Mvb12a (multivesicular body subunit 12A) - Rat Genome Database
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Gene: Mvb12a (multivesicular body subunit 12A) Mus musculus
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Symbol: Mvb12a
Name: multivesicular body subunit 12A
RGD ID: 1331926
MGI Page MGI
Description: Predicted to have lipid binding activity and ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and virus maturation. Predicted to localize to several cellular components, including ESCRT I complex; Golgi apparatus; and centrosome. Orthologous to human MVB12A (multivesicular body subunit 12A); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1110012M11Rik; ESCRT-I complex subunit MVB12A; Fam12; Fam125a; family with sequence similarity 125, member A; MGC99951
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,995,552 - 72,000,670 (+)NCBIGRCm39mm39
GRCm38871,542,907 - 71,548,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,542,922 - 71,548,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,066,829 - 74,071,925 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,471,919 - 74,477,015 (+)NCBImm8
Celera874,053,836 - 74,058,731 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (IBA,ISO)
endosome  (IEA)
ESCRT I complex  (IBA,ISO)
Golgi apparatus  (ISO)
membrane  (IEA)
nucleoplasm  (ISO)
nucleus  (IEA)
vesicle  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:21677750   PMID:21873635   PMID:32325033  


Genomics

Comparative Map Data
Mvb12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,995,552 - 72,000,670 (+)NCBIGRCm39mm39
GRCm38871,542,907 - 71,548,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,542,922 - 71,548,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,066,829 - 74,071,925 (+)NCBIGRCm37mm9NCBIm37
MGSCv36874,471,919 - 74,477,015 (+)NCBImm8
Celera874,053,836 - 74,058,731 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
MVB12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,405,722 - 17,433,724 (+)EnsemblGRCh38hg38GRCh38
GRCh381917,405,741 - 17,425,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,516,512 - 17,536,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,391,912 - 17,397,140 (+)NCBINCBI36hg18NCBI36
Celera1917,432,663 - 17,437,892 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,096,852 - 17,102,055 (+)NCBIHuRef
CHM1_11917,516,004 - 17,535,650 (+)NCBICHM1_1
Mvb12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,973,611 - 19,978,479 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,973,636 - 19,978,478 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,833,926 - 19,838,784 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,726,945 - 18,731,772 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,726,942 - 18,731,769 (+)NCBI
Celera1618,457,206 - 18,462,083 (+)NCBICelera
Cytogenetic Map16p14NCBI
Mvb12a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524839,328 - 840,664 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955524839,328 - 842,160 (-)NCBIChiLan1.0ChiLan1.0
MVB12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,880,073 - 17,885,546 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,880,073 - 17,894,044 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,906,449 - 16,911,717 (+)NCBIMhudiblu_PPA_v0panPan3
MVB12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,365,852 - 45,370,014 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,365,850 - 45,370,114 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mvb12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,478,142 - 3,481,968 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MVB12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,271,026 - 60,275,971 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,271,020 - 60,275,972 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MVB12A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,917,568 - 15,923,168 (+)NCBI
ChlSab1.1 Ensembl615,917,539 - 15,923,361 (+)Ensembl
Mvb12a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908562,380 - 582,765 (-)NCBI

Position Markers
UniSTS:235924  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,547,898 - 71,548,188UniSTSGRCm38
MGSCv37874,071,797 - 74,072,087UniSTSGRCm37
Celera874,058,603 - 74,058,893UniSTS
Cytogenetic Map8C1UniSTS
RH140984  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,547,764 - 71,547,966UniSTSGRCm38
MGSCv37874,071,663 - 74,071,865UniSTSGRCm37
Celera874,058,469 - 74,058,671UniSTS
Cytogenetic Map8C1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:201
Interacting mature miRNAs:221
Transcripts:ENSMUST00000034272
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034272   ⟹   ENSMUSP00000034272
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,542,930 - 71,548,026 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212234
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,542,939 - 71,543,555 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212326   ⟹   ENSMUSP00000148449
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,542,943 - 71,545,720 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212336
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,546,732 - 71,548,085 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212341
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,542,928 - 71,544,521 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212659
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,544,859 - 71,545,951 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212954   ⟹   ENSMUSP00000148630
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,542,922 - 71,545,576 (+)Ensembl
RefSeq Acc Id: NM_028617   ⟹   NP_082893
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,995,574 - 72,000,670 (+)NCBI
GRCm38871,542,930 - 71,548,026 (+)NCBI
MGSCv37874,066,829 - 74,071,925 (+)RGD
Celera874,053,836 - 74,058,731 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242330   ⟹   XP_011240632
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,995,552 - 72,000,670 (+)NCBI
GRCm38871,542,907 - 71,548,026 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243804   ⟹   XP_030099664
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,995,552 - 72,000,670 (+)NCBI
GRCm38871,542,907 - 71,548,026 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082893   ⟸   NM_028617
- UniProtKB: Q78HU3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240632   ⟸   XM_011242330
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030099664   ⟸   XM_030243804
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000034272   ⟸   ENSMUST00000034272
RefSeq Acc Id: ENSMUSP00000148630   ⟸   ENSMUST00000212954
RefSeq Acc Id: ENSMUSP00000148449   ⟸   ENSMUST00000212326
Protein Domains
MABP   UMA

Promoters
RGD ID:8667407
Promoter ID:EPDNEW_M11735
Type:initiation region
Name:Mvb12a_1
Description:Mus musculus multivesicular body subunit 12A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,542,922 - 71,542,982EPDNEW
RGD ID:6842467
Promoter ID:MM_KWN:54794
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_028617,   UC009MDS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,066,536 - 74,067,072 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920961 AgrOrtholog
Ensembl Genes ENSMUSG00000031813 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034272 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148449 UniProtKB/TrEMBL
  ENSMUSP00000148630 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034272 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000212326 UniProtKB/TrEMBL
  ENSMUST00000212954 UniProtKB/TrEMBL
InterPro MABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MVB12A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MVB12A/B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UMA UniProtKB/Swiss-Prot
KEGG Report mmu:73711 UniProtKB/Swiss-Prot
MGD MGI:1920961 ENTREZGENE
NCBI Gene 73711 ENTREZGENE
PANTHER PTHR31612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF2464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mvb12a PhenoGen
PROSITE MABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UMA UniProtKB/Swiss-Prot
UniGene Mm.307770 ENTREZGENE
UniProt A0A1D5RLP2_MOUSE UniProtKB/TrEMBL
  A0A1D5RM52_MOUSE UniProtKB/TrEMBL
  MB12A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-08 Mvb12a  multivesicular body subunit 12A  Fam125a  family with sequence similarity 125, member A  Symbol and/or name change 5135510 APPROVED