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Gene: DUSP4 (dual specificity phosphatase 4) Homo sapiens

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Symbol:

DUSP4

Name:

dual specificity phosphatase 4

RGD ID:

1348525

HGNC Page

HGNC:3070

Description:

Enables MAP kinase serine/threonine phosphatase activity; protein tyrosine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Involved in dephosphorylation and negative regulation of ERK1 and ERK2 cascade. Located in nucleoplasm.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

dual specificity protein phosphatase 4; dual specificity protein phosphatase hVH2; HVH2; MAP kinase phosphatase 2; mitogen-activated protein kinase phosphatase 2; MKP-2; MKP2; serine/threonine specific protein phosphatase; TYP; VH1 homologous phosphatase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	29,333,064 - 29,350,684 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	29,333,064 - 29,350,684 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	29,190,581 - 29,208,201 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	29,249,530 - 29,264,104 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	29,249,538 - 29,262,241	NCBI
Celera	8	28,153,208 - 28,167,802 (-)	NCBI		Celera
Cytogenetic Map	8	p12	NCBI
HuRef	8	27,734,943 - 27,752,631 (-)	NCBI		HuRef
CHM1_1	8	29,392,567 - 29,410,254 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	29,611,341 - 29,628,961 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP4	Human	juvenile rheumatoid arthritis		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19565504

