Akr1e1 (aldo-keto reductase family 1, member E1)

Gene: Akr1e1 (aldo-keto reductase family 1, member E1) Mus musculus

Analyze

Symbol:

Akr1e1

Name:

aldo-keto reductase family 1, member E1

RGD ID:

1320024

MGI Page

MGI

Description:

Predicted to enable alditol:NADP+ 1-oxidoreductase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; embryo; and retina. Orthologous to human AKR1E2 (aldo-keto reductase family 1 member E2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1,5-anhydro-D-fructose reductase; 1810061I10Rik; AF reductase; Akr1e2; aldo-keto reductase family 1 member C-like protein 2; aldo-keto reductase family 1 member E1; aldo-keto reductase family 1 member E2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AKR1E2 (aldo-keto reductase family 1 member E2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Akr1e2 (aldo-keto reductase family 1, member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Akr1e2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Akr1e2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AKR1E2 (aldo-keto reductase family 1 member E2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Akr1e2 (aldo-keto reductase family 1, member E2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AKR1E2 (aldo-keto reductase family 1 member E2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6084	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GCY1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GRE3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)
Caenorhabditis elegans (roundworm):	Y39G8B.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YPR1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	akr1b1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	4,641,122 - 4,659,163 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	4,640,749 - 4,659,173 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	4,591,123 - 4,609,164 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	4,590,750 - 4,609,174 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	4,591,736 - 4,608,410 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	4,591,777 - 4,608,381 (-)	NCBI		MGSCv36	mm8
Celera	13	4,571,016 - 4,587,416 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	2.57	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hypoparathyroidism-deafness-renal disease syndrome (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

amitrole (ISO)

Aroclor 1254 (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

carbon nanotube (EXP)

chlordecone (EXP)

clofibrate (EXP)

cocaine (ISO)

dorsomorphin (ISO)

epoxiconazole (EXP)

fipronil (ISO)

glafenine (ISO)

malathion (ISO)

methimazole (ISO)

methotrexate (EXP)

N-nitrosodiethylamine (ISO)

nickel sulfate (ISO)

ozone (EXP,ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (EXP)

phenobarbital (EXP)

quercetin (ISO)

rotenone (ISO)

SB 431542 (ISO)

sulfadimethoxine (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

trichloroethene (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA)

cytosol (IBA)

Molecular Function

1,5-anhydro-D-fructose reductase activity (IEA)

aldose reductase (NADPH) activity (IBA)

oxidoreductase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:9059651	PMID:10349636	PMID:11042159	PMID:11076861	PMID:12477932	PMID:12562828	PMID:14681479	PMID:15226823	PMID:15489334	PMID:16141072	PMID:16141073
PMID:18323634	PMID:21677750	PMID:21873635

Genomics

Comparative Map Data

Akr1e1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	4,641,122 - 4,659,163 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	4,640,749 - 4,659,173 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	4,591,123 - 4,609,164 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	4,590,750 - 4,609,174 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	4,591,736 - 4,608,410 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	4,591,777 - 4,608,381 (-)	NCBI		MGSCv36	mm8
Celera	13	4,571,016 - 4,587,416 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	2.57	NCBI

AKR1E2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	4,824,973 - 4,873,237 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	4,786,629 - 4,848,062 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	4,868,369 - 4,890,254 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	4,858,402 - 4,880,254 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	4,858,425 - 4,880,249	NCBI
Celera	10	4,811,323 - 4,833,177 (+)	NCBI		Celera
Cytogenetic Map	10	p15.1	NCBI
HuRef	10	4,802,403 - 4,824,264 (+)	NCBI		HuRef
CHM1_1	10	4,868,717 - 4,890,574 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	4,825,330 - 4,873,573 (+)	NCBI		T2T-CHM13v2.0

