  THAP_Znf UniProtKB/Swiss-Prot
  THAP_Znf_sf UniProtKB/Swiss-Prot
KEGG Report rno:363291 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93755 IMAGE-MGC_LOAD
NCBI Gene 363291 ENTREZGENE
PANTHER PEROXYNITRITE ISOMERASE THAP4 UniProtKB/Swiss-Prot
  PTHR15854 UniProtKB/Swiss-Prot
Pfam DUF1794 UniProtKB/Swiss-Prot
  THAP UniProtKB/Swiss-Prot
PhenoGen Thap4 PhenoGen
PROSITE ZF_THAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018351 RatGTEx
SMART DM3 UniProtKB/Swiss-Prot
  THAP UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF50814 UniProtKB/Swiss-Prot
UniProt A0A8I5YBX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5M2_RAT UniProtKB/TrEMBL
  A0A8I6ANL8 ENTREZGENE, UniProtKB/TrEMBL
  A6JR27 ENTREZGENE, UniProtKB/TrEMBL
  A6JR28_RAT UniProtKB/TrEMBL
  A6JR29_RAT UniProtKB/TrEMBL
  Q642B6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Thap4  THAP domain containing 4      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Thap4  THAP domain containing 4      Symbol and Name status set to provisional 70820 PROVISIONAL