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP4	Human	(+)-schisandrin B	multiple interactions	ISO	Dusp4 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DUSP4 mRNA]	CTD	PMID:31150632
DUSP4	Human	(-)-demecolcine	increases expression	EXP		6480464	Demecolcine results in increased expression of DUSP4 mRNA	CTD	PMID:23649840
DUSP4	Human	(-)-epigallocatechin 3-gallate	increases expression	EXP		6480464	epigallocatechin gallate results in increased expression of DUSP4 mRNA	CTD	PMID:16084531
DUSP4	Human	(1->4)-beta-D-glucan	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of DUSP4 mRNA	CTD	PMID:36331819
DUSP4	Human	1,2-dimethylhydrazine	increases expression	ISO	Dusp4 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in increased expression of DUSP4 mRNA	CTD	PMID:22206623
DUSP4	Human	1-chloro-2,4-dinitrobenzene	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Dinitrochlorobenzene results in increased expression of DUSP4 mRNA	CTD	PMID:18242016
DUSP4	Human	17beta-estradiol	multiple interactions	EXP		6480464	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNA and [Estradiol co-treated with TGFB1 protein] results in increased expression of DUSP4 mRNA	CTD	PMID:19619570 and PMID:30165855
DUSP4	Human	17beta-estradiol	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Estradiol results in increased expression of DUSP4 mRNA	CTD	PMID:19484750
DUSP4	Human	17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of DUSP4 mRNA	CTD	PMID:19153601 more ...
DUSP4	Human	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of DUSP4 mRNA	CTD	PMID:16202921
DUSP4	Human	17beta-hydroxy-5alpha-androstan-3-one	increases expression	EXP		6480464	Dihydrotestosterone results in increased expression of DUSP4 mRNA	CTD	PMID:29581250
DUSP4	Human	2,2',4,4'-Tetrabromodiphenyl ether	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[Flame Retardants results in increased abundance of 2 more ...	CTD	PMID:38995820
DUSP4	Human	2,2',5,5'-tetrachlorobiphenyl	increases expression	EXP		6480464	2 more ...	CTD	PMID:36804509
DUSP4	Human	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		6480464	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNA	CTD	PMID:19619570
DUSP4	Human	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in decreased expression of DUSP4 mRNA	CTD	PMID:33387578 and PMID:34747641
DUSP4	Human	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in increased expression of DUSP4 mRNA	CTD	PMID:32109520
DUSP4	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Dusp4 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of DUSP4 mRNA	CTD	PMID:21570461 and PMID:24680724
DUSP4	Human	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of DUSP4 mRNA	CTD	PMID:17101203 and PMID:19619570
DUSP4	Human	2,4-diaminotoluene	increases expression	ISO	Dusp4 (Mus musculus)	6480464	2 and 4-diaminotoluene results in increased expression of DUSP4 mRNA	CTD	PMID:20713471
DUSP4	Human	2,4-dibromophenyl 2,4,5-tribromophenyl ether	affects expression	ISO	Dusp4 (Mus musculus)	6480464	2 more ...	CTD	PMID:38648751
DUSP4	Human	2-hydroxypropanoic acid	increases expression	EXP		6480464	Lactic Acid results in increased expression of DUSP4 mRNA	CTD	PMID:30851411
DUSP4	Human	3,3',5,5'-tetrabromobisphenol A	increases expression	ISO	Dusp4 (Mus musculus)	6480464	tetrabromobisphenol A results in increased expression of DUSP4 mRNA	CTD	PMID:25172293
DUSP4	Human	3-methylcholanthrene	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Methylcholanthrene results in increased expression of DUSP4 mRNA	CTD	PMID:20713471
DUSP4	Human	4,4'-sulfonyldiphenol	increases expression	ISO	Dusp4 (Mus musculus)	6480464	bisphenol S results in increased expression of DUSP4 mRNA	CTD	PMID:30951980
DUSP4	Human	4-(ethoxymethylene)-2-phenyloxazol-5-one	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Oxazolone results in increased expression of DUSP4 mRNA	CTD	PMID:18242016
DUSP4	Human	8-Br-cAMP	increases expression	EXP		6480464	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of DUSP4 mRNA	CTD	PMID:20147733
DUSP4	Human	acetamide	decreases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	acetamide results in decreased expression of DUSP4 mRNA	CTD	PMID:31881176
DUSP4	Human	afimoxifene	multiple interactions	EXP		6480464	GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]	CTD	PMID:19153601
DUSP4	Human	afimoxifene	increases expression	EXP		6480464	afimoxifene results in increased expression of DUSP4 mRNA	CTD	PMID:19153601
DUSP4	Human	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of DUSP4 mRNA	CTD	PMID:22100608 and PMID:27153756
DUSP4	Human	all-trans-retinoic acid	increases expression	EXP		6480464	Tretinoin results in increased expression of DUSP4 mRNA	CTD	PMID:33167477
DUSP4	Human	ammonium chloride	affects expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Ammonium Chloride affects the expression of DUSP4 mRNA	CTD	PMID:16483693
DUSP4	Human	antimycin A	increases expression	EXP		6480464	Antimycin A results in increased expression of DUSP4 mRNA	CTD	PMID:33512557
DUSP4	Human	aripiprazole	multiple interactions	EXP		6480464	[Aripiprazole co-treated with Ozone] results in increased expression of DUSP4 mRNA	CTD	PMID:31476115
DUSP4	Human	arsenite(3-)	increases expression	ISO	Dusp4 (Mus musculus)	6480464	arsenite results in increased expression of DUSP4 mRNA	CTD	PMID:18929588
DUSP4	Human	arsenous acid	decreases expression	EXP		6480464	Arsenic Trioxide results in decreased expression of DUSP4 mRNA	CTD	PMID:15725085
DUSP4	Human	atrazine	decreases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Atrazine results in decreased expression of DUSP4 mRNA	CTD	PMID:36841081
DUSP4	Human	avobenzone	increases expression	EXP		6480464	avobenzone results in increased expression of DUSP4 mRNA	CTD	PMID:31016361
DUSP4	Human	bathocuproine disulfonic acid	multiple interactions	EXP		6480464	bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]]	CTD	PMID:15477007
DUSP4	Human	benzene	increases expression	EXP		6480464	Benzene results in increased expression of DUSP4 mRNA	CTD	PMID:19162166
DUSP4	Human	benzo[a]pyrene	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of DUSP4 mRNA]	CTD	PMID:22228805
DUSP4	Human	benzo[a]pyrene	increases methylation	EXP		6480464	Benzo(a)pyrene results in increased methylation of DUSP4 promoter	CTD	PMID:27901495
DUSP4	Human	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of DUSP4 mRNA	CTD	PMID:30453624 and PMID:32234424
DUSP4	Human	benzo[a]pyrene	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Benzo(a)pyrene results in increased expression of DUSP4 mRNA	CTD	PMID:19770486 more ...
DUSP4	Human	benzo[a]pyrene diol epoxide I	decreases expression	EXP		6480464	7 more ...	CTD	PMID:19150397
DUSP4	Human	benzo[e]pyrene	increases methylation	EXP		6480464	benzo(e)pyrene results in increased methylation of DUSP4 intron	CTD	PMID:30157460
DUSP4	Human	beta-lapachone	increases expression	EXP		6480464	beta-lapachone results in increased expression of DUSP4 mRNA	CTD	PMID:38218311
DUSP4	Human	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of DUSP4 mRNA	CTD	PMID:39150890
DUSP4	Human	bis(2-ethylhexyl) phthalate	multiple interactions	EXP		6480464	[Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of DUSP4 gene	CTD	PMID:33872906
DUSP4	Human	bisphenol A	increases expression	ISO	Dusp4 (Mus musculus)	6480464	bisphenol A results in increased expression of DUSP4 mRNA	CTD	PMID:26063408 and PMID:32156529
DUSP4	Human	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of DUSP4 mRNA	CTD	PMID:33670352
DUSP4	Human	bisphenol A	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	bisphenol A results in increased expression of DUSP4 mRNA	CTD	PMID:30816183 and PMID:34947998
DUSP4	Human	bisphenol A	decreases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of DUSP4 mRNA	CTD	PMID:25181051
DUSP4	Human	bisphenol F	affects expression	ISO	Dusp4 (Mus musculus)	6480464	bisphenol F affects the expression of DUSP4 mRNA	CTD	PMID:30951980
DUSP4	Human	bisphenol F	increases expression	ISO	Dusp4 (Mus musculus)	6480464	bisphenol F results in increased expression of DUSP4 mRNA	CTD	PMID:38685157
DUSP4	Human	bortezomib	decreases expression	EXP		6480464	Bortezomib results in decreased expression of DUSP4 mRNA	CTD	PMID:20977926
DUSP4	Human	butanal	increases expression	EXP		6480464	butyraldehyde results in increased expression of DUSP4 mRNA	CTD	PMID:26079696
DUSP4	Human	Butylbenzyl phthalate	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of DUSP4 mRNA	CTD	PMID:39150890
DUSP4	Human	cadmium atom	increases expression	EXP		6480464	Cadmium results in increased expression of DUSP4 mRNA	CTD	PMID:22562489
DUSP4	Human	cannabidiol	increases expression	EXP		6480464	Cannabidiol results in increased expression of DUSP4 mRNA	CTD	PMID:33244087
DUSP4	Human	choline	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DUSP4 gene	CTD	PMID:20938992
DUSP4	Human	chromium(6+)	multiple interactions	EXP		6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression of DUSP4 mRNA	CTD	PMID:38479592
DUSP4	Human	copper atom	multiple interactions	EXP		6480464	[Chelating Agents binds to Copper] which results in increased expression of DUSP4 mRNA	CTD	PMID:30911355
DUSP4	Human	copper(0)	multiple interactions	EXP		6480464	[Chelating Agents binds to Copper] which results in increased expression of DUSP4 mRNA	CTD	PMID:30911355
DUSP4	Human	copper(II) chloride	increases expression	EXP		6480464	cupric chloride results in increased expression of DUSP4 mRNA	CTD	PMID:38568856
DUSP4	Human	crocidolite asbestos	affects expression	EXP		6480464	Asbestos and Crocidolite affects the expression of DUSP4 mRNA	CTD	PMID:25757056
DUSP4	Human	crocidolite asbestos	increases expression	EXP		6480464	Asbestos and Crocidolite results in increased expression of DUSP4 mRNA	CTD	PMID:25351596
DUSP4	Human	cumene	decreases expression	ISO	Dusp4 (Mus musculus)	6480464	cumene results in decreased expression of DUSP4 mRNA	CTD	PMID:18648096
DUSP4	Human	Cuprizon	decreases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Cuprizone results in decreased expression of DUSP4 mRNA	CTD	PMID:26577399
DUSP4	Human	cyclosporin A	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Cyclosporine results in increased expression of DUSP4 mRNA	CTD	PMID:19770486
DUSP4	Human	cyclosporin A	decreases expression	EXP		6480464	Cyclosporine results in decreased expression of DUSP4 mRNA	CTD	PMID:27989131
DUSP4	Human	cyclosporin A	increases expression	EXP		6480464	Cyclosporine results in increased expression of DUSP4 mRNA	CTD	PMID:25562108
DUSP4	Human	cylindrospermopsin	increases expression	EXP		6480464	cylindrospermopsin results in increased expression of DUSP4 mRNA	CTD	PMID:24921660
DUSP4	Human	cytarabine	decreases expression	EXP		6480464	Cytarabine results in decreased expression of DUSP4 mRNA	CTD	PMID:19194470
DUSP4	Human	daidzein	decreases expression	EXP		6480464	daidzein results in decreased expression of DUSP4 mRNA	CTD	PMID:16865672
DUSP4	Human	daunorubicin	increases expression	EXP		6480464	Daunorubicin results in increased expression of DUSP4 mRNA	CTD	PMID:26537877 and PMID:28940058
DUSP4	Human	DDE	increases expression	EXP		6480464	Dichlorodiphenyl Dichloroethylene results in increased expression of DUSP4 mRNA	CTD	PMID:38568856
DUSP4	Human	deguelin	increases expression	EXP		6480464	deguelin results in increased expression of DUSP4 mRNA	CTD	PMID:33512557
DUSP4	Human	dexamethasone	decreases expression	ISO	Dusp4 (Mus musculus)	6480464	Dexamethasone results in decreased expression of DUSP4 mRNA	CTD	PMID:22733784
DUSP4	Human	diarsenic trioxide	decreases expression	EXP		6480464	Arsenic Trioxide results in decreased expression of DUSP4 mRNA	CTD	PMID:15725085
DUSP4	Human	Dibutyl phosphate	affects expression	EXP		6480464	di-n-butylphosphoric acid affects the expression of DUSP4 mRNA	CTD	PMID:37042841
DUSP4	Human	dibutyl phthalate	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Dibutyl Phthalate results in increased expression of DUSP4 mRNA	CTD	PMID:21266533
DUSP4	Human	dibutyl phthalate	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of DUSP4 mRNA	CTD	PMID:39150890
DUSP4	Human	dibutyl phthalate	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Dibutyl Phthalate results in increased expression of DUSP4 mRNA	CTD	PMID:17361019 and PMID:21266533
DUSP4	Human	diethyl phthalate	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of DUSP4 mRNA	CTD	PMID:39150890
DUSP4	Human	diisobutyl phthalate	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of DUSP4 mRNA	CTD	PMID:39150890
DUSP4	Human	diisononyl phthalate	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of DUSP4 mRNA	CTD	PMID:39150890
DUSP4	Human	dinophysistoxin 1	increases expression	EXP		6480464	dinophysistoxin 1 results in increased expression of DUSP4 mRNA	CTD	PMID:28939011
DUSP4	Human	dioxygen	decreases expression	EXP		6480464	Oxygen deficiency results in decreased expression of DUSP4 mRNA	CTD	PMID:26516004
DUSP4	Human	dioxygen	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of DUSP4 mRNA	CTD	PMID:30529165
DUSP4	Human	dorsomorphin	multiple interactions	EXP		6480464	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
DUSP4	Human	doxorubicin	increases expression	EXP		6480464	Doxorubicin results in increased expression of DUSP4 mRNA	CTD	PMID:26537877 more ...
DUSP4	Human	doxorubicin	affects expression	EXP		6480464	Doxorubicin affects the expression of DUSP4 mRNA	CTD	PMID:29803840
DUSP4	Human	endosulfan	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Endosulfan results in increased expression of DUSP4 mRNA	CTD	PMID:29391264
DUSP4	Human	entinostat	decreases expression	EXP		6480464	entinostat results in decreased expression of DUSP4 mRNA	CTD	PMID:27188386
DUSP4	Human	equol	decreases expression	EXP		6480464	Equol results in decreased expression of DUSP4 mRNA	CTD	PMID:16865672
DUSP4	Human	ethanol	affects expression	ISO	Dusp4 (Mus musculus)	6480464	Ethanol affects the expression of DUSP4 mRNA	CTD	PMID:30319688
DUSP4	Human	ethyl methanesulfonate	increases expression	EXP		6480464	Ethyl Methanesulfonate results in increased expression of DUSP4 mRNA	CTD	PMID:23649840
DUSP4	Human	etoposide	affects response to substance	EXP		6480464	DUSP4 protein affects the susceptibility to Etoposide	CTD	PMID:16217747
DUSP4	Human	etoposide	increases expression	EXP		6480464	Etoposide results in increased expression of DUSP4 mRNA	CTD	PMID:29397400
DUSP4	Human	febuxostat	increases expression	EXP		6480464	Febuxostat results in increased expression of DUSP4 mRNA	CTD	PMID:35866629
DUSP4	Human	fenpyroximate	increases expression	EXP		6480464	fenpyroximate results in increased expression of DUSP4 mRNA	CTD	PMID:33512557
DUSP4	Human	ferric oxide	increases expression	ISO	Dusp4 (Mus musculus)	6480464	ferric oxide analog results in increased expression of DUSP4 mRNA	CTD	PMID:25086211
DUSP4	Human	fluoranthene	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP4 mRNA	CTD	PMID:28329830
DUSP4	Human	folic acid	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DUSP4 gene	CTD	PMID:20938992
DUSP4	Human	folic acid	decreases expression	ISO	Dusp4 (Mus musculus)	6480464	Folic Acid results in decreased expression of DUSP4 mRNA	CTD	PMID:25629700
DUSP4	Human	fonofos	increases methylation	EXP		6480464	Fonofos results in increased methylation of DUSP4 promoter	CTD	PMID:22847954
DUSP4	Human	formaldehyde	decreases expression	EXP		6480464	Formaldehyde results in decreased expression of DUSP4 mRNA	CTD	PMID:20655997
DUSP4	Human	formaldehyde	increases expression	EXP		6480464	Formaldehyde results in increased expression of DUSP4 mRNA	CTD	PMID:23649840
DUSP4	Human	furan	decreases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	furan results in decreased expression of DUSP4 mRNA	CTD	PMID:25539665
DUSP4	Human	genistein	decreases expression	EXP		6480464	Genistein results in decreased expression of DUSP4 mRNA	CTD	PMID:16865672
DUSP4	Human	gentamycin	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Gentamicins results in increased expression of DUSP4 mRNA	CTD	PMID:33387578
DUSP4	Human	glyphosate	affects expression	EXP		6480464	Glyphosate affects the expression of DUSP4 mRNA	CTD	PMID:31295307
DUSP4	Human	GSK-J4	decreases expression	EXP		6480464	GSK-J4 results in decreased expression of DUSP4 mRNA	CTD	PMID:29301935
DUSP4	Human	indole-3-methanol	affects expression	ISO	Dusp4 (Rattus norvegicus)	6480464	indole-3-carbinol affects the expression of DUSP4 mRNA	CTD	PMID:21396975
DUSP4	Human	ionomycin	multiple interactions	EXP		6480464	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA more ...	CTD	PMID:15477007
DUSP4	Human	isoflavones	decreases expression	EXP		6480464	Isoflavones results in decreased expression of DUSP4 mRNA	CTD	PMID:17374662
DUSP4	Human	isoprenaline	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Isoproterenol results in increased expression of DUSP4 mRNA	CTD	PMID:20003209
DUSP4	Human	isotretinoin	decreases expression	EXP		6480464	Isotretinoin results in decreased expression of DUSP4 mRNA	CTD	PMID:20436886
DUSP4	Human	L-methionine	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DUSP4 gene	CTD	PMID:20938992
DUSP4	Human	lead diacetate	increases expression	EXP		6480464	lead acetate results in increased expression of DUSP4 mRNA	CTD	PMID:38568856
DUSP4	Human	lipopolysaccharide	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Lipopolysaccharides results in increased expression of DUSP4 mRNA and Lipopolysaccharides results in increased expression of DUSP4 protein	CTD	PMID:16880258
DUSP4	Human	manganese(II) chloride	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	manganese chloride results in increased expression of DUSP4 mRNA	CTD	PMID:28801915
DUSP4	Human	metacetamol	decreases expression	ISO	Dusp4 (Mus musculus)	6480464	3-hydroxyacetanilide results in decreased expression of DUSP4 mRNA	CTD	PMID:18544908
DUSP4	Human	metformin	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Metformin results in increased expression of DUSP4 mRNA	CTD	PMID:19664596
DUSP4	Human	methapyrilene	increases methylation	EXP		6480464	Methapyrilene results in increased methylation of DUSP4 intron	CTD	PMID:30157460
DUSP4	Human	methotrexate	affects response to substance	EXP		6480464	DUSP4 protein affects the susceptibility to Methotrexate	CTD	PMID:16217747
DUSP4	Human	methylmercury chloride	increases expression	EXP		6480464	methylmercuric chloride results in increased expression of DUSP4 mRNA	CTD	PMID:28001369
DUSP4	Human	mitomycin C	affects response to substance	EXP		6480464	DUSP4 protein affects the susceptibility to Mitomycin	CTD	PMID:16217747
DUSP4	Human	mitoxantrone	affects response to substance	EXP		6480464	DUSP4 protein affects the susceptibility to Mitoxantrone	CTD	PMID:16217747
DUSP4	Human	mitoxantrone	increases expression	EXP		6480464	Mitoxantrone results in increased expression of DUSP4 mRNA	CTD	PMID:26537877 and PMID:28940058
DUSP4	Human	mono(2-ethylhexyl) phthalate	multiple interactions	EXP		6480464	[Diethylhexyl Phthalate results in increased abundance of mono-(2-ethylhexyl)phthalate] which results in increased methylation of DUSP4 gene	CTD	PMID:33872906
DUSP4	Human	mono(2-ethylhexyl) phthalate	increases expression	EXP		6480464	mono-(2-ethylhexyl)phthalate results in increased expression of DUSP4 mRNA	CTD	PMID:36695872
DUSP4	Human	N-acetyl-L-cysteine	increases expression	EXP		6480464	Acetylcysteine results in increased expression of DUSP4 mRNA	CTD	PMID:16084531
DUSP4	Human	N-methyl-4-phenylpyridinium	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	1-Methyl-4-phenylpyridinium results in increased expression of DUSP4 mRNA	CTD	PMID:28801915
DUSP4	Human	N-nitrosodiethylamine	decreases expression	ISO	Dusp4 (Mus musculus)	6480464	Diethylnitrosamine results in decreased expression of DUSP4 mRNA	CTD	PMID:18691550
DUSP4	Human	N-nitrosodiethylamine	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	IKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DUSP4 mRNA] and MAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DUSP4 mRNA]	CTD	PMID:18691550
DUSP4	Human	N-Nitrosopyrrolidine	increases expression	EXP		6480464	N-Nitrosopyrrolidine results in increased expression of DUSP4 mRNA	CTD	PMID:32234424
DUSP4	Human	nickel sulfate	increases expression	EXP		6480464	nickel sulfate results in increased expression of DUSP4 mRNA	CTD	PMID:16780908
DUSP4	Human	niclosamide	increases expression	EXP		6480464	Niclosamide results in increased expression of DUSP4 mRNA	CTD	PMID:36318118
DUSP4	Human	okadaic acid	increases expression	EXP		6480464	Okadaic Acid results in increased expression of DUSP4 mRNA	CTD	PMID:38832940
DUSP4	Human	okadaic acid	decreases expression	EXP		6480464	Okadaic Acid results in decreased expression of DUSP4 protein	CTD	PMID:38832940
DUSP4	Human	ozone	increases expression	EXP		6480464	Ozone results in increased expression of DUSP4 mRNA	CTD	PMID:31476115
DUSP4	Human	ozone	multiple interactions	EXP		6480464	[Aripiprazole co-treated with Ozone] results in increased expression of DUSP4 mRNA	CTD	PMID:31476115
DUSP4	Human	panobinostat	decreases expression	EXP		6480464	panobinostat results in decreased expression of DUSP4 mRNA	CTD	PMID:26272509
DUSP4	Human	panobinostat	multiple interactions	EXP		6480464	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA	CTD	PMID:27188386
DUSP4	Human	paracetamol	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Acetaminophen results in increased expression of DUSP4 mRNA	CTD	PMID:18544908
DUSP4	Human	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of DUSP4 mRNA	CTD	PMID:29067470
DUSP4	Human	paracetamol	affects expression	ISO	Dusp4 (Mus musculus)	6480464	Acetaminophen affects the expression of DUSP4 mRNA	CTD	PMID:17562736
DUSP4	Human	parathion	increases methylation	EXP		6480464	Parathion results in increased methylation of DUSP4 promoter	CTD	PMID:22847954
DUSP4	Human	PD 0325901	multiple interactions	EXP		6480464	[mirdametinib co-treated with (+)-JQ1 compound] results in decreased expression of DUSP4 mRNA	CTD	PMID:25119042
DUSP4	Human	PD 0325901	decreases expression	EXP		6480464	mirdametinib results in decreased expression of DUSP4 mRNA	CTD	PMID:25119042
DUSP4	Human	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	Dusp4 (Mus musculus)	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of DUSP4 mRNA	CTD	PMID:36331819
DUSP4	Human	phorbol 13-acetate 12-myristate	multiple interactions	EXP		6480464	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA more ...	CTD	PMID:15477007
DUSP4	Human	picoxystrobin	decreases expression	EXP		6480464	picoxystrobin results in decreased expression of DUSP4 mRNA	CTD	PMID:33512557
DUSP4	Human	pirinixic acid	increases expression	ISO	Dusp4 (Mus musculus)	6480464	pirinixic acid results in increased expression of DUSP4 mRNA	CTD	PMID:23811191
DUSP4	Human	potassium chromate	decreases expression	EXP		6480464	potassium chromate(VI) results in decreased expression of DUSP4 mRNA	CTD	PMID:22714537
DUSP4	Human	pyrrolidine dithiocarbamate	multiple interactions	EXP		6480464	bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]] and pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]	CTD	PMID:15477007
DUSP4	Human	quercetin	increases expression	EXP		6480464	Quercetin results in increased expression of DUSP4 mRNA	CTD	PMID:21632981
DUSP4	Human	rac-lactic acid	increases expression	EXP		6480464	Lactic Acid results in increased expression of DUSP4 mRNA	CTD	PMID:30851411
DUSP4	Human	raloxifene	decreases expression	EXP		6480464	Raloxifene Hydrochloride results in decreased expression of DUSP4 mRNA	CTD	PMID:16497877
DUSP4	Human	Rebamipide	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	rebamipide results in increased expression of DUSP4 mRNA	CTD	PMID:15104358
DUSP4	Human	rotenone	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Rotenone results in increased expression of DUSP4 mRNA	CTD	PMID:19664596
DUSP4	Human	SB 431542	multiple interactions	EXP		6480464	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...	CTD	PMID:27188386
DUSP4	Human	silver atom	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Silver results in increased expression of DUSP4 mRNA	CTD	PMID:27131904
DUSP4	Human	silver(0)	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Silver results in increased expression of DUSP4 mRNA	CTD	PMID:27131904
DUSP4	Human	sodium arsenite	decreases methylation	EXP		6480464	sodium arsenite results in decreased methylation of DUSP4 gene	CTD	PMID:25199682
DUSP4	Human	Soman	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Soman results in increased expression of DUSP4 mRNA	CTD	PMID:19281266
DUSP4	Human	sotorasib	multiple interactions	EXP		6480464	[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP4 mRNA	CTD	PMID:36139627
DUSP4	Human	sulforaphane	increases expression	EXP		6480464	sulforaphane results in increased expression of DUSP4 mRNA	CTD	PMID:31838189
DUSP4	Human	sunitinib	increases expression	EXP		6480464	Sunitinib results in increased expression of DUSP4 mRNA	CTD	PMID:31533062
DUSP4	Human	tebufenpyrad	increases expression	EXP		6480464	4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of DUSP4 mRNA	CTD	PMID:33512557
DUSP4	Human	terbufos	increases methylation	EXP		6480464	terbufos results in increased methylation of DUSP4 promoter	CTD	PMID:22847954
DUSP4	Human	testosterone	decreases expression	EXP		6480464	Testosterone results in decreased expression of DUSP4 mRNA	CTD	PMID:33359661
DUSP4	Human	tetrachloromethane	multiple interactions	ISO	Dusp4 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of DUSP4 mRNA]	CTD	PMID:31150632
DUSP4	Human	tetrachloromethane	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Carbon Tetrachloride results in increased expression of DUSP4 mRNA	CTD	PMID:31150632
DUSP4	Human	thifluzamide	increases expression	EXP		6480464	thifluzamide results in increased expression of DUSP4 mRNA	CTD	PMID:33512557
DUSP4	Human	thioacetamide	increases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Thioacetamide results in increased expression of DUSP4 mRNA	CTD	PMID:34492290
DUSP4	Human	titanium dioxide	decreases methylation	ISO	Dusp4 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of DUSP4 gene and titanium dioxide results in decreased methylation of DUSP4 promoter	CTD	PMID:35295148
DUSP4	Human	toluene 2,4-diisocyanate	increases expression	ISO	Dusp4 (Mus musculus)	6480464	Toluene 2 and 4-Diisocyanate results in increased expression of DUSP4 mRNA	CTD	PMID:18242016
DUSP4	Human	trametinib	multiple interactions	EXP		6480464	[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of DUSP4 mRNA	CTD	PMID:36139627
DUSP4	Human	trichostatin A	decreases expression	EXP		6480464	trichostatin A results in decreased expression of DUSP4 mRNA	CTD	PMID:24935251 and PMID:26272509
DUSP4	Human	trichostatin A	affects expression	EXP		6480464	trichostatin A affects the expression of DUSP4 mRNA	CTD	PMID:28542535
DUSP4	Human	trichostatin A	multiple interactions	EXP		6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA	CTD	PMID:27188386
DUSP4	Human	trimellitic anhydride	increases expression	ISO	Dusp4 (Mus musculus)	6480464	trimellitic anhydride results in increased expression of DUSP4 mRNA	CTD	PMID:19042947
DUSP4	Human	valproic acid	increases methylation	EXP		6480464	Valproic Acid results in increased methylation of DUSP4 gene	CTD	PMID:29154799
DUSP4	Human	valproic acid	decreases expression	ISO	Dusp4 (Rattus norvegicus)	6480464	Valproic Acid results in decreased expression of DUSP4 mRNA	CTD	PMID:29427782
DUSP4	Human	valproic acid	decreases expression	EXP		6480464	Valproic Acid results in decreased expression of DUSP4 mRNA	CTD	PMID:23179753 more ...
DUSP4	Human	valproic acid	multiple interactions	EXP		6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA	CTD	PMID:27188386
DUSP4	Human	valproic acid	affects expression	ISO	Dusp4 (Mus musculus)	6480464	Valproic Acid affects the expression of DUSP4 mRNA	CTD	PMID:17963808
DUSP4	Human	valproic acid	affects expression	EXP		6480464	Valproic Acid affects the expression of DUSP4 mRNA	CTD	PMID:25979313
DUSP4	Human	vincristine	increases expression	EXP		6480464	Vincristine results in increased expression of DUSP4 mRNA	CTD	PMID:23649840
DUSP4	Human	vorinostat	decreases expression	EXP		6480464	vorinostat results in decreased expression of DUSP4 mRNA	CTD	PMID:27188386
DUSP4	Human	zoledronic acid	decreases expression	EXP		6480464	zoledronic acid results in decreased expression of DUSP4 mRNA	CTD	PMID:24714768

