Fktn (fukutin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Fktn (fukutin) Mus musculus
Analyze
Symbol: Fktn
Name: fukutin
RGD ID: 1320792
MGI Page MGI
Description: Enables phosphotransferase activity, for other substituted phosphate groups. Acts upstream of or within several processes, including basement membrane organization; brain development; and skeletal muscle fiber differentiation. Located in Golgi membrane. Is expressed in several structures, including central nervous system; future brain; genitourinary system; sensory organ; and spinal ganglion. Used to study Fukuyama congenital muscular dystrophy and muscular dystrophy-dystroglycanopathy type B1. Human ortholog(s) of this gene implicated in dilated cardiomyopathy (multiple) and muscular dystrophy (multiple). Orthologous to human FKTN (fukutin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D830030O17Rik; Fcmd; Fukut; Fukuyama type congenital muscular dystrophy (fukutin); Fukuyama type congenital muscular dystrophy homolog; ribitol-5-phosphate transferase; ribitol-5-phosphate transferase FKTN
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39453,713,745 - 53,765,785 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl453,713,998 - 53,777,890 (+)EnsemblGRCm39 Ensembl
GRCm38453,714,107 - 53,765,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl453,713,998 - 53,777,890 (+)EnsemblGRCm38mm10GRCm38
MGSCv37453,727,054 - 53,776,143 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36453,735,282 - 53,784,371 (+)NCBIMGSCv36mm8
Celera453,671,147 - 53,720,238 (+)NCBICelera
Cytogenetic Map4B2NCBI
cM Map428.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cis-Golgi network  (ISO,ISS)
endoplasmic reticulum  (ISO,ISS)
Golgi apparatus  (IDA,ISO)
Golgi membrane  (IBA,IDA,ISO,ISS)
nucleus  (ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal developmental patterning  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal muscle precursor cell morphology  (IAGP)
abnormal muscle precursor cell physiology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal Reichert's membrane morphology  (IAGP)
abnormal Reichert's membrane thickness  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal visceral yolk sac cavity morphology  (IAGP)
absent Reichert's membrane  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
decreased body weight  (IAGP)
decreased embryo size  (IAGP)
decreased grip strength  (IAGP)
decreased satellite cell number  (IAGP)
decreased skeletal muscle weight  (IAGP)
dystrophic muscle  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality between implantation and placentation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
impaired basement membrane formation  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased collagen deposition in the muscles  (IAGP)
increased embryonic epiblast cell apoptosis  (IAGP)
increased variability of skeletal muscle fiber size  (IAGP)
myositis  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
skeletal muscle atrophy  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
skeletal muscle fiber necrosis  (IAGP)
skeletal muscle fibrosis  (IAGP)
skeletal muscle necrosis  (IAGP)
weakness  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Founder Fukutin mutation causes Walker-Warburg syndrome in four Ashkenazi Jewish families. Chang W, etal., Prenat Diagn. 2009 Jun;29(6):560-9. doi: 10.1002/pd.2238.
2. Functional requirements for fukutin-related protein in the Golgi apparatus. Esapa CT, etal., Hum Mol Genet 2002 Dec 15;11(26):3319-31.
3. Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue. Fortunato MJ, etal., PLoS One. 2014 May 13;9(5):e97567. doi: 10.1371/journal.pone.0097567. eCollection 2014.
4. Fukutin gene mutations in steroid-responsive limb girdle muscular dystrophy. Godfrey C, etal., Ann Neurol. 2006 Nov;60(5):603-10.
5. Selective deficiency of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy. Hayashi YK, etal., Neurology. 2001 Jul 10;57(1):115-21.
6. An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Kobayashi K, etal., Nature. 1998 Jul 23;394(6691):388-92.
7. Novel mutations and genotype-phenotype relationships in 107 families with Fukuyama-type congenital muscular dystrophy (FCMD). Kondo-Iida E, etal., Hum Mol Genet. 1999 Nov;8(12):2303-9.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Fukutin gene mutations cause dilated cardiomyopathy with minimal muscle weakness. Murakami T, etal., Ann Neurol. 2006 Nov;60(5):597-602.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Further evidence of Fukutin mutations as a cause of childhood onset limb-girdle muscular dystrophy without mental retardation. Puckett RL, etal., Neuromuscul Disord. 2009 May;19(5):352-6. doi: 10.1016/j.nmd.2009.03.001. Epub 2009 Apr 1.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Fukutin protein is expressed in neurons of the normal developing human brain but is reduced in Fukuyama-type congenital muscular dystrophy brain. Saito Y, etal., Ann Neurol. 2000 Jun;47(6):756-64.
