MIXL1 (Mix paired-like homeobox) - Rat Genome Database

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Gene: MIXL1 (Mix paired-like homeobox) Canis lupus familiaris
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Symbol: MIXL1
Name: Mix paired-like homeobox
RGD ID: 13351420
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cell migration involved in gastrulation (ortholog); digestive tract development (ortholog); endoderm development (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); parathyroid carcinoma (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein MIXL1; LOC111096717; uncharacterized LOC111096717
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,651,481 - 38,652,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,132,918 - 38,135,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,485,283 - 38,487,650 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1738,323,946 - 38,326,305 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,330,845 - 38,333,218 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,602,254 - 38,605,581 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MIXL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,651,481 - 38,652,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,132,918 - 38,135,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,485,283 - 38,487,650 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1738,323,946 - 38,326,305 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,330,845 - 38,333,218 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,602,254 - 38,605,581 (-)NCBIUU_Cfam_GSD_1.0
MIXL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,223,664 - 226,227,060 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,223,618 - 226,227,060 (+)EnsemblGRCh38hg38GRCh38
GRCh371226,411,365 - 226,414,761 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,478,006 - 224,480,136 (+)NCBINCBI36Build 36hg18NCBI36
Build 341222,718,117 - 222,720,248NCBI
Celera1199,602,144 - 199,604,274 (+)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1196,928,386 - 196,930,516 (+)NCBIHuRef
CHM1_11227,684,126 - 227,686,256 (+)NCBICHM1_1
T2T-CHM13v2.01225,411,532 - 225,414,928 (+)NCBIT2T-CHM13v2.0
Mixl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,520,608 - 180,524,599 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,520,608 - 180,524,599 (-)EnsemblGRCm39 Ensembl
GRCm381180,693,043 - 180,697,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,693,043 - 180,697,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,623,174 - 182,627,165 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,529,718 - 182,533,709 (-)NCBIMGSCv36mm8
Celera1187,754,505 - 187,758,493 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.46NCBI
Mixl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81394,953,907 - 94,957,938 (-)NCBIGRCr8
mRatBN7.21392,422,031 - 92,426,065 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,422,031 - 92,426,065 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1394,927,431 - 94,931,466 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,327,378 - 96,331,405 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,502,070 - 93,506,101 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01397,278,258 - 97,282,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,973,041 - 98,975,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1397,278,258 - 97,282,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,973,473 - 103,977,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,427,597 - 96,431,628 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,618,156 - 96,620,542 (-)NCBI
Celera1391,967,784 - 91,971,815 (-)NCBICelera
Cytogenetic Map13q26NCBI
Mixl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955489418,650 - 422,428 (+)NCBIChiLan1.0ChiLan1.0
MIXL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,312,503 - 23,316,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,260,972 - 23,264,778 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01201,682,488 - 201,686,358 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11206,671,344 - 206,679,904 (+)NCBIpanpan1.1PanPan1.1panPan2
Mixl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,756,331 - 51,762,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365262,984,907 - 2,987,893 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365262,984,900 - 2,989,494 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIXL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,102,290 - 14,105,983 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,102,273 - 14,105,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21015,667,360 - 15,670,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIXL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,542,923 - 3,546,561 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,544,169 - 3,546,305 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660553,543,098 - 3,548,489 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mixl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624807322,723 - 326,149 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624807322,723 - 325,089 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MIXL1
12 total Variants

Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_038482568   ⟹   XP_038338496
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1738,323,946 - 38,326,305 (-)NCBI
RefSeq Acc Id: XM_038541801   ⟹   XP_038397729
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0738,602,254 - 38,605,581 (-)NCBI
RefSeq Acc Id: XM_038579576   ⟹   XP_038435504
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha738,132,918 - 38,135,788 (-)NCBI
RefSeq Acc Id: XM_038605928   ⟹   XP_038461856
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0738,330,845 - 38,333,218 (-)NCBI
RefSeq Acc Id: XM_038670634   ⟹   XP_038526562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0738,485,283 - 38,487,650 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038338496 (Get FASTA)   NCBI Sequence Viewer  
  XP_038397729 (Get FASTA)   NCBI Sequence Viewer  
  XP_038435504 (Get FASTA)   NCBI Sequence Viewer  
  XP_038461856 (Get FASTA)   NCBI Sequence Viewer  
  XP_038526562 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00040018796.1
RefSeq Acc Id: XP_038338496   ⟸   XM_038482568
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038461856   ⟸   XM_038605928
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038526562   ⟸   XM_038670634
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SCN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038435504   ⟸   XM_038579576
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038397729   ⟸   XM_038541801
- Peptide Label: isoform X3
- UniProtKB: A0A8C0SCN1 (UniProtKB/TrEMBL)
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00040011701 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00040021655.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  MIXL1 UniProtKB/TrEMBL
NCBI Gene LOC111096717 ENTREZGENE
PANTHER HOMEOBOX PROTEIN MIXL UniProtKB/TrEMBL
  HOMEOBOX PROTEIN MIXL1 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain-like UniProtKB/TrEMBL
UniProt A0A8C0SCN1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-12 MIXL1  Mix paired-like homeobox  LOC111096717  uncharacterized LOC111096717  Symbol and/or name change 5135510 APPROVED