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP4	Human	dephosphorylation	involved_in	IDA		150520179	PMID:24531476	UniProt	PMID:24531476
DUSP4	Human	endoderm formation	involved_in	IBA	PANTHER:PTN000017039 and ZFIN:ZDB-GENE-040426-709	150520179		GO_Central	GO_REF:0000033
DUSP4	Human	negative regulation of ERK1 and ERK2 cascade	involved_in	IMP		150520179	PMID:7535768	UniProt	PMID:7535768
DUSP4	Human	negative regulation of MAPK cascade	involved_in	IBA	FB:FBgn0036844 more ...	150520179		GO_Central	GO_REF:0000033
DUSP4	Human	protein dephosphorylation		ISO	Dusp4 (Rattus norvegicus)	9068941		RGD	PMID:12435803 and REF_RGD_ID:633811
DUSP4	Human	signal transduction	involved_in	IBA	CGD:CAL0000191382 more ...	150520179		GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP4	Human	cytoplasm	is_active_in	IBA	FB:FBgn0036844 more ...	150520179		GO_Central	GO_REF:0000033
DUSP4	Human	nucleoplasm	located_in	TAS		150520179		Reactome	Reactome:R-HSA-203797
DUSP4	Human	nucleoplasm	located_in	IDA		150520179		HPA	GO_REF:0000052
DUSP4	Human	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
DUSP4	Human	nucleus	is_active_in	IBA	PANTHER:PTN000806857 more ...	150520179		GO_Central	GO_REF:0000033
DUSP4	Human	nucleus	located_in	IDA		150520179	PMID:7535768	UniProt	PMID:7535768
DUSP4	Human	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP4	Human	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
DUSP4	Human	MAP kinase serine/threonine phosphatase activity	enables	IDA		150520179	PMID:7535768	UniProt	PMID:7535768
DUSP4	Human	MAP kinase tyrosine/serine/threonine phosphatase activity		ISO	Dusp4 (Rattus norvegicus)	9068941		RGD	PMID:7782322 and REF_RGD_ID:633293
DUSP4	Human	MAP kinase tyrosine/serine/threonine phosphatase activity	enables	IEA	InterPro:IPR008343	150520179		InterPro	GO_REF:0000002
DUSP4	Human	phosphatase activity	enables	IDA		150520179	PMID:24531476	UniProt	PMID:24531476
DUSP4	Human	phosphoprotein phosphatase activity	enables	IEA	UniProtKB-KW:KW-0904	150520179		UniProt	GO_REF:0000043
DUSP4	Human	phosphoprotein phosphatase activity	enables	IBA	CGD:CAL0000191382 more ...	150520179		GO_Central	GO_REF:0000033
DUSP4	Human	phosphoprotein phosphatase activity	enables	IEA	ARBA:ARBA00027651	150520179		UniProt	GO_REF:0000117
DUSP4	Human	protein binding	enables	IPI	UniProtKB:P45984	150520179	PMID:25241761	IntAct	PMID:25241761
DUSP4	Human	protein binding	enables	IPI	UniProtKB:P28482	150520179	PMID:16038800 more ...	IntAct	PMID:16038800 more ...
DUSP4	Human	protein binding	enables	IPI	UniProtKB:P28482 more ...	150520179	PMID:32296183	IntAct	PMID:32296183
DUSP4	Human	protein serine/threonine phosphatase activity	enables	IEA	RHEA:20629 and RHEA:47004	150520179		RHEA	GO_REF:0000116
DUSP4	Human	protein serine/threonine phosphatase activity	enables	IEA	EC:3.1.3.16	150520179		UniProt	GO_REF:0000003
DUSP4	Human	protein tyrosine phosphatase activity	enables	IEA	RHEA:10684	150520179		RHEA	GO_REF:0000116
DUSP4	Human	protein tyrosine phosphatase activity	enables	IEA	EC:3.1.3.48	150520179		UniProt	GO_REF:0000003
DUSP4	Human	protein tyrosine phosphatase activity	enables	IDA		150520179	PMID:7535768	UniProt	PMID:7535768
DUSP4	Human	protein tyrosine phosphatase activity	enables	TAS		150520179		Reactome	Reactome:R-HSA-203797
DUSP4	Human	protein tyrosine/threonine phosphatase activity	enables	IDA		150520179	PMID:7535768	UniProt	PMID:7535768

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
DUSP4	Human	mitogen activated protein kinase signaling pathway		IEA		6907045		KEGG	hsa:04010

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis.	Hofken T, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):680-5.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:7535768	PMID:8545112	PMID:8626452	PMID:8889548	PMID:9205128	PMID:10862698	PMID:11062068	PMID:11387337	PMID:12477932	PMID:15276183	PMID:15489334	PMID:16038800
PMID:16344560	PMID:17145763	PMID:17322878	PMID:17452331	PMID:18178562	PMID:19415758	PMID:19525976	PMID:19843478	PMID:20124482	PMID:20339536	PMID:20725992	PMID:20860659
PMID:21084841	PMID:21832049	PMID:21873635	PMID:21900206	PMID:22430215	PMID:22434910	PMID:22965873	PMID:23048029	PMID:23223570	PMID:23749251	PMID:23812841	PMID:23875912
PMID:23966295	PMID:24222120	PMID:24308939	PMID:24531476	PMID:24658355	PMID:25027955	PMID:25204653	PMID:25241761	PMID:25281216	PMID:25733583	PMID:25847947	PMID:25943894
PMID:26760575	PMID:26941286	PMID:27393618	PMID:27432908	PMID:27880917	PMID:27957827	PMID:28283554	PMID:28675297	PMID:29150975	PMID:29509059	PMID:29852174	PMID:31480854
PMID:31653682	PMID:31801953	PMID:31839677	PMID:31980649	PMID:32296183	PMID:32505357	PMID:32613839	PMID:32890776	PMID:32951127	PMID:33402458	PMID:33495832	PMID:33621155
PMID:33760201	PMID:33961781	PMID:34143206	PMID:34320342	PMID:34652441	PMID:34857952	PMID:34937541	PMID:35189148	PMID:35338857	PMID:35745205	PMID:35864956	PMID:36308185
PMID:36576731	PMID:36705792	PMID:37086337	PMID:38071325	PMID:38254666	PMID:38262246	PMID:38286920	PMID:38824257

