MIR151A (microRNA 151a) - Rat Genome Database

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Gene: MIR151A (microRNA 151a) Homo sapiens
Analyze
Symbol: MIR151A
Name: microRNA 151a
RGD ID: 1345628
HGNC Page HGNC:31762
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated gene silencing by mRNA destabilization and positive regulation of cell migration. Located in extracellular space. Biomarker of colon cancer.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-151; hsa-mir-151a; MIR151; MIRN151
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388140,732,564 - 140,732,653 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8140,732,564 - 140,732,653 (-)EnsemblGRCh38hg38GRCh38
GRCh378141,742,663 - 141,742,752 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,811,844 - 141,811,933 (-)NCBINCBI36Build 36hg18NCBI36
Celera8137,911,117 - 137,911,206 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8137,053,393 - 137,053,482 (-)NCBIHuRef
CHM1_18141,782,913 - 141,783,002 (-)NCBICHM1_1
T2T-CHM13v2.08141,852,546 - 141,852,635 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
3. MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Teng Y, etal., Nat Commun. 2017 Feb 17;8:14448. doi: 10.1038/ncomms14448.
Additional References at PubMed
PMID:14691248   PMID:15634332   PMID:15978578   PMID:16381832   PMID:17599088   PMID:17604727   PMID:17616659   PMID:20305651   PMID:21456068   PMID:22489664   PMID:22909203   PMID:23416081  
PMID:23458262   PMID:23574937   PMID:26626315   PMID:26646931   PMID:26761212   PMID:26771704   PMID:26801621   PMID:26943954   PMID:27191259   PMID:27385001   PMID:27930738   PMID:27992076  
PMID:29773107   PMID:29881991   PMID:30102952   PMID:30992025   PMID:32246100   PMID:32633369   PMID:32706759   PMID:33029507   PMID:33896797   PMID:34519373   PMID:34535770   PMID:35482475  
PMID:35786451   PMID:36704851  


Genomics

Comparative Map Data
MIR151A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388140,732,564 - 140,732,653 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8140,732,564 - 140,732,653 (-)EnsemblGRCh38hg38GRCh38
GRCh378141,742,663 - 141,742,752 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,811,844 - 141,811,933 (-)NCBINCBI36Build 36hg18NCBI36
Celera8137,911,117 - 137,911,206 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8137,053,393 - 137,053,482 (-)NCBIHuRef
CHM1_18141,782,913 - 141,783,002 (-)NCBICHM1_1
T2T-CHM13v2.08141,852,546 - 141,852,635 (-)NCBIT2T-CHM13v2.0
Mir151
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391573,126,664 - 73,126,731 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1573,126,664 - 73,126,731 (-)EnsemblGRCm39 Ensembl
GRCm381573,254,815 - 73,254,882 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,254,815 - 73,254,882 (-)EnsemblGRCm38mm10GRCm38
MGSCv371573,085,245 - 73,085,312 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1574,755,362 - 74,755,429 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1533.95NCBI
Mir151
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87107,061,380 - 107,061,476 (-)NCBIGRCr8
mRatBN7.27105,172,377 - 105,172,473 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx7106,921,033 - 106,921,129 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07109,142,616 - 109,142,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07109,090,644 - 109,090,740 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07114,485,547 - 114,485,643 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07114,421,107 - 114,421,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7101,580,549 - 101,580,645 (-)NCBICelera
Cytogenetic Map7q34NCBI
MIR151
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,353,689 - 35,353,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,353,689 - 35,353,744 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1335,212,289 - 35,212,344 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01335,737,989 - 35,738,044 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11335,458,052 - 35,458,107 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01335,547,996 - 35,548,051 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01335,967,807 - 35,967,862 (-)NCBIUU_Cfam_GSD_1.0
MIR151
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl42,849,038 - 2,849,130 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.142,849,041 - 2,849,120 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:130115518-141228210)x3 copy number gain See cases [RCV000133621] Chr8:130115518..141228210 [GRCh38]
Chr8:131127764..142238309 [GRCh37]
Chr8:131196946..142307491 [NCBI36]
Chr8:8q24.21-24.3		 pathogenic
GRCh38/hg38 8q24.3(chr8:139864393-141031612)x3 copy number gain See cases [RCV000134143] Chr8:139864393..141031612 [GRCh38]
Chr8:140876636..142041711 [GRCh37]
Chr8:140945818..142110893 [NCBI36]
Chr8:8q24.3		 uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3		 pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3		 likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3		 likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3		 pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3		 pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3		 pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3		 pathogenic
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3		 pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3		 pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3		 pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
E2F6hsa-miR-151a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20445018
MPLhsa-miR-151a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20445018
ARHGDIAhsa-miR-151a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20305651
SETD1Bhsa-miR-151a-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
TBC1D10Bhsa-miR-151a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
SETD1Bhsa-miR-151a-5pTarbaseexternal_infoSequencingPOSITIVE
CASZ1hsa-miR-151a-5pOncomiRDBexternal_infoNANA22928040
ARHGDIAhsa-miR-151a-5pOncomiRDBexternal_infoNANA20305651
ZNF763hsa-miR-151a-3pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20591824
NTRK3hsa-miR-151a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21143953
UTP25hsa-miR-151a-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
CCNE1hsa-miR-151a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23416081
PIM3hsa-miR-151a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
GOLM2hsa-miR-151a-3pTarbaseexternal_infoSequencingPOSITIVE

Predicted Targets
Summary Value
Count of predictions:18394
Count of gene targets:8454
Count of transcripts:15363
Interacting mature miRNAs:hsa-miR-151a-3p, hsa-miR-151a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 3 1
Low 29 13 17 9 42 12 88 24 57 23 63 70 2 1 16 2
Below cutoff 31 8 10 1 25 1 26 22 33 14 18 27 3 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000521276
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl8140,732,564 - 140,732,653 (-)Ensembl
RefSeq Acc Id: NR_029892
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388140,732,564 - 140,732,653 (-)NCBI
GRCh378141,742,663 - 141,742,752 (-)RGD
Celera8137,911,117 - 137,911,206 (-)RGD
HuRef8137,053,393 - 137,053,482 (-)RGD
CHM1_18141,782,913 - 141,783,002 (-)NCBI
T2T-CHM13v2.08141,852,546 - 141,852,635 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31762 AgrOrtholog
COSMIC MIR151A COSMIC
Ensembl Genes ENSG00000254324 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000521276 ENTREZGENE
GTEx ENSG00000254324 GTEx
HGNC ID HGNC:31762 ENTREZGENE
Human Proteome Map MIR151A Human Proteome Map
miRBase MI0000809 ENTREZGENE
NCBI Gene 442893 ENTREZGENE
OMIM 620127 OMIM
PharmGKB PA164722507 PharmGKB
RNAcentral URS000016C318 RNACentral
  URS00002ECE14 RNACentral
  URS00005F8E5B RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-11-22 MIR151A  microRNA 151a  MIR151  microRNA 151  Symbol and/or name change 5135510 APPROVED