POLR1H (RNA polymerase I subunit H) - Rat Genome Database

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Gene: POLR1H (RNA polymerase I subunit H) Homo sapiens
Analyze
Symbol: POLR1H
Name: RNA polymerase I subunit H
RGD ID: 1351679
HGNC Page HGNC:13182
Description: Predicted to enable DNA-directed RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to be involved in termination of RNA polymerase I transcription. Part of RNA polymerase I complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A12.2; DNA-directed RNA polymerase I subunit H; DNA-directed RNA polymerase I subunit RPA12; HTEX-6; HTEX6; hZR14; MGC13376; RNA polymerase I small specific subunit Rpa12; Rpa12; tctex-6; TCTEX6; TEX6; transcription-associated zinc ribbon protein; zinc ribbon domain containing 1; zinc ribbon domain containing, 1; zinc ribbon domain-containing protein 1; ZNRD1; ZR14
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,060,062 - 30,064,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,058,899 - 30,064,909 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,029,042 - 30,032,684 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,137,015 - 30,140,665 (+)NCBINCBI36Build 36hg18NCBI36
Build 34630,137,014 - 30,140,664NCBI
Celera631,627,294 - 31,630,939 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,827,192 - 29,830,858 (+)NCBIHuRef
CHM1_1630,031,066 - 30,034,735 (+)NCBICHM1_1
T2T-CHM13v2.0629,925,545 - 29,929,181 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHumanmegacolon  IAGPRGD:414076048554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHumanExperimental Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16609701
POLR1HHumanStomach Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16609701

1 to 20 of 83 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHuman1,2-dimethylhydrazine multiple interactionsISORGD:13324486480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of POLR1H mRNACTDPMID:22206623
POLR1HHuman1,2-dimethylhydrazine decreases expressionISORGD:133244864804641,2-Dimethylhydrazine results in decreased expression of POLR1H mRNACTDPMID:22206623
POLR1HHuman17alpha-ethynylestradiol multiple interactionsISORGD:13324486480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR1H mRNACTDPMID:17942748
POLR1HHuman2,2',4,4'-Tetrabromodiphenyl ether affects expressionISORGD:133244864804642,2',4,4'-tetrabromodiphenyl ether affects the expression of POLR1H mRNACTDPMID:30294300
POLR1HHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13031146480464Tetrachlorodibenzodioxin results in decreased expression of POLR1H mRNACTDPMID:21215274
POLR1HHuman2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13031146480464Tetrachlorodibenzodioxin affects the expression of POLR1H mRNACTDPMID:32109520
POLR1HHuman2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13324486480464Tetrachlorodibenzodioxin affects the expression of POLR1H mRNACTDPMID:21570461
POLR1HHuman2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:13324486480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR1H mRNA; [TIPARP gene mutant more ...CTDPMID:17942748|PMID:25975270
POLR1HHuman2,4-dinitrotoluene affects expressionISORGD:130311464804642,4-dinitrotoluene affects the expression of POLR1H mRNACTDPMID:21346803
POLR1HHuman2,6-dinitrotoluene affects expressionISORGD:130311464804642,6-dinitrotoluene affects the expression of POLR1H mRNACTDPMID:21346803
POLR1HHuman2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactionsEXP 6480464Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the more ...CTDPMID:14726695
POLR1HHuman2-hydroxypropanoic acid decreases expressionEXP 6480464Lactic Acid results in decreased expression of POLR1H mRNACTDPMID:30851411
POLR1HHuman2-methylcholine affects expressionEXP 6480464beta-methylcholine affects the expression of POLR1H mRNACTDPMID:21179406
POLR1HHuman4,4'-diaminodiphenylmethane affects expressionISORGD:133244864804644,4'-diaminodiphenylmethane affects the expression of POLR1H mRNACTDPMID:18648102
POLR1HHuman4,4'-sulfonyldiphenol decreases expressionISORGD:13324486480464bisphenol S results in decreased expression of POLR1H mRNACTDPMID:39298647
POLR1HHuman4-phenylbutyric acid decreases expressionEXP 64804644-phenylbutyric acid results in decreased expression of POLR1H mRNACTDPMID:14583596
POLR1HHumanaflatoxin B1 increases expressionISORGD:13324486480464Aflatoxin B1 results in increased expression of POLR1H mRNACTDPMID:19770486
POLR1HHumanalpha-Zearalanol multiple interactionsISORGD:13031146480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of ZNRD1 mRNACTDPMID:35163327
POLR1HHumanantirheumatic drug increases expressionEXP 6480464Antirheumatic Agents results in increased expression of POLR1H mRNACTDPMID:24449571
POLR1HHumanarsane multiple interactionsEXP 6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHumanDNA-templated transcription involved_inIEAInterPro:IPR001222|InterPro:IPR012164150520179 InterProGO_REF:0000002
POLR1HHumannucleobase-containing compound metabolic process involved_inTAS 150520179 PMID:10662553PINCPMID:10662553
POLR1HHumantermination of RNA polymerase I transcription involved_inIBAPANTHER:PTN000133053|PomBase:SPCC1259.03|SGD:S000003824150520179 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHumanDNA-directed RNA polymerase complex part_ofIEAUniProtKB-KW:KW-0240150520179 UniProtGO_REF:0000043
POLR1HHumannucleolus located_inIEAUniProtKB-SubCell:SL-0188150520179 UniProtGO_REF:0000044
POLR1HHumannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-5250930|Reactome:R-HSA-5250938|Reactome:R-HSA-5250947|Reactome:R-HSA-73757|Reactome:R-HSA-73758|Reactome:R-HSA-73769|Reactome:R-HSA-74986|Reactome:R-HSA-74992|Reactome:R-HSA-74993|Reactome:R-HSA-74994
POLR1HHumannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
POLR1HHumanRNA polymerase I complex part_ofIBAPANTHER:PTN000133053|PomBase:SPCC1259.03|SGD:S000003824|UniProtKB:Q9P1U0150520179 GO_CentralGO_REF:0000033
POLR1HHumanRNA polymerase I complex part_ofIDA 150520179 PMID:34671025, PMID:36271492UniProtPMID:34671025|PMID:36271492