DUSP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	29,333,064 - 29,350,684 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	29,333,064 - 29,350,684 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	29,190,581 - 29,208,201 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	29,249,530 - 29,264,104 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	29,249,538 - 29,262,241	NCBI
Celera	8	28,153,208 - 28,167,802 (-)	NCBI		Celera
Cytogenetic Map	8	p12	NCBI
HuRef	8	27,734,943 - 27,752,631 (-)	NCBI		HuRef
CHM1_1	8	29,392,567 - 29,410,254 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	29,611,341 - 29,628,961 (-)	NCBI		T2T-CHM13v2.0

Dusp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	35,274,448 - 35,289,106 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	35,274,451 - 35,287,048 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	34,807,610 - 34,819,894 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	34,807,297 - 34,819,894 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	35,870,664 - 35,882,948 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	36,276,127 - 36,288,411 (+)	NCBI		MGSCv36	mm8
Celera	8	37,423,596 - 37,435,832 (+)	NCBI		Celera
Cytogenetic Map	8	A4	NCBI
cM Map	8	21.16	NCBI

Dusp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	64,079,893 - 64,101,396 (-)	NCBI		GRCr8
mRatBN7.2	16	57,376,659 - 57,398,161 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	57,377,229 - 57,398,138 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	62,711,691 - 62,721,924 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	66,125,603 - 66,135,836 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	61,345,654 - 61,355,885 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	61,080,767 - 61,090,973 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	61,078,175 - 61,091,169 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	60,749,903 - 60,769,025 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	61,109,626 - 61,119,981 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	61,109,700 - 61,120,056 (-)	NCBI
Celera	16	55,427,894 - 55,438,053 (-)	NCBI		Celera
Cytogenetic Map	16	q12.2	NCBI

Dusp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	5,778,700 - 5,794,282 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955463	5,778,945 - 5,794,282 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	47,882,880 - 47,900,548 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	23,598,583 - 23,616,218 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	28,623,777 - 28,641,432 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	25,816,714 - 25,834,307 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	25,819,989 - 25,834,332 (-)	Ensembl	panpan1.1		panPan2

DUSP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ROS_Cfam_1.0	16	36,828,592 - 36,844,313 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	36,828,997 - 36,841,190 (+)	Ensembl		ROS_Cfam_1.0 Ensembl

