Mvb12a (multivesicular body subunit 12A)

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Gene: Mvb12a (multivesicular body subunit 12A) Mus musculus

Analyze

Symbol:

Mvb12a

Name:

multivesicular body subunit 12A

RGD ID:

1331926

MGI Page

MGI

Description:

Predicted to have lipid binding activity and ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and virus maturation. Predicted to localize to several cellular components, including ESCRT I complex; Golgi apparatus; and centrosome. Orthologous to human MVB12A (multivesicular body subunit 12A); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

1110012M11Rik; ESCRT-I complex subunit MVB12A; Fam12; Fam125a; family with sequence similarity 125, member A; MGC99951

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MVB12A (multivesicular body subunit 12A)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Mvb12a (multivesicular body subunit 12A)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Mvb12a (multivesicular body subunit 12A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MVB12A (multivesicular body subunit 12A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MVB12A (multivesicular body subunit 12A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mvb12a (multivesicular body subunit 12A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MVB12A (multivesicular body subunit 12A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MVB12A (multivesicular body subunit 12A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mvb12a (multivesicular body subunit 12A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Mvb12a (multivesicular body subunit 12A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	MVB12A (multivesicular body subunit 12A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	mvb12a (multivesicular body subunit 12A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|ZFIN)
Caenorhabditis elegans (roundworm):	mvb-12	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Drosophila melanogaster (fruit fly):	Mvb12	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,995,552 - 72,000,670 (+)	NCBI	GRCm39		mm39
GRCm38	8	71,542,907 - 71,548,026 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	71,542,922 - 71,548,085 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,066,829 - 74,071,925 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	74,471,919 - 74,477,015 (+)	NCBI			mm8
Celera	8	74,053,836 - 74,058,731 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

human immunodeficiency virus infectious disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (EXP)

4-hydroxyphenyl retinamide (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (ISO)

cadmium dichloride (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cytarabine (ISO)

dibutyl phthalate (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

folic acid (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

panobinostat (ISO)

paracetamol (EXP)

phenylmercury acetate (ISO)

propanal (ISO)

SB 431542 (ISO)

tetrachloroethene (EXP)

thapsigargin (EXP)

thimerosal (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endosome to lysosome transport via multivesicular body sorting pathway (IBA)

protein transport (IEA)

receptor catabolic process (IBA)

regulation of epidermal growth factor receptor signaling pathway (IBA,ISO)

viral budding (IBA,ISO)

virus maturation (IBA,ISO)

Cellular Component

centrosome (ISO)

cytoplasm (IEA)

cytoskeleton (IEA)

cytosol (IBA,ISO)

endosome (IEA)

ESCRT I complex (IBA,ISO)

Golgi apparatus (ISO)

membrane (IEA)

nucleoplasm (ISO)

nucleus (IEA)

vesicle (ISO)

Molecular Function

lipid binding (ISO)

protein binding (ISO)

SH3 domain binding (IEA)

ubiquitin binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

References

References - curated


1.	MGD and Homologene mouse data transfer
2.	Pipeline to import KEGG annotations from KEGG into RGD
3.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11125038	PMID:11217851	PMID:12466851	PMID:12477932	PMID:14610273	PMID:15489334	PMID:15782199	PMID:16141072
PMID:16141073	PMID:21677750	PMID:21873635	PMID:32325033

Genomics

Comparative Map Data

Mvb12a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,995,552 - 72,000,670 (+)	NCBI	GRCm39		mm39
GRCm38	8	71,542,907 - 71,548,026 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	71,542,922 - 71,548,085 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,066,829 - 74,071,925 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	74,471,919 - 74,477,015 (+)	NCBI			mm8
Celera	8	74,053,836 - 74,058,731 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI

MVB12A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	17,405,722 - 17,433,724 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	17,405,741 - 17,425,332 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	17,516,512 - 17,536,141 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	17,391,912 - 17,397,140 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	19	17,432,663 - 17,437,892 (+)	NCBI
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	17,096,852 - 17,102,055 (+)	NCBI		HuRef
CHM1_1	19	17,516,004 - 17,535,650 (+)	NCBI		CHM1_1

