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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320024
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1e1
Name: aldo-keto reductase family 1, member E1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1e1increases expressionISORGD:13200236480464CTDValproic Acid results in increased expression of AKR1E2 mRNA

PMID:26272509, PMID:28001369
Akr1e1increases methylationISORGD:13200236480464CTDValproic Acid results in increased methylation of AKR1E2 gene

PMID:29154799
Akr1e1multiple interactionsISORGD:13200236480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1E2 mRNA

PMID:27188386
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.