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
POLR1HHumanDNA-directed RNA polymerase activity enablesIEAUniRule:UR002017278150520179 UniProtGO_REF:0000104
POLR1HHumanDNA-directed RNA polymerase activity enablesIEAInterPro:IPR012164150520179 InterProGO_REF:0000002
POLR1HHumanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
POLR1HHumannucleic acid binding enablesIEAUniRule:UR002017278150520179 UniProtGO_REF:0000104
POLR1HHumannucleic acid binding enablesIEAInterPro:IPR001222150520179 InterProGO_REF:0000002
POLR1HHumanprotein binding enablesIPIUniProtKB:P06396|UniProtKB:P54253|UniProtKB:Q9Y649150520179 PMID:32814053IntActPMID:32814053
POLR1HHumanprotein binding enablesIPIUniProtKB:Q8N7C3150520179 PMID:32296183IntActPMID:32296183
POLR1HHumanzinc ion binding enablesIEAInterPro:IPR001222150520179 InterProGO_REF:0000002
POLR1HHumanzinc ion binding enablesIEAUniProtKB-KW:KW-0863150520179 UniProtGO_REF:0000043
1 to 9 of 9 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHumanRNA polymerase I transcription pathway   TAS 9588244 RGD 
POLR1HHumanRNA polymerase I transcription pathway   TAS 9588262 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHumanpurine metabolic pathway  IEA 6907045 KEGGhsa:00230
POLR1HHumanpyrimidine metabolic pathway  IEA 6907045 KEGGhsa:00240
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
POLR1HHumanMegacolon  IAGPRGD:414076048554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA Gene. 2012 Feb 10;493(2):176-84. doi: 10.1016/j.gene.2011.08.006. Epub 2011 Aug 26.
6. Conservation between the RNA polymerase I, II, and III transcription initiation machineries. Vannini A and Cramer P, Mol Cell. 2012 Feb 24;45(4):439-46. doi: 10.1016/j.molcel.2012.01.023.
PMID:8125298   PMID:8938444   PMID:10662553   PMID:11130983   PMID:12477932   PMID:12795835   PMID:14574404   PMID:14726695   PMID:15358150   PMID:15489334   PMID:15662122   PMID:16189514  
PMID:16341674   PMID:16713569   PMID:17389617   PMID:17492506   PMID:17709345   PMID:18058465   PMID:18187620   PMID:18564169   PMID:18594968   PMID:18982067   PMID:19050382   PMID:19115949  
PMID:19693088   PMID:19851445   PMID:20041166   PMID:20192730   PMID:20211142   PMID:20587610   PMID:21080911   PMID:21873635   PMID:21988832   PMID:22697009   PMID:23150253   PMID:23453885  
PMID:23874430   PMID:23893241   PMID:24489884   PMID:24842830   PMID:24981860   PMID:25110835   PMID:25416956   PMID:25814554   PMID:26344197   PMID:26496610   PMID:27083073   PMID:27166266  
PMID:30033366   PMID:30463901   PMID:30585266   PMID:31637871   PMID:31782860   PMID:32296183   PMID:32454947   PMID:32694731   PMID:32814053   PMID:33961781   PMID:33984768   PMID:34671025  
PMID:35944360   PMID:36271492   PMID:37167337  



POLR1H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,060,062 - 30,064,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,058,899 - 30,064,909 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,029,042 - 30,032,684 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,137,015 - 30,140,665 (+)NCBINCBI36Build 36hg18NCBI36
Build 34630,137,014 - 30,140,664NCBI
Celera631,627,294 - 31,630,939 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,827,192 - 29,830,858 (+)NCBIHuRef
CHM1_1630,031,066 - 30,034,735 (+)NCBICHM1_1
T2T-CHM13v2.0629,925,545 - 29,929,181 (+)NCBIT2T-CHM13v2.0
Polr1h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391737,265,250 - 37,269,417 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1737,265,248 - 37,269,451 (-)EnsemblGRCm39 Ensembl
GRCm381736,954,358 - 36,958,525 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1736,954,356 - 36,958,559 (-)EnsemblGRCm38mm10GRCm38
MGSCv371737,091,303 - 37,095,373 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361736,562,411 - 36,566,481 (-)NCBIMGSCv36mm8
Celera1740,377,895 - 40,381,965 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1719.16NCBI
Polr1h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,600,170 - 1,604,088 (+)NCBIGRCr8
mRatBN7.2201,594,936 - 1,598,854 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,594,936 - 1,598,854 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx201,647,698 - 1,651,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,651,195 - 1,655,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,592,702 - 1,596,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,088,518 - 2,092,436 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,088,533 - 2,092,436 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0204,125,232 - 4,129,150 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4201,687,673 - 1,691,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1201,687,849 - 1,691,468 (+)NCBI
Celera202,303,510 - 2,307,419 (+)NCBICelera
Cytogenetic Map20p12NCBI
Polr1h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583191,564 - 195,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955583191,252 - 195,563 (+)NCBIChiLan1.0ChiLan1.0
POLR1H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2544,654,673 - 44,658,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1640,617,667 - 40,621,308 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0629,839,067 - 29,842,692 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1630,509,326 - 30,512,956 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl630,509,326 - 30,512,956 (+)Ensemblpanpan1.1panPan2
POLR1H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13526,285,520 - 26,288,550 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3526,285,538 - 26,288,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.03526,594,054 - 26,597,115 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13526,248,647 - 26,251,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03526,309,259 - 26,312,356 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03527,779,521 - 27,782,596 (+)NCBIUU_Cfam_GSD_1.0
Polr1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494632,608,011 - 32,612,807 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936723978,613 - 984,405 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936723979,076 - 983,814 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR1H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl722,626,846 - 22,631,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1722,626,871 - 22,631,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2725,156,351 - 25,161,054 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLR1H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11742,434,992 - 42,438,993 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1742,435,196 - 42,438,981 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604429,716,158 - 29,720,178 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Polr1h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475425,340,155 - 25,344,380 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475425,340,498 - 25,344,032 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in POLR1H
8 total Variants

1 to 10 of 22 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33
pathogenic
NM_021959.2(PPP1R11):c.361C>T (p.Pro121Ser) single nucleotide variant Malignant melanoma [RCV000061381] Chr6:30069286 [GRCh38]
Chr6:30037063 [GRCh37]
Chr6:30145042 [NCBI36]
Chr6:6p22.1
not provided
NM_021959.2(PPP1R11):c.332C>T (p.Pro111Leu) single nucleotide variant Malignant melanoma [RCV000067266] Chr6:30069257 [GRCh38]
Chr6:30037034 [GRCh37]
Chr6:30145013 [NCBI36]
Chr6:6p22.1
not provided
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p22.1(chr6:30029374-30036983)x3 copy number gain Breast ductal adenocarcinoma [RCV000207038] Chr6:30029374..30036983 [GRCh37]
Chr6:6p22.1
uncertain significance
chr6:29910378..30075843 complex variant complex Breast ductal adenocarcinoma [RCV000207211] Chr6:29910378..30075843 [GRCh37]
Chr6:6p22.1
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
1 to 10 of 22 rows

Predicted Target Of
Summary Value
Count of predictions:823
Count of miRNA genes:214
Interacting mature miRNAs:219
Transcripts:ENST00000332435, ENST00000359374, ENST00000376782, ENST00000376785, ENST00000463141, ENST00000471008
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
596989777GWAS1109296_Hhemoglobin measurement QTL GWAS1109296 (human)5e-28hemoglobin measurement63006008330060084Human
1643377BW325_HBody weight QTL 325 (human)2.320.0005Body fat amount6691196032911960Human
1643569GLUCO21_HGlucose level QTL 21 (human)0.021Glucose levelnon-insulin-dependent6691196032911960Human
1298458BW9_HBody weight QTL 9 (human)2.70.0002Body fat amount6691196032911960Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
1358854MULTSCL4_HMultiple sclerosis susceptibility QTL 4 (human)Multiple sclerosis susceptibility6691196032911960Human
596968966GWAS1088485_Hrheumatoid arthritis, multiple sclerosis QTL GWAS1088485 (human)4e-10rheumatoid arthritis, multiple sclerosis63006233730062338Human
596964135GWAS1083654_Hattention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder QTL GWAS1083654 (human)8e-09attention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder63006474530064746Human
407015476GWAS664452_Hattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia QTL GWAS664452 (human)8e-09attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia63006474530064746Human

1 to 10 of 15 rows



adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4973 1726 2351 6 624 1951 465 2269 7306 6472 53 3734 1 852 1744 1617 175 1


1 to 30 of 45 rows
RefSeq Transcripts NM_001278785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_103864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047418695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054330287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054330578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054331319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB088087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB202082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF024616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF024617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF230337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF230338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF238320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF238321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG503963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM798114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ690150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX088647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX927229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 45 rows

Ensembl Acc Id: ENST00000332435   ⟹   ENSP00000331111
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,061,265 - 30,064,907 (+)Ensembl
Ensembl Acc Id: ENST00000359374   ⟹   ENSP00000352333
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,061,259 - 30,064,909 (+)Ensembl
Ensembl Acc Id: ENST00000376782   ⟹   ENSP00000365978
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,061,257 - 30,064,909 (+)Ensembl
Ensembl Acc Id: ENST00000376785   ⟹   ENSP00000365981
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,061,263 - 30,064,909 (+)Ensembl
Ensembl Acc Id: ENST00000463141
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,061,330 - 30,064,909 (+)Ensembl
Ensembl Acc Id: ENST00000471008
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl630,058,899 - 30,064,909 (+)Ensembl
RefSeq Acc Id: NM_001278785   ⟹   NP_001265714
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,061,265 - 30,064,907 (+)NCBI
GRCh37630,029,017 - 30,032,686 (+)NCBI
HuRef629,827,192 - 29,830,858 (+)NCBI
CHM1_1630,031,066 - 30,034,735 (+)NCBI
T2T-CHM13v2.0629,925,545 - 29,929,181 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278786   ⟹   NP_001265715
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,061,265 - 30,064,907 (+)NCBI
GRCh37630,029,017 - 30,032,686 (+)NCBI
HuRef629,827,192 - 29,830,858 (+)NCBI
CHM1_1630,031,066 - 30,034,735 (+)NCBI
T2T-CHM13v2.0629,925,545 - 29,929,181 (+)NCBI
Sequence:
RefSeq Acc Id: NM_014596   ⟹   NP_055411
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,061,265 - 30,064,907 (+)NCBI
GRCh37630,029,017 - 30,032,686 (+)NCBI
Build 36630,137,015 - 30,140,665 (+)NCBI Archive
HuRef629,827,192 - 29,830,858 (+)NCBI
CHM1_1630,031,066 - 30,034,735 (+)NCBI
T2T-CHM13v2.0629,925,545 - 29,929,181 (+)NCBI
Sequence:
RefSeq Acc Id: NM_170783   ⟹   NP_740753
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,061,265 - 30,064,907 (+)NCBI
GRCh37630,029,017 - 30,032,686 (+)NCBI
Build 36630,137,015 - 30,140,665 (+)NCBI Archive
HuRef629,827,192 - 29,830,858 (+)NCBI
CHM1_1630,031,066 - 30,034,735 (+)NCBI
T2T-CHM13v2.0629,925,545 - 29,929,181 (+)NCBI
Sequence:
RefSeq Acc Id: NR_103864
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,061,265 - 30,064,907 (+)NCBI
GRCh37630,029,017 - 30,032,686 (+)NCBI
HuRef629,827,192 - 29,830,858 (+)NCBI
CHM1_1630,031,066 - 30,034,735 (+)NCBI
T2T-CHM13v2.0629,925,545 - 29,929,181 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047418695   ⟹   XP_047274651
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,060,062 - 30,064,907 (+)NCBI
1 to 30 of 59 rows
Protein RefSeqs NP_001265714 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265715 (Get FASTA)   NCBI Sequence Viewer  
  NP_055411 (Get FASTA)   NCBI Sequence Viewer  
  NP_740753 (Get FASTA)   NCBI Sequence Viewer  
  XP_047274651 (Get FASTA)   NCBI Sequence Viewer  
  XP_054185774 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186262 (Get FASTA)   NCBI Sequence Viewer  
  XP_054186553 (Get FASTA)   NCBI Sequence Viewer  
  XP_054187294 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF40469 (Get FASTA)   NCBI Sequence Viewer  
  AAG50159 (Get FASTA)   NCBI Sequence Viewer  
  AAG50160 (Get FASTA)   NCBI Sequence Viewer  
  AAH10898 (Get FASTA)   NCBI Sequence Viewer  
  AAH50608 (Get FASTA)   NCBI Sequence Viewer  
  AQY77238 (Get FASTA)   NCBI Sequence Viewer  
  AQY77239 (Get FASTA)   NCBI Sequence Viewer  
  AQY77240 (Get FASTA)   NCBI Sequence Viewer  
  BAE78600 (Get FASTA)   NCBI Sequence Viewer  
  CAG33390 (Get FASTA)   NCBI Sequence Viewer  
  EAX03250 (Get FASTA)   NCBI Sequence Viewer  
  EAX03251 (Get FASTA)   NCBI Sequence Viewer  
  EAX03252 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000331111
  ENSP00000331111.5
  ENSP00000352333
  ENSP00000352333.4
  ENSP00000365978
  ENSP00000365978.2
  ENSP00000365981
  ENSP00000365981.2
1 to 30 of 59 rows
RefSeq Acc Id: NP_740753   ⟸   NM_170783
- UniProtKB: Q9P1U0 (UniProtKB/Swiss-Prot),   Q2L6J2 (UniProtKB/TrEMBL),   A0A1U9X8Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_055411   ⟸   NM_014596
- UniProtKB: Q9P1U0 (UniProtKB/Swiss-Prot),   Q2L6J2 (UniProtKB/TrEMBL),   A0A1U9X8Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001265715   ⟸   NM_001278786
- UniProtKB: Q9P1U0 (UniProtKB/Swiss-Prot),   Q2L6J2 (UniProtKB/TrEMBL),   A0A1U9X8Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001265714   ⟸   NM_001278785
- UniProtKB: Q9P1U0 (UniProtKB/Swiss-Prot),   Q2L6J2 (UniProtKB/TrEMBL),   A0A1U9X8Y8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000352333   ⟸   ENST00000359374
TFIIS-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q9P1U0-F1-model_v2 AlphaFold Q9P1U0 1-126 view protein structure

RGD ID:6872350
Promoter ID:EPDNEW_H9339
Type:initiation region
Name:ZNRD1_1
Description:zinc ribbon domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,061,265 - 30,061,325EPDNEW
RGD ID:6803994
Promoter ID:HG_KWN:52792
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Jurkat,   K562,   Lymphoblastoid
Transcripts:ENST00000376782,   ENST00000376785,   NM_014596,   OTTHUMT00000076272,   OTTHUMT00000076273,   OTTHUMT00000076274
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,137,526 - 30,138,026 (+)MPROMDB


1 to 40 of 80 rows
Database
Acc Id
Source(s)
COSMIC POLR1H COSMIC
Ensembl Genes ENSG00000066379 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000206502 UniProtKB/Swiss-Prot
  ENSG00000224859 UniProtKB/Swiss-Prot
  ENSG00000233795 UniProtKB/Swiss-Prot
  ENSG00000235176 UniProtKB/Swiss-Prot
  ENSG00000235443 UniProtKB/Swiss-Prot
  ENSG00000236808 UniProtKB/Swiss-Prot
  ENSG00000236949 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000332435 ENTREZGENE
  ENST00000332435.10 UniProtKB/Swiss-Prot
  ENST00000359374 ENTREZGENE
  ENST00000359374.8 UniProtKB/Swiss-Prot
  ENST00000376782 ENTREZGENE
  ENST00000376782.6 UniProtKB/Swiss-Prot
  ENST00000376785 ENTREZGENE
  ENST00000376785.2 UniProtKB/Swiss-Prot
  ENST00000383613.6 UniProtKB/Swiss-Prot
  ENST00000400659.1 UniProtKB/Swiss-Prot
  ENST00000400660.7 UniProtKB/Swiss-Prot
  ENST00000400662.7 UniProtKB/Swiss-Prot
  ENST00000412396.1 UniProtKB/Swiss-Prot
  ENST00000417275.6 UniProtKB/Swiss-Prot
  ENST00000417738.6 UniProtKB/Swiss-Prot
  ENST00000420100.5 UniProtKB/Swiss-Prot
  ENST00000428913.5 UniProtKB/Swiss-Prot
  ENST00000429558.5 UniProtKB/Swiss-Prot
  ENST00000431032.5 UniProtKB/Swiss-Prot
  ENST00000431416.1 UniProtKB/Swiss-Prot
  ENST00000432227.6 UniProtKB/Swiss-Prot
  ENST00000432545.1 UniProtKB/Swiss-Prot
  ENST00000432904.6 UniProtKB/Swiss-Prot
  ENST00000433264.6 UniProtKB/Swiss-Prot
  ENST00000437373.6 UniProtKB/Swiss-Prot
  ENST00000437507.5 UniProtKB/Swiss-Prot
  ENST00000441251.6 UniProtKB/Swiss-Prot
  ENST00000442585.6 UniProtKB/Swiss-Prot
  ENST00000443142.6 UniProtKB/Swiss-Prot
  ENST00000443494.6 UniProtKB/Swiss-Prot
  ENST00000444027.1 UniProtKB/Swiss-Prot
1 to 40 of 80 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-20 POLR1H  RNA polymerase I subunit H  ZNRD1  zinc ribbon domain containing 1  Symbol and/or name change 19259463 PROVISIONAL