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Gene: Thap4 (THAP domain containing 4) Rattus norvegicus

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Symbol:

Thap4

Name:

THAP domain containing 4

RGD ID:

1359473

Description:

Predicted to enable several functions, including heme binding activity; nitric oxide binding activity; and peroxynitrite isomerase activity. Predicted to be involved in nitrate metabolic process and tyrosine metabolic process. Predicted to be located in cytosol and nucleoplasm. Orthologous to human THAP4 (THAP domain containing 4); INTERACTS WITH (+)-schisandrin B; bisphenol A; diuron.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ferric nitrobindin; MGC93755; Nb(III); peroxynitrite isomerase THAP4; THAP domain-containing protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	THAP4 (THAP domain containing 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Thap4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Thap4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	THAP4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	THAP4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Thap4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	THAP4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	THAP4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Thap4 (THAP domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	THAP4 (THAP domain containing 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Thap4 (THAP domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	thap4 (THAP domain containing 4)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C15F1.1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	C15F1.1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C28H8.5	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	C28H8.5	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C52G5.2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F21A3.3	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	T28H10.2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	thap4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	thap4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	101,689,935 - 101,729,656 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	101,689,936 - 101,729,441 (-)	Ensembl				GRCr8
mRatBN7.2	9	94,242,581 - 94,282,312 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	94,242,581 - 94,282,306 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	102,678,061 - 102,717,571 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	107,813,709 - 107,853,217 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	106,169,811 - 106,209,318 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	100,848,597 - 100,888,107 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	100,848,598 - 100,888,107 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	100,501,661 - 100,541,256 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	92,989,072 - 93,031,408 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	91,777,055 - 91,816,491 (-)	NCBI		Celera
RGSC_v3.1	9	93,193,841 - 93,236,177 (-)	NCBI
Cytogenetic Map	9	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bethlem Myopathy 1A (ISO)

chromosome 2q37 deletion syndrome (ISO)

D-2-hydroxyglutaric aciduria 1 (ISO)

hereditary spastic paraplegia 30 (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

disodium selenite (ISO)

diuron (EXP)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

GSK-J4 (ISO)

menadione (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

N(4)-hydroxycytidine (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

rotenone (EXP)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nitrate metabolic process (IEA,ISO,ISS)

tyrosine metabolic process (IEA,ISO,ISS)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

heme binding (IEA,ISO)

identical protein binding (IEA,ISO)

isomerase activity (IEA)

metal ion binding (IEA)

nitric oxide binding (IEA,ISO,ISS)

peroxynitrite isomerase activity (IEA,ISO,ISS)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	null	JRS Domain-based curation
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:21387410	PMID:30524950	PMID:38658415

Genomics

Comparative Map Data

Thap4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	101,689,935 - 101,729,656 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	101,689,936 - 101,729,441 (-)	Ensembl				GRCr8
mRatBN7.2	9	94,242,581 - 94,282,312 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	94,242,581 - 94,282,306 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	102,678,061 - 102,717,571 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	107,813,709 - 107,853,217 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	106,169,811 - 106,209,318 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	100,848,597 - 100,888,107 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	100,848,598 - 100,888,107 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	100,501,661 - 100,541,256 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	92,989,072 - 93,031,408 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	91,777,055 - 91,816,491 (-)	NCBI		Celera
RGSC_v3.1	9	93,193,841 - 93,236,177 (-)	NCBI
Cytogenetic Map	9	q36	NCBI

THAP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	241,584,405 - 241,637,576 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	241,584,405 - 241,637,158 (-)	Ensembl			hg38	GRCh38
GRCh37	2	242,523,820 - 242,576,573 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	242,172,493 - 242,225,328 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	2	236,191,554 - 236,248,451 (-)	NCBI		Celera
Cytogenetic Map	2	q37.3	NCBI
HuRef	2	234,277,652 - 234,329,989 (-)	NCBI		HuRef
CHM1_1	2	242,529,419 - 242,582,861 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	242,084,274 - 242,140,900 (-)	NCBI		T2T-CHM13v2.0

Thap4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	93,633,113 - 93,682,560 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	93,629,657 - 93,682,586 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	93,705,391 - 93,754,838 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	93,701,935 - 93,754,864 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	95,601,968 - 95,651,415 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	95,535,797 - 95,585,244 (-)	NCBI		MGSCv36	mm8
MGSCv36	1	94,158,268 - 94,207,849 (-)	NCBI		MGSCv36	mm8
Celera	1	96,650,530 - 96,699,008 (-)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	47.29	NCBI

