Agmo (alkylglycerol monooxygenase) - Rat Genome Database

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Gene: Agmo (alkylglycerol monooxygenase) Mus musculus
Analyze
Symbol: Agmo
Name: alkylglycerol monooxygenase
RGD ID: 1323813
MGI Page MGI
Description: Enables glyceryl-ether monooxygenase activity. Involved in triglyceride biosynthetic process. Is active in endoplasmic reticulum membrane. Orthologous to human AGMO (alkylglycerol monooxygenase).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A530016O06Rik; AI790538; Tmem195; transmembrane protein 195
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391237,291,638 - 37,632,201 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1237,291,640 - 37,632,201 (+)EnsemblGRCm39 Ensembl
GRCm381237,241,639 - 37,581,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1237,241,641 - 37,582,202 (+)EnsemblGRCm38mm10GRCm38
MGSCv371237,968,226 - 38,308,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361237,752,045 - 37,914,494 (+)NCBIMGSCv36mm8
Celera1238,679,380 - 39,021,590 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1216.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:20643956   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23743196  
PMID:25675482   PMID:32554809   PMID:33726865   PMID:33844153   PMID:35537527   PMID:36690320   PMID:38355793  


Genomics

Comparative Map Data
Agmo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391237,291,638 - 37,632,201 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1237,291,640 - 37,632,201 (+)EnsemblGRCm39 Ensembl
GRCm381237,241,639 - 37,581,932 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1237,241,641 - 37,582,202 (+)EnsemblGRCm38mm10GRCm38
MGSCv371237,968,226 - 38,308,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361237,752,045 - 37,914,494 (+)NCBIMGSCv36mm8
Celera1238,679,380 - 39,021,590 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1216.84NCBI
AGMO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38715,117,223 - 15,562,015 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl715,200,317 - 15,562,015 (-)EnsemblGRCh38hg38GRCh38
GRCh37715,239,942 - 15,601,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36715,206,468 - 15,568,165 (-)NCBINCBI36Build 36hg18NCBI36
Celera715,219,639 - 15,581,346 (-)NCBICelera
Cytogenetic Map7p21.2NCBI
HuRef715,123,252 - 15,486,473 (-)NCBIHuRef
CHM1_1715,239,321 - 15,601,040 (-)NCBICHM1_1
T2T-CHM13v2.0715,250,047 - 15,695,255 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2715,291,248 - 15,654,751 (-)NCBI
Agmo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8659,713,495 - 60,044,851 (+)NCBIGRCr8
mRatBN7.2653,986,236 - 54,317,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl653,986,292 - 54,317,623 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx654,286,337 - 54,629,952 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0654,601,226 - 54,944,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0654,073,814 - 54,404,607 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0656,846,859 - 57,193,918 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl656,846,789 - 57,193,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0666,448,763 - 66,793,166 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4656,042,873 - 56,380,045 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1656,045,999 - 56,382,545 (+)NCBI
Celera653,118,342 - 53,442,669 (+)NCBICelera
Cytogenetic Map6q21NCBI
Agmo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541018,713,191 - 18,881,824 (-)NCBIChiLan1.0ChiLan1.0
AGMO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2620,032,513 - 20,444,733 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1768,357,236 - 68,769,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0715,863,957 - 16,219,070 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1715,194,384 - 15,549,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl715,180,426 - 15,549,016 (-)Ensemblpanpan1.1panPan2
AGMO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11429,863,011 - 30,208,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1429,864,318 - 30,324,006 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1429,386,911 - 29,730,252 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01429,779,813 - 30,123,841 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1429,778,469 - 30,123,636 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11429,875,816 - 30,219,301 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01429,602,388 - 29,946,221 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01429,912,164 - 30,256,735 (-)NCBIUU_Cfam_GSD_1.0
Agmo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511874,180,126 - 74,504,534 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365461,855,801 - 2,179,461 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365461,993,477 - 2,179,623 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGMO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl984,551,889 - 84,894,843 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1984,551,874 - 84,931,146 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2993,083,980 - 93,427,801 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGMO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12142,525,086 - 42,877,237 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2142,525,847 - 42,876,970 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604261,619,472 - 61,972,804 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agmo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473914,587,427 - 14,775,057 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agmo
12431 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:886
Count of miRNA genes:532
Interacting mature miRNAs:644
Transcripts:ENSMUST00000049874, ENSMUST00000159998, ENSMUST00000160158, ENSMUST00000160390, ENSMUST00000160768
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
12879483Asp1_maudiogenic seizure prone 1 (mouse)123528549646801733Mouse

