Advanced Search (OLGA)

Gene: SLC5A8 (solute carrier family 5 member 8) Homo sapiens

Subscribe to Updates

Analyze

Symbol:

SLC5A8

Name:

solute carrier family 5 member 8

RGD ID:

1352176

HGNC Page

HGNC:19119

Description:

Enables monocarboxylate:sodium symporter activity. Involved in monoatomic anion transport; monocarboxylic acid transport; and nitrate transmembrane transport. Located in apical plasma membrane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AIT; apical iodide transporter; electrogenic sodium monocarboxylate cotransporter; MGC125354; SMCT; SMCT1; sodium iodide-related cotransporter; sodium-coupled monocarboxylate transporter 1; solute carrier family 5 (iodide transporter), member 8; solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Slc5a8 (solute carrier family 5 (iodide transporter), member 8)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Slc5a8 (solute carrier family 5 member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Slc5a8 (solute carrier family 5 member 8)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	SLC5A8 (solute carrier family 5 member 8)	NCBI	Ortholog
Canis lupus familiaris (dog):	SLC5A8 (solute carrier family 5 member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc5a8 (solute carrier family 5 member 8)	NCBI	Ortholog
Sus scrofa (pig):	SLC5A8 (solute carrier family 5 member 8)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	SLC5A8 (solute carrier family 5 member 8)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Slc5a8 (solute carrier family 5 member 8)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Slc5a12 (solute carrier family 5 (sodium/glucose cotransporter), member 12)	HGNC	OrthoMCL
Alliance orthologs ³
Mus musculus (house mouse):	Slc5a8 (solute carrier family 5 (iodide transporter), member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Slc5a8 (solute carrier family 5 member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc5a8l (solute carrier family 5 member 8, like)	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	slc5a8 (solute carrier family 5 member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|ZFIN)
Drosophila melanogaster (fruit fly):	CG10444	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK822.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG2187	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31262	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31668	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG32669	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG33124	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG42235	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG5687	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6723	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	CG9657	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	SLC5A11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	Smvt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Drosophila melanogaster (fruit fly):	salt	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	slc5a8.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	slc5a8.1.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	101,155,493 - 101,210,238 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	101,155,493 - 101,210,238 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	101,549,271 - 101,604,016 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	100,073,402 - 100,128,120 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	100,051,745 - 100,106,457	NCBI
Celera	12	101,215,310 - 101,269,325 (-)	NCBI		Celera
Cytogenetic Map	12	q23.1-q23.2	NCBI
HuRef	12	98,610,304 - 98,664,323 (-)	NCBI		HuRef
CHM1_1	12	101,515,979 - 101,569,971 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	101,117,226 - 101,171,943 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SLC5A8	Human	Colonic Neoplasms		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:15090606 and PMID:16670197
SLC5A8	Human	hyperuricemia		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:20589576

