Mixl1 (Mix1 homeobox-like 1 (Xenopus laevis)) - Rat Genome Database

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Gene: Mixl1 (Mix1 homeobox-like 1 (Xenopus laevis)) Mus musculus
Analyze
Symbol: Mixl1
Name: Mix1 homeobox-like 1 (Xenopus laevis)
RGD ID: 1320667
MGI Page MGI
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and protein homodimerization activity. Involved in several processes, including gastrulation; hematopoietic progenitor cell differentiation; and positive regulation of mesoderm development. Localizes to chromatin and nucleus. Is expressed in several structures, including early embryo; egg cylinder; embryo mesoderm; metanephros; and primitive streak. Orthologous to human MIXL1 (Mix paired-like homeobox); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein MIXL1; homeodomain protein MIX; Mix-like; mix.1 homeobox-like protein; MIX1 homeobox-like protein 1; Mm; Mm1; mMix; Mml
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,520,608 - 180,524,599 (-)NCBIGRCm39mm39
GRCm39 Ensembl1180,520,608 - 180,524,599 (-)Ensembl
GRCm381180,693,043 - 180,697,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,693,043 - 180,697,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,623,174 - 182,627,165 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,529,718 - 182,533,709 (-)NCBImm8
Celera1187,754,505 - 187,758,493 (-)NCBICelera
Cytogenetic Map1H4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA)
nucleoplasm  (ISO)
nucleus  (IDA)

References

Additional References at PubMed
PMID:10349636   PMID:10495285   PMID:11042159   PMID:11076861   PMID:11084649   PMID:11217851   PMID:12095687   PMID:12117810   PMID:12381664   PMID:12431380   PMID:12477932   PMID:12619131  
PMID:14648878   PMID:15215210   PMID:15618518   PMID:15673572   PMID:16141072   PMID:16141073   PMID:16403910   PMID:16887818   PMID:17060613   PMID:17151016   PMID:17568773   PMID:18056627  
PMID:18171685   PMID:18287559   PMID:18403408   PMID:19038793   PMID:19711456   PMID:20059953   PMID:20211142   PMID:20573702   PMID:20630950   PMID:21267068   PMID:21731673   PMID:21873635  
PMID:22164283   PMID:22265737   PMID:22912414   PMID:23487311   PMID:23651855   PMID:23747598   PMID:24475213   PMID:24596343   PMID:24632399   PMID:24698271   PMID:24952961   PMID:25192056  
PMID:25739401   PMID:25912690   PMID:27760115   PMID:28087629   PMID:28322735   PMID:29915126   PMID:30559277   PMID:31371508  


Genomics

Comparative Map Data
Mixl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,520,608 - 180,524,599 (-)NCBIGRCm39mm39
GRCm39 Ensembl1180,520,608 - 180,524,599 (-)Ensembl
GRCm381180,693,043 - 180,697,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,693,043 - 180,697,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv371182,623,174 - 182,627,165 (-)NCBIGRCm37mm9NCBIm37
MGSCv361182,529,718 - 182,533,709 (-)NCBImm8
Celera1187,754,505 - 187,758,493 (-)NCBICelera
Cytogenetic Map1H4NCBI
MIXL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1226,223,618 - 226,227,054 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1226,223,618 - 226,227,060 (+)EnsemblGRCh38hg38GRCh38
GRCh381226,223,664 - 226,227,060 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,411,365 - 226,414,761 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,478,006 - 224,480,136 (+)NCBINCBI36hg18NCBI36
Build 341222,718,117 - 222,720,248NCBI
Celera1199,602,144 - 199,604,274 (+)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1196,928,386 - 196,930,516 (+)NCBIHuRef
CHM1_11227,684,062 - 227,687,491 (+)NCBICHM1_1
Mixl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21392,422,031 - 92,426,065 (-)NCBI
Rnor_6.0 Ensembl1397,278,258 - 97,282,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,973,041 - 98,975,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01397,278,258 - 97,282,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013103,973,473 - 103,977,504 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,427,597 - 96,431,628 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,618,156 - 96,620,542 (-)NCBI
Celera1391,967,784 - 91,971,815 (-)NCBICelera
Cytogenetic Map13q26NCBI
Mixl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955489418,650 - 422,428 (+)NCBIChiLan1.0ChiLan1.0
MIXL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11206,671,344 - 206,679,904 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01201,682,488 - 201,686,358 (+)NCBIMhudiblu_PPA_v0panPan3
MIXL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,651,481 - 38,652,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha738,132,918 - 38,135,788 (-)NCBI
ROS_Cfam_1.0738,485,283 - 38,487,650 (-)NCBI
UMICH_Zoey_3.1738,323,946 - 38,326,305 (-)NCBI
UNSW_CanFamBas_1.0738,330,845 - 38,333,218 (-)NCBI
UU_Cfam_GSD_1.0738,602,254 - 38,605,581 (-)NCBI
Mixl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,756,331 - 51,762,377 (-)NCBI
SpeTri2.0NW_0049365262,984,900 - 2,989,494 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIXL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,102,395 - 14,104,982 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,102,273 - 14,105,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21015,667,360 - 15,670,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIXL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,542,923 - 3,546,561 (-)NCBI
ChlSab1.1 Ensembl253,544,169 - 3,546,305 (-)Ensembl
Mixl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624807322,723 - 325,089 (+)NCBI