Dusp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	44,363,746 - 44,376,514 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936573	765,927 - 781,567 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936573	765,954 - 778,524 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	55,491,087 - 55,508,455 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	55,491,084 - 55,508,460 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	62,906,062 - 62,923,413 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	27,459,455 - 27,473,811 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	27,456,430 - 27,473,352 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	14,654,175 - 14,671,595 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624839	5,870,274 - 5,887,741 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in DUSP4
33 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3	copy number gain	See cases [RCV000050294]	Chr8:12609975..42085703 [GRCh38] Chr8:12467484..41943221 [GRCh37] Chr8:12511855..42062378 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3	copy number gain	See cases [RCV000050904]	Chr8:25832130..48521849 [GRCh38] Chr8:25689646..49434409 [GRCh37] Chr8:25745563..49596962 [NCBI36] Chr8:8p21.2-q11.21	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3	copy number gain	See cases [RCV000050912]	Chr8:12728904..43673207 [GRCh38] Chr8:12586413..43528350 [GRCh37] Chr8:12630784..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3	copy number gain	See cases [RCV000051145]	Chr8:12383584..36370018 [GRCh38] Chr8:12241093..36227536 [GRCh37] Chr8:12285464..36347088 [NCBI36] Chr8:8p23.1-12	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3	copy number gain	See cases [RCV000053630]	Chr8:12609975..43336172 [GRCh38] Chr8:12467484..43191315 [GRCh37] Chr8:12511855..43310472 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]\|See cases [RCV000053631]	Chr8:12609975..43255410 [GRCh38] Chr8:12467484..43110553 [GRCh37] Chr8:12511855..43229710 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3	copy number gain	See cases [RCV000053632]	Chr8:12750796..43532444 [GRCh38] Chr8:12608305..43387587 [GRCh37] Chr8:12652676..43506744 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-12(chr8:12750796-29445409)x3	copy number gain	See cases [RCV000053633]	Chr8:12750796..29445409 [GRCh38] Chr8:12608305..29302926 [GRCh37] Chr8:12652676..29358845 [NCBI36] Chr8:8p23.1-12	pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3	copy number gain	See cases [RCV000053635]	Chr8:14940110..47929925 [GRCh38] Chr8:14797619..48842485 [GRCh37] Chr8:14841990..49005038 [NCBI36] Chr8:8p22-q11.21	pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3	copy number gain	See cases [RCV000053629]	Chr8:12609975..37892000 [GRCh38] Chr8:12467484..37749518 [GRCh37] Chr8:12511855..37868676 [NCBI36] Chr8:8p23.1-11.23	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]\|See cases [RCV000053604]	Chr8:244417..145054775 [GRCh38] Chr8:194417..146280161 [GRCh37] Chr8:184417..146250965 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31210737)x1	copy number loss	See cases [RCV000054237]	Chr8:24910364..31210737 [GRCh38] Chr8:24767877..31068253 [GRCh37] Chr8:24823781..31187795 [NCBI36] Chr8:8p21.2-12	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3	copy number gain	See cases [RCV000135786]	Chr8:12609975..43673207 [GRCh38] Chr8:12467484..43528350 [GRCh37] Chr8:12511855..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3	copy number gain	See cases [RCV000135566]	Chr8:12383584..43673207 [GRCh38] Chr8:12241093..43528350 [GRCh37] Chr8:12285464..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3	copy number gain	See cases [RCV000136516]	Chr8:12728904..40169194 [GRCh38] Chr8:12586413..40026713 [GRCh37] Chr8:12630784..40145870 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31196357)x1	copy number loss	See cases [RCV000136120]	Chr8:24910364..31196357 [GRCh38] Chr8:24767877..31053873 [GRCh37] Chr8:24823781..31173415 [NCBI36] Chr8:8p21.2-12	pathogenic
GRCh38/hg38 8p23.1-12(chr8:12725750-30180521)x3	copy number gain	See cases [RCV000136825]	Chr8:12725750..30180521 [GRCh38] Chr8:12583259..30038037 [GRCh37] Chr8:12627630..30157579 [NCBI36] Chr8:8p23.1-12	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3	copy number gain	See cases [RCV000051206]	Chr8:241530..145049449 [GRCh38] Chr8:191530..146274835 [GRCh37] Chr8:181530..146245639 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3	copy number gain	See cases [RCV000051110]	Chr8:12728904..41928741 [GRCh38] Chr8:12586413..41786259 [GRCh37] Chr8:12630784..41905416 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3	copy number gain	See cases [RCV000053602]	Chr8:241530..145054634 [GRCh38] Chr8:191530..146280020 [GRCh37] Chr8:181530..146250824 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.3-12(chr8:96310-30614703)x3	copy number gain	See cases [RCV000053599]	Chr8:96310..30614703 [GRCh38] Chr8:46310..30472220 [GRCh37] Chr8:36310..30591762 [NCBI36] Chr8:8p23.3-12	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3	copy number gain	See cases [RCV000137249]	Chr8:12182421..43673207 [GRCh38] Chr8:12039930..43528350 [GRCh37] Chr8:12077339..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3	copy number gain	See cases [RCV000138058]	Chr8:12698495..35476082 [GRCh38] Chr8:12556004..35333600 [GRCh37] Chr8:12600375..35453142 [NCBI36] Chr8:8p23.1-12	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3	copy number gain	See cases [RCV000138643]	Chr8:241605..145054781 [GRCh38] Chr8:191605..146280167 [GRCh37] Chr8:181605..146250971 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3	copy number gain	See cases [RCV000139891]	Chr8:7141697..38695546 [GRCh38] Chr8:6999219..38553064 [GRCh37] Chr8:6986629..38672221 [NCBI36] Chr8:8p23.1-11.22	pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3	copy number gain	See cases [RCV000139770]	Chr8:12729023..39235934 [GRCh38] Chr8:12586532..39093453 [GRCh37] Chr8:12630903..39212610 [NCBI36] Chr8:8p23.1-11.22	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3	copy number gain	See cases [RCV000139796]	Chr8:12646123..43686843 [GRCh38] Chr8:12503632..43541986 [GRCh37] Chr8:12548003..43661143 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p21.2-12(chr8:25171103-31750600)x1	copy number loss	See cases [RCV000138081]	Chr8:25171103..31750600 [GRCh38] Chr8:25028618..31608116 [GRCh37] Chr8:25084535..31727658 [NCBI36] Chr8:8p21.2-12	pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3	copy number gain	See cases [RCV000137807]	Chr8:226452..38021728 [GRCh38] Chr8:176452..37879246 [GRCh37] Chr8:166452..37998403 [NCBI36] Chr8:8p23.3-11.23	pathogenic\|likely pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3	copy number gain	See cases [RCV000138831]	Chr8:241605..31091074 [GRCh38] Chr8:191605..30948590 [GRCh37] Chr8:181605..31068132 [NCBI36] Chr8:8p23.3-12	pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3	copy number gain	See cases [RCV000139549]	Chr8:11851113..37216333 [GRCh38] Chr8:11708622..37073851 [GRCh37] Chr8:11746031..37193009 [NCBI36] Chr8:8p23.1-11.23	pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3	copy number gain	See cases [RCV000141410]	Chr8:226452..34491890 [GRCh38] Chr8:176452..34349408 [GRCh37] Chr8:166452..34468950 [NCBI36] Chr8:8p23.3-12	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3	copy number gain	See cases [RCV000141808]	Chr8:208048..145070385 [GRCh38] Chr8:158048..146295771 [GRCh37] Chr8:148048..146266575 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3	copy number gain	See cases [RCV000142021]	Chr8:21291522..145070385 [GRCh38] Chr8:21149033..146295771 [GRCh37] Chr8:21193313..146266575 [NCBI36] Chr8:8p21.3-q24.3	pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1	copy number loss	See cases [RCV000142747]	Chr8:18972996..33619264 [GRCh38] Chr8:18830506..33476782 [GRCh37] Chr8:18874786..33596324 [NCBI36] Chr8:8p22-12	pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3	copy number gain	See cases [RCV000148092]	Chr8:241530..145054634 [GRCh38] Chr8:191530..146280020 [GRCh37] Chr8:181530..146250824 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3	copy number gain	See cases [RCV000143508]	Chr8:12633490..40685533 [GRCh38] Chr8:12490999..40543052 [GRCh37] Chr8:12535370..40662209 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3	copy number gain	See cases [RCV000148237]	Chr8:12728904..43673207 [GRCh38] Chr8:12586413..43528350 [GRCh37] Chr8:12630784..43647507 [NCBI36] Chr8:8p23.1-11.1	pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3	copy number gain	See cases [RCV000148249]	Chr8:12609975..42085703 [GRCh38] Chr8:12467484..41943221 [GRCh37] Chr8:12511855..42062378 [NCBI36] Chr8:8p23.1-11.21	pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3	copy number gain	See cases [RCV000511325]	Chr8:12528482..39593802 [GRCh37] Chr8:8p23.1-11.22	pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30262760)x3	copy number gain	See cases [RCV000449225]	Chr8:158048..30262760 [GRCh37] Chr8:8p23.3-12	pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3	copy number gain	See cases [RCV000447913]	Chr8:12580132..43388233 [GRCh37] Chr8:8p23.1-11.1	pathogenic
GRCh37/hg19 8p21.2-12(chr8:24514488-34808438)	copy number gain	See cases [RCV000448582]	Chr8:24514488..34808438 [GRCh37] Chr8:8p21.2-12	pathogenic
GRCh37/hg19 8p21.1-12(chr8:28688366-29220890)x1	copy number loss	See cases [RCV000510190]	Chr8:28688366..29220890 [GRCh37] Chr8:8p21.1-12	uncertain significance
GRCh37/hg19 8p21.1-12(chr8:27501662-29342607)x3	copy number gain	See cases [RCV000510519]	Chr8:27501662..29342607 [GRCh37] Chr8:8p21.1-12	uncertain significance
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1	copy number loss	not provided [RCV000509389]	Chr8:16992973..32612724 [GRCh37] Chr8:8p22-12	not provided
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3	copy number gain	See cases [RCV000511028]	Chr8:11935023..43824035 [GRCh37] Chr8:8p23.1-11.1	pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3	copy number gain	See cases [RCV000510899]	Chr8:11945855..34875355 [GRCh37] Chr8:8p23.1-12	pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3	copy number gain	not provided [RCV000683043]	Chr8:12552775..35935825 [GRCh37] Chr8:8p23.1-12	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3	copy number gain	not provided [RCV000747254]	Chr8:164984..146293414 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3	copy number gain	not provided [RCV000762735]	Chr8:12556004..34374150 [GRCh37] Chr8:8p23.1-12	likely pathogenic
GRCh37/hg19 8p12(chr8:29103983-35728509)x1	copy number loss	not provided [RCV000846377]	Chr8:29103983..35728509 [GRCh37] Chr8:8p12	uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3	copy number gain	not provided [RCV000848478]	Chr8:158048..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p21.2-11.22(chr8:26808969-38346383)x1	copy number loss	not provided [RCV002472596]	Chr8:26808969..38346383 [GRCh37] Chr8:8p21.2-11.22	pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776)	copy number gain	Abnormal fetal cardiovascular morphology [RCV001291977]	Chr8:176814..43396776 [GRCh37] Chr8:8p23.3-11.1	pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-29886483)x3	copy number gain	not provided [RCV001260030]	Chr8:12528482..29886483 [GRCh37] Chr8:8p23.1-12	likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)	copy number gain	Polydactyly [RCV002280629]	Chr8:158048..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
Single allele	complex	8p inverted duplication/deletion syndrome [RCV002280753]	Chr8:158048..43019304 [GRCh37] Chr8:8p23.3-11.21	pathogenic
Single allele	complex	See cases [RCV002292428]	Chr8:6999114..11935023 [GRCh37] Chr8:8p23.3-11.21	pathogenic
NM_001394.7(DUSP4):c.1150C>G (p.Leu384Val)	single nucleotide variant	not specified [RCV004329182]	Chr8:29337061 [GRCh38] Chr8:29194578 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.1174C>G (p.Pro392Ala)	single nucleotide variant	not specified [RCV004242547]	Chr8:29337037 [GRCh38] Chr8:29194554 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.1120G>A (p.Val374Met)	single nucleotide variant	not specified [RCV004101182]	Chr8:29337091 [GRCh38] Chr8:29194608 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.938G>A (p.Arg313His)	single nucleotide variant	not specified [RCV004136805]	Chr8:29337273 [GRCh38] Chr8:29194790 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.538G>T (p.Asp180Tyr)	single nucleotide variant	not specified [RCV004093400]	Chr8:29340139 [GRCh38] Chr8:29197656 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.509C>T (p.Pro170Leu)	single nucleotide variant	not specified [RCV004234246]	Chr8:29340168 [GRCh38] Chr8:29197685 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.594G>T (p.Glu198Asp)	single nucleotide variant	not specified [RCV004131334]	Chr8:29338487 [GRCh38] Chr8:29196004 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.637C>T (p.Arg213Trp)	single nucleotide variant	not specified [RCV004228060]	Chr8:29338444 [GRCh38] Chr8:29195961 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.488C>G (p.Ala163Gly)	single nucleotide variant	not specified [RCV004115774]	Chr8:29340189 [GRCh38] Chr8:29197706 [GRCh37] Chr8:8p12	uncertain significance
GRCh37/hg19 8p23.2-11.21(chr8:2201405-41723095)x3	copy number gain	not provided [RCV003484713]	Chr8:2201405..41723095 [GRCh37] Chr8:8p23.2-11.21	pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12560782-38748763)x3	copy number gain	not provided [RCV003484724]	Chr8:12560782..38748763 [GRCh37] Chr8:8p23.1-11.22	pathogenic
GRCh37/hg19 8p22-11.1(chr8:14240573-43824035)x3	copy number gain	not provided [RCV003484725]	Chr8:14240573..43824035 [GRCh37] Chr8:8p22-11.1	pathogenic
NM_001394.7(DUSP4):c.573C>T (p.His191=)	single nucleotide variant	not provided [RCV003436836]	Chr8:29340104 [GRCh38] Chr8:29197621 [GRCh37] Chr8:8p12	likely benign
Single allele	duplication	not provided [RCV003448693]	Chr8:12530550..43483193 [GRCh37] Chr8:8p23.1-11.1	pathogenic
NM_001394.7(DUSP4):c.846G>A (p.Ala282=)	single nucleotide variant	not provided [RCV003436835]	Chr8:29337365 [GRCh38] Chr8:29194882 [GRCh37] Chr8:8p12	likely benign
GRCh37/hg19 8p21.2-12(chr8:23754939-30219110)x1	copy number loss	not specified [RCV003986748]	Chr8:23754939..30219110 [GRCh37] Chr8:8p21.2-12	pathogenic
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3	copy number gain	not specified [RCV003986754]	Chr8:27024288..89410121 [GRCh37] Chr8:8p21.2-q21.3	pathogenic
GRCh37/hg19 8p21.3-11.1(chr8:20136266-43786723)x3	copy number gain	not specified [RCV003986767]	Chr8:20136266..43786723 [GRCh37] Chr8:8p21.3-11.1	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3	copy number gain	not specified [RCV003986742]	Chr8:158048..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
NM_001394.7(DUSP4):c.102C>G (p.His34Gln)	single nucleotide variant	not specified [RCV004379725]	Chr8:29350177 [GRCh38] Chr8:29207694 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.1072G>C (p.Ala358Pro)	single nucleotide variant	not specified [RCV004379726]	Chr8:29337139 [GRCh38] Chr8:29194656 [GRCh37] Chr8:8p12	likely benign
NM_001394.7(DUSP4):c.597C>G (p.Ile199Met)	single nucleotide variant	not specified [RCV004379730]	Chr8:29338484 [GRCh38] Chr8:29196001 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.532C>G (p.Pro178Ala)	single nucleotide variant	not specified [RCV004379729]	Chr8:29340145 [GRCh38] Chr8:29197662 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.1021G>T (p.Ala341Ser)	single nucleotide variant	not specified [RCV004379724]	Chr8:29337190 [GRCh38] Chr8:29194707 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.638G>A (p.Arg213Gln)	single nucleotide variant	not specified [RCV004379731]	Chr8:29338443 [GRCh38] Chr8:29195960 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.737C>G (p.Pro246Arg)	single nucleotide variant	not specified [RCV004379732]	Chr8:29338344 [GRCh38] Chr8:29195861 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.316A>C (p.Ile106Leu)	single nucleotide variant	not specified [RCV004379727]	Chr8:29349963 [GRCh38] Chr8:29207480 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.457G>A (p.Glu153Lys)	single nucleotide variant	not specified [RCV004379728]	Chr8:29340220 [GRCh38] Chr8:29197737 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.508C>T (p.Pro170Ser)	single nucleotide variant	not specified [RCV004617207]	Chr8:29340169 [GRCh38] Chr8:29197686 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.668C>A (p.Thr223Lys)	single nucleotide variant	not specified [RCV004617204]	Chr8:29338413 [GRCh38] Chr8:29195930 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.496G>A (p.Ala166Thr)	single nucleotide variant	not specified [RCV004620173]	Chr8:29340181 [GRCh38] Chr8:29197698 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.1114G>A (p.Val372Met)	single nucleotide variant	not specified [RCV004617206]	Chr8:29337097 [GRCh38] Chr8:29194614 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.319G>C (p.Val107Leu)	single nucleotide variant	not specified [RCV004906722]	Chr8:29349960 [GRCh38] Chr8:29207477 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.471C>A (p.Phe157Leu)	single nucleotide variant	not specified [RCV004906723]	Chr8:29340206 [GRCh38] Chr8:29197723 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.565C>G (p.Pro189Ala)	single nucleotide variant	not specified [RCV004906725]	Chr8:29340112 [GRCh38] Chr8:29197629 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.1022C>T (p.Ala341Val)	single nucleotide variant	not specified [RCV004906726]	Chr8:29337189 [GRCh38] Chr8:29194706 [GRCh37] Chr8:8p12	likely benign
NM_001394.7(DUSP4):c.928G>A (p.Val310Ile)	single nucleotide variant	not specified [RCV004906727]	Chr8:29337283 [GRCh38] Chr8:29194800 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.820G>A (p.Gly274Arg)	single nucleotide variant	not specified [RCV004617205]	Chr8:29337391 [GRCh38] Chr8:29194908 [GRCh37] Chr8:8p12	uncertain significance
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3	copy number gain	See cases [RCV000142858]	Chr8:226452..145068712 [GRCh38] Chr8:176452..146294098 [GRCh37] Chr8:166452..146264902 [NCBI36] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3	copy number gain	See cases [RCV000446588]	Chr8:24772064..24813176 [GRCh37] Chr8:8p21.2-q12.1	uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3	copy number gain	See cases [RCV000447507]	Chr8:158991..146280828 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3	copy number gain	See cases [RCV000447909]	Chr8:158048..43786723 [GRCh37] Chr8:8p23.3-11.1	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)	copy number gain	See cases [RCV000510234]	Chr8:158049..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3	copy number gain	See cases [RCV000510571]	Chr8:12528482..33684786 [GRCh37] Chr8:8p23.1-12	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3	copy number gain	See cases [RCV000511095]	Chr8:158049..146295771 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3	copy number gain	See cases [RCV000512169]	Chr8:12490999..146295771 [GRCh37] Chr8:8p23.1-q24.3	pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3	copy number gain	not provided [RCV000747248]	Chr8:10213..146293414 [GRCh37] Chr8:8p23.3-q24.3	pathogenic
Single allele	duplication	not provided [RCV000768452]	Chr8:12546855..35816855 [GRCh37] Chr8:8p23.1-12	likely pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30187456)x1	copy number loss	See cases [RCV002286343]	Chr8:158048..30187456 [GRCh37] Chr8:8p23.3-12	pathogenic
GRCh38/hg38 8p23.1-12(chr8:12721809-30183737)x1	copy number loss	Microcephaly [RCV003327707]	Chr8:12721809..30183737 [GRCh38] Chr8:8p23.1-12	pathogenic
NM_001394.7(DUSP4):c.466G>C (p.Glu156Gln)	single nucleotide variant	not specified [RCV004341939]	Chr8:29340211 [GRCh38] Chr8:29197728 [GRCh37] Chr8:8p12	uncertain significance
GRCh37/hg19 8p23.1-11.23(chr8:11945856-37902453)x3	copy number gain	not provided [RCV003484722]	Chr8:11945856..37902453 [GRCh37] Chr8:8p23.1-11.23	pathogenic
GRCh37/hg19 8p23.3-11.21(chr8:158048-41600696)x3	copy number gain	not specified [RCV003986756]	Chr8:158048..41600696 [GRCh37] Chr8:8p23.3-11.21	pathogenic
NM_001394.7(DUSP4):c.1093G>A (p.Val365Ile)	single nucleotide variant	not specified [RCV004620174]	Chr8:29337118 [GRCh38] Chr8:29194635 [GRCh37] Chr8:8p12	uncertain significance
NM_001394.7(DUSP4):c.272A>C (p.Glu91Ala)	single nucleotide variant	not specified [RCV004620176]	Chr8:29350007 [GRCh38] Chr8:29207524 [GRCh37] Chr8:8p12	uncertain significance

Predicted Target Of

	Summary Value
Count of predictions:	2149
Count of miRNA genes:	932
Interacting mature miRNAs:	1107
Transcripts:	ENST00000240100, ENST00000240101
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298482	BP2_H	Blood pressure QTL 2 (human)	1.8		Blood pressure	diastolic	8	6953256	32953256	Human
406979664	GWAS628640_H	heel bone mineral density QTL GWAS628640 (human)		3e-08	heel bone mineral density	bone mineral density (CMO:0001226)	8	29344706	29344707	Human
1558703	SCL6_H	Serum cholesterol level QTL 1 (human)	1.2		Lipid level	HDL cholesterol	8	12468635	38468635	Human