Thap4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	195,088 - 217,831 (+)	Ensembl
ChiLan1.0	NW_004955542	192,888 - 217,985 (+)	NCBI	ChiLan1.0	ChiLan1.0

THAP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	144,290,268 - 144,345,336 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	144,305,143 - 144,360,216 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	128,858,512 - 128,913,474 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	247,650,249 - 247,684,576 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	247,650,249 - 247,701,219 (-)	Ensembl			panPan2	panpan1.1

THAP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	51,456,349 - 51,480,753 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	51,456,344 - 51,494,367 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	51,674,803 - 51,713,677 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	51,654,937 - 51,693,321 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	51,654,925 - 51,693,318 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	51,504,264 - 51,543,189 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	51,244,160 - 51,282,359 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	51,520,478 - 51,559,045 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Thap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	192,881,163 - 192,902,172 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936745	316,748 - 338,142 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936745	324,988 - 338,257 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

THAP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	140,185,682 - 140,223,477 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	140,190,198 - 140,223,454 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	154,825,625 - 154,838,103 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

THAP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	127,643,567 - 127,689,582 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	127,643,102 - 127,689,377 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	71,633,005 - 71,678,844 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Thap4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624847	5,578,001 - 5,605,423 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624847	5,579,521 - 5,605,447 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Thap4
215 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	187
Count of miRNA genes:	145
Interacting mature miRNAs:	157
Transcripts:	ENSRNOT00000024794
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
724547	Cm21	Cardiac mass QTL 21	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	86720043	110356905	Rat
2303178	Bp334	Blood pressure QTL 334	3.7	0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	86720043	121768150	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	83161999	118999486	Rat
4889852	Pur26	Proteinuria QTL 26	15	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	85262459	109044727	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	85262459	118999486	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat

Markers in Region

AA924144

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	94,242,657 - 94,242,852 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	100,848,674 - 100,848,868	NCBI	Rnor6.0
Rnor_5.0	9	100,501,738 - 100,501,932	UniSTS	Rnor5.0
RGSC_v3.4	9	92,989,149 - 92,989,343	UniSTS	RGSC3.4
Celera	9	91,777,132 - 91,777,326	UniSTS
RH 3.4 Map	9	806.7	UniSTS
Cytogenetic Map	9	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024794 ⟹ ENSRNOP00000024794

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	101,689,936 - 101,729,441 (-)	Ensembl
mRatBN7.2 Ensembl	9	94,242,581 - 94,282,125 (-)	Ensembl
Rnor_6.0 Ensembl	9	100,848,598 - 100,888,107 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096279 ⟹ ENSRNOP00000088157

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	94,242,605 - 94,282,111 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100100 ⟹ ENSRNOP00000094711

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	94,242,581 - 94,282,306 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103287 ⟹ ENSRNOP00000077619

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	101,689,936 - 101,722,608 (-)	Ensembl
mRatBN7.2 Ensembl	9	94,242,581 - 94,265,301 (-)	Ensembl

RefSeq Acc Id:

NM_001005564 ⟹ NP_001005564

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	101,689,935 - 101,729,441 (-)	NCBI
mRatBN7.2	9	94,242,581 - 94,282,090 (-)	NCBI
Rnor_6.0	9	100,848,597 - 100,888,107 (-)	NCBI
Rnor_5.0	9	100,501,661 - 100,541,256 (-)	NCBI
RGSC_v3.4	9	92,989,072 - 93,031,408 (-)	RGD
Celera	9	91,777,055 - 91,816,491 (-)	RGD

Sequence:

show sequence

AGGATCGGAGCCTGGCGACGCTCACGACCGAGGCCCGCAATGGTGATCTGCTGCGCGGCCGTGA
ACTGTTCCAACAGGCAGGGCAAGGGCGAGAAACGCGCTGTCTCCTTCCACAGGTTTCCCCTAAA
GGACTCCAAACGACTGATCCAGTGGTTAAAAGCTGTTCAGAGGGATAACTGGACCCCAACTAAG
TATTCATTCCTCTGTAGTGAGCATTTTACCAAAGACAGCTTCTCCAAAAGGCTAGAGGACCAGC
ATCGCCTGCTGAAGCCCACGGCTGTGCCCTCTATTTTCCACCTGTCAGAGAAGAAGAGGGGGGC
TGGAGGACATGGCCCTGCTAGGAGAAAGACCACAGGGGCCATGAGGGGCCACACAAGTGCAGCA
ACAGGGAAAGGAACCATAGGGTCTTCACTATCTTCAAGTGATAACTTGATGGCCAAGCCAGAAT
CCCGAAAGTTGAAGCGAGCTTCTCCACAAGATGATACAGCCCCCAAGGCCACCCCGGGTGCTGT
CAGTCAGGAGCCGGGTCAGTCTCTGGAAAGAACTCCAGGTGACCAGGCTGCCCCATTGGCCAGA
GGCCAGGAAGAGGCACAAGTGTCTGCTACAGAGGCTGACCACCAGAAGGCTTCTTCCTCTGCTG
CCGACGCAGGTGGAGCAGACAAGAGTGGCATTTCTATGGACGACTTCACACCCCCGGGATCTGG
CGCTTGCAAGTTCATTGGCTCACTTCATTCATATAGTTTCTCCTCCAAGCACACTCGAGAGAGG
CCGTCTGTCCCTCGTGAGCCCATGGACCGCAAGAGGCTGAAGAGAGACATAGAGCCAAGGTGCA
GTGGGAATAGTGTGGCCCAGAGTCCCCCAAGTTCCTCACTTACAGCAACCCCTCAAAAGGCTTC
CCAGAGCCCCTCCGCCCCACCCACTGATGTAACCCCAAAGCCAGCGGCAGAAGCCGTGCAGAGT
GAGCACAGTGATGCCAATCCCATGTCCATCAATGAGGTCATCCTGTCAGCCTCAGGGGCCTGCA
AGCTCATCGACTCCCTGCACTCCTACTGCTTCTCGGCTCGGCAGAACAAGAGCCAGGTATGCTG
CCTGCGGGAGCAGGTTGAGAAGAAGAACGGAGAGCTAAAGAGCCTTCGGCAGAGGGTCAGCCGA
TCTGACAGCCAGGTGCGCAAGCTGCGGGAGAAGCTGGACGAGCTGAGAAGAGCAAGTCTCCCTT
ACCTCCCCTACCTAAGTGGTCTGCTGCCCCCCAGTCACGAGCCTCCCAAGCTGAATCCAGTGGT
GGAGCCGTTGTCCTGGATGCTGGGTACCTGGCTGTCAGAGCCGCCGGGAGTTGGTACCTTCCCA
ACACTGCAACCCTTCCAGTACCTGGAGGAGGTGCACATCTCCCATGTGGGTCAGCCTATGCTCA
ACTTCTCGTTCAACTCCTTCCATCCAGAAACACACAAGCCAATGCACAGAGAATGTGGCTTCAT
CCGCCTCAAGCCTGACACCAACAAGGTGGCCTTCGTCAGTGCCCAGAACACAGGTGTTGTGGAA
GTGGAGGAGGGTGAAGTGAATGGGCAGGAGCTGTGTGTTTCATCCCATTCCATCTCCAGGATCT
CCTTTGCCAAGGAGCCCCATGTGCAGCAGATCACGCGGAAATTCAGGCTGAATTCTGAAGGCAA
ACTTGAACAGACGGTCTCTATGGCAACCACTACACAGCCAATGACTCAGCATCTTCACATTACC
TACAAGAAGGTGACCCCTTAACCCGGAGCCCCTCCTAGAGCCTGGTGAGGAGCCTGGCTCCTGC
ATCTAGCCCCCCAGTTTAGTAGACATGGTGTGGTCTCAGGCTCTGCTGACACTGAAGTGTTGTC
CAGATGTTCTTGTAATGGCATAGAAAACCAAATAAAAGGCCTTTATTTTTATGGCTGAAGATTT
TGAATATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008767380 ⟹ XP_008765602

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	101,689,935 - 101,720,079 (-)	NCBI
mRatBN7.2	9	94,242,581 - 94,265,160 (-)	NCBI
Rnor_6.0	9	100,848,597 - 100,872,100 (-)	NCBI