Akr1e2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	70,645,835 - 70,660,366 (+)	NCBI		GRCr8
mRatBN7.2	17	65,735,909 - 65,750,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	65,735,943 - 65,750,441 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,231,629 - 69,246,118 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,060,477 - 73,074,961 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	67,103,460 - 67,117,949 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	69,365,437 - 69,379,944 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	69,365,453 - 69,379,947 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,079,217 - 71,093,701 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,011,336 - 77,025,824 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,022,168 - 77,036,651 (+)	NCBI
Celera	17	65,268,655 - 65,283,123 (+)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

Akr1e2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	715,157 - 731,303 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	714,843 - 731,285 (-)	NCBI	ChiLan1.0	ChiLan1.0

AKR1E2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	17,376,873 - 17,506,881 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	17,379,890 - 17,404,469 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	10	4,850,001 - 4,872,215 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	4,850,001 - 4,872,210 (+)	Ensembl	panpan1.1		panPan2

AKR1E2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	30,694,119 - 30,706,693 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	30,694,249 - 30,706,637 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	27,723,671 - 27,736,248 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	31,074,880 - 31,087,459 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	31,074,883 - 31,087,898 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	28,164,234 - 28,176,774 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	29,001,557 - 29,014,106 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	29,725,464 - 29,738,044 (-)	NCBI		UU_Cfam_GSD_1.0

Akr1e2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	33,305,613 - 33,325,444 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	9,474,458 - 9,490,676 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	9,472,920 - 9,490,624 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKR1E2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	65,680,332 - 65,702,190 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	65,680,314 - 65,704,701 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	72,108,978 - 72,133,547 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AKR1E2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	5,012,793 - 5,033,946 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	5,013,032 - 5,033,947 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	10,188,747 - 10,209,140 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Akr1e1
592 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1187
Count of miRNA genes:	566
Interacting mature miRNAs:	677
Transcripts:	ENSMUST00000091848, ENSMUST00000110691, ENSMUST00000131982
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301890	Adip7_m	adiposity 7 (mouse)			Not determined		13	1	23454672	Mouse
1301227	Skull19_m	skull morphology 19 (mouse)			Not determined		13	1	23454672	Mouse
1301661	Tshp13_m	tooth shape 13 (mouse)			Not determined		13	1	23454672	Mouse
1301255	Cd4ts6_m	CD4 T cell subset 6 (mouse)			Not determined		13	168545	34168684	Mouse
10449140	Eosn2_m	eosinophil differential 2 (mouse)					13	221311	34221311	Mouse
15039338	Nmrs34_m	NAFLD-associated magnetic resonance shift 34 (mouse)					13	221311	34221311	Mouse
1301455	Bmd3_m	bone mineral density 3 (mouse)			Not determined		13	3477612	37477820	Mouse
10045624	Heal24_m	wound healing/regeneration (mouse)			Not determined		13	3477612	37477820	Mouse
10045625	Heal23_m	wound healing/regeneration 23 (mouse)			Not determined		13	3477612	37477820	Mouse
1301367	Twq1_m	testis weight QTL 1 (mouse)			Not determined		13	3615512	37615672	Mouse
1301733	Heal3_m	wound healing/regeneration 3 (mouse)			Not determined		13	3680200	37680343	Mouse
26884393	Humsd7_m	humerus midshaft diameter 7, 16 week (mouse)					13	3950000	76048119	Mouse
1558898	Hpi1_m	hapatic PMN infiltration 1 (mouse)			Not determined		13	4414025	53101640	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_018859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006516485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC164613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI893997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK002507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK007924	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK028605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC012692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ174229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U68535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000091848 ⟹ ENSMUSP00000089459

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	4,640,749 - 4,659,173 (-)	Ensembl
GRCm38.p6 Ensembl	13	4,590,750 - 4,609,174 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000110691 ⟹ ENSMUSP00000106319

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	4,640,756 - 4,659,173 (-)	Ensembl
GRCm38.p6 Ensembl	13	4,590,757 - 4,609,174 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000131982

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	4,651,276 - 4,659,133 (-)	Ensembl
GRCm38.p6 Ensembl	13	4,601,277 - 4,609,134 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000220936