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SLC5A8	Human	1,2-dimethylhydrazine	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in decreased expression of SLC5A8 mRNA	CTD	PMID:22206623
SLC5A8	Human	17beta-estradiol	multiple interactions	ISO	Slc5a8 (Rattus norvegicus)	6480464	[Testosterone co-treated with Estradiol] results in increased expression of SLC5A8 mRNA	CTD	PMID:32741896
SLC5A8	Human	2-hydroxypropanoic acid	multiple interactions	EXP		6480464	SLC5A8 protein results in increased transport of [Lactic Acid co-treated with Sodium]	CTD	PMID:15090606
SLC5A8	Human	3-chloropropane-1,2-diol	decreases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	alpha-Chlorohydrin results in decreased expression of SLC5A8 protein	CTD	PMID:34915118
SLC5A8	Human	4,4'-diaminodiphenylmethane	increases expression	ISO	Slc5a8 (Mus musculus)	6480464	4 and 4'-diaminodiphenylmethane results in increased expression of SLC5A8 mRNA	CTD	PMID:18648102
SLC5A8	Human	5-aza-2'-deoxycytidine	multiple interactions	EXP		6480464	[Decitabine affects the methylation of SLC5A8 gene] which affects the expression of SLC5A8 mRNA	CTD	PMID:18559491
SLC5A8	Human	acrolein	decreases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	Acrolein results in decreased expression of SLC5A8 mRNA	CTD	PMID:38090360
SLC5A8	Human	amitrole	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	Amitrole results in increased expression of SLC5A8 mRNA	CTD	PMID:30047161
SLC5A8	Human	arsenite(3-)	increases methylation	EXP		6480464	arsenite results in increased methylation of SLC5A8 promoter	CTD	PMID:23974009
SLC5A8	Human	atrazine	decreases expression	EXP		6480464	Atrazine results in decreased expression of SLC5A8 mRNA	CTD	PMID:22378314
SLC5A8	Human	Azoxymethane	multiple interactions	ISO	Slc5a8 (Mus musculus)	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC5A8 mRNA	CTD	PMID:29950665
SLC5A8	Human	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of SLC5A8 mRNA	CTD	PMID:22316170
SLC5A8	Human	benzo[a]pyrene	affects methylation	EXP		6480464	Benzo(a)pyrene affects the methylation of SLC5A8 exon and Benzo(a)pyrene affects the methylation of SLC5A8 promoter	CTD	PMID:27901495
SLC5A8	Human	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of SLC5A8 protein	CTD	PMID:36781136
SLC5A8	Human	bisphenol A	multiple interactions	ISO	Slc5a8 (Rattus norvegicus)	6480464	[bisphenol A co-treated with Genistein] results in increased methylation of SLC5A8 gene	CTD	PMID:28505145
SLC5A8	Human	bisphenol A	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	bisphenol A results in increased expression of SLC5A8 mRNA	CTD	PMID:27257137
SLC5A8	Human	bromobenzene	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	bromobenzene results in increased expression of SLC5A8 mRNA	CTD	PMID:32479839
SLC5A8	Human	caffeine	increases phosphorylation	EXP		6480464	Caffeine results in increased phosphorylation of SLC5A8 protein	CTD	PMID:35688186
SLC5A8	Human	CGP 52608	multiple interactions	EXP		6480464	CGP 52608 promotes the reaction [RORA protein binds to SLC5A8 gene]	CTD	PMID:28238834
SLC5A8	Human	ciguatoxin CTX1B	affects expression	ISO	Slc5a8 (Mus musculus)	6480464	Ciguatoxins affects the expression of SLC5A8 mRNA	CTD	PMID:18353800
SLC5A8	Human	cisplatin	multiple interactions	EXP		6480464	[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of SLC5A8 mRNA	CTD	PMID:30871063
SLC5A8	Human	dextran sulfate	multiple interactions	ISO	Slc5a8 (Mus musculus)	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC5A8 mRNA	CTD	PMID:29950665
SLC5A8	Human	ethanol	multiple interactions	ISO	Slc5a8 (Mus musculus)	6480464	kaempferol inhibits the reaction [Ethanol results in decreased expression of SLC5A8 protein]	CTD	PMID:31785310
SLC5A8	Human	ethanol	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	Ethanol results in decreased expression of SLC5A8 protein	CTD	PMID:31785310
SLC5A8	Human	fonofos	increases methylation	EXP		6480464	Fonofos results in increased methylation of SLC5A8 promoter	CTD	PMID:22847954
SLC5A8	Human	furan	decreases methylation	ISO	Slc5a8 (Rattus norvegicus)	6480464	furan results in decreased methylation of SLC5A8 gene	CTD	PMID:27387713
SLC5A8	Human	furan	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	furan results in increased expression of SLC5A8 mRNA	CTD	PMID:27387713
SLC5A8	Human	genistein	multiple interactions	ISO	Slc5a8 (Rattus norvegicus)	6480464	[bisphenol A co-treated with Genistein] results in increased methylation of SLC5A8 gene	CTD	PMID:28505145
SLC5A8	Human	genistein	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	Genistein results in decreased expression of SLC5A8 mRNA	CTD	PMID:32186404
SLC5A8	Human	hydrazine	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	hydrazine results in decreased expression of SLC5A8 mRNA	CTD	PMID:15282401
SLC5A8	Human	hydrogen peroxide	affects expression	EXP		6480464	Hydrogen Peroxide affects the expression of SLC5A8 mRNA	CTD	PMID:21179406
SLC5A8	Human	ibuprofen	decreases activity	EXP		6480464	Ibuprofen results in decreased activity of SLC5A8 protein	CTD	PMID:15090606 and PMID:16670197
SLC5A8	Human	kaempferol	multiple interactions	ISO	Slc5a8 (Mus musculus)	6480464	kaempferol inhibits the reaction [Ethanol results in decreased expression of SLC5A8 protein]	CTD	PMID:31785310
SLC5A8	Human	lead diacetate	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	lead acetate results in decreased expression of SLC5A8 mRNA	CTD	PMID:21829687
SLC5A8	Human	methimazole	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	Methimazole results in increased expression of SLC5A8 mRNA	CTD	PMID:30047161
SLC5A8	Human	ozone	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	Ozone results in decreased expression of SLC5A8 mRNA	CTD	PMID:33026818
SLC5A8	Human	parathion	increases methylation	EXP		6480464	Parathion results in increased methylation of SLC5A8 promoter	CTD	PMID:22847954
SLC5A8	Human	phenobarbital	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	Phenobarbital results in increased expression of SLC5A8 mRNA	CTD	PMID:30047161
SLC5A8	Human	pirinixic acid	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	pirinixic acid results in decreased expression of SLC5A8 mRNA	CTD	PMID:17426115
SLC5A8	Human	probenecid	decreases activity	EXP		6480464	Probenecid results in decreased activity of SLC5A8 protein	CTD	PMID:15090606
SLC5A8	Human	progesterone	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	Progesterone results in decreased expression of SLC5A8 protein	CTD	PMID:21360409
SLC5A8	Human	rac-lactic acid	multiple interactions	EXP		6480464	SLC5A8 protein results in increased transport of [Lactic Acid co-treated with Sodium]	CTD	PMID:15090606
SLC5A8	Human	sodium atom	multiple interactions	EXP		6480464	SLC5A8 protein results in increased transport of [Butyrates co-treated with Sodium] more ...	CTD	PMID:15090606
SLC5A8	Human	sodium fluoride	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	Sodium Fluoride results in increased expression of SLC5A8 mRNA	CTD	PMID:27257137
SLC5A8	Human	sulfadimethoxine	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	Sulfadimethoxine results in increased expression of SLC5A8 mRNA	CTD	PMID:30047161
SLC5A8	Human	terbufos	increases methylation	EXP		6480464	terbufos results in increased methylation of SLC5A8 promoter	CTD	PMID:22847954
SLC5A8	Human	testosterone	increases expression	ISO	Slc5a8 (Mus musculus)	6480464	Testosterone results in increased expression of SLC5A8 mRNA	CTD	PMID:20589576
SLC5A8	Human	testosterone	multiple interactions	ISO	Slc5a8 (Rattus norvegicus)	6480464	[Testosterone co-treated with Estradiol] results in increased expression of SLC5A8 mRNA	CTD	PMID:32741896
SLC5A8	Human	testosterone	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	Testosterone results in increased expression of SLC5A8 mRNA	CTD	PMID:27684650
SLC5A8	Human	titanium dioxide	decreases expression	ISO	Slc5a8 (Mus musculus)	6480464	titanium dioxide results in decreased expression of SLC5A8 mRNA	CTD	PMID:23557971
SLC5A8	Human	titanium dioxide	increases methylation	ISO	Slc5a8 (Mus musculus)	6480464	titanium dioxide results in increased methylation of SLC5A8 promoter	CTD	PMID:35295148
SLC5A8	Human	titanium dioxide	decreases methylation	ISO	Slc5a8 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of SLC5A8 gene	CTD	PMID:35295148
SLC5A8	Human	titanium dioxide	multiple interactions	ISO	Slc5a8 (Mus musculus)	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC5A8 mRNA	CTD	PMID:29950665
SLC5A8	Human	triadimefon	increases expression	ISO	Slc5a8 (Rattus norvegicus)	6480464	triadimefon results in increased expression of SLC5A8 mRNA	CTD	PMID:30047161
SLC5A8	Human	triptonide	increases expression	ISO	Slc5a8 (Mus musculus)	6480464	triptonide results in increased expression of SLC5A8 mRNA	CTD	PMID:33045310
SLC5A8	Human	valproic acid	affects expression	ISO	Slc5a8 (Mus musculus)	6480464	Valproic Acid affects the expression of SLC5A8 mRNA	CTD	PMID:17963808
SLC5A8	Human	vancomycin	increases expression	ISO	Slc5a8 (Mus musculus)	6480464	Vancomycin results in increased expression of SLC5A8 mRNA	CTD	PMID:18930951