Sequence:

show sequence

AAAGGAAAAAAAAAATGCCTTGGTCACCTCAAAGACTGGGCAGCTCTAATCAAGAAAATACCCT
GCAGACTTACTTACAGGCATTGGGACAGTGGCCTTTTCTCTTTTTACAAGACTGAGGTTTTTCT
TCCCAGATAAGTTTAGCTTGTGTCAAGTTGACCAAAACAAAAAAGCAACCATTTATTAGAGTCT
ATCATTCTAATAGTCTCGGTGGACTAACTAGATAAACATCATCTTTGCAGAGAATAACATTAGA
GGCTGTTTTATATGTTGTGTTGAAATCTGTAGGAGTTCTCTTTTCCATTCATCATCTCTGGTTT
TCCTCTGTCCCTGTGTGCTCCTCTCTGTTGTGAATGGTCAGTTGGACCTTGCTGTCATGTTGAT
GCTCGTAGGACCCAGACCCCGCACCTCGTGCTACCCTGCACCTCCTCAGTGTCCTGAAGAGCCA
GCTTCTGCTGGGTGCTTTGGTGGTAGCTTTTTGACTGTGTAGTGCTGTATGATTAGCCTCGTTT
TTTCTGCTTGACACAGCAGGAAACTCTGTTATTGTCAACAGAGCAATGGTATGAGGGTAAGAAT
CATGAACAGTTTTCTCCCCAGGACCCAGAAAGCATATCTACCCATGTCCTCTCACCAGGCCCCA
CGACCCATTTGCCCTCTGAAAACTCCCATGTTTAGAGCTAAGCTAAGCTAAGCAGAAAGGCATC
CGTGAAGACAACAGAGTGTATTAGGAGCCTAAGCTCCTGGCAAATGTTCCTGAAGAAACAGCTT
CTGTTCTGTGCCTGCCCTGCTGTGCATTTGATTTAGTGAGTTGATTCCCTCGGCTCCACTCTGT
GGAAACAACAGAGGGTAGAATTCCTGTTCCTTATCTGGATGGGACAGCTAACTCCCTGGCCTAG
TGCTGACATGTAAGATGCCGCTCAGTCTCCAGAGCTCCTTTAGCTCTGAAGCTCTGTGATCTCC
ACATTCTTCTAAGACGGAGCCTTTTAATAATGGACTACAATTCCCAGAATGCTCTCTTTGGATT
GGCATTCATTTCCTGCAATGCCTTAACAGCCAGGTGCACACATTTCCCCGGCAATTGGCAGAAA
ATAACCTTGAGGAACCTTGACGGAGTGTATCGGAGTTCAGAAAACTTAGGGATGGAGCCTCCCA
AGCTGAATCCAGTGGTGGAGCCGTTGTCCTGGATGCTGGGTACCTGGCTGTCAGAGCCGCCGGG
AGTTGGTACCTTCCCAACACTGCAACCCTTCCAGTACCTGGAGGAGGTGCACATCTCCCATGTG
GGTCAGCCTATGCTCAACTTCTCGTTCAACTCCTTCCATCCAGAAACACACAAGCCAATGCACA
GAGAATGTGGCTTCATCCGCCTCAAGCCTGACACCAACAAGGTGGCCTTCGTCAGTGCCCAGAA
CACAGGTGTTGTGGAAGTGGAGGAGGGTGAAGTGAATGGGCAGGAGCTGTGTGTTTCATCCCAT
TCCATCTCCAGGATCTCCTTTGCCAAGGAGCCCCATGTGCAGCAGATCACGCGGAAATTCAGGC
TGAATTCTGAAGGCAAACTTGAACAGACGGTCTCTATGGCAACCACTACACAGCCAATGACTCA
GCATCTTCACATTACCTACAAGAAGGTGACCCCTTAACCCGGAGCCCCTCCTAGAGCCTGGTGA
GGAGCCTGGCTCCTGCATCTAGCCCCCCAGTTTAGTAGACATGGTGTGGTCTCAGGCTCTGCTG
ACACTGAAGTGTTGTCCAGATGTTCTTGTAATGGCATAGAAAACCAAATAAAAGGCCTTTATTT
TTATGGCTGAAGATTTTGAATATTA

hide sequence

RefSeq Acc Id:

XM_039083932 ⟹ XP_038939860

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	101,689,935 - 101,729,656 (-)	NCBI
mRatBN7.2	9	94,242,581 - 94,282,312 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001005564	(Get FASTA)	NCBI Sequence Viewer
	XP_008765602	(Get FASTA)	NCBI Sequence Viewer
	XP_038939860	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81882	(Get FASTA)	NCBI Sequence Viewer
	EDL91908	(Get FASTA)	NCBI Sequence Viewer
	EDL91909	(Get FASTA)	NCBI Sequence Viewer
	EDL91910	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024794
	ENSRNOP00000024794.4
GenBank Protein	Q642B6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001005564 ⟸ NM_001005564

- UniProtKB:

Q642B6 (UniProtKB/Swiss-Prot), A6JR27 (UniProtKB/TrEMBL), A0A8I6ANL8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDS
FSKRLEDQHRLLKPTAVPSIFHLSEKKRGAGGHGPARRKTTGAMRGHTSAATGKGTIGSSLSSS
DNLMAKPESRKLKRASPQDDTAPKATPGAVSQEPGQSLERTPGDQAAPLARGQEEAQVSATEAD
HQKASSSAADAGGADKSGISMDDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPMDRKRL
KRDIEPRCSGNSVAQSPPSSSLTATPQKASQSPSAPPTDVTPKPAAEAVQSEHSDANPMSINEV
ILSASGACKLIDSLHSYCFSARQNKSQVCCLREQVEKKNGELKSLRQRVSRSDSQVRKLREKLD
ELRRASLPYLPYLSGLLPPSHEPPKLNPVVEPLSWMLGTWLSEPPGVGTFPTLQPFQYLEEVHI
SHVGQPMLNFSFNSFHPETHKPMHRECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCV
SSHSISRISFAKEPHVQQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHITYKKVTP

hide sequence

RefSeq Acc Id:	XP_008765602 ⟸ XM_008767380
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5YBX9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDYNSQNALFGLAFISCNALTARCTHFPGNWQKITLRNLDGVYRSSENLGMEPPKLNPVVEPLS WMLGTWLSEPPGVGTFPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPETHKPMHRECGFIRLKP DTNKVAFVSAQNTGVVEVEEGEVNGQELCVSSHSISRISFAKEPHVQQITRKFRLNSEGKLEQT VSMATTTQPMTQHLHITYKKVTP hide sequence

Ensembl Acc Id:

ENSRNOP00000024794 ⟸ ENSRNOT00000024794

RefSeq Acc Id:	XP_038939860 ⟸ XM_039083932
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ANL8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000094711 ⟸ ENSRNOT00000100100

Ensembl Acc Id:

ENSRNOP00000077619 ⟸ ENSRNOT00000103287

Ensembl Acc Id:

ENSRNOP00000088157 ⟸ ENSRNOT00000096279

Protein Domains

THAP-type THAP4-like heme-binding beta-barrel

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q642B6-F1-model_v2	AlphaFold	Q642B6	1-569	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696881

Promoter ID:

EPDNEW_R7405

Type:

initiation region

Name:

Thap4_1

Description:

THAP domain containing 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	100,888,145 - 100,888,205	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359473	AgrOrtholog
BioCyc Gene	G2FUF-26632	BioCyc
Ensembl Genes	ENSRNOG00000018351	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000024794	ENTREZGENE
	ENSRNOT00000024794.5	UniProtKB/Swiss-Prot
Gene3D-CATH	2.40.128.20	UniProtKB/Swiss-Prot
	6.20.210.20	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7108379	IMAGE-MGC_LOAD
InterPro	Calycin	UniProtKB/Swiss-Prot
	DUF1794	UniProtKB/Swiss-Prot
	THAP4-like	UniProtKB/Swiss-Prot
	THAP_Znf	UniProtKB/Swiss-Prot
	THAP_Znf_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:363291	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93755	IMAGE-MGC_LOAD
NCBI Gene	363291	ENTREZGENE
PANTHER	PEROXYNITRITE ISOMERASE THAP4	UniProtKB/Swiss-Prot
	PTHR15854	UniProtKB/Swiss-Prot
Pfam	DUF1794	UniProtKB/Swiss-Prot
	THAP	UniProtKB/Swiss-Prot
PhenoGen	Thap4	PhenoGen
PROSITE	ZF_THAP	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000018351	RatGTEx
SMART	DM3	UniProtKB/Swiss-Prot
	THAP	UniProtKB/Swiss-Prot
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/Swiss-Prot
	SSF50814	UniProtKB/Swiss-Prot
UniProt	A0A8I5YBX9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A5M2_RAT	UniProtKB/TrEMBL
	A0A8I6ANL8	ENTREZGENE, UniProtKB/TrEMBL
	A6JR27	ENTREZGENE, UniProtKB/TrEMBL
	A6JR28_RAT	UniProtKB/TrEMBL
	A6JR29_RAT	UniProtKB/TrEMBL
	Q642B6	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Thap4	THAP domain containing 4			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Thap4	THAP domain containing 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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