A004W39

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	29,190,723 - 29,190,843	UniSTS	GRCh37
Build 36	8	29,246,642 - 29,246,762	RGD	NCBI36
Celera	8	28,150,320 - 28,150,440	RGD
Cytogenetic Map	8	p12-p11	UniSTS
HuRef	8	27,735,087 - 27,735,207	UniSTS
GeneMap99-GB4 RH Map	8	116.89	UniSTS
Whitehead-RH Map	8	117.5	UniSTS

D8S1424E

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	29,192,280 - 29,192,487	UniSTS	GRCh37
Build 36	8	29,248,199 - 29,248,406	RGD	NCBI36
Celera	8	28,151,877 - 28,152,084	RGD
Cytogenetic Map	8	p12-p11	UniSTS
HuRef	8	27,736,644 - 27,736,851	UniSTS

SGC35388

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	29,194,276 - 29,194,478	UniSTS	GRCh37
Build 36	8	29,250,195 - 29,250,397	RGD	NCBI36
Celera	8	28,153,873 - 28,154,075	RGD
Cytogenetic Map	8	p12-p11	UniSTS
HuRef	8	27,738,640 - 27,738,842	UniSTS
GeneMap99-GB4 RH Map	8	116.89	UniSTS
Whitehead-RH Map	8	117.1	UniSTS

RH18016

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	29,194,024 - 29,194,231	UniSTS	GRCh37
Build 36	8	29,249,943 - 29,250,150	RGD	NCBI36
Celera	8	28,153,621 - 28,153,828	RGD
Cytogenetic Map	8	p12-p11	UniSTS
HuRef	8	27,738,388 - 27,738,595	UniSTS
GeneMap99-GB4 RH Map	8	116.78	UniSTS

RH36102

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	29,190,736 - 29,190,851	UniSTS	GRCh37
Build 36	8	29,246,655 - 29,246,770	RGD	NCBI36
Celera	8	28,150,333 - 28,150,448	RGD
Cytogenetic Map	8	p12-p11	UniSTS
HuRef	8	27,735,100 - 27,735,215	UniSTS
GeneMap99-GB4 RH Map	8	116.99	UniSTS

WI-22140

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	29,202,647 - 29,202,792	UniSTS	GRCh37
Build 36	8	29,258,566 - 29,258,711	RGD	NCBI36
Celera	8	28,162,246 - 28,162,391	RGD
Cytogenetic Map	8	p12-p11	UniSTS
HuRef	8	27,747,011 - 27,747,156	UniSTS
GeneMap99-GB4 RH Map	8	116.99	UniSTS
Whitehead-RH Map	8	117.7	UniSTS

DUSP4_590.2

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	8	29,194,006 - 29,194,849	UniSTS	GRCh37
Build 36	8	29,249,925 - 29,250,768	RGD	NCBI36
Celera	8	28,153,603 - 28,154,446	RGD
HuRef	8	27,738,370 - 27,739,213	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2438	2788	2245	4974	1725	2346	5	623	1902	464	2270	7262	6430	51	3734	1	852	1743	1613	174	1


RefSeq Transcripts	NM_001394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_057158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011544428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC084262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI123616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK314820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL137704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC002671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC012900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC014565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG760517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU742141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA645190	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S80632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U21108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U48807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000240100 ⟹ ENSP00000240100

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	8	29,333,064 - 29,350,684 (-)	Ensembl

Ensembl Acc Id:

ENST00000240101 ⟹ ENSP00000240101

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	8	29,336,539 - 29,348,805 (-)	Ensembl

RefSeq Acc Id:

NM_001394 ⟹ NP_001385

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	8	29,333,064 - 29,350,684 (-)	NCBI
GRCh37	8	29,190,579 - 29,208,267 (-)	ENTREZGENE
Build 36	8	29,249,539 - 29,264,104 (-)	NCBI Archive
HuRef	8	27,734,943 - 27,752,631 (-)	ENTREZGENE
CHM1_1	8	29,392,567 - 29,410,254 (-)	NCBI
T2T-CHM13v2.0	8	29,611,341 - 29,628,961 (-)	NCBI

Sequence:

show sequence

CTGGCTGGGGCAGTGCGCTGAGCGCCGGAGGAGCGTAGGCAGGGCAGCGCTGGCGCCAGTGGCGACAGGAGCCGCGCGACCGGCAAAAATACACGGGAGGCCGTCGCCGAAAAGAGTCCGCGGTCCTC
TCTCGTAAACACACTCTCCTCCACCGGCGCCTCCCCCTCCGCTCTGCGCGCCGCCCGGCTGGGCGCCCGAGGCCGCTCCGACTGCTATGTGACCGCGAGGCTGCGGGAGGAAGGGGACAGGGAAGAAG
AGGCTCTCCCGCGGGAGCCCTTGAGGACCAAGTTTGCGGCCACTTCTGCAGGCGTCCCTTCTTAGCTCTCGCCCGCCCCTTTCTGCAGCCTAGGCGGCCCGGGTTCTCTTCTCTTCCTCGCGCGCCCA
GCCGCCTCGGTTCCCGGCGACCATGGTGACGATGGAGGAGCTGCGGGAGATGGACTGCAGTGTGCTCAAAAGGCTGATGAACCGGGACGAGAATGGCGGCGGCGCGGGCGGCAGCGGCAGCCACGGCA
CCCTGGGGCTGCCGAGCGGCGGCAAGTGCCTGCTGCTGGACTGCAGACCGTTCCTGGCGCACAGCGCGGGCTACATCCTAGGTTCGGTCAACGTGCGCTGTAACACCATCGTGCGGCGGCGGGCTAAG
GGCTCCGTGAGCCTGGAGCAGATCCTGCCCGCCGAGGAGGAGGTACGCGCCCGCTTGCGCTCCGGCCTCTACTCGGCGGTCATCGTCTACGACGAGCGCAGCCCGCGCGCCGAGAGCCTCCGCGAGGA
CAGCACCGTGTCGCTGGTGGTGCAGGCGCTGCGCCGCAACGCCGAGCGCACCGACATCTGCCTGCTCAAAGGCGGCTATGAGAGGTTTTCCTCCGAGTACCCAGAATTCTGTTCTAAAACCAAGGCCC
TGGCAGCCATCCCACCCCCGGTTCCCCCCAGTGCCACAGAGCCCTTGGACCTGGGCTGCAGCTCCTGTGGGACCCCACTACACGACCAGGGGGGTCCTGTGGAGATCCTTCCCTTCCTCTACCTCGGC
AGTGCCTACCATGCTGCCCGGAGAGACATGCTGGACGCCCTGGGCATCACGGCTCTGTTGAATGTCTCCTCGGACTGCCCAAACCACTTTGAAGGACACTATCAGTACAAGTGCATCCCAGTGGAAGA
TAACCACAAGGCCGACATCAGCTCCTGGTTCATGGAAGCCATAGAGTACATCGATGCCGTGAAGGACTGCCGTGGGCGCGTGCTGGTGCACTGCCAGGCGGGCATCTCGCGGTCGGCCACCATCTGCC
TGGCCTACCTGATGATGAAGAAACGGGTGAGGCTGGAGGAGGCCTTCGAGTTCGTTAAGCAGCGCCGCAGCATCATCTCGCCCAACTTCAGCTTCATGGGGCAGCTGCTGCAGTTCGAGTCCCAGGTG
CTGGCCACGTCCTGTGCTGCGGAGGCTGCTAGCCCCTCGGGACCCCTGCGGGAGCGGGGCAAGACCCCCGCCACCCCCACCTCGCAGTTCGTCTTCAGCTTTCCGGTCTCCGTGGGCGTGCACTCGGC
CCCCAGCAGCCTGCCCTACCTGCACAGCCCCATCACCACCTCTCCCAGCTGTTAGAGCCGCCCTGGGGGCCCCAGAACCAGAGCTGGCTCCCAGCAAGGGTAGGACGGGCCGCATGCGGGCAGAAAGT
TGGGACTGAGCAGCTGGGAGCAGGCGACCGAGCTCCTTCCCCATCATTTCTCCTTGGCCAACGACGAGGCCAGCCAGAATGGCAATAAGGACTCCGAATACATAATAAAAGCAAACAGAACACTCCAA
CTTAGAGCAATAACGGCTGCCGCAGCAGCCAGGGAAGACCTTGGTTTGGTTTATGTGTCAGTTTCACTTTTCCGATAGAAATTTCTTACCTCATTTTTTTAAGCAGTAAGGCTTGAAGTGATGAAACC
CACAGATCCTAGCAAATGTGCCCAACCAGCTTTACTAAAGGGGGAGGAAGGGAGGGCAAAGGGATGAGAAGACAAGTTTCCCAGAAGTGCCTGGTTCTGTGTACTTGTCCCTTTGTTGTCGTTGTTGT
AGTTAAAGGAATTTCATTTTTTAAAAGAAATCTTCGAAGGTGTGGTTTTCATTTCTCAGTCACCAACAGATGAATAATTATGCTTAATAATAAAGTATTTATTAAGACTTTCTTCAGAGTATGAAAGT
ACAAAAAGTCTAGTTACAGTGGATTTAGAATATATTTATGTTGATGTCAAACAGCTGAGCACCGTAGCATGCAGATGTCAAGGCAGTTAGGAAGTAAATGGTGTCTTGTAGATATGTGCAAGGTAGCA
TGATGAGCAACTTGAGTTTGTTGCCACTGAGAAGCAGGCGGGTTGGGTGGGAGGAGGAAGAAAGGGAAGAATTAGGTTTGAATTGCTTTTTAAAAAAAAAAGAAAAGAAAAAGACAGCATCTCACTAT
GTTGCCAAGGCTCATCTTGAGAAGCAGGCGGGTTGGGTGGGAGGAGGAAGAAAGGGAAGAATTAGGTTTGAATTGCTTTTTTAAAAAAAAAGAAAAGAAAAAAAAAGACAGCATCTCACTATGTTGCC
AAGGCTCATCTCAAGCTCTTGGGCTCAAGAGATCCTCCCACCTCGGCCTCCTGAGTAGCTGGGACTGCAGGTGTGTGTCATCATGACCAATGTGAATTGCTTTTGAAGCTGGTTCATGGGCATGTAGG
CCACCGAAGCAATTTTAGACCACAGTAAGTCAAGCTTTTTTCCCTCCGATGATCACTGGGTGGTTGCAGCATTTTTTGCATAAACCTGCCTAAGACTTGTCTATCGTCTGTGATCAATATGCCATATT
ACACTAAGGTGCTCCTGGAAAATTGGGTGCAGTTCAAATTTTCCTACAGCAAATCATTTGGCAAGGCCAGCCATTGGGGAAACCAGACAACTAGAGATAACCCTGAAATGAATCCTTTTGTAAATTGA
AGCACCATCTTTTCTTTTTTTGCATAAATTGGAGGTTTTAATTTTAGGGCAGTTACCTGAAGTGAAATATACCAACAATTTCTTGTGTTCTTTAAATTCCTAGTTAGGTGAATATTTTTGAAGGTCCT
CTTTTGAATAAAGAGGGGAATGGACACCACATTTCAGGTCTTCTCGAAGTGTGGAAGGGCAAGAGAGCATCAGTGAGCTGATGGTGGATTGCTTACATCGGATTCCATTGGTATGAATTTCCCAAACT
GGAAATCAAAGCGCCAGGGTGGGGTTGGGGCTGACTGCTGGTGAGGGGGCTGGCCGCTGGCTCCCGTGACGTGCGTCATGGGCACGCAGGCGCCATTTTGAATCTATCGTCGGCACGTGGGTGCCATT
TTGAATCCTTAGTTGGGCCTTTCTAAATGGAGAATGGCTTTGGAGGGAGACACGTTTTCTGTGGGGAGGGTTTGGGGGGGAGGGAGGAGGGAACAAGCTACATGCTATTTTGTTTGTAGTATTGTGGA
ACAGTCTTGTTATGGAGTGCCAGCTTAGAGGTTGTTGCAAACTTGTCTAGAAGTGAGAGCATGGTTTTTTTTAGCCCTTTGAGAGTCTACATCTAATGAACATTCTTGCTCACCCATAAATAACGTCA
AGCCTCAATGTCACCGTCACGTTGGGATACTCTTTCTCATCTGGCATCCTAGACAGGACAAGGTTGGTTACCTTTCCTTCCATGAACCATGAACCTGTGACGGCATCATTCATCCTGACTTCACCAAG
CTCCGCCTGTGGGTGAGGCCAGAGCTCCCACTGGCAATTTTTAGAAGAGCCAGAGGCTCCCTGCTTCCTCTAGAAATAACAGTTCAGGGTGAAGCATGGAGGGTTTCAGTTCCCAGACAATGGAACCA
TTTAGAGACAACACAGTTGGACATTTCCACTTTTTCCTTGATTCCTGGAAGTCCAGTGGGTTCTGCAGCTGAAAAAGCCCTGGGTCCCAGCAGCAGAGAGACAGGACAGAGGGGATGCTTGGGCGGGG
AGGGACGGTAACCTGCAGAACAGATTCCATTTTTATAGAACGAGTACACGTTTGCTAAAACAGTCCTGCTTTCCCAGACTGGATTCCCACCACAGGGACAGTCGGAACTCAGGACTAGCTCCAGCGAC
ATCTTTCCTCCGAATTCAAGCCTTCTATCACAATGTCAAAACAGCTATTTATAAAGCCATTTTCATTGTACTTGATAACAGCACGAGTCCCAAAACTTTTAGAAATAAAATAGGACATTGGCTTGATT
GAAAAGAGGGACTTTTTAAAAATTGTTCTTTCGTCAGAAGCCTTTTGGATGACTTACAATAGCTCTGATGAAGATACCACCCCAGCGTCAGTCCAATAGGTCAGTGAGTTTCAACAGGCATCCATCCC
TCCCATGAAGGGATTCTGGTGATGGGAAGTTTCTGTAATGACAGGAAAGCATTGACCCTCATTGATTGTCAACTTTGGTATTAGCCATGAAAGACAGGATGCTCATTGGGTGTTCTGTAGAGTGAGGA
ATGCTGCCTATTCCCTCCCAGAACGTCTGACCCAGGGGTGTGTGTTGAGGAGCCCTGGGGGAAATGGACCAAGTTTTCCCACAGAGCAGTATTAGGCTGAAGAGCAGGTGACTGGTAGGCCCCAGCTC
CCATCATTCCCTCCCAAAGCCATTTTGTTCAGTTGCTCATCCACGCTGGATTCCAGAGAGTTTTCCAATTTGGGAAGCCATGAGAAAGGTTTTTAAATCTTGGGAAGATGGAGAGAGGGACATAGGAT
AGTTGACTCCAACATGACAGGAAGAGGCTGGAGATTGGGAATTGGCCATCAACCAAGCCTGTAGTAGTAAAGCCATGGTCCCGCATTGGAATTACTTGGGGAACTTATACAGTTCTGATACCCAGGCT
CTCCTAGACCAGTTCAACCAATTCTAGGTGGGGGACTCAGGCATCAGTGTGTTTCGTAGCTCCCCGGGTGTTTTCCCTGTGCAGCCGAGCTTGGGAAACTGCCATGCTTTTTGGATGTCAAGGCGCTG
TTGGAGGCTGGGTGTGACAGCACAGAGCCAGGTTGTCTTGTGGAAACCACAGCCACGGGTTTGCCACTGGCTCAGCATGGCCTCACTGCCAGTCCCAGCCTGGCTGAGGGACAAGATGGTTTCTCTTG
GGAGTTCCTGAGTGGAGCACCCTTCCAGGCTTTTTGAAAGCCAGCTGATCTGTGGAGCCTTGTTAAGGGACTCAATACGGTGTTTGGATATTGATGTTTTTCCTTGAGACTGTCTTGTCCATCAATAA
AGATGGAGGATGTCTCCTCTTTGAACCCCGCTTCCCCACCAGTACTCTCTCTCCCTTAGAGTTTATGAGTTATTCAAGGAGGAGACTTCTTAAAGACAGCAACGCAATTCTTGTAACTTGTGTAAATA
GCCCCATCTTTCAGAGTGATACCATTTCTACATTTGATAATGCCTGTATTCCTGTAGGATGTATATAGTTTAGGGGATTTTTTTTTTGTTTGGTTTTGTTTTTTAGAAGTCAATATGTCTGGTTTTAT
TTATTGCTTGAAAAAGATCATTTGAAAAAAATAAATACATTTTCAACCA