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SLC5A8	Human	acetate transport	involved_in	IDA		150520179	PMID:14966140 and PMID:15090606	UniProt	PMID:14966140 and PMID:15090606
SLC5A8	Human	apoptotic process	involved_in	IEA	UniProtKB-KW:KW-0053	150520179		UniProt	GO_REF:0000043
SLC5A8	Human	chloride transport	involved_in	IDA		150520179	PMID:19864324	UniProt	PMID:19864324
SLC5A8	Human	iodide transport	involved_in	IDA		150520179	PMID:12107270 and PMID:19864324	UniProt	PMID:12107270 and PMID:19864324
SLC5A8	Human	lactate transmembrane transport	involved_in	IEA	GO:0015129	150520179		GOC	GO_REF:0000108
SLC5A8	Human	lactate transport	involved_in	IDA		150520179	PMID:14966140 more ...	UniProt	PMID:14966140 more ...
SLC5A8	Human	monoatomic ion transport	involved_in	IEA	UniProtKB-KW:KW-0406	150520179		UniProt	GO_REF:0000043
SLC5A8	Human	monoatomic ion transport	involved_in	TAS		150520179		Reactome	Reactome:R-HSA-425393
SLC5A8	Human	monocarboxylic acid transport	acts_upstream_of_or_within	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	nicotinate transport	involved_in	IDA		150520179	PMID:14966140 more ...	UniProt	PMID:14966140 more ...
SLC5A8	Human	nicotinate transport	involved_in	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	nitrate transmembrane transport	involved_in	IDA		150520179	PMID:19864324	UniProt	PMID:19864324
SLC5A8	Human	propanoate transmembrane transport	involved_in	IBA	MGI:2384916 more ...	150520179		GO_Central	GO_REF:0000033
SLC5A8	Human	propanoate transmembrane transport	acts_upstream_of_or_within	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	propanoate transmembrane transport	involved_in	IDA		150520179	PMID:14966140 more ...	UniProt	PMID:14966140 more ...
SLC5A8	Human	pyruvate transport	involved_in	IDA		150520179	PMID:14966140 more ...	UniProt	PMID:14966140 more ...
SLC5A8	Human	short-chain fatty acid transmembrane transport	acts_upstream_of_or_within	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	sodium ion transport	involved_in	IBA	PANTHER:PTN000213468 and Slc5a5 (Rattus norvegicus)	150520179		GO_Central	GO_REF:0000033
SLC5A8	Human	sodium ion transport	involved_in	IEA	UniProtKB-KW:KW-0739	150520179		UniProt	GO_REF:0000043
SLC5A8	Human	transmembrane transport	involved_in	IEA	InterPro:IPR001734	150520179		InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SLC5A8	Human	apical plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0015	150520179		UniProt	GO_REF:0000044
SLC5A8	Human	apical plasma membrane	located_in	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	apical plasma membrane	located_in	IDA		150520179	PMID:12107270 and PMID:17245649	UniProt	PMID:12107270 and PMID:17245649
SLC5A8	Human	extracellular exosome	located_in	HDA		150520179	PMID:19056867 and PMID:23533145	UniProt	PMID:19056867 and PMID:23533145
SLC5A8	Human	GINS complex	part_of	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	membrane	located_in	IEA	InterPro:IPR001734	150520179		InterPro	GO_REF:0000002
SLC5A8	Human	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
SLC5A8	Human	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	150520179		UniProt	GO_REF:0000043
SLC5A8	Human	plasma membrane	located_in	TAS		150520179		Reactome	Reactome:R-HSA-429749 and Reactome:R-HSA-429767

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SLC5A8	Human	iodide channel activity	enables	TAS		150520179		Reactome	Reactome:R-HSA-429767
SLC5A8	Human	lactate transmembrane transporter activity	enables	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	monocarboxylate:sodium symporter activity	enables	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	monocarboxylate:sodium symporter activity	enables	IDA		150520179	PMID:14966140 more ...	UniProt	PMID:14966140 more ...
SLC5A8	Human	monocarboxylic acid transmembrane transporter activity	enables	TAS		150520179		Reactome	Reactome:R-HSA-429749
SLC5A8	Human	organic acid:sodium symporter activity	enables	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	organic acid:sodium symporter activity	enables	IBA	MGI:2384916 more ...	150520179		GO_Central	GO_REF:0000033
SLC5A8	Human	propionate transmembrane transporter activity	enables	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	protein binding	enables	IPI	UniProtKB:Q5T2W1	150520179	PMID:30604288	UniProt	PMID:30604288
SLC5A8	Human	short-chain fatty acid transmembrane transporter activity	enables	IEA	UniProtKB:Q8BYF6 and ensembl:ENSMUSP00000020255	150520179		Ensembl	GO_REF:0000107
SLC5A8	Human	symporter activity	enables	IEA	UniProtKB-KW:KW-0769	150520179		UniProt	GO_REF:0000043
SLC5A8	Human	transmembrane transporter activity	enables	IEA	InterPro:IPR001734	150520179		InterPro	GO_REF:0000002
SLC5A8	Human	transmembrane transporter activity	enables	IEA	ARBA:ARBA00028127	150520179		UniProt	GO_REF:0000117

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SLC5A8	Human	nicotinamide adenine dinucleotide metabolic pathway		TAS		11251687		RGD

#	Reference Title	Reference Citation
1.	The human NAD metabolome: Functions, metabolism and compartmentalization.	Nikiforov A, etal., Crit Rev Biochem Mol Biol. 2015;50(4):284-97. doi: 10.3109/10409238.2015.1028612. Epub 2015 Apr 2.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12107270	PMID:12477932	PMID:12829793	PMID:14966140	PMID:15001644	PMID:15090606	PMID:15322102	PMID:15867356	PMID:16344560	PMID:16375929	PMID:16670197	PMID:16729224
PMID:16805814	PMID:16858683	PMID:16873376	PMID:17178845	PMID:17245649	PMID:17526579	PMID:17692818	PMID:18037591	PMID:18437076	PMID:18559491	PMID:18566324	PMID:18661192
PMID:19056867	PMID:19730683	PMID:19864324	PMID:20029986	PMID:20082847	PMID:20211600	PMID:20403997	PMID:20671196	PMID:20965718	PMID:21687703	PMID:21802122	PMID:21873635
PMID:22450368	PMID:23167260	PMID:23273563	PMID:23533145	PMID:23918800	PMID:25827678	PMID:26285906	PMID:27465549	PMID:27488665	PMID:27801863	PMID:28514442	PMID:29131623
PMID:29772533	PMID:30604288	PMID:30896789	PMID:31098988	PMID:32017063	PMID:32432731	PMID:32918875	PMID:33961781	PMID:34231393	PMID:34880492	PMID:34964946	PMID:37788672
PMID:38007446	PMID:38287802

SLC5A8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	101,155,493 - 101,210,238 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	101,155,493 - 101,210,238 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	101,549,271 - 101,604,016 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	100,073,402 - 100,128,120 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	100,051,745 - 100,106,457	NCBI
Celera	12	101,215,310 - 101,269,325 (-)	NCBI		Celera
Cytogenetic Map	12	q23.1-q23.2	NCBI
HuRef	12	98,610,304 - 98,664,323 (-)	NCBI		HuRef
CHM1_1	12	101,515,979 - 101,569,971 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	101,117,226 - 101,171,943 (-)	NCBI		T2T-CHM13v2.0

Slc5a8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	88,721,854 - 88,765,377 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	88,721,854 - 88,765,377 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	88,885,992 - 88,929,515 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	88,885,992 - 88,929,515 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	88,348,737 - 88,392,260 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	88,315,836 - 88,365,884 (+)	NCBI		MGSCv36	mm8
MGSCv36	10	89,074,526 - 89,117,897 (+)	NCBI		MGSCv36	mm8
Celera	10	90,866,357 - 90,911,145 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	44.34	NCBI

Slc5a8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	25,160,280 - 25,201,185 (+)	NCBI		GRCr8
mRatBN7.2	7	23,272,891 - 23,313,811 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	23,272,427 - 23,314,642 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	25,267,453 - 25,308,367 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	27,429,993 - 27,470,903 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	27,207,192 - 27,248,116 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	29,434,175 - 29,476,807 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	29,435,444 - 29,477,947 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	29,534,554 - 29,578,495 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	25,585,545 - 25,626,486 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	20,428,427 - 20,468,519 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