18. Four Caucasian patients with mutations in the fukutin gene and variable clinical phenotype. Vuillaumier-Barrot S, etal., Neuromuscul Disord. 2009 Mar;19(3):182-8. doi: 10.1016/j.nmd.2008.12.005.
19. Fukutin mutations in non-Japanese patients with congenital muscular dystrophy: less severe mutations predominate in patients with a non-Walker-Warburg phenotype. Yis U, etal., Neuromuscul Disord. 2011 Jan;21(1):20-30. doi: 10.1016/j.nmd.2010.08.007. Epub 2010 Oct 18.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12408965   PMID:12467726   PMID:12477932   PMID:12670716   PMID:12783852   PMID:14610273   PMID:15351499  
PMID:15489334   PMID:15614444   PMID:15837576   PMID:15907289   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16778019   PMID:17034757   PMID:17326765   PMID:17376776   PMID:18287559  
PMID:19017726   PMID:19501082   PMID:20117215   PMID:20944549   PMID:21873635   PMID:21979053   PMID:22275357   PMID:22922256   PMID:23562821   PMID:24256719   PMID:24722207   PMID:25198651  
PMID:25661440   PMID:26751696   PMID:26923585   PMID:27257474   PMID:27496765   PMID:29360985   PMID:31848331   PMID:32433954   PMID:32833332   PMID:34127677  


Genomics

Comparative Map Data
Fktn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39453,713,745 - 53,765,785 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl453,713,998 - 53,777,890 (+)EnsemblGRCm39 Ensembl
GRCm38453,714,107 - 53,765,785 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl453,713,998 - 53,777,890 (+)EnsemblGRCm38mm10GRCm38
MGSCv37453,727,054 - 53,776,143 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36453,735,282 - 53,784,371 (+)NCBIMGSCv36mm8
Celera453,671,147 - 53,720,238 (+)NCBICelera
Cytogenetic Map4B2NCBI
cM Map428.74NCBI
FKTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389105,558,130 - 105,641,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9105,558,122 - 105,653,820 (+)EnsemblGRCh38hg38GRCh38
GRCh379108,320,411 - 108,403,399 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369107,360,232 - 107,443,220 (+)NCBINCBI36Build 36hg18NCBI36
Build 349105,399,978 - 105,482,953NCBI
Celera978,825,571 - 78,908,566 (+)NCBICelera
Cytogenetic Map9q31.2NCBI
HuRef977,921,830 - 78,004,880 (+)NCBIHuRef
CHM1_19108,467,406 - 108,550,392 (+)NCBICHM1_1
T2T-CHM13v2.09117,732,799 - 117,815,798 (+)NCBIT2T-CHM13v2.0
Fktn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8573,134,746 - 73,191,772 (+)NCBIGRCr8
mRatBN7.2568,339,803 - 68,396,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl568,340,028 - 68,396,409 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx570,227,762 - 70,281,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0572,044,733 - 72,098,826 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0572,016,575 - 72,070,620 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0570,522,001 - 70,578,270 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl570,528,688 - 70,578,273 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0574,697,518 - 74,754,106 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4571,155,051 - 71,208,525 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1571,168,040 - 71,211,945 (+)NCBI
Celera567,234,078 - 67,287,987 (+)NCBICelera
Cytogenetic Map5q24NCBI
Fktn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541920,933,662 - 20,994,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541920,933,662 - 20,994,793 (-)NCBIChiLan1.0ChiLan1.0
FKTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21133,736,875 - 33,835,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1933,739,744 - 33,839,021 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0976,723,071 - 76,821,611 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19104,849,447 - 104,926,414 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9104,849,496 - 104,925,422 (+)Ensemblpanpan1.1panPan2
FKTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11161,394,002 - 61,462,056 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1161,405,034 - 61,461,396 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1159,854,900 - 59,922,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01162,541,606 - 62,598,262 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1162,530,493 - 62,597,602 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11161,048,756 - 61,131,662 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01161,079,051 - 61,135,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01161,760,632 - 61,835,969 (+)NCBIUU_Cfam_GSD_1.0