hide sequence

RefSeq Acc Id:

NM_057158 ⟹ NP_476499

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	8	29,333,064 - 29,348,805 (-)	NCBI
GRCh37	8	29,190,579 - 29,208,267 (-)	ENTREZGENE
Build 36	8	29,249,530 - 29,262,241 (-)	NCBI Archive
HuRef	8	27,734,943 - 27,752,631 (-)	ENTREZGENE
CHM1_1	8	29,392,567 - 29,408,309 (-)	NCBI
T2T-CHM13v2.0	8	29,611,341 - 29,627,082 (-)	NCBI

Sequence:

show sequence

GCAGTTCAGACCCCCCCACACCCATCAAAGAGCCGCTCCTCCCCCCCGCAGGCGCCTTCGCCGC
CTCCCTCCCTTCCTTTCCTTTCCGCTCCTCTTCCGACCTGTCCACCCGGGAGGAAGGGAGCTGGAAAGGGGGCGGAAACCTCTCCCCTCCAAAAAGCACAACAAAACTGTTCAGTGCGGAGGAGCCGG
GTTCGCCCCTGCCGGACAGCGGGGGGCTTTGTTCCCCGCAGTTGTTTCCTGCCCATTTGACCTGTCAGCTGCTGGGGAAACGCTGCTGTTGACCTTTGGTTGAACTGCTAAGGCGATTTTGCTGATTT
TTCTTTCTTTTTCCGCGAGGGCTGTCTTTTGCTCCTCCAAATGAGCCCAGTCCCCCTCCCTTCTCCCCAAAGCGCTCCAAGAGAAAGTGCCAGGAAGGGGCTTGTCCCGGAAGGCCTGGCGGCTGAGC
GGGGCCAGGTCCTGGTTAGGCCACCAGGGTGGGCGTCCGCGCCATTGTTTGAGCTTGTCGGCGCTGGTGGGAGAGATGAGGGCAATTCCTCTGGGACGCAAGTCCCCTCGAATGGCCGGGGCTGGCCG
GGATGTTCCCCGCACGGCGCTGCCCTCGAGTCCCCCCGATGGAGAGCGCGGGCGCGCCTTCCTTCGCTGGCGTCCAAACCCGGGACCAGCTAGAACACAGCAGGGCTGGGACTGGGTTCCAGCCCCAC
GTGGAGTCTGGATTTGTTTTGTTGTGTTTTGCTTTCCTTCCTGGAAGAAATCCCGAGGGGACCGCCCTAGAGCGGCAGCTCCAGGACCTCGGCCCTTGGGCTTCCGGGGGTGCAGCCACTTAGGCCCC
GCTCCCGGGGAGAGAGGGATTATTTTTTAAGATTTATCCCCAGGGCGCGCGGCATTTCCCTGTCCCTCGTGAATCCCGTTGAGAGTCCTCCCTCCCCAACCTCCTCCATTTCCCCAGCCAGACCGATT
CGAGAGCCCTGGAGATTCTGGGCGAGGCTAGTGACTGGGTAGTACAGGCCTCTAGCCCCACCATTGCTCTCTCTGTCTTCAGTTCCCCAGGAGGGCAATGGCATCAAACAGCACAGCTCTGGGGGATG
TCAATATTGCATACCTTTTCTACCTAAAGGGAAAATGACTCGCTTTTCTGCTTGCAAATATGGTAGTTTCTGCTTACAAATGTAATACAATGCCCATGACAGCCAAGGACTGGAAGCATAAGTTGCTA
GGTCTTACAGGTGATTTTTTACAATGAAGCAAACTCACTATGTTAGACACCATTTACATTGGATGTCTCCAACTAACAAAAGTAACTAAAGACAGATGTAGGTGTAAATTGAGAGTGAAATTTGACCC
TTTAGACCGTCACAACTTCCTTGGGCTTATCCTGGGTGCTTATAGGAGAGGTGGGCTCCACCCACAAAAATGGACTGCTCAGAAAAATGAGGGAGAGAGAAAGGGTGGCCACTTTCCCGAGCCAAGAA
ATTCCTTGAAAAAAAATCAGAACATCTGAAACCAGAGAGCCGATTTCCTTACCGGGAGGCAGTTCCTGGCTAACGAAGAGGAAGCACGATGGGAAGAAAAGTTCACTCCAACGGAAGCCAGTTTGCTG
AACATAGCAGATCGCCCAGGAGGACTGGGAGAGACTGCAAACCAGTTCGAGCCCCCAGCATGGCGTTAGGTGTCAGCCAGCTGGCAGGAAGGTCCAGGTGTCTGTGTTCAGAGTCTCAAGGCGGCTAT
GAGAGGTTTTCCTCCGAGTACCCAGAATTCTGTTCTAAAACCAAGGCCCTGGCAGCCATCCCACCCCCGGTTCCCCCCAGTGCCACAGAGCCCTTGGACCTGGGCTGCAGCTCCTGTGGGACCCCACT
ACACGACCAGGGGGGTCCTGTGGAGATCCTTCCCTTCCTCTACCTCGGCAGTGCCTACCATGCTGCCCGGAGAGACATGCTGGACGCCCTGGGCATCACGGCTCTGTTGAATGTCTCCTCGGACTGCC
CAAACCACTTTGAAGGACACTATCAGTACAAGTGCATCCCAGTGGAAGATAACCACAAGGCCGACATCAGCTCCTGGTTCATGGAAGCCATAGAGTACATCGATGCCGTGAAGGACTGCCGTGGGCGC
GTGCTGGTGCACTGCCAGGCGGGCATCTCGCGGTCGGCCACCATCTGCCTGGCCTACCTGATGATGAAGAAACGGGTGAGGCTGGAGGAGGCCTTCGAGTTCGTTAAGCAGCGCCGCAGCATCATCTC
GCCCAACTTCAGCTTCATGGGGCAGCTGCTGCAGTTCGAGTCCCAGGTGCTGGCCACGTCCTGTGCTGCGGAGGCTGCTAGCCCCTCGGGACCCCTGCGGGAGCGGGGCAAGACCCCCGCCACCCCCA
CCTCGCAGTTCGTCTTCAGCTTTCCGGTCTCCGTGGGCGTGCACTCGGCCCCCAGCAGCCTGCCCTACCTGCACAGCCCCATCACCACCTCTCCCAGCTGTTAGAGCCGCCCTGGGGGCCCCAGAACC
AGAGCTGGCTCCCAGCAAGGGTAGGACGGGCCGCATGCGGGCAGAAAGTTGGGACTGAGCAGCTGGGAGCAGGCGACCGAGCTCCTTCCCCATCATTTCTCCTTGGCCAACGACGAGGCCAGCCAGAA
TGGCAATAAGGACTCCGAATACATAATAAAAGCAAACAGAACACTCCAACTTAGAGCAATAACGGCTGCCGCAGCAGCCAGGGAAGACCTTGGTTTGGTTTATGTGTCAGTTTCACTTTTCCGATAGA
AATTTCTTACCTCATTTTTTTAAGCAGTAAGGCTTGAAGTGATGAAACCCACAGATCCTAGCAAATGTGCCCAACCAGCTTTACTAAAGGGGGAGGAAGGGAGGGCAAAGGGATGAGAAGACAAGTTT
CCCAGAAGTGCCTGGTTCTGTGTACTTGTCCCTTTGTTGTCGTTGTTGTAGTTAAAGGAATTTCATTTTTTAAAAGAAATCTTCGAAGGTGTGGTTTTCATTTCTCAGTCACCAACAGATGAATAATT
ATGCTTAATAATAAAGTATTTATTAAGACTTTCTTCAGAGTATGAAAGTACAAAAAGTCTAGTTACAGTGGATTTAGAATATATTTATGTTGATGTCAAACAGCTGAGCACCGTAGCATGCAGATGTC
AAGGCAGTTAGGAAGTAAATGGTGTCTTGTAGATATGTGCAAGGTAGCATGATGAGCAACTTGAGTTTGTTGCCACTGAGAAGCAGGCGGGTTGGGTGGGAGGAGGAAGAAAGGGAAGAATTAGGTTT
GAATTGCTTTTTAAAAAAAAAAGAAAAGAAAAAGACAGCATCTCACTATGTTGCCAAGGCTCATCTTGAGAAGCAGGCGGGTTGGGTGGGAGGAGGAAGAAAGGGAAGAATTAGGTTTGAATTGCTTT
TTTAAAAAAAAAGAAAAGAAAAAAAAAGACAGCATCTCACTATGTTGCCAAGGCTCATCTCAAGCTCTTGGGCTCAAGAGATCCTCCCACCTCGGCCTCCTGAGTAGCTGGGACTGCAGGTGTGTGTC
ATCATGACCAATGTGAATTGCTTTTGAAGCTGGTTCATGGGCATGTAGGCCACCGAAGCAATTTTAGACCACAGTAAGTCAAGCTTTTTTCCCTCCGATGATCACTGGGTGGTTGCAGCATTTTTTGC
ATAAACCTGCCTAAGACTTGTCTATCGTCTGTGATCAATATGCCATATTACACTAAGGTGCTCCTGGAAAATTGGGTGCAGTTCAAATTTTCCTACAGCAAATCATTTGGCAAGGCCAGCCATTGGGG
AAACCAGACAACTAGAGATAACCCTGAAATGAATCCTTTTGTAAATTGAAGCACCATCTTTTCTTTTTTTGCATAAATTGGAGGTTTTAATTTTAGGGCAGTTACCTGAAGTGAAATATACCAACAAT
TTCTTGTGTTCTTTAAATTCCTAGTTAGGTGAATATTTTTGAAGGTCCTCTTTTGAATAAAGAGGGGAATGGACACCACATTTCAGGTCTTCTCGAAGTGTGGAAGGGCAAGAGAGCATCAGTGAGCT
GATGGTGGATTGCTTACATCGGATTCCATTGGTATGAATTTCCCAAACTGGAAATCAAAGCGCCAGGGTGGGGTTGGGGCTGACTGCTGGTGAGGGGGCTGGCCGCTGGCTCCCGTGACGTGCGTCAT
GGGCACGCAGGCGCCATTTTGAATCTATCGTCGGCACGTGGGTGCCATTTTGAATCCTTAGTTGGGCCTTTCTAAATGGAGAATGGCTTTGGAGGGAGACACGTTTTCTGTGGGGAGGGTTTGGGGGG
GAGGGAGGAGGGAACAAGCTACATGCTATTTTGTTTGTAGTATTGTGGAACAGTCTTGTTATGGAGTGCCAGCTTAGAGGTTGTTGCAAACTTGTCTAGAAGTGAGAGCATGGTTTTTTTTAGCCCTT
TGAGAGTCTACATCTAATGAACATTCTTGCTCACCCATAAATAACGTCAAGCCTCAATGTCACCGTCACGTTGGGATACTCTTTCTCATCTGGCATCCTAGACAGGACAAGGTTGGTTACCTTTCCTT
CCATGAACCATGAACCTGTGACGGCATCATTCATCCTGACTTCACCAAGCTCCGCCTGTGGGTGAGGCCAGAGCTCCCACTGGCAATTTTTAGAAGAGCCAGAGGCTCCCTGCTTCCTCTAGAAATAA
CAGTTCAGGGTGAAGCATGGAGGGTTTCAGTTCCCAGACAATGGAACCATTTAGAGACAACACAGTTGGACATTTCCACTTTTTCCTTGATTCCTGGAAGTCCAGTGGGTTCTGCAGCTGAAAAAGCC
CTGGGTCCCAGCAGCAGAGAGACAGGACAGAGGGGATGCTTGGGCGGGGAGGGACGGTAACCTGCAGAACAGATTCCATTTTTATAGAACGAGTACACGTTTGCTAAAACAGTCCTGCTTTCCCAGAC
TGGATTCCCACCACAGGGACAGTCGGAACTCAGGACTAGCTCCAGCGACATCTTTCCTCCGAATTCAAGCCTTCTATCACAATGTCAAAACAGCTATTTATAAAGCCATTTTCATTGTACTTGATAAC
AGCACGAGTCCCAAAACTTTTAGAAATAAAATAGGACATTGGCTTGATTGAAAAGAGGGACTTTTTAAAAATTGTTCTTTCGTCAGAAGCCTTTTGGATGACTTACAATAGCTCTGATGAAGATACCA
CCCCAGCGTCAGTCCAATAGGTCAGTGAGTTTCAACAGGCATCCATCCCTCCCATGAAGGGATTCTGGTGATGGGAAGTTTCTGTAATGACAGGAAAGCATTGACCCTCATTGATTGTCAACTTTGGT
ATTAGCCATGAAAGACAGGATGCTCATTGGGTGTTCTGTAGAGTGAGGAATGCTGCCTATTCCCTCCCAGAACGTCTGACCCAGGGGTGTGTGTTGAGGAGCCCTGGGGGAAATGGACCAAGTTTTCC
CACAGAGCAGTATTAGGCTGAAGAGCAGGTGACTGGTAGGCCCCAGCTCCCATCATTCCCTCCCAAAGCCATTTTGTTCAGTTGCTCATCCACGCTGGATTCCAGAGAGTTTTCCAATTTGGGAAGCC
ATGAGAAAGGTTTTTAAATCTTGGGAAGATGGAGAGAGGGACATAGGATAGTTGACTCCAACATGACAGGAAGAGGCTGGAGATTGGGAATTGGCCATCAACCAAGCCTGTAGTAGTAAAGCCATGGT
CCCGCATTGGAATTACTTGGGGAACTTATACAGTTCTGATACCCAGGCTCTCCTAGACCAGTTCAACCAATTCTAGGTGGGGGACTCAGGCATCAGTGTGTTTCGTAGCTCCCCGGGTGTTTTCCCTG
TGCAGCCGAGCTTGGGAAACTGCCATGCTTTTTGGATGTCAAGGCGCTGTTGGAGGCTGGGTGTGACAGCACAGAGCCAGGTTGTCTTGTGGAAACCACAGCCACGGGTTTGCCACTGGCTCAGCATG
GCCTCACTGCCAGTCCCAGCCTGGCTGAGGGACAAGATGGTTTCTCTTGGGAGTTCCTGAGTGGAGCACCCTTCCAGGCTTTTTGAAAGCCAGCTGATCTGTGGAGCCTTGTTAAGGGACTCAATACG
GTGTTTGGATATTGATGTTTTTCCTTGAGACTGTCTTGTCCATCAATAAAGATGGAGGATGTCTCCTCTTTGAACCCCGCTTCCCCACCAGTACTCTCTCTCCCTTAGAGTTTATGAGTTATTCAAGG
AGGAGACTTCTTAAAGACAGCAACGCAATTCTTGTAACTTGTGTAAATAGCCCCATCTTTCAGAGTGATACCATTTCTACATTTGATAATGCCTGTATTCCTGTAGGATGTATATAGTTTAGGGGATT
TTTTTTTTGTTTGGTTTTGTTTTTTAGAAGTCAATATGTCTGGTTTTATTTATTGCTTGAAAAAGATCATTTGAAAAAAATAAATACATTTTCAACCA