Slc5a8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	36,725,892 - 36,769,074 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	36,717,579 - 36,769,074 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC5A8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	109,218,024 - 109,280,585 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	109,214,072 - 109,276,983 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	98,735,175 - 98,795,478 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	102,137,701 - 102,198,184 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	102,137,701 - 102,198,148 (-)	Ensembl	panpan1.1		panPan2

SLC5A8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	40,176,479 - 40,239,859 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	40,179,872 - 40,239,634 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	40,544,936 - 40,608,134 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	40,830,422 - 40,893,672 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	40,833,812 - 40,893,628 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	40,087,024 - 40,150,008 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	40,194,458 - 40,257,689 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	40,468,399 - 40,531,641 (-)	NCBI		UU_Cfam_GSD_1.0

Slc5a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	19,737,204 - 19,784,989 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	12,746,996 - 12,795,421 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	12,747,654 - 12,792,865 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC5A8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	82,973,284 - 83,031,157 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	82,973,179 - 83,088,542 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	87,012,757 - 87,066,769 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC5A8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	96,431,253 - 96,489,267 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	96,431,548 - 96,487,856 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	148,536,549 - 148,593,899 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc5a8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	6,681,142 - 6,729,896 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624750	6,603,668 - 6,731,219 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in SLC5A8
56 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 12q23.1-23.3(chr12:100670616-108583607)x1	copy number loss	See cases [RCV000051320]	Chr12:100670616..108583607 [GRCh38] Chr12:101064394..108977383 [GRCh37] Chr12:99588525..107501512 [NCBI36] Chr12:12q23.1-23.3	pathogenic
NM_145913.3(SLC5A8):c.1527-1479C>A	single nucleotide variant	Lung cancer [RCV000087796]	Chr12:101163556 [GRCh38] Chr12:101557334 [GRCh37] Chr12:12q23.1	uncertain significance
GRCh38/hg38 12q23.2(chr12:101203029-101486159)x3	copy number gain	See cases [RCV000136989]	Chr12:101203029..101486159 [GRCh38] Chr12:101596807..101879937 [GRCh37] Chr12:100120938..100404068 [NCBI36] Chr12:12q23.2	benign
GRCh38/hg38 12q23.1-23.2(chr12:97394550-101410225)x3	copy number gain	See cases [RCV000137891]	Chr12:97394550..101410225 [GRCh38] Chr12:97788328..101804003 [GRCh37] Chr12:96312459..100328134 [NCBI36] Chr12:12q23.1-23.2	likely pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3	copy number gain	See cases [RCV000139555]	Chr12:121271..133196807 [GRCh38] Chr12:282465..133773393 [GRCh37] Chr12:100698..132283466 [NCBI36] Chr12:12p13.33-q24.33	pathogenic
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3	copy number gain	See cases [RCV000142447]	Chr12:91044318..109133210 [GRCh38] Chr12:91438095..109571015 [GRCh37] Chr12:89962226..108055398 [NCBI36] Chr12:12q21.33-24.11	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3	copy number gain	See cases [RCV000258805]	Chr12:1..133851895 [GRCh37] Chr12:12p13.33-q24.33	pathogenic\|likely pathogenic
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075)x3	copy number gain	See cases [RCV000445929]	Chr12:100580198..105804075 [GRCh37] Chr12:12q23.1-23.3	uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3	copy number gain	See cases [RCV000510482]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)	copy number gain	See cases [RCV000511643]	Chr12:173787..133777902 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3	copy number gain	not provided [RCV000750253]	Chr12:621220..133779118 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3	copy number gain	not provided [RCV000750246]	Chr12:191619..133777645 [GRCh37] Chr12:12p13.33-q24.33	pathogenic
GRCh37/hg19 12q22-23.2(chr12:94881995-103635998)x3	copy number gain	not provided [RCV000750524]	Chr12:94881995..103635998 [GRCh37] Chr12:12q22-23.2	pathogenic
NM_145913.5(SLC5A8):c.751T>G (p.Phe251Val)	single nucleotide variant	not provided [RCV000886453]	Chr12:101190550 [GRCh38] Chr12:101584328 [GRCh37] Chr12:12q23.1	benign
NM_145913.5(SLC5A8):c.84C>T (p.Ile28=)	single nucleotide variant	not provided [RCV000954967]	Chr12:101209765 [GRCh38] Chr12:101603543 [GRCh37] Chr12:12q23.2	benign
NM_145913.5(SLC5A8):c.1825C>T (p.Arg609Cys)	single nucleotide variant	not provided [RCV000947481]	Chr12:101157287 [GRCh38] Chr12:101551065 [GRCh37] Chr12:12q23.1	benign
NM_145913.5(SLC5A8):c.491G>T (p.Gly164Val)	single nucleotide variant	not specified [RCV004284473]	Chr12:101195141 [GRCh38] Chr12:101588919 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.351+7G>C	single nucleotide variant	not provided [RCV000892657]	Chr12:101209491 [GRCh38] Chr12:101603269 [GRCh37] Chr12:12q23.2	benign
GRCh37/hg19 12q23.1-23.2(chr12:101447925-102593349)x3	copy number gain	not provided [RCV000847334]	Chr12:101447925..102593349 [GRCh37] Chr12:12q23.1-23.2	uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:100667424-101651880)x3	copy number gain	See cases [RCV000510816]	Chr12:100667424..101651880 [GRCh37] Chr12:12q23.1-23.2	uncertain significance
NM_145913.5(SLC5A8):c.30C>A (p.Phe10Leu)	single nucleotide variant	not provided [RCV000953485]	Chr12:101209819 [GRCh38] Chr12:101603597 [GRCh37] Chr12:12q23.2	benign
GRCh37/hg19 12q23.1-23.2(chr12:101549198-101624899)x1	copy number loss	not provided [RCV001006526]	Chr12:101549198..101624899 [GRCh37] Chr12:12q23.1-23.2	uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:101273182-101745632)x3	copy number gain	not provided [RCV001006525]	Chr12:101273182..101745632 [GRCh37] Chr12:12q23.1-23.2	uncertain significance
NM_145913.5(SLC5A8):c.800A>C (p.Tyr267Ser)	single nucleotide variant	not specified [RCV004683820]	Chr12:101190501 [GRCh38] Chr12:101584279 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1814G>A (p.Ser605Asn)	single nucleotide variant	not specified [RCV004325377]	Chr12:101157298 [GRCh38] Chr12:101551076 [GRCh37] Chr12:12q23.1	uncertain significance
GRCh37/hg19 12q23.1-23.3(chr12:100580198-105804075)	copy number gain	not specified [RCV002053014]	Chr12:100580198..105804075 [GRCh37] Chr12:12q23.1-23.3	uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:100564593-103021075)	copy number loss	not specified [RCV002053013]	Chr12:100564593..103021075 [GRCh37] Chr12:12q23.1-23.2	uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:101272963-101745632)x3	copy number gain	not provided [RCV002473589]	Chr12:101272963..101745632 [GRCh37] Chr12:12q23.1-23.2	uncertain significance