Fktn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947176,585,787 - 176,685,702 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365596,581,622 - 6,581,948 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049365596,619,531 - 6,670,727 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365596,612,318 - 6,680,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11246,852,387 - 246,916,650 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21276,542,569 - 276,576,326 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FKTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11233,872,165 - 33,964,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1233,900,362 - 33,953,377 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660358,677,300 - 8,770,035 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fktn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247585,792,514 - 5,877,709 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247585,750,804 - 5,877,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fktn
1927 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2724
Count of miRNA genes:764
Interacting mature miRNAs:1030
Transcripts:ENSMUST00000061771, ENSMUST00000107638, ENSMUST00000128667
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301213Lgth3_mbody length 3 (mouse)Not determined45010026284100408Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1558794Agnm1_mautoimmune glomerulonephritis in MRL 1 (mouse)Not determined44633264655755867Mouse
13207572Spir2_mStreptococcus pneumoniae infection resistance 2 (mouse)45068279588510637Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
13432173Actrse1_mactivity response to saline/ethanol 1 (mouse)45328712856987128Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
13432189Actrse2_mactivity response to saline/ethanol 2 (mouse)45298712854587128Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
1301995Lprm1_mlymphoproliferation modifier 1 (mouse)Not determined45010026284100408Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse

Markers in Region
Fktn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38453,720,007 - 53,720,209UniSTSGRCm38
MGSCv37453,732,879 - 53,733,081UniSTSGRCm37
Celera453,676,973 - 53,677,175UniSTS
Cytogenetic Map4B2UniSTS
cM Map422.0UniSTS
Fktn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001363126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_156448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003954949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003954950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003954951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003954952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_881064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_881065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB077383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB077384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ511807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL807745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL844585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ699942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000061771   ⟹   ENSMUSP00000061489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl453,720,005 - 53,763,271 (+)Ensembl
GRCm38.p6 Ensembl453,720,005 - 53,763,271 (+)Ensembl
Ensembl Acc Id: ENSMUST00000107638   ⟹   ENSMUSP00000138774
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl453,714,163 - 53,762,787 (+)Ensembl
GRCm38.p6 Ensembl453,714,163 - 53,762,787 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128667   ⟹   ENSMUSP00000114699
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl453,713,998 - 53,765,785 (+)Ensembl
GRCm38.p6 Ensembl453,713,998 - 53,765,785 (+)Ensembl
Ensembl Acc Id: ENSMUST00000221657   ⟹   ENSMUSP00000152867
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl453,714,188 - 53,765,785 (+)Ensembl
GRCm38.p6 Ensembl453,714,188 - 53,765,785 (+)Ensembl
Ensembl Acc Id: ENSMUST00000222290   ⟹   ENSMUSP00000152154
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl453,714,163 - 53,777,890 (+)Ensembl
GRCm38.p6 Ensembl453,714,163 - 53,777,890 (+)Ensembl
RefSeq Acc Id: NM_001363126   ⟹   NP_001350055
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,154 - 53,765,785 (+)NCBI
GRCm38453,714,154 - 53,765,785 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001363127   ⟹   NP_001350056
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,154 - 53,765,785 (+)NCBI
GRCm38453,714,154 - 53,765,785 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001363128   ⟹   NP_001350057
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,154 - 53,765,785 (+)NCBI
GRCm38453,714,154 - 53,765,785 (+)NCBI
Sequence:
RefSeq Acc Id: NM_139309   ⟹   NP_647470
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,154 - 53,765,785 (+)NCBI
GRCm38453,714,154 - 53,765,785 (+)NCBI
MGSCv37453,727,054 - 53,776,143 (+)RGD
Celera453,671,147 - 53,720,238 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_156448