Mvb12a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	16	19,973,611 - 19,978,479 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	19,973,636 - 19,978,478 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,833,926 - 19,838,784 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,726,945 - 18,731,772 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	18,726,942 - 18,731,769 (+)	NCBI
Celera	16	18,457,206 - 18,462,083 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Mvb12a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	839,328 - 840,664 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	839,328 - 842,160 (-)	NCBI	ChiLan1.0	ChiLan1.0

MVB12A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	17,880,073 - 17,885,546 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	17,880,073 - 17,894,044 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	16,906,449 - 16,911,717 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

MVB12A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	45,365,852 - 45,370,014 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	45,365,850 - 45,370,114 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Mvb12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936596	3,478,142 - 3,481,968 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MVB12A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	60,271,026 - 60,275,971 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	60,271,020 - 60,275,972 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MVB12A
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	15,917,568 - 15,923,168 (+)	NCBI
ChlSab1.1 Ensembl	6	15,917,539 - 15,923,361 (+)	Ensembl

Mvb12a
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624908	562,380 - 582,765 (-)	NCBI

Position Markers

UniSTS:235924

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	71,547,898 - 71,548,188	UniSTS	GRCm38
MGSCv37	8	74,071,797 - 74,072,087	UniSTS	GRCm37
Celera	8	74,058,603 - 74,058,893	UniSTS
Cytogenetic Map	8	C1	UniSTS

RH140984

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	71,547,764 - 71,547,966	UniSTS	GRCm38
MGSCv37	8	74,071,663 - 74,071,865	UniSTS	GRCm37
Celera	8	74,058,469 - 74,058,671	UniSTS
Cytogenetic Map	8	C1	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32016544	117238700	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	34642776	114837007	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36163000	92728652	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37400000	109600000	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	39709256	94689598	Mouse
1301544	Iba3_m	induction of brown adipocytes 3 (mouse)			Not determined		8	44294880	78295025	Mouse
1301717	Adip4_m	adiposity 4 (mouse)			Not determined		8	47637030	81637146	Mouse
10766453	Char11_m	P. chabaudi malaria resistance QTL 11 (mouse)					8	47637030	81637146	Mouse
1301441	Skull11_m	skull morphology 11 (mouse)			Not determined		8	47737134	81737254	Mouse
1357715	Alaa3_m	alopecia areata 3 (mouse)			Not determined		8	48792939	82793021	Mouse
14746987	Manh64_m	mandible shape 64 (mouse)					8	50053306	84053306	Mouse
14747005	Mancz7_m	mandible centroid size 7 (mouse)					8	50053306	84053306	Mouse
14700686	Civq3_m	cerebral infarct volume QTL 3 (mouse)					8	51882191	85882191	Mouse
1301506	Aevm1_m	autoimmune extremity vasculitis in MRL mice 1 (mouse)			Not determined		8	54287817	88287993	Mouse
1301952	Im3_m	immunoregulatory 3 (mouse)			Not determined		8	54706614	88706763	Mouse
10412287	Carg3_m	Candida albicans resistance gene 3 (mouse)			Not determined		8	55545028	89545028	Mouse
11353828	Gf7_m	gonadal fat pad weight 7 (mouse)					8	58201479	92201479	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	58409776	92409776	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	60786850	94786976	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			63460107	97460107	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	63939547	97939696	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	65357768	99357920	Mouse
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	65600207	99600347	Mouse
10766466	Char12_m	P. chabaudi malaria resistance QTL 12 (mouse)					8	68269827	82600347	Mouse
1301767	Fcsa2_m	femoral cross-sectional area 2 (mouse)			Not determined		8	70305375	104305495	Mouse
4142283	Imraq2_m	immune response to AAV2 QTL 2 (mouse)			Not determined		8	70305375	104305495	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71102903	105103009	Mouse
4141395	Char2a_m	P. chabaudi malaria resistance QTL 2a (mouse)			Not determined			71136783	90202598	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71287817	123895615	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71287817	123895615	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	71396181	105396393	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	231
Count of miRNA genes:	201
Interacting mature miRNAs:	221
Transcripts:	ENSMUST00000034272
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_028617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011242330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_030243804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC162033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK003644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK199858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC020119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC027419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC096439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000034272 ⟹ ENSMUSP00000034272

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	71,542,930 - 71,548,026 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000212234

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	71,542,939 - 71,543,555 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000212326 ⟹ ENSMUSP00000148449

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	71,542,943 - 71,545,720 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000212336

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	71,546,732 - 71,548,085 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000212341