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	4,657,084 - 4,659,117 (-)	Ensembl
GRCm38.p6 Ensembl	13	4,607,085 - 4,609,118 (-)	Ensembl

RefSeq Acc Id:

NM_018859 ⟹ NP_061347

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	4,642,489 - 4,659,163 (-)	NCBI
GRCm38	13	4,592,490 - 4,609,164 (-)	ENTREZGENE
MGSCv37	13	4,591,736 - 4,608,410 (-)	RGD
Celera	13	4,571,016 - 4,587,416 (-)	RGD
cM Map	13		ENTREZGENE

Sequence:

show sequence

AAAGTGCAGGAAGAGGCTGAGCCTTTGAGCAAAGGGGAACCATGGAAAACATCCCTACAGTGGG
CTTGGGCACCTGGAAGGCCTCCCCAGGAGAAGTGACTGATGCAGTTAAGTTGGCTATCAACCTG
GGCTACCGGCACTTCGATTGTGCTTACTTATACCACAATGAGAGCGAGGTGGGAATGGGAATCA
GTGAGAAGATCAAGGAGGGCGTGGTGAAGAGAGAGGATCTCTTTGTAGTCAGTAAGCTGTGGTG
TACCTGCCACAAGAAGTCATTGGTGAAAACAGCATGCACCAATACCCTGGAAGCCCTAAACTTG
GATTACCTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTGGGGAAAAAGATATCC
CTTTGGATCGCAATGGCAAGGTCATACCCAGTCACACCAGCTTTCTTGACACTTGGGAGGCCAT
GGAGGACCTGGTGTTTGAGGGTCTGGTGAAGAACCTTGGGGTGTCCAACTTTAACCATGAACAG
CTTGAGAGGCTTTTGGATAAGCCTGGTTTGAGGGTCAGGCCGATAACTAACCAGATTGAATGTC
ACCCATATCTTAATCAAAAGAAGCTGATTGATTTTTGCCATAAAAGAAATGTGTCTGTGACTGC
TTACCGTCCCCTCGGTGGCTCAGGAGGTGGGTTTCACTTGATGGATGATACTGTCATTCGAAAG
ATTGCAAAGAAGCATGGGAAGTCTCCTGCTCAGATTTTGATCCGATTTCAGATCCAAAGGAACT
TAATAGTGATCCCCAAATCTGTCACCCCAAGTCGGATTAGAGAGAATATCCAGGTATTTGATTT
TGAATTAACTGAAAAAGATATGGAGGAACTCCTCAGCCTAGACAAGAACCTCCGTTTGGCCACA
TTCCCCACAACTGAAAATCACCAAGACTATCCTTTCCACATAGAGTATTGAAAACAGCTTCACT
CGCCATCATCTCTGCTCAGCAGAACCAGATCACCAAGCTCTGATCCAACTCTGTAAAGGCTATG
TGGTCCCTGTGTGACCACAGCACCAGACACAGACACAGCCAAGAATGACAACAGAGTAAGAACA
AGGAAATCCTACCTAGAACAGAACCAGTTCAGAGAAAAAATAAAGACCTAGGTATGAGACAGGG
AAAGACCATGGAGGCTGTGGCTGCTTCCAAGTTGTTAGGAATAGCTGAGTGCAAAGAATATTGT
AATTGTTGTCAGTTAGTCGTAGCCTTTCTGGCTTCTATTTTCAGAAGTGAAATGCTAATTGCTC
ACGAATTAAAATTACCTTCACATTTTAAGAAAACCTGCTTGACAGAAGTGTTTGAATAATATGT
AAGATTTGAGAAATTAGTATAATTAATATCCATGAGATGGTTTCAGTAACCACGGACCTGAGGC
TGATTGTGTACTCTACTCTCCCATAATTTTCTAGATGATATTGAAGCAAAATTTTCCTGTATTT
AAGAGAAGAAAAGGCTATGGAGCTGAGACCCCAGCTCAGACAAAATGTGTTTTTAATTTTTCTT
ACTTAAAAACTTCTGTGTGACTCATTCCTACCTACCCTACTGCCATGCGAATGAGGATGGAATT
CCATAAAACTGATGGTCCAGAACTTGTTCCTGTCTGTATTATGAGAATATAAAGTATCACCATT
TTTTCCTAGCCAACTGTTAGTTGGAATAAAGAAAATGTGGGAGCCCCAAAAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_006516485 ⟹ XP_006516548