Position Markers
UniSTS:234289  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381180,693,490 - 180,693,818UniSTSGRCm38
MGSCv371182,623,621 - 182,623,949UniSTSGRCm37
Celera1187,754,952 - 187,755,280UniSTS
Cytogenetic Map1H4UniSTS
Mixl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H4UniSTS
cM Map184.46UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1104005680191493284Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128800000181500000Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147249520183092234Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147249520189251027Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147391821181391821Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147391821181391821Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9148047933182048047Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1148047933182048047Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150317922188627115Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150317922188627115Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150317922188627115Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150929168184929353Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151358674185358833Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined152007542186007711Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152211172186211344Mouse
4142119Bpq21_mblood pressure QTL 21 (mouse)Not determined1152211172186211344Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152211172186211344Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152211172186211344Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152211172186211344Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152211172186211344Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152305175186305175Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152305175186305175Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152919071186706423Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153848421187848536Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153885284187885284Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154582944188582944Mouse
1301164Tir3c_mtrypansomiasis infection response 3c (mouse)Not determined1154804480188804689Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155175373189175373Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155175373189175373Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155175373189175373Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155698056189699966Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155699229189699330Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155706491186261999Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155888654189888802Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155888654189888802Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155888654189888802Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155893961189895041Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined156004198190004325Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1156004198190004325Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1156004198190004325Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1156004198190004325Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156774467189571420Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156774467189571420Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157628733191628870Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157628733191628870Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157628733191628870Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157628733191628870Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157628733191628870Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157628733191628870Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157628733191628870Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158641251192641372Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158641251192641372Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158641251192641372Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158641251192641372Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158641251192641372Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158641251192641372Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159435007193435127Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160269591194269591Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160269591194269591Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160285202194285317Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161373696195373830Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162317638194429220Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1163149528186261999Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164315658190802075Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1166092111195471971Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167730317195471971Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167730317195471971Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167730317195471971Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167758517191493284Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167929168189571420Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1168222387195471971Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168481626195471971Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170647303195471971Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171804480189571420Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171804480192998742Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1172250913195471971Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172571254195471971Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172571254195471971Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172571254195471971Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172800000195471971Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172900000195471971Mouse
10045887Cplaq13_mcircadian period of locomotor activity 13 (mouse)Not determined1173004198181573094Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175529010195471971Mouse
1300960Hpic2_mhaloperidol induced catalepsy 2 (mouse)Not determined1175641251181573094Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175641251194429220Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:564
Count of miRNA genes:390
Interacting mature miRNAs:431
Transcripts:ENSMUST00000027778
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000027778   ⟹   ENSMUSP00000027778
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1180,693,043 - 180,697,034 (-)Ensembl
RefSeq Acc Id: NM_013729   ⟹   NP_038757
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391180,520,608 - 180,524,599 (-)NCBI
GRCm381180,693,043 - 180,697,034 (-)NCBI
MGSCv371182,623,174 - 182,627,165 (-)RGD
Celera1187,754,505 - 187,758,493 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038757   ⟸   NM_013729
- UniProtKB: Q9WUI0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027778   ⟸   ENSMUST00000027778

Promoters
RGD ID:6875926
Promoter ID:EPDNEW_M1414
Type:single initiation site
Name:Mixl1_1
Description:Mus musculus Mix1 homeobox-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381180,696,968 - 180,697,028EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351322 AgrOrtholog
Ensembl Genes ENSMUSG00000026497 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000027778 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027778 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  MIXL1 UniProtKB/Swiss-Prot
KEGG Report mmu:27217 UniProtKB/Swiss-Prot
MGD MGI:1351322 ENTREZGENE
NCBI Gene 27217 ENTREZGENE
PANTHER PTHR47656 UniProtKB/Swiss-Prot
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Mixl1 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt MIXL1_MOUSE UniProtKB/Swiss-Prot
  Q3UUT2_MOUSE UniProtKB/TrEMBL
  Q9WUI0 ENTREZGENE
UniProt Secondary Q9QZ61 UniProtKB/Swiss-Prot