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	71,542,928 - 71,544,521 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000212659

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	71,544,859 - 71,545,951 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000212954 ⟹ ENSMUSP00000148630

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	71,542,922 - 71,545,576 (+)	Ensembl

RefSeq Acc Id:

NM_028617 ⟹ NP_082893

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	71,995,574 - 72,000,670 (+)	NCBI
GRCm38	8	71,542,930 - 71,548,026 (+)	NCBI
MGSCv37	8	74,066,829 - 74,071,925 (+)	RGD
Celera	8	74,053,836 - 74,058,731 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GGTCCCTCCGAGGGCTGTAGCTGCCTTCTGAGCTCCCAGGAAGGATGGATCCCGGGACGGACTC
GGCGCCGCTTGCTGGCTTGGTTTGGTCGTCGGCCTCGGCGCCGCCGCCGCCGGGTTTCAGCGCG
ATCACCTGCACCGTGGAGGGCGGGACGGCCAGCTTCGGCCGAGGCTTCGCGCAGAAAGCCGGCT
ACTTCCTGTGCCTGAGCACGCTGGGCATCCCGGAGAACCCTCAGGACAATGTGGTAGTGGACAT
GCAGATCGTGATGGACAAGGGCCCACTGCCGTCAGGCTTCTCTGCAGTCAACGACCCTCAGGAT
ATCAAGGCCTCTGTGTCCAAGAAGAAACGCATGTGTGTGAAGCTGATGCCCCTGGGGACAGCTG
ACGTGGTTGTGAGTGACGTGAAGCTGAGTGGGAAGACTAAGACCGTGCCTGGATACCTGCGTGT
GGGGGACATTGGTGGCTTTGCCATCTGGTGCAAGAAATCCAAAGCCCCAAGGCCGGTGCCCAAG
CCCCGCACGCTCAGCCAGGACATGCGAGGCCTCTCCCTGGACCCACCCAAAGAGCCCAGCAAAG
GAAGCCACCCAGAGCGGACCCTGTCCAGGCTGGGCTCTCGGGCCTCCACTCTACGGAGGACCGA
CTCCATCTATGAGGCATCCAGTCTCTATGGCATATCAGCCATGGACGGAGTCCCCTTTACCCTG
CACCCAAGATTTGAGGGCAAGAGCTGTGGGCCCTTGAACTTGTCTGCTTTTGGGGACCTGACGA
TCAAATCACTGGCAGACATTGAGAAGGAGTATAACTATGGCTTCGTGGTGGAGAAGACTGCAGC
TGCACGCCTGCCTCCCAGCGTCTCATAGACCAGCCCCAGGTGCCACCTGGTCGCCTCCTGCCTT
GCAGATACTGCTGATTGACACCCAGCCTCTCTGTCCAACTGCTTGCACAAAGGGTCTCTTGCCT
GGTGGTGCAGGGGCGGCCTGGGCAGAGCAGTGGCCTTCTCTCACAGAAGTCTGTGTCTAGAGGC
CACATATGCACCAGCAGTAAACGCTACCTGGGACCCACAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_011242330 ⟹ XP_011240632

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	71,995,552 - 72,000,670 (+)	NCBI
GRCm38	8	71,542,907 - 71,548,026 (+)	NCBI

Sequence:

show sequence

TGGGAGTTGTAGTCCGAGGTTCCGGTCCCTCCGAGGGCTGTAGCTGCCTTCTGAGCTCCCAGGA
AGGATGGATCCCGGGACGGACTCGGCGCCGCTTGCTGGCTTGGTTTGGTCGTCGGCCTCGGCGC
CGCCGCCGCCGGGTTTCAGCGCGATCACCTGCACCGTGGAGGGCGGGACGGCCAGCTTCGGCCG
AGGCTTCGCGCAGAAAGCCGGCTACTTCCTGTGCCTGAGCACGCTGGGCATCCCGGAGGCTCTT
GCACTGCGAGTCCACCTGGAACTGGCTTCCCCTGTTCTCTGCATAGCTCAGCCTCCCCTCTCCC
TTCTCCCCTGCCTGACCCAGCTGCCCGCCTCCCCGATGGTGCTTGGTTCTCTCGGTGTCTTTAG
TGACCGCTGGCAGGCTGCCGTGCAGAGGGTCAGAGGCCTCTGTGTCCAAGAAGAAACGCATGTG
TGTGAAGCTGATGCCCCTGGGGACAGCTGACGTGGTTGTGAGTGACGTGAAGCTGAGTGGGAAG
ACTAAGACCGTGCCTGGATACCTGCGTGTGGGGGACATTGGTGGCTTTGCCATCTGGTGCAAGA
AATCCAAAGCCCCAAGGCCGGTGCCCAAGCCCCGCACGCTCAGCCAGGACATGCGAGGCCTCTC
CCTGGACCCACCCAAAGAGCCCAGCAAAGGAAGCCACCCAGAGCGGACCCTGTCCAGGCTGGGC
TCTCGGGCCTCCACTCTACGGAGGACCGACTCCATCTATGAGGCATCCAGTCTCTATGGCATAT
CAGCCATGGACGGAGTCCCCTTTACCCTGCACCCAAGATTTGAGGGCAAGAGCTGTGGGCCCTT
GAACTTGTCTGCTTTTGGGGACCTGACGATCAAATCACTGGCAGACATTGAGAAGGAGTATAAC
TATGGCTTCGTGGTGGAGAAGACTGCAGCTGCACGCCTGCCTCCCAGCGTCTCATAGACCAGCC
CCAGGTGCCACCTGGTCGCCTCCTGCCTTGCAGATACTGCTGATTGACACCCAGCCTCTCTGTC
CAACTGCTTGCACAAAGGGTCTCTTGCCTGGTGGTGCAGGGGCGGCCTGGGCAGAGCAGTGGCC
TTCTCTCACAGAAGTCTGTGTCTAGAGGCCACATATGCACCAGCAGTAAACGCTACCTGGGACC
CAC

hide sequence

RefSeq Acc Id:

XM_030243804 ⟹ XP_030099664

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	71,995,552 - 72,000,670 (+)	NCBI
GRCm38	8	71,542,907 - 71,548,026 (+)	NCBI

Sequence:

show sequence

TGGGAGTTGTAGTCCGAGGTTCCGGTCCCTCCGAGGGCTGTAGCTGCCTTCTGAGCTCCCAGGA
AGGATGGATCCCGGGACGGACTCGGCGCCGCTTGCTGGCTTGGTTTGGTCGTCGGCCTCGGCGC
CGCCGCCGCCGGGTTTCAGCGCGATCACCTGCACCGTGGAGGGCGGGACGGCCAGCTTCGGCCG
AGGCTTCGCGCAGAAAGCCGGCTACTTCCTGTGCCTGAGCACGCTGGGCATCCCGGAGAACCCT
CAGGACAATGTGGTAGTGGACATGCAGATCGTGATGGACAAGGGCCCACTGCCGTCAGGCTTCT
CTGCAGTCAACGACCCTCAGGATATCAGCTCTTGCACTGCGAGTCCACCTGGAACTGGCTTCCC
CTGTTCTCTGCATAGCTCAGCCTCCCCTCTCCCTTCTCCCCTGCCTGACCCAGCTGCCCGCCTC
CCCGATGGTGCTTGGTTCTCTCGGTGTCTTTAGTGACCGCTGGCAGGCTGCCGTGCAGAGGGTC
AGAGGCCTCTGTGTCCAAGAAGAAACGCATGTGTGTGAAGCTGATGCCCCTGGGGACAGCTGAC
GTGGTTGTGAGTGACGTGAAGCTGAGTGGGAAGACTAAGACCGTGCCTGGATACCTGCGTGTGG
GGGACATTGGTGGCTTTGCCATCTGGTGCAAGAAATCCAAAGCCCCAAGGCCGGTGCCCAAGCC
CCGCACGCTCAGCCAGGACATGCGAGGCCTCTCCCTGGACCCACCCAAAGAGCCCAGCAAAGGA
AGCCACCCAGAGCGGACCCTGTCCAGGCTGGGCTCTCGGGCCTCCACTCTACGGAGGACCGACT
CCATCTATGAGGCATCCAGTCTCTATGGCATATCAGCCATGGACGGAGTCCCCTTTACCCTGCA
CCCAAGATTTGAGGGCAAGAGCTGTGGGCCCTTGAACTTGTCTGCTTTTGGGGACCTGACGATC
AAATCACTGGCAGACATTGAGAAGGAGTATAACTATGGCTTCGTGGTGGAGAAGACTGCAGCTG
CACGCCTGCCTCCCAGCGTCTCATAGACCAGCCCCAGGTGCCACCTGGTCGCCTCCTGCCTTGC
AGATACTGCTGATTGACACCCAGCCTCTCTGTCCAACTGCTTGCACAAAGGGTCTCTTGCCTGG
TGGTGCAGGGGCGGCCTGGGCAGAGCAGTGGCCTTCTCTCACAGAAGTCTGTGTCTAGAGGCCA
CATATGCACCAGCAGTAAACGCTACCTGGGACCCAC

hide sequence

Protein Sequences


Protein RefSeqs	NP_082893	(Get FASTA)	NCBI Sequence Viewer
	XP_011240632	(Get FASTA)	NCBI Sequence Viewer
	XP_030099664	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH20119	(Get FASTA)	NCBI Sequence Viewer
	AAH27419	(Get FASTA)	NCBI Sequence Viewer
	AAH87734	(Get FASTA)	NCBI Sequence Viewer
	EDL28933	(Get FASTA)	NCBI Sequence Viewer
	EDL28934	(Get FASTA)	NCBI Sequence Viewer
	Q78HU3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_082893 ⟸ NM_028617

- UniProtKB:

Q78HU3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDPGTDSAPLAGLVWSSASAPPPPGFSAITCTVEGGTASFGRGFAQKAGYFLCLSTLGIPENPQ
DNVVVDMQIVMDKGPLPSGFSAVNDPQDIKASVSKKKRMCVKLMPLGTADVVVSDVKLSGKTKT
VPGYLRVGDIGGFAIWCKKSKAPRPVPKPRTLSQDMRGLSLDPPKEPSKGSHPERTLSRLGSRA
STLRRTDSIYEASSLYGISAMDGVPFTLHPRFEGKSCGPLNLSAFGDLTIKSLADIEKEYNYGF
VVEKTAAARLPPSVS

hide sequence

RefSeq Acc Id:	XP_011240632 ⟸ XM_011242330
- Peptide Label:	isoform X1
- Sequence:	show sequence MDPGTDSAPLAGLVWSSASAPPPPGFSAITCTVEGGTASFGRGFAQKAGYFLCLSTLGIPEALA LRVHLELASPVLCIAQPPLSLLPCLTQLPASPMVLGSLGVFSDRWQAAVQRVRGLCVQEETHVC EADAPGDS hide sequence

RefSeq Acc Id:	XP_030099664 ⟸ XM_030243804
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSMUSP00000034272 ⟸ ENSMUST00000034272

RefSeq Acc Id:

ENSMUSP00000148630 ⟸ ENSMUST00000212954

RefSeq Acc Id:

ENSMUSP00000148449 ⟸ ENSMUST00000212326

Protein Domains

MABP UMA

Promoters

RGD ID:

8667407

Promoter ID:

EPDNEW_M11735

Type:

initiation region

Name:

Mvb12a_1

Description:

Mus musculus multivesicular body subunit 12A , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	71,542,922 - 71,542,982	EPDNEW

RGD ID:

6842467

Promoter ID:

MM_KWN:54794

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day2, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_028617, UC009MDS.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	74,066,536 - 74,067,072 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1920961	AgrOrtholog
Ensembl Genes	ENSMUSG00000031813	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000034272	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000148449	UniProtKB/TrEMBL
	ENSMUSP00000148630	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000034272	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000212326	UniProtKB/TrEMBL
	ENSMUST00000212954	UniProtKB/TrEMBL
InterPro	MABP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MVB12A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MVB12A/B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UMA	UniProtKB/Swiss-Prot
KEGG Report	mmu:73711	UniProtKB/Swiss-Prot
MGD	MGI:1920961	ENTREZGENE
NCBI Gene	73711	ENTREZGENE
PANTHER	PTHR31612	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DUF2464	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mvb12a	PhenoGen
PROSITE	MABP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UMA	UniProtKB/Swiss-Prot
UniGene	Mm.307770	ENTREZGENE
UniProt	A0A1D5RLP2_MOUSE	UniProtKB/TrEMBL
	A0A1D5RM52_MOUSE	UniProtKB/TrEMBL
	MB12A_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-01-08	Mvb12a	multivesicular body subunit 12A	Fam125a	family with sequence similarity 125, member A	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)