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,154 - 53,765,785 (+)NCBI
GRCm38453,714,154 - 53,765,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006537941   ⟹   XP_006538004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,765,785 (+)NCBI
GRCm38453,714,194 - 53,765,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006537943   ⟹   XP_006538006
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,765,785 (+)NCBI
GRCm38453,714,190 - 53,761,301 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030253578   ⟹   XP_030109438
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,106 - 53,765,785 (+)NCBI
GRCm38453,714,107 - 53,765,785 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003954949
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,765,784 (+)NCBI
GRCm38453,714,181 - 53,765,784 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003954950
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,106 - 53,765,784 (+)NCBI
GRCm38453,714,107 - 53,765,784 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003954951
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,765,784 (+)NCBI
GRCm38453,714,188 - 53,765,784 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003954952
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,714,106 - 53,765,784 (+)NCBI
GRCm38453,714,107 - 53,765,784 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004941904
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,748,480 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004941905
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,765,784 (+)NCBI
Sequence:
RefSeq Acc Id: XR_881064
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,742,580 (+)NCBI
GRCm38453,714,188 - 53,742,580 (+)NCBI
Sequence:
RefSeq Acc Id: XR_881065
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39453,713,745 - 53,742,526 (+)NCBI
GRCm38453,714,188 - 53,742,526 (+)NCBI
Sequence:
RefSeq Acc Id: NP_647470   ⟸   NM_139309
- Peptide Label: isoform 1
- UniProtKB: Q8VD64 (UniProtKB/Swiss-Prot),   Q8R507 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006538004   ⟸   XM_006537941
- Peptide Label: isoform X1
- UniProtKB: A0A1Y7VM91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538006   ⟸   XM_006537943
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030109438   ⟸   XM_030253578
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001350057   ⟸   NM_001363128
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001350056   ⟸   NM_001363127
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001350055   ⟸   NM_001363126
- Peptide Label: isoform 2
- UniProtKB: Q3UMQ5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000152154   ⟸   ENSMUST00000222290
Ensembl Acc Id: ENSMUSP00000138774   ⟸   ENSMUST00000107638
Ensembl Acc Id: ENSMUSP00000061489   ⟸   ENSMUST00000061771
Ensembl Acc Id: ENSMUSP00000114699   ⟸   ENSMUST00000128667
Ensembl Acc Id: ENSMUSP00000152867   ⟸   ENSMUST00000221657
Protein Domains
LicD/FKTN/FKRP nucleotidyltransferase   Ribitol-5-phosphate transferase FKTN N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R507-F1-model_v2 AlphaFold Q8R507 1-461 view protein structure

Promoters
RGD ID:6883460
Promoter ID:EPDNEW_M5181
Type:multiple initiation site
Name:Fktn_1
Description:Mus musculus fukutin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38453,714,154 - 53,714,214EPDNEW
RGD ID:6835330
Promoter ID:MM_KWN:37674
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000061771,   ENSMUST00000098071,   OTTMUST00000016204,   OTTMUST00000016205,   UC008SXF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36453,726,809 - 53,727,309 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2179507 AgrOrtholog
Ensembl Genes ENSMUSG00000028414 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000061771.9 UniProtKB/Swiss-Prot
  ENSMUST00000107638.4 UniProtKB/TrEMBL
  ENSMUST00000128667 ENTREZGENE
  ENSMUST00000128667.8 UniProtKB/Swiss-Prot
  ENSMUST00000221657 ENTREZGENE
  ENSMUST00000221657.2 UniProtKB/TrEMBL
  ENSMUST00000222290.2 UniProtKB/TrEMBL
InterPro FKTN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fukutin-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LicD_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:246179 UniProtKB/Swiss-Prot
MGD MGI:2179507 ENTREZGENE
NCBI Gene 246179 ENTREZGENE
PANTHER FUKUTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15407 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FKTN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LicD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fktn PhenoGen
UniProt A0A1Y7VM91 ENTREZGENE, UniProtKB/TrEMBL
  FKTN_MOUSE UniProtKB/Swiss-Prot
  Q3UMQ5 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4R2_MOUSE UniProtKB/TrEMBL
  Q8R507 ENTREZGENE
  Q8VD64 ENTREZGENE
UniProt Secondary Q8VD64 UniProtKB/Swiss-Prot