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	4,641,122 - 4,659,151 (-)	NCBI
GRCm38	13	4,591,123 - 4,609,157 (-)	NCBI

Sequence:

show sequence

GAGGCTGAGCCTTTGAGCAAAGGGGAACCATGGAAAACATCCCTACAGTGGGCTTGGGCACCTG
GAAGGCCTCCCCAGGAGAAGTGACTGATGCAGTTAAGTTGGCTATCAACCTGGGCTACCGGCAC
TTCGATTGTGCTTACTTATACCACAATGAGAGCGAGGTGGGAATGGGAATCAGTGAGAAGATCA
AGGAGGGCGTGGTGAAGAGAGAGGATCTCTTTGTAGTCAGTAAGCTGTGGTGTACCTGCCACAA
GAAGTCATTGGTGAAAACAGCATGCACCAATACCCTGGAAGCCCTAAACTTGGATTACCTGGAC
CTCTACCTCATACACTGGCCCATGGGTTTCAAGTCTTGTGATGGATGATGGCACAAACATCAGT
AAGCTTCTCTTCTTCTGGTTCTCACAGCCTGGGGAAAAAGATATCCCTTTGGATCGCAATGGCA
AGGTCATACCCAGTCACACCAGCTTTCTTGACACTTGGGAGGCCATGGAGGACCTGGTGTTTGA
GGGTCTGGTGAAGAACCTTGGGGTGTCCAACTTTAACCATGAACAGCTTGAGAGGCTTTTGGAT
AAGCCTGGTTTGAGGGTCAGGCCGATAACTAACCAGATTGAATGTCACCCATATCTTAATCAAA
AGAAGCTGATTGATTTTTGCCATAAAAGAAATGTGTCTGTGACTGCTTACCGTCCCCTCGGTGG
CTCAGGAGGTGGGTTTCACTTGATGGATGATACTGTCATTCGAAAGATTGCAAAGAAGCATGGG
AAGTCTCCTGCTCAGATTTTGATCCGATTTCAGATCCAAAGGAACTTAATAGTGATCCCCAAAT
CTGTCACCCCAAGTCGGATTAGAGAGAATATCCAGGTATTTGATTTTGAATTAACTGAAAAAGA
TATGGAGGAACTCCTCAGCCTAGACAAGAACCTCCGTTTGGCCACATTCCCCACAACTGAAAAT
CACCAAGACTATCCTTTCCACATAGAGTATTGAAAACAGCTTCACTCGCCATCATCTCTGCTCA
GCAGAACCAGATCACCAAGCTCTGATCCAACTCTGTAAAGGCTATGTGGTCCCTGTGTGACCAC
AGCACCAGACACAGACACAGCCAAGAATGACAACAGAGTAAGAACAAGGAAATCCTACCTAGAA
CAGAACCAGTTCAGAGAAAAAATAAAGACCTAGGTATGAGACAGGGAAAGACCATGGAGGCTGT
GGCTGCTTCCAAGTTGTTAGGAATAGCTGAGTGCAAAGAATATTGTAATTGTTGTCAGTTAGTC
GTAGCCTTTCTGGCTTCTATTTTCAGAAGTGAAATGCTAATTGCTCACGAATTAAAATTACCTT
CACATTTTAAGAAAACCTGCTTGACAGAAGTGTTTGAATAATATGTAAGATTTGAGAAATTAGT
ATAATTAATATCCATGAGATGGTTTCAGTAACCACGGACCTGAGGCTGATTGTGTACTCTACTC
TCCCATAATTTTCTAGATGATATTGAAGCAAAATTTTCCTGTATTTAAGAGAAGAAAAGGCTAT
GGAGCTGAGACCCCAGCTCAGACAAAATGTGTTTTTAATTTTTCTTACTTAAAAACTTCTGTGT
GACTCATTCCTACCTACCCTACTGCCATGCGAATGAGGATGGAATTCCATAAAACTGATGGTCC
AGAACTTGTTCCTGTCTGTATTATGAGAATATAAAGTATCACCATTTTTTCCTAGCCAACTGTT
AGTTGGAATAAAGAAAATGTGGGAGCCCCAATCCTCTGTGTAAAGACACTGACTATCCCGTGAG