NM_145913.5(SLC5A8):c.845T>C (p.Ile282Thr)	single nucleotide variant	not specified [RCV004220119]	Chr12:101187504 [GRCh38] Chr12:101581282 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1787A>T (p.Glu596Val)	single nucleotide variant	not specified [RCV004144892]	Chr12:101157325 [GRCh38] Chr12:101551103 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1433A>C (p.Gln478Pro)	single nucleotide variant	not specified [RCV004135975]	Chr12:101166587 [GRCh38] Chr12:101560365 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.533C>T (p.Thr178Ile)	single nucleotide variant	not specified [RCV004132931]	Chr12:101195099 [GRCh38] Chr12:101588877 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1826G>A (p.Arg609His)	single nucleotide variant	not specified [RCV004185952]	Chr12:101157286 [GRCh38] Chr12:101551064 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.710T>C (p.Leu237Ser)	single nucleotide variant	not specified [RCV004230289]	Chr12:101190591 [GRCh38] Chr12:101584369 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1717C>A (p.His573Asn)	single nucleotide variant	not specified [RCV004180041]	Chr12:101157395 [GRCh38] Chr12:101551173 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.665A>G (p.Tyr222Cys)	single nucleotide variant	not specified [RCV004130251]	Chr12:101193652 [GRCh38] Chr12:101587430 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.749C>A (p.Thr250Asn)	single nucleotide variant	not specified [RCV004096277]	Chr12:101190552 [GRCh38] Chr12:101584330 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.763A>G (p.Ser255Gly)	single nucleotide variant	not specified [RCV004256536]	Chr12:101190538 [GRCh38] Chr12:101584316 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.112G>T (p.Gly38Cys)	single nucleotide variant	not specified [RCV004277013]	Chr12:101209737 [GRCh38] Chr12:101603515 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.746G>A (p.Gly249Glu)	single nucleotide variant	not specified [RCV004290229]	Chr12:101190555 [GRCh38] Chr12:101584333 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.771C>T (p.Tyr257=)	single nucleotide variant	not provided [RCV003391954]	Chr12:101190530 [GRCh38] Chr12:101584308 [GRCh37] Chr12:12q23.1	likely benign
NM_145913.5(SLC5A8):c.1111C>T (p.Pro371Ser)	single nucleotide variant	not specified [RCV004464131]	Chr12:101182857 [GRCh38] Chr12:101576635 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1276G>A (p.Gly426Ser)	single nucleotide variant	not specified [RCV004464133]	Chr12:101168140 [GRCh38] Chr12:101561918 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1793A>T (p.Asn598Ile)	single nucleotide variant	not specified [RCV004464135]	Chr12:101157319 [GRCh38] Chr12:101551097 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.314C>T (p.Pro105Leu)	single nucleotide variant	not specified [RCV004464137]	Chr12:101209535 [GRCh38] Chr12:101603313 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.20T>C (p.Ile7Thr)	single nucleotide variant	not specified [RCV004464136]	Chr12:101209829 [GRCh38] Chr12:101603607 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.383G>A (p.Arg128His)	single nucleotide variant	not specified [RCV004464138]	Chr12:101204534 [GRCh38] Chr12:101598312 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.272C>T (p.Thr91Ile)	single nucleotide variant	not specified [RCV004674920]	Chr12:101209577 [GRCh38] Chr12:101603355 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.197T>C (p.Met66Thr)	single nucleotide variant	not specified [RCV004674921]	Chr12:101209652 [GRCh38] Chr12:101603430 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.1513T>C (p.Tyr505His)	single nucleotide variant	not specified [RCV004674922]	Chr12:101166507 [GRCh38] Chr12:101560285 [GRCh37] Chr12:12q23.1	likely benign
NM_145913.5(SLC5A8):c.415A>G (p.Thr139Ala)	single nucleotide variant	not specified [RCV004674923]	Chr12:101204502 [GRCh38] Chr12:101598280 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.349G>C (p.Glu117Gln)	single nucleotide variant	not specified [RCV004862319]	Chr12:101209500 [GRCh38] Chr12:101603278 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.1412T>G (p.Leu471Trp)	single nucleotide variant	not specified [RCV004862320]	Chr12:101166608 [GRCh38] Chr12:101560386 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.380T>A (p.Val127Asp)	single nucleotide variant	not specified [RCV004862324]	Chr12:101204537 [GRCh38] Chr12:101598315 [GRCh37] Chr12:12q23.2	uncertain significance
GRCh37/hg19 12q23.1-23.2(chr12:99848062-103511070)x1	copy number loss	not provided [RCV004819851]	Chr12:99848062..103511070 [GRCh37] Chr12:12q23.1-23.2	uncertain significance
NM_145913.5(SLC5A8):c.1468A>C (p.Met490Leu)	single nucleotide variant	not specified [RCV004872734]	Chr12:101166552 [GRCh38] Chr12:101560330 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.434T>C (p.Ile145Thr)	single nucleotide variant	not specified [RCV004872735]	Chr12:101202199 [GRCh38] Chr12:101595977 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.918T>G (p.His306Gln)	single nucleotide variant	not specified [RCV004872736]	Chr12:101187431 [GRCh38] Chr12:101581209 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1651G>T (p.Asp551Tyr)	single nucleotide variant	not specified [RCV004872737]	Chr12:101158308 [GRCh38] Chr12:101552086 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1031G>C (p.Cys344Ser)	single nucleotide variant	not specified [RCV004872738]	Chr12:101184155 [GRCh38] Chr12:101577933 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.295A>C (p.Ser99Arg)	single nucleotide variant	not specified [RCV004872739]	Chr12:101209554 [GRCh38] Chr12:101603332 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.1187G>A (p.Cys396Tyr)	single nucleotide variant	not specified [RCV004862323]	Chr12:101180075 [GRCh38] Chr12:101573853 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1808G>A (p.Gly603Asp)	single nucleotide variant	not specified [RCV004683818]	Chr12:101157304 [GRCh38] Chr12:101551082 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.427A>G (p.Thr143Ala)	single nucleotide variant	not specified [RCV004683819]	Chr12:101202206 [GRCh38] Chr12:101595984 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.1771G>C (p.Ala591Pro)	single nucleotide variant	not specified [RCV004265013]	Chr12:101157341 [GRCh38] Chr12:101551119 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.821T>G (p.Phe274Cys)	single nucleotide variant	not specified [RCV004338870]	Chr12:101190480 [GRCh38] Chr12:101584258 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1006G>A (p.Gly336Arg)	single nucleotide variant	not specified [RCV004355617]	Chr12:101184180 [GRCh38] Chr12:101577958 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1175A>G (p.Tyr392Cys)	single nucleotide variant	not specified [RCV004355988]	Chr12:101180087 [GRCh38] Chr12:101573865 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.403T>G (p.Phe135Val)	single nucleotide variant	not specified [RCV004464139]	Chr12:101204514 [GRCh38] Chr12:101598292 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.632A>T (p.Gln211Leu)	single nucleotide variant	not specified [RCV004464140]	Chr12:101193685 [GRCh38] Chr12:101587463 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1223C>T (p.Ala408Val)	single nucleotide variant	not specified [RCV004464132]	Chr12:101180039 [GRCh38] Chr12:101573817 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.1784T>G (p.Ile595Ser)	single nucleotide variant	not specified [RCV004464134]	Chr12:101157328 [GRCh38] Chr12:101551106 [GRCh37] Chr12:12q23.1	uncertain significance
NM_145913.5(SLC5A8):c.443A>G (p.Tyr148Cys)	single nucleotide variant	not specified [RCV004862321]	Chr12:101202190 [GRCh38] Chr12:101595968 [GRCh37] Chr12:12q23.2	uncertain significance
NM_145913.5(SLC5A8):c.1122A>T (p.Arg374Ser)	single nucleotide variant	not specified [RCV004862322]	Chr12:101182846 [GRCh38] Chr12:101576624 [GRCh37] Chr12:12q23.1	uncertain significance