Markers in Region
AI790538  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381237,581,783 - 37,581,932UniSTSGRCm38
MGSCv371238,308,370 - 38,308,519UniSTSGRCm37
Celera1239,021,441 - 39,021,590UniSTS
Cytogenetic Map12A3UniSTS
Whitehead/MRC_RH12350.01UniSTS
30.MMHAP9FRB12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381237,383,016 - 37,383,208UniSTSGRCm38
MGSCv371238,109,603 - 38,109,795UniSTSGRCm37
Celera1238,822,552 - 38,822,744UniSTS
Cytogenetic Map12A3UniSTS
Whitehead_YAC9 UniSTS
D17867  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381237,581,962 - 37,582,157UniSTSGRCm38
MGSCv371238,308,549 - 38,308,744UniSTSGRCm37
Celera1239,021,620 - 39,021,815UniSTS
Cytogenetic Map12A3UniSTS
Whitehead_YAC9 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000049874   ⟹   ENSMUSP00000051441
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1237,291,640 - 37,632,201 (+)Ensembl
GRCm38.p6 Ensembl1237,241,641 - 37,582,202 (+)Ensembl
Ensembl Acc Id: ENSMUST00000159998   ⟹   ENSMUSP00000123801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1237,291,859 - 37,471,746 (+)Ensembl
GRCm38.p6 Ensembl1237,241,860 - 37,421,747 (+)Ensembl
Ensembl Acc Id: ENSMUST00000160158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1237,291,778 - 37,454,227 (+)Ensembl
GRCm38.p6 Ensembl1237,241,779 - 37,404,228 (+)Ensembl
Ensembl Acc Id: ENSMUST00000160390   ⟹   ENSMUSP00000125639
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1237,292,041 - 37,615,392 (+)Ensembl
GRCm38.p6 Ensembl1237,242,042 - 37,565,393 (+)Ensembl
Ensembl Acc Id: ENSMUST00000160768   ⟹   ENSMUSP00000124044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1237,291,749 - 37,294,502 (+)Ensembl
GRCm38.p6 Ensembl1237,241,750 - 37,244,503 (+)Ensembl
Ensembl Acc Id: ENSMUST00000221949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1237,495,184 - 37,632,199 (+)Ensembl
GRCm38.p6 Ensembl1237,445,185 - 37,582,200 (+)Ensembl
RefSeq Acc Id: NM_178767   ⟹   NP_848882
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391237,291,638 - 37,631,931 (+)NCBI
GRCm381237,241,639 - 37,581,932 (+)NCBI
MGSCv371237,968,226 - 38,308,519 (+)RGD
Celera1238,679,380 - 39,021,590 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011243875   ⟹   XP_011242177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391237,291,778 - 37,471,270 (+)NCBI
GRCm381237,241,779 - 37,421,271 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004937507
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391237,291,778 - 37,632,201 (+)NCBI
Sequence:
RefSeq Acc Id: NP_848882   ⟸   NM_178767
- UniProtKB: Q8C7H5 (UniProtKB/Swiss-Prot),   Q3TR15 (UniProtKB/Swiss-Prot),   Q8CAA6 (UniProtKB/Swiss-Prot),   Q8BS35 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011242177   ⟸   XM_011243875
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000123801   ⟸   ENSMUST00000159998
Ensembl Acc Id: ENSMUSP00000125639   ⟸   ENSMUST00000160390
Ensembl Acc Id: ENSMUSP00000124044   ⟸   ENSMUST00000160768
Ensembl Acc Id: ENSMUSP00000051441   ⟸   ENSMUST00000049874
Protein Domains
Fatty acid hydroxylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BS35-F1-model_v2 AlphaFold Q8BS35 1-447 view protein structure

Promoters
RGD ID:8678198
Promoter ID:EPDNEW_M17116
Type:initiation region
Name:Agmo_2
Description:Mus musculus alkylglycerol monooxygenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17117  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381237,241,639 - 37,241,699EPDNEW
RGD ID:8678172
Promoter ID:EPDNEW_M17117
Type:initiation region
Name:Agmo_1
Description:Mus musculus alkylglycerol monooxygenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17116  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381237,241,881 - 37,241,941EPDNEW
RGD ID:6822632
Promoter ID:MM_KWN:11527
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:NM_178767,   UC007NKG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361237,968,196 - 37,968,696 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442495 AgrOrtholog
Ensembl Genes ENSMUSG00000050103 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049874 ENTREZGENE
  ENSMUST00000049874.14 UniProtKB/Swiss-Prot
  ENSMUST00000159998 ENTREZGENE
  ENSMUST00000159998.8 UniProtKB/Swiss-Prot
  ENSMUST00000160390.2 UniProtKB/Swiss-Prot
  ENSMUST00000160768.8 UniProtKB/TrEMBL
InterPro Fatty_acid_hydroxylase UniProtKB/Swiss-Prot
  Sterol_Desaturase/TMEM195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319660 UniProtKB/Swiss-Prot
MGD MGI:2442495 ENTREZGENE
NCBI Gene 319660 ENTREZGENE
PANTHER ALKYLGLYCEROL MONOOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROL DESATURASE-RELATED PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FA_hydroxylase UniProtKB/Swiss-Prot
PhenoGen Agmo PhenoGen
UniProt ALKMO_MOUSE UniProtKB/Swiss-Prot
  E0CYN0_MOUSE UniProtKB/TrEMBL
  Q3TR15 ENTREZGENE
  Q8BS35 ENTREZGENE
  Q8C7H5 ENTREZGENE
  Q8CAA6 ENTREZGENE
UniProt Secondary Q3TR15 UniProtKB/Swiss-Prot
  Q8C7H5 UniProtKB/Swiss-Prot
  Q8CAA6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Agmo  alkylglycerol monooxygenase  Tmem195  transmembrane protein 195  Symbol and/or name change 5135510 APPROVED