AACATGCTTTCAAAGCAATTATTTTAAGAAACATACATAAATATTTCTTTCAGGCCACAGCCAT
GTCTACCCTATGAAAATCTAAATACCCCCTTCTTAGCTAGGGAAGCATGTGGTGTCTCATCTTA
TATCAAAGTTTTGTCATCCTGCTGCCTTCCAAACTACAGGGAACCTAAAACTTGCTGGTGATAT
AGAAACAATGATTTTCAACTTGATTCCCAAAAGGAAAATATTTTTATTAGATATATTCTCTATT
TACATTTCAAATGTTATCCCCTTTCCTATTTTCCCTTCTGAAAATTCTCTATCCTCTCCCCACA
CCACCTGCTCCCCAAAACACCCACTCCAGATTCCTTGTCCAGGCATTCCTGTATACTGGGGCAT
AAAACCTTCACAGGACCAAGGGCCTCTCCTCCCATTGATGACTGACTAGGCCATCCTCTCCTAC
ATATACAGCTAGAGCCACGAATCCCTCTGTGTGTTTTCTTTGATTGGTGGGTTAGTCCCAGGGA
GCTCTGGGGTTACTGGTTAGTTCATATTGTTGTTCCTCCTAGAGGTCTGCAAACCCCTTCAGCT
CCCGGGGAACTTTCTCTAGCTCCTTCATTGGGGACCCTATGCTTTTTCTAATGGATGACTGTGA
GCATCCACTTCTGTAATTTTTATCTCCTTCATTTCATCTTCGGAGAGAAGCAATGGGGGTCATT
TTGCTTTGTGGGGTTGTCTTCAGAACAGGCTTCCAAAGGCTAAGTGGAAGGTAACCATCTTCAG
AGCATCCTCAGACTTCTCCAAAATCTCTGTCACCCAGCCCTGACTTCAGGTCAGTTGCTGGCAA
ATGAACTTGTGATAGCTCCATGAGGGGGGACATGACTGTGTTTGTCTGGTCCTCGTCTTTCATC
CTGGCAACTCCAAACATGAGGCTGGCATACAGCTGGTGCTCAACAGTAATTTGCTGGGTTGCTG
TCCAATGGCCTCTACCAAGGAAGGAGAGAAAGTACAGTAGGGATGGCCCAAGCTTTGGAGCTGG
ACAGACTTGAGCTTAACCTTTCAGCCACCTTAACTTCAGACTGTGCTGTCCCTCTCACCCAACA
ACTTCACCACAGCACCTCAGCGAGCTCTTAGGAGTGTCAGGAAATAGCAGAAAAAGCCTTTAGT
CAACAAAGGCAGAAACTTCTGCTTTGTTTTCAGTCCACAAACATTTAGCACTCAACTATATGCA
AGATACTGTTCAAGCATAGTGGGCAATCCCATGTCATAATGGCTTCAGTTAGTTTTCGTGACAA
TCCTCTGAAGTTGGGTCTGCTTACCACCCTCCTTTGCAGCTTCAGGCTTTGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_061347	(Get FASTA)	NCBI Sequence Viewer
	XP_006516548	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB37274	(Get FASTA)	NCBI Sequence Viewer
	AAH12692	(Get FASTA)	NCBI Sequence Viewer
	BAB22152	(Get FASTA)	NCBI Sequence Viewer
	BAC26029	(Get FASTA)	NCBI Sequence Viewer
	EDL32255	(Get FASTA)	NCBI Sequence Viewer
	EDL32256	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000089459
	ENSMUSP00000089459.6
	ENSMUSP00000106319.4
GenBank Protein	Q9DCT1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_061347 ⟸ NM_018859