Predicted Target Of

	Summary Value
Count of predictions:	511
Count of miRNA genes:	427
Interacting mature miRNAs:	447
Transcripts:	ENST00000536262
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1559125	SPSL2_H	Serum P-selectin level QTL 2 (human)	2.59		Serum P-selectin level		12	89897665	115897665	Human
597021831	GWAS1117905_H	interleukin 2 measurement QTL GWAS1117905 (human)		0.000008	blood interleukin-2 amount (VT:0008598)		12	101204232	101204233	Human
1643258	BW205_H	Body weight QTL 205 (human)	4.08	0.00001	Body fat amount	percent body fat	12	96630114	122630114	Human
597166558	GWAS1262632_H	BMI-adjusted waist-hip ratio QTL GWAS1262632 (human)		4e-08	body size trait (VT:0100005)		12	101208325	101208326	Human
1643264	BW195_H	Body weight QTL 195 (human)		0.0151	Body weight	BMI	12	89897665	115897665	Human
597066539	GWAS1162613_H	susceptibility to shingles measurement QTL GWAS1162613 (human)		0.000004	susceptibility to shingles measurement		12	101170056	101170057	Human
597223669	GWAS1319743_H	BMI-adjusted waist circumference QTL GWAS1319743 (human)		1e-08	body size trait (VT:0100005)		12	101208325	101208326	Human
1357387	BW58_H	Body weight QTL 58 (human)	2.3	0.0001	Body weight	fat free mass after exercise training	12	89438856	115438856	Human
1358827	MULTSCL22_H	Multiple sclerosis susceptibility QTL 22 (human)			Multiple sclerosis susceptibility		12	89897665	115897665	Human

SHGC-106056

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	12	101,582,613 - 101,582,950	UniSTS	GRCh37
Build 36	12	100,106,744 - 100,107,081	RGD	NCBI36
Celera	12	101,247,929 - 101,248,266	RGD
Cytogenetic Map	12	q23.1	UniSTS
HuRef	12	98,642,929 - 98,643,266	UniSTS
TNG Radiation Hybrid Map	12	50545.0	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
455	1057	1697	825	4251	1323	1721	239	504	86	1482	3059	2377	13	2914	613	1284	1376	153


RefSeq Transcripts	NM_145913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017018910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054371292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_007063055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008485650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008488548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_944503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC079953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC225709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF536216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF536217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK075263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK313788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY081220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC110492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DB229173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000536262 ⟹ ENSP00000445340

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	12	101,155,493 - 101,210,238 (-)	Ensembl

RefSeq Acc Id:

NM_145913 ⟹ NP_666018

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	101,155,493 - 101,210,238 (-)	NCBI
GRCh37	12	101,549,994 - 101,604,016 (-)	ENTREZGENE
Build 36	12	100,073,402 - 100,128,120 (-)	NCBI Archive
HuRef	12	98,610,304 - 98,664,323 (-)	ENTREZGENE
CHM1_1	12	101,515,979 - 101,569,971 (-)	NCBI
T2T-CHM13v2.0	12	101,117,226 - 101,171,943 (-)	NCBI

Sequence:

show sequence

GAACAAAACCTGCCCAGAGCGCTCCCTGTGTAGATTCGCTGGAAGCAGCTGGAGGCTCCAGTTCTCATCTGCTCAGGTGTCCCCGGCGCCTTGGCGAACTCGGCCACTCCAGTTCCTCACGTGGTGAG
CACTCAGGGCAGCGGGTCGATTTTCCGAGGTCCCATACCTGGGTTTGAGGGGCGCGGCTCGCAGCGGCGGGTGCAGGGGCGACTGCCAGCCCTCACCCCGCCTCGGGGTGCGTTCGGAGGCCGACACC
TGGAGGACGCCTCCAGTCCCCGCGGGACGCCACGCCTGCGCGCCAGGGATCCGGGATAAGAAGTGCGCGCCGGGCTCCGGCTGCGCGCCGCGGGGCCACCAGTTTGCGCGCAGGGCTCAGGCGACCGT
GCGGCCATGGACACGCCACGGGGCATCGGCACCTTCGTGGTGTGGGACTACGTGGTGTTCGCGGGCATGCTGGTCATCTCGGCCGCCATCGGCATCTACTACGCCTTCGCTGGGGGCGGCCAGCAGAC
CTCCAAGGACTTCCTGATGGGCGGCCGCAGAATGACCGCAGTGCCCGTGGCGCTGTCCCTCACCGCTAGCTTCATGTCAGCCGTCACTGTCCTGGGCACCCCCTCCGAGGTCTACCGTTTTGGGGCCA
TTTTTAGCATCTTTGCCTTCACCTACTTCTTTGTGGTGGTCATCAGCGCGGAGGTCTTCCTCCCGGTGTTCTACAAACTGGGAATTACCAGCACCTACGAGTATTTAGAACTTCGATTTAACAAATGT
GTTCGTCTCTGTGGAACAGTCCTCTTCATTGTTCAAACAATTCTGTATACTGGAATTGTTATTTATGCCCCTGCCCTGGCTTTGAATCAAGTCACAGGATTTGATCTGTGGGGCGCGGTAGTGGCAAC
GGGGGTGGTCTGCACATTCTACTGCACACTGGGTGGTCTTAAAGCAGTTATCTGGACAGATGTTTTTCAAGTTGGGATCATGGTGGCTGGATTTGCATCCGTGATTATACAGGCTGTGGTGATGCAAG
GTGGAATCAGCACTATTTTAAATGATGCCTATGATGGTGGAAGATTAAATTTCTGGAATTTTAATCCTAACCCTTTGCAAAGACACACCTTCTGGACAATTATTATAGGAGGGACCTTCACATGGACC
AGCATCTACGGTGTCAACCAATCCCAGGTGCAGAGATATATTTCTTGTAAAAGCAGATTCCAGGCAAAACTGTCTCTCTACATCAATCTTGTGGGACTCTGGGCAATCCTCACATGCTCAGTGTTTTG
TGGGCTCGCCCTATATTCCAGGTACCATGACTGTGATCCTTGGACAGCCAAGAAAGTGTCTGCACCAGACCAGCTCATGCCTTATTTGGTACTGGACATTCTGCAAGATTATCCAGGACTTCCTGGAC
TTTTTGTGGCCTGTGCTTACAGTGGGACATTAAGCACAGTGTCCTCCAGTATTAATGCCTTAGCAGCAGTAACTGTGGAAGATCTAATCAAACCTTACTTCAGATCGCTCTCAGAAAGGTCTCTGTCT
TGGATTTCCCAAGGAATGAGTGTGGTGTATGGAGCCCTGTGTATTGGAATGGCTGCGCTGGCGTCACTTATGGGAGCTTTGTTGCAGGCAGCACTCAGCGTATTTGGTATGGTTGGTGGACCACTTAT
GGGCCTGTTCGCTTTGGGCATTTTGGTTCCCTTTGCCAACTCAATTGGAGCACTTGTTGGTCTGATGGCTGGATTTGCCATTTCTCTATGGGTTGGAATTGGAGCTCAAATATATCCTCCACTTCCTG
AGAGAACATTGCCATTGCACCTTGATATCCAAGGCTGTAACAGCACCTACAATGAGACAAATTTGATGACAACCACAGAAATGCCATTTACTACTAGTGTTTTTCAAATATACAATGTTCAAAGGACT
CCACTGATGGATAACTGGTATTCTTTATCATATCTGTACTTCAGCACTGTTGGAACTTTGGTAACATTATTAGTGGGGATACTTGTCAGTTTATCAACAGGAGGAAGAAAACAGAACTTAGACCCCAG
ATACATACTAACCAAAGAGGACTTTTTATCCAATTTTGATATTTTTAAGAAAAAGAAGCATGTTTTGAGCTATAAATCACATCCAGTGGAAGATGGTGGAACTGATAATCCTGCTTTCAACCACATTG
AATTGAACTCAGATCAGAGTGGCAAGAGCAATGGGACTCGTTTGTGAAGCTGCTCTGATACTAGATATCCTTAAATGATGTTTCAATTTTATATGTTTTCTAAGATAATTGGATCAGGTTTTCTTTGT
GTGTGTGTGTGTGTTGTATCATGAGTGTTTGGGGGATAAGTTTTTGTTAAAACAAAGTCTGGACTATCTTCATTTACTACATCATTAATTGATGTTACTCTGGAGTTTAGAATTCTGGCATTGACATT
TCCCTCTCTTTCCTTTATTTCGATGAAGCTATAATTGTGAAAATTGTAACTACATAGATGCTGAAAGGCTAATACACACATATGCACATGTATTTGATTGTCAAAGGTATATTCTTAAATTTGGGTAT
TATTGAAAATATTTTCCATGCCTTGGTGCTAGCATATAAGTTTGGAAGTTTGCCAACATCACAATTCATCTTGAAAAGAGCTTTTTTCCCTCCTACCACATACACCATTCTTAGGGAGCAATGAGGTA
ACAGGTCTGTGTTGTCTAGATCTTTGCTTTTTATCCCCCTATCAGTCCAGGGCATATACTAACCTGCAAACTGATTCTGAATCAGGAAGGTGGTAATCAATAAGTATTCTGGCTGGGAAAGACCGTGG
GCCCAATGATCAAAGTCTTCTTGGTGCTGTTCATTAATTCTTGTGCCTTTTGGCTTGTTTTCTAGAGTTTCTGGGCTTTGGCTGCTGATACTGCCTTTCTTAGACTGTAATTTTTATCTGCATGCCCA
GTTTCTGACCTATCAACTTGGGTTTTATTGTGCACTCTAACTGAGCTTGTCTTCATAATTTTCTGTTTATTGCCCTGGGCTTGGATATGTCTCAAGACACTCATGTGAATCATGCCACCCCAAATCCT
GGCTTATCAAGTCCCAGACTATAAATTATGAACTCCCATTAGCTTGGTACTAACATATACTTGATGTAGGTATTTATGGACTTGATGATCCAAGAATATTATATTCTTCAAAATGGTTAAGCTCCATG
GAGTTAGATGACTACACTTAATGCTATTAAGTTGAACTTTTGAATGTCAACTAATTTGCAATCAATTAAAGATACATATGCCTAGAAATTTTGAAATTTCGGTATATTTATCCAGTTAAAGGGCTAAA
TTATATAAGCAAACACTACTTTTTTTAAAACGTCTGGACTCAAAAAATGCTTTGTTCCATGTTTTAAAATTTTTAAGTAGCAGTCTCAAAGTTGCTTAGCTGTTTATTTTGCTATGTTCCTAGCTAAG
AGTTTGGTTATAGGAGTTCATCAATAACTTATTTTTTGTACAGTTCCCACATTAGATACTGTTTAAAAGTTCTTTTTTAAACTCAATTTTTTTTAGAAACATAAGAGAAATATTTAGATACATACAAA
TGTTTTTATGATTAAATAATTTTATGCTTATTTTCTGATACGTGTTATTTAGGTAATCATGCCCTGTACATTTAGAGGTTGCTAACTGACAATGTTAAGAAATTTAAAAAAAAAAAAAAGCCTGGGCA
TGATGGCTCATGCTTGTAATCTGAACATTTGGGAGGCTGAGGCAGGAAGATCGCTTGAGGTCCAGAGTTTAAGTCCAGCCTGGAAACATAGTTAGACCTCATCTCTACAAAAATAAAAAATAAAAATA
AAAAAAACTTAGCTAGGCATGTTGCCACATACTTGTAGTCCCAGTTATTAGGGAAGCTGAGGTGGGAGGATAGCTTAAGCCCAGGATTTCAAGGCTGCATTGAGCTATGATTACACCACTGCACTCCA
GCCTGGGTAACAGAGTGAAATCTTGTCTCTGGGAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017018910 ⟹ XP_016874399

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	101,166,709 - 101,210,238 (-)	NCBI

Sequence:

show sequence

GCGCGCCGCGGGGCCACCAGTTTGCGCGCAGGGCTCAGGCGACCGTGCGGCCATGGACACGCCA
CGGGGCATCGGCACCTTCGTGGTGTGGGACTACGTGGTGTTCGCGGGCATGCTGGTCATCTCGGCCGCCATCGGCATCTACTACGCCTTCGCTGGGGGCGGCCAGCAGACCTCCAAGGACTTCCTGAT
GGGCGGCCGCAGAATGACCGCAGTGCCCGTGGCGCTGTCCCTCACCGCTAGCTTCATGTCAGCCGTCACTGTCCTGGGCACCCCCTCCGAGGTCTACCGTTTTGGGGCCATTTTTAGCATCTTTGCCT
TCACCTACTTCTTTGTGGTGGTCATCAGCGCGGAGGTCTTCCTCCCGGTGTTCTACAAACTGGGAATTACCAGCACCTACGAGTATTTAGAACTTCGATTTAACAAATGTGTTCGTCTCTGTGGAACA
GTCCTCTTCATTGTTCAAACAATTCTGTATACTGGAATTGTTATTTATGCCCCTGCCCTGGCTTTGAATCAAGTCACAGGATTTGATCTGTGGGGCGCGGTAGTGGCAACGGGGGTGGTCTGCACATT
CTACTGCACACTGGGTGGTCTTAAAGCAGTTATCTGGACAGATGTTTTTCAAGTTGGGATCATGGTGGCTGGATTTGCATCCGTGATTATACAGGCTGTGGTGATGCAAGGTGGAATCAGCACTATTT
TAAATGATGCCTATGATGGTGGAAGATTAAATTTCTGGAATTTTAATCCTAACCCTTTGCAAAGACACACCTTCTGGACAATTATTATAGGAGGGACCTTCACATGGACCAGCATCTACGGTGTCAAC
CAATCCCAGGTGCAGAGATATATTTCTTGTAAAAGCAGATTCCAGGCAAAACTGTCTCTCTACATCAATCTTGTGGGACTCTGGGCAATCCTCACATGCTCAGTGTTTTGTGGGCTCGCCCTATATTC
CAGGTACCATGACTGTGATCCTTGGACAGCCAAGAAAGTGTCTGCACCAGACCAGCTCATGCCTTATTTGGTACTGGACATTCTGCAAGATTATCCAGGACTTCCTGGACTTTTTGTGGCCTGTGCTT
ACAGTGGGACATTAAGCACAGTGTCCTCCAGTATTAATGCCTTAGCAGCAGTAACTGTGGAAGATCTAATCAAACCTTACTTCAGATCGCTCTCAGAAAGGTCTCTGTCTTGGATTTCCCAAGGAATG
AGTGTGGTGTATGGAGCCCTGTGTATTGGAATGGCTGCGCTGGCGTCACTTATGGGAGCTTTGTTGCAGGCAGCACTCAGCGTATTTGGTATGGTTGGTGGACCACTTATGGGCCTGTTCGCTTTGGG
CATTTTGGTTCCCTTTGCCAACTCAATTATTTTTATGGGCTGAGCACTATCTTGGGAGGAGAGAGCGTTGAATGTTTCTGCCCTTGTGAGTTTTATAATTTCGTGCCATGTTGAACTTGGCTTTCTAA
TATTAATTTTGACATCAAAGCAAATTGTATTATTTTTCTTTTAAAGGCATTCTTG

hide sequence

RefSeq Acc Id:

XM_054371292 ⟹ XP_054227267

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	12	101,128,415 - 101,171,943 (-)	NCBI

RefSeq Acc Id:

XR_007063055

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	101,158,249 - 101,210,238 (-)	NCBI

RefSeq Acc Id:

XR_008488548

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	12	101,119,983 - 101,171,943 (-)	NCBI


Protein RefSeqs	NP_666018	(Get FASTA)	NCBI Sequence Viewer
	XP_016874399	(Get FASTA)	NCBI Sequence Viewer
	XP_054185541	(Get FASTA)	NCBI Sequence Viewer
	XP_054227267	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI10493	(Get FASTA)	NCBI Sequence Viewer
	AAL88746	(Get FASTA)	NCBI Sequence Viewer
	AAP46193	(Get FASTA)	NCBI Sequence Viewer
	AAP46194	(Get FASTA)	NCBI Sequence Viewer
	BAG36525	(Get FASTA)	NCBI Sequence Viewer
	EAW97648	(Get FASTA)	NCBI Sequence Viewer
	EAW97649	(Get FASTA)	NCBI Sequence Viewer
	EAW97650	(Get FASTA)	NCBI Sequence Viewer
	EAW97651	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000445340
	ENSP00000445340.2
	ENSP00000461697.2
GenBank Protein	Q8N695	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_666018 ⟸ NM_145913

- UniProtKB:

Q2TB99 (UniProtKB/Swiss-Prot), Q7Z2H9 (UniProtKB/Swiss-Prot), Q8N695 (UniProtKB/Swiss-Prot), B2R9H8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVR
LCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSI
YGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWI
SQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLMTTTEMPFTTSVFQIYNVQRTPL
MDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL

hide sequence

RefSeq Acc Id:

XP_016874399 ⟸ XM_017018910

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVR
LCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSI
YGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWI
SQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIIFMG

hide sequence

Ensembl Acc Id:

ENSP00000445340 ⟸ ENST00000536262

RefSeq Acc Id:	XP_054227267 ⟸ XM_054371292
- Peptide Label:	isoform X1

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8N695-F1-model_v2	AlphaFold	Q8N695	1-610	view protein structure

RGD ID:

7225159

Promoter ID:

EPDNEW_H18325

Type:

initiation region

Name:

SLC5A8_1

Description:

solute carrier family 5 member 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	12	101,210,238 - 101,210,298	EPDNEW

Database	Acc Id	Source(s)
COSMIC	SLC5A8	COSMIC
Ensembl Genes	ENSG00000256870	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSG00000262217	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000536262	ENTREZGENE
	ENST00000536262.3	UniProtKB/Swiss-Prot
	ENST00000572861.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1730.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000256870	GTEx
	ENSG00000262217	GTEx
HGNC ID	HGNC:19119	ENTREZGENE
Human Proteome Map	SLC5A8	Human Proteome Map
InterPro	Na/Glc_symporter_sf	UniProtKB/Swiss-Prot
	Na/solute_symporter	UniProtKB/Swiss-Prot
	SLC5sbd_SMCT1	UniProtKB/Swiss-Prot
	Sodium:Solute_Symporter_SSF	UniProtKB/Swiss-Prot
KEGG Report	hsa:160728	UniProtKB/Swiss-Prot
NCBI Gene	160728	ENTREZGENE
OMIM	608044	OMIM
PANTHER	SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER	UniProtKB/Swiss-Prot
	SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1	UniProtKB/Swiss-Prot
Pfam	SSF	UniProtKB/Swiss-Prot
PharmGKB	PA134989874	PharmGKB
PROSITE	NA_SOLUT_SYMP_3	UniProtKB/Swiss-Prot
UniProt	B2R9H8	ENTREZGENE, UniProtKB/TrEMBL
	Q2TB99	ENTREZGENE
	Q7Z2H9	ENTREZGENE
	Q8N695	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q2TB99	UniProtKB/Swiss-Prot
	Q7Z2H9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-23	SLC5A8	solute carrier family 5 member 8	SLC5A8	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	Symbol and/or name change	5135510	APPROVED
2013-07-23	SLC5A8	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	SLC5A8	solute carrier family 5 (iodide transporter), member 8	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
		Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Send us a Message

Imported Disease Annotations - CTD

RGD Manual Annotations