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Gene: DUSP4 (dual specificity phosphatase 4) Homo sapiens
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Symbol: DUSP4
Name: dual specificity phosphatase 4
Description: Exhibits MAP kinase serine/threonine phosphatase activity; protein tyrosine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Involved in negative regulation of MAPK cascade and protein dephosphorylation. Localizes to the nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity protein phosphatase 4; dual specificity protein phosphatase hVH2; HVH2; MAP kinase phosphatase 2; mitogen-activated protein kinase phosphatase 2; MKP-2; MKP2; serine/threonine specific protein phosphatase; TYP; VH1 homologous phosphatase 2
Orthologs:
Mus musculus (house mouse) : Dusp4 (dual specificity phosphatase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dusp4 (dual specificity phosphatase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp4 (dual specificity phosphatase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP4 (dual specificity phosphatase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp4 (dual specificity phosphatase 4)
Sus scrofa (pig) : DUSP4 (dual specificity phosphatase 4)
Chlorocebus sabaeus (African green monkey) : DUSP4 (dual specificity phosphatase 4)
Heterocephalus glaber (naked mole-rat) : Dusp4 (dual specificity phosphatase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl829,333,064 - 29,350,684 (-)Ensembl
GRCh38829,333,062 - 29,350,684 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37829,190,579 - 29,208,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36829,249,530 - 29,264,104 (-)NCBINCBI36hg18NCBI36
Build 34829,249,538 - 29,262,241NCBI
Celera828,153,208 - 28,167,802 (-)NCBI
Cytogenetic Map8p12NCBI
HuRef827,734,943 - 27,752,631 (-)NCBIHuRef
CHM1_1829,392,567 - 29,410,254 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on DUSP4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348525
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.