- UniProtKB:

O09125 (UniProtKB/Swiss-Prot), Q9DCT1 (UniProtKB/Swiss-Prot), Q8CEB6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MENIPTVGLGTWKASPGEVTDAVKLAINLGYRHFDCAYLYHNESEVGMGISEKIKEGVVKREDL
FVVSKLWCTCHKKSLVKTACTNTLEALNLDYLDLYLIHWPMGFKPGEKDIPLDRNGKVIPSHTS
FLDTWEAMEDLVFEGLVKNLGVSNFNHEQLERLLDKPGLRVRPITNQIECHPYLNQKKLIDFCH
KRNVSVTAYRPLGGSGGGFHLMDDTVIRKIAKKHGKSPAQILIRFQIQRNLIVIPKSVTPSRIR
ENIQVFDFELTEKDMEELLSLDKNLRLATFPTTENHQDYPFHIEY

hide sequence

RefSeq Acc Id:

XP_006516548 ⟸ XM_006516485

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDDGTNISKLLFFWFSQPGEKDIPLDRNGKVIPSHTSFLDTWEAMEDLVFEGLVKNLGVSNFNH
EQLERLLDKPGLRVRPITNQIECHPYLNQKKLIDFCHKRNVSVTAYRPLGGSGGGFHLMDDTVI
RKIAKKHGKSPAQILIRFQIQRNLIVIPKSVTPSRIRENIQVFDFELTEKDMEELLSLDKNLRL
ATFPTTENHQDYPFHIEY

hide sequence

RefSeq Acc Id:

ENSMUSP00000089459 ⟸ ENSMUST00000091848

RefSeq Acc Id:

ENSMUSP00000106319 ⟸ ENSMUST00000110691

Protein Domains

NADP-dependent oxidoreductase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9DCT1-F1-model_v2	AlphaFold	Q9DCT1	1-301	view protein structure

Promoters

RGD ID:

6823694

Promoter ID:

MM_KWN:13160

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6

Transcripts:

ENSMUST00000110692, OTTMUST00000068541, OTTMUST00000068542, OTTMUST00000068543

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	13	4,608,001 - 4,608,501 (-)	MPROMDB

RGD ID:

8679534

Promoter ID:

EPDNEW_M17798

Type:

initiation region

Name:

Akr1e1_1

Description:

Mus musculus aldo-keto reductase family 1, member E1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	13	4,609,157 - 4,609,217	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1914758	AgrOrtholog
Ensembl Genes	ENSMUSG00000045410	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000091848	ENTREZGENE
	ENSMUST00000091848.7	UniProtKB/Swiss-Prot
	ENSMUST00000110691.10	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.100	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Aldo/ket_reductase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Aldo/keto_reductase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADP_OxRdtase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:56043	UniProtKB/Swiss-Prot
MGD	MGI:1914758	ENTREZGENE
NCBI Gene	56043	ENTREZGENE
PANTHER	1,5-ANHYDRO-D-FRUCTOSE REDUCTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDO/KETO REDUCTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Akr1e1	PhenoGen
PIRSF	AKR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	ALDKETRDTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/Swiss-Prot
	ALDOKETO_REDUCTASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51430	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	AKCL2_MOUSE	UniProtKB/Swiss-Prot
	O09125	ENTREZGENE
	Q8CEB6	ENTREZGENE, UniProtKB/TrEMBL
	Q9DCT1	ENTREZGENE
UniProt Secondary	O09125	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar