AKR1E2 (aldo-keto reductase family 1 member E2)

Gene: AKR1E2 (aldo-keto reductase family 1 member E2) Pan paniscus

Analyze

Symbol:

AKR1E2

Name:

aldo-keto reductase family 1 member E2

RGD ID:

11793717

Description:

ENCODES a protein that exhibits aldose reductase (NADPH) activity (inferred); oxidoreductase activity (inferred); ASSOCIATED WITH genetic disease (ortholog); hypoparathyroidism-deafness-renal disease syndrome (ortholog); schizophrenia (ortholog); FOUND IN cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

1,5-anhydro-D-fructose reductase

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	17,376,873 - 17,506,881 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	17,379,890 - 17,404,469 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	10	4,850,001 - 4,872,215 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	4,850,001 - 4,872,210 (+)	Ensembl	panpan1.1		panPan2

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hypoparathyroidism-deafness-renal disease syndrome (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytosol (IEA)

Molecular Function

aldose reductase (NADPH) activity (IEA)

oxidoreductase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

AKR1E2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	17,376,873 - 17,506,881 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	17,379,890 - 17,404,469 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	10	4,850,001 - 4,872,215 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	4,850,001 - 4,872,210 (+)	Ensembl	panpan1.1		panPan2

AKR1E2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	4,824,973 - 4,873,237 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	4,786,629 - 4,848,062 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	4,868,369 - 4,890,254 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	4,858,402 - 4,880,254 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	4,858,425 - 4,880,249	NCBI
Celera	10	4,811,323 - 4,833,177 (+)	NCBI		Celera
Cytogenetic Map	10	p15.1	NCBI
HuRef	10	4,802,403 - 4,824,264 (+)	NCBI		HuRef
CHM1_1	10	4,868,717 - 4,890,574 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	4,825,330 - 4,873,573 (+)	NCBI		T2T-CHM13v2.0

Akr1e1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	4,641,122 - 4,659,163 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	4,640,749 - 4,659,173 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	4,591,123 - 4,609,164 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	4,590,750 - 4,609,174 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	4,591,736 - 4,608,410 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	4,591,777 - 4,608,381 (-)	NCBI		MGSCv36	mm8
Celera	13	4,571,016 - 4,587,416 (-)	NCBI		Celera
Cytogenetic Map	13	A1	NCBI
cM Map	13	2.57	NCBI

Akr1e2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	70,645,835 - 70,660,366 (+)	NCBI		GRCr8
mRatBN7.2	17	65,735,909 - 65,750,441 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	65,735,943 - 65,750,441 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	69,231,629 - 69,246,118 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	73,060,477 - 73,074,961 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	67,103,460 - 67,117,949 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	69,365,437 - 69,379,944 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	69,365,453 - 69,379,947 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	71,079,217 - 71,093,701 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	77,011,336 - 77,025,824 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	77,022,168 - 77,036,651 (+)	NCBI
Celera	17	65,268,655 - 65,283,123 (+)	NCBI		Celera
Cytogenetic Map	17	q12.2	NCBI

Akr1e2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	715,157 - 731,303 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	714,843 - 731,285 (-)	NCBI	ChiLan1.0	ChiLan1.0

AKR1E2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	30,694,119 - 30,706,693 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	30,694,249 - 30,706,637 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	27,723,671 - 27,736,248 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	31,074,880 - 31,087,459 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	31,074,883 - 31,087,898 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	28,164,234 - 28,176,774 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	29,001,557 - 29,014,106 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	29,725,464 - 29,738,044 (-)	NCBI		UU_Cfam_GSD_1.0

Akr1e2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	33,305,613 - 33,325,444 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	9,474,458 - 9,490,676 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	9,472,920 - 9,490,624 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKR1E2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	65,680,332 - 65,702,190 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	65,680,314 - 65,704,701 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	72,108,978 - 72,133,547 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AKR1E2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	5,012,793 - 5,033,946 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	5,013,032 - 5,033,947 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	10,188,747 - 10,209,140 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003827773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008953100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000058981 ⟹ ENSPPAP00000036091

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	10	4,850,001 - 4,872,210 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000058985 ⟹ ENSPPAP00000036095

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	10	4,850,001 - 4,872,210 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000058988 ⟹ ENSPPAP00000036098

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	10	4,850,001 - 4,872,210 (+)	Ensembl

RefSeq Acc Id:

XM_003827773 ⟹ XP_003827821

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	8	17,376,873 - 17,506,881 (+)	NCBI
NHGRI_mPanPan1	10	17,382,162 - 17,404,469 (+)	NCBI
PanPan1.1	10	4,850,001 - 4,872,215 (+)	NCBI

Sequence:

show sequence

GGCGCGCGACACCAGCAGTCAGGAAGCCCTGCGTTCATGCTTCCAGCCATTGTCGGAGTGTCAA
CCGTCACAAGGCACTTCCAGCCAGTCGCAACGGCAGGTCGCCAGCGCCGCAGTAGCTCGCGCGG
TGCCTGTCGGTAGTCGCGTGCGGGGCGGCGGGGCGGCGGGGCGGCGGGCGGCGGCCATGGGAGA
TATCCCAGCCGTGGGCCTCAGCTCCTGGAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAA
GAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGG
TTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGC
CACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAGGAGTCTC
AAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTC
CTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCA
GGACTTGCCTCTGGACGAGAGCAACATGGTCATTCCCAGTGACACGGACTTCCTGGACACGTGG
GAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACC
ATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGAT
TGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCC
GTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACGACCCTGTAA
TCCAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCA
GAGGAACGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTG
TTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGAC
TGGCCACGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACA
GCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACCATTGGCAATGTTGACCCTCC
TCTGTCATCACAGTGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGGTGC
AAGAGCCGCCTTCTCTGACAAATCCGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTT
CTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAATGAAATTT
GCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAA
ACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCTACCCATTGTGCCCCAGGCCAGCCCGCGT
CACCTTCACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCC
TTCCCCCAGTGGGAAGGAAAATGGGATAAGTCTGGGACACTGTTTCAGTTCAATAAAGAGGCTT
TTTTCTTCCTTAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003827821	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000036091.1
	ENSPPAP00000036095.1
	ENSPPAP00000036098.1

RefSeq Acc Id:

XP_003827821 ⟸ XM_003827773

- Sequence:

show sequence

MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDL
FIATKLWCTCHKKSLVETACRRSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHP
RVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLT
NQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDDPVIQRIAKEHGKSPAQILIRF
QIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLATFPITKNHKDYPFHIEY

hide sequence

RefSeq Acc Id:

ENSPPAP00000036098 ⟸ ENSPPAT00000058988

RefSeq Acc Id:

ENSPPAP00000036091 ⟸ ENSPPAT00000058981

RefSeq Acc Id:

ENSPPAP00000036095 ⟸ ENSPPAT00000058985

Protein Domains

NADP-dependent oxidoreductase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000040822	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000058981.1	UniProtKB/TrEMBL
	ENSPPAT00000058985.1	UniProtKB/TrEMBL
	ENSPPAT00000058988.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.100	UniProtKB/TrEMBL
InterPro	AKR	UniProtKB/TrEMBL
	AKR1E2	UniProtKB/TrEMBL
	Aldo/ket_reductase_CS	UniProtKB/TrEMBL
	NADP_OxRdtase_dom	UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/TrEMBL
KEGG Report	pps:100985849	UniProtKB/TrEMBL
NCBI Gene	AKR1E2	ENTREZGENE
PANTHER	1,5-ANHYDRO-D-FRUCTOSE REDUCTASE	UniProtKB/TrEMBL
	ALDO/KETO REDUCTASE	UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/TrEMBL
PIRSF	AKR	UniProtKB/TrEMBL
PRINTS	ALDKETRDTASE	UniProtKB/TrEMBL
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51430	UniProtKB/TrEMBL
UniProt	A0A2R9C2D6_PANPA	UniProtKB/TrEMBL
	A0A2R9C2E4_PANPA	UniProtKB/TrEMBL
	A0A2R9C5C9_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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