hide sequence


Protein RefSeqs	NP_001385	(Get FASTA)	NCBI Sequence Viewer
	NP_476499	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA85119	(Get FASTA)	NCBI Sequence Viewer
	AAB35870	(Get FASTA)	NCBI Sequence Viewer
	AAC50452	(Get FASTA)	NCBI Sequence Viewer
	AAH02671	(Get FASTA)	NCBI Sequence Viewer
	AAH14565	(Get FASTA)	NCBI Sequence Viewer
	BAG37342	(Get FASTA)	NCBI Sequence Viewer
	EAW63481	(Get FASTA)	NCBI Sequence Viewer
	EAW63482	(Get FASTA)	NCBI Sequence Viewer
	EAW63483	(Get FASTA)	NCBI Sequence Viewer
	EAW63484	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000240100
	ENSP00000240100.2
	ENSP00000240101
	ENSP00000240101.2
GenBank Protein	Q13115	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001385 ⟸ NM_001394
- Peptide Label:	isoform 1
- UniProtKB:	G5E930 (UniProtKB/Swiss-Prot), D3DSU4 (UniProtKB/Swiss-Prot), B2RBU5 (UniProtKB/Swiss-Prot), Q13524 (UniProtKB/Swiss-Prot), Q13115 (UniProtKB/Swiss-Prot), Q13649 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVV QALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADIS SWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYL HSPITTSPSC hide sequence

RefSeq Acc Id:	NP_476499 ⟸ NM_057158
- Peptide Label:	isoform 2
- UniProtKB:	Q13115 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGRKVHSNGSQFAEHSRSPRRTGRDCKPVRAPSMALGVSQLAGRSRCLCSESQGGYERFSSEYP EFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAG ISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC hide sequence

Ensembl Acc Id:

ENSP00000240100 ⟸ ENST00000240100

Ensembl Acc Id:

ENSP00000240101 ⟸ ENST00000240101

Protein Domains

Rhodanese Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q13115-F1-model_v2	AlphaFold	Q13115	1-394	view protein structure

RGD ID:

6806644

Promoter ID:

HG_KWN:61031

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, Lymphoblastoid

Transcripts:

ENST00000404690

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	8	29,258,786 - 29,259,592 (-)	MPROMDB

RGD ID:

6806614

Promoter ID:

HG_KWN:61032

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, HeLa_S3, K562, Lymphoblastoid

Transcripts:

NM_057158

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	8	29,261,841 - 29,263,187 (-)	MPROMDB

RGD ID:

6806616

Promoter ID:

HG_KWN:61033

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, HeLa_S3, K562, Lymphoblastoid, NB4

Transcripts:

OTTHUMT00000257249, OTTHUMT00000259143, OTTHUMT00000259144

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	8	29,263,391 - 29,265,107 (-)	MPROMDB

RGD ID:

7213009

Promoter ID:

EPDNEW_H12250

Type:

initiation region

Name:

DUSP4_2

Description:

dual specificity phosphatase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H12251 EPDNEW_H12252

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	8	29,348,729 - 29,348,789	EPDNEW

RGD ID:

7213011

Promoter ID:

EPDNEW_H12251

Type:

initiation region

Name:

DUSP4_3

Description:

dual specificity phosphatase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H12250 EPDNEW_H12252

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	8	29,350,323 - 29,350,383	EPDNEW

RGD ID:

7213013

Promoter ID:

EPDNEW_H12252

Type:

initiation region

Name:

DUSP4_1

Description:

dual specificity phosphatase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H12250 EPDNEW_H12251

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	8	29,350,682 - 29,350,742	EPDNEW

Database	Acc Id	Source(s)
COSMIC	DUSP4	COSMIC
Ensembl Genes	ENSG00000120875	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000240100	ENTREZGENE
	ENST00000240100.7	UniProtKB/Swiss-Prot
	ENST00000240101	ENTREZGENE
	ENST00000240101.2	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.250.10	UniProtKB/Swiss-Prot
	3.90.190.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000120875	GTEx
HGNC ID	HGNC:3070	ENTREZGENE
Human Proteome Map	DUSP4	Human Proteome Map
InterPro	Dual-sp_phosphatase_cat-dom	UniProtKB/Swiss-Prot
	MKP	UniProtKB/Swiss-Prot
	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot
	Rhodanese-like_dom	UniProtKB/Swiss-Prot
	Rhodanese-like_dom_sf	UniProtKB/Swiss-Prot
	Tyr_Pase_AS	UniProtKB/Swiss-Prot
	Tyr_Pase_cat	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_dom	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/Swiss-Prot
KEGG Report	hsa:1846	UniProtKB/Swiss-Prot
NCBI Gene	1846	ENTREZGENE
OMIM	602747	OMIM
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot
	DUAL SPECIFICITY PROTEIN PHOSPHATASE 4	UniProtKB/Swiss-Prot
Pfam	DSPc	UniProtKB/Swiss-Prot
	Rhodanese	UniProtKB/Swiss-Prot
PharmGKB	PA27527	PharmGKB
PIRSF	MAPK_Ptase	UniProtKB/Swiss-Prot
PRINTS	MAPKPHPHTASE	UniProtKB/Swiss-Prot
PROSITE	RHODANESE_3	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_1	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot
	TYR_PHOSPHATASE_DUAL	UniProtKB/Swiss-Prot
SMART	DSPc	UniProtKB/Swiss-Prot
	PTPc_motif	UniProtKB/Swiss-Prot
	RHOD	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52799	UniProtKB/Swiss-Prot
	SSF52821	UniProtKB/Swiss-Prot
UniProt	B2RBU5	ENTREZGENE
	D3DSU4	ENTREZGENE
	DUS4_HUMAN	UniProtKB/Swiss-Prot
	G5E930	ENTREZGENE
	Q13115	ENTREZGENE
	Q13524	ENTREZGENE
	Q13649	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	B2RBU5	UniProtKB/Swiss-Prot
	D3DSU4	UniProtKB/Swiss-Prot
	G5E930	UniProtKB/Swiss-Prot
	Q13524	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)