Fes (feline sarcoma oncogene) - Rat Genome Database

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Gene: Fes (feline sarcoma oncogene) Mus musculus
Analyze
Symbol: Fes
Name: feline sarcoma oncogene
RGD ID: 1319653
MGI Page MGI
Description: Enables microtubule binding activity and protein kinase activity. Acts upstream of or within centrosome cycle and microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI586313; BB137047; c-fe; c-fes; FPS; proto-oncogene c-Fes; proto-oncogene tyrosine-protein kinase Fes/Fps; tyrosine kinase Fps/Fes; tyrosine-protein kinase Fes/Fps
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,027,506 - 80,037,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,027,504 - 80,037,694 (-)EnsemblGRCm39 Ensembl
GRCm38780,377,758 - 80,387,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,377,756 - 80,387,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,522,644 - 87,532,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,251,286 - 80,260,905 (-)NCBIMGSCv36mm8
Celera777,777,722 - 77,787,907 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone marrow cell morphology/development  (IAGP)
abnormal frontal lobe morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal megakaryocyte progenitor cell morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal vasculogenesis  (IAGP)
conjunctivitis  (IAGP)
decreased B cell number  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased tumor latency  (IAGP)
dilated heart ventricle  (IAGP)
distended abdomen  (IAGP)
down-turned corners of mouth  (IAGP)
downturned snout  (IAGP)
enlarged heart  (IAGP)
enlarged lateral ventricles  (IAGP)
gastrointestinal hemorrhage  (IAGP)
hemorrhage  (IAGP)
hydrops fetalis  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fetal weight  (IAGP)
increased granulocyte number  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin content  (IAGP)
increased litter size  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver hemorrhage  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
skin lesions  (IAGP)
thin myocardium compact layer  (IAGP)
thymus hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1. Aponte JL, etal., Proc Natl Acad Sci U S A 2001 Jan 16;98(2):641-5.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Identification of FES as a Novel Radiosensitizing Target in Human Cancers. Kim BH, etal., Clin Cancer Res. 2020 Jan 1;26(1):265-273. doi: 10.1158/1078-0432.CCR-19-0610. Epub 2019 Oct 1.
4. Prognostic CpG methylation biomarkers identified by methylation array in esophageal squamous cell carcinoma patients. Kuo IY, etal., Int J Med Sci. 2014 May 30;11(8):779-87. doi: 10.7150/ijms.7405. eCollection 2014.
5. Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7. Matsunaga T, etal., Biochemistry 1990 Feb 6;29(5):1329-41.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Jak2 is essential for signaling through a variety of cytokine receptors. Parganas E, etal., Cell 1998 May 1;93(3):385-95.
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. An identity crisis for fps/fes: oncogene or tumor suppressor? Sangrar W, etal., Cancer Res. 2005 May 1;65(9):3518-22. doi: 10.1158/0008-5472.CAN-04-3468.
14. Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction. Zhang C, etal., J Gastroenterol Hepatol. 2019 Oct;34(10):1869-1877. doi: 10.1111/jgh.14694. Epub 2019 Jun 20.
Additional References at PubMed
PMID:1303276   PMID:1347472   PMID:1354647   PMID:1507224   PMID:1981054   PMID:2110547   PMID:2179816   PMID:2185890   PMID:2307474   PMID:2426571   PMID:2482828   PMID:2548293  
PMID:3060793   PMID:6254060   PMID:6290870   PMID:6328281   PMID:6594688   PMID:6864883   PMID:7767008   PMID:7806222   PMID:7894156   PMID:7920633   PMID:8114702   PMID:8223273  
PMID:8422502   PMID:8703122   PMID:8787751   PMID:8792159   PMID:8809411   PMID:8916957   PMID:8943574   PMID:9344654   PMID:10349636   PMID:10523632   PMID:10679268   PMID:11021537  
PMID:11042159   PMID:11076861   PMID:11108845   PMID:11114734   PMID:11130975   PMID:11641724   PMID:11909942   PMID:11977979   PMID:12093729   PMID:12192036   PMID:12466851   PMID:12477932  
PMID:12584192   PMID:12871378   PMID:12901971   PMID:14525765   PMID:14551201   PMID:15254900   PMID:15322554   PMID:15498858   PMID:15504549   PMID:15550033   PMID:15713745   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:16731527   PMID:16884713   PMID:16959897   PMID:17627769   PMID:18053124   PMID:19732771   PMID:19892014   PMID:20117079   PMID:21159660   PMID:21308778  
PMID:21873635   PMID:22522491   PMID:22589410   PMID:23355730   PMID:23493555   PMID:28463229   PMID:32325033   PMID:32554809   PMID:36321446   PMID:37122758   PMID:38355793  


Genomics

Comparative Map Data
Fes
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,027,506 - 80,037,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,027,504 - 80,037,694 (-)EnsemblGRCm39 Ensembl
GRCm38780,377,758 - 80,387,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,377,756 - 80,387,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,522,644 - 87,532,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,251,286 - 80,260,905 (-)NCBIMGSCv36mm8
Celera777,777,722 - 77,787,907 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
FES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,884,504 - 90,895,776 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,883,695 - 90,895,776 (+)EnsemblGRCh38hg38GRCh38
GRCh371591,427,734 - 91,439,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,228,713 - 89,240,010 (+)NCBINCBI36Build 36hg18NCBI36
Build 341589,228,712 - 89,240,010NCBI
Celera1567,836,636 - 67,847,969 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,539,170 - 67,550,515 (+)NCBIHuRef
CHM1_11591,269,239 - 91,280,594 (+)NCBICHM1_1
T2T-CHM13v2.01588,643,915 - 88,655,365 (+)NCBIT2T-CHM13v2.0
Fes
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,746,945 - 143,756,181 (-)NCBIGRCr8
mRatBN7.21134,337,698 - 134,346,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,337,698 - 134,346,934 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,246,565 - 142,255,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,415,959 - 149,425,199 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,333,966 - 142,343,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,174,648 - 142,183,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,174,648 - 142,183,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,127,277 - 143,136,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,199,523 - 136,208,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1126,397,304 - 126,406,534 (-)NCBICelera
Cytogenetic Map1q31NCBI
Fes
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,948,123 - 14,960,005 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,948,121 - 14,959,035 (+)NCBIChiLan1.0ChiLan1.0
FES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,437,700 - 80,449,677 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,135,731 - 84,147,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,576,936 - 69,588,834 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,774,967 - 88,786,965 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,774,965 - 88,786,965 (+)Ensemblpanpan1.1panPan2
FES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,346,975 - 53,356,547 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,347,012 - 53,356,516 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,984,668 - 55,994,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,763,060 - 53,772,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,763,067 - 53,772,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,282,201 - 53,291,832 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,493,421 - 53,503,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,833,898 - 53,843,534 (-)NCBIUU_Cfam_GSD_1.0
Fes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,199,476 - 130,210,580 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,123,779 - 16,135,044 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,123,938 - 16,135,044 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,472,947 - 53,485,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,472,947 - 53,485,084 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,504,744 - 58,516,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,967,542 - 8,979,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,965,997 - 8,979,361 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,746,110 - 37,758,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fes
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,359,196 - 17,372,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,360,602 - 17,372,563 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fes
764 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:164
Interacting mature miRNAs:178
Transcripts:ENSMUST00000080932
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884381Bzwq2_mbi-zygomatic width QTL 2, 5 week (mouse)76524974896949207Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76413542498135653Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76644974898349207Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
4142212Png1_mPostnatal growth 1 (mouse)Not determined7432612192394346Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
4142319Powg_mpost-ovarectomy weight gain (mouse)Not determined7285710592582163Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
13513916Heal53_mwound healing/ regeneration 53 (mouse)77945491380630796Mouse
12801463Rta1_mretinal aging 1 (mouse)76716802789089989Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse

Markers in Region
AI586313  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38780,377,811 - 80,377,914UniSTSGRCm38
MGSCv37787,522,697 - 87,522,800UniSTSGRCm37
Celera777,777,775 - 77,777,878UniSTS
Cytogenetic Map7D3UniSTS
cM Map739.0UniSTS
Whitehead/MRC_RH7778.28UniSTS
BB137047  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38780,377,807 - 80,377,914UniSTSGRCm38
MGSCv37787,522,693 - 87,522,800UniSTSGRCm37
Celera777,777,771 - 77,777,878UniSTS
Cytogenetic Map7D3UniSTS
cM Map739.0UniSTS
Whitehead/MRC_RH7778.28UniSTS
RH94589  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38780,389,200 - 80,389,396UniSTSGRCm38
MGSCv37787,534,086 - 87,534,282UniSTSGRCm37
Celera777,789,173 - 77,789,370UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map7D3UniSTS
cM Map739.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003946388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF542394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X92716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X92717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X92718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X92719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000080932   ⟹   ENSMUSP00000079733
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,027,506 - 80,037,694 (-)Ensembl
GRCm38.p6 Ensembl780,377,758 - 80,387,946 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205617   ⟹   ENSMUSP00000145612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,027,504 - 80,037,684 (-)Ensembl
GRCm38.p6 Ensembl780,377,756 - 80,387,936 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206002
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,027,506 - 80,030,184 (-)Ensembl
GRCm38.p6 Ensembl780,377,758 - 80,380,436 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206271
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,036,787 - 80,037,642 (-)Ensembl
GRCm38.p6 Ensembl780,387,039 - 80,387,894 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206479   ⟹   ENSMUSP00000145917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,027,512 - 80,037,689 (-)Ensembl
GRCm38.p6 Ensembl780,377,764 - 80,387,941 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206539   ⟹   ENSMUSP00000146078
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,033,958 - 80,037,643 (-)Ensembl
GRCm38.p6 Ensembl780,384,210 - 80,387,895 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206698   ⟹   ENSMUSP00000145937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,036,661 - 80,037,629 (-)Ensembl
GRCm38.p6 Ensembl780,386,913 - 80,387,881 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206728   ⟹   ENSMUSP00000146041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,027,521 - 80,037,167 (-)Ensembl
GRCm38.p6 Ensembl780,377,773 - 80,387,419 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206735   ⟹   ENSMUSP00000146058
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,027,506 - 80,029,378 (-)Ensembl
GRCm38.p6 Ensembl780,377,758 - 80,379,630 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206744   ⟹   ENSMUSP00000146281
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl780,027,511 - 80,037,619 (-)Ensembl
GRCm38.p6 Ensembl780,377,763 - 80,387,871 (-)Ensembl
RefSeq Acc Id: NM_010194   ⟹   NP_034324
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39780,027,506 - 80,037,694 (-)NCBI
GRCm38780,377,758 - 80,387,946 (-)NCBI
MGSCv37787,522,644 - 87,532,832 (-)RGD
Celera777,777,722 - 77,787,907 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540604   ⟹   XP_006540667
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39780,027,506 - 80,037,687 (-)NCBI
GRCm38780,377,758 - 80,387,936 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152669   ⟹   XP_036008562
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39780,030,082 - 80,037,702 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003946388
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39780,027,506 - 80,037,702 (-)NCBI
GRCm38780,377,758 - 80,387,954 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034324   ⟸   NM_010194
- UniProtKB: Q62122 (UniProtKB/Swiss-Prot),   Q3TD20 (UniProtKB/Swiss-Prot),   Q8CG02 (UniProtKB/Swiss-Prot),   P16879 (UniProtKB/Swiss-Prot),   A0A0U1RPM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540667   ⟸   XM_006540604
- Peptide Label: isoform X1
- UniProtKB: Q62122 (UniProtKB/Swiss-Prot),   Q3TD20 (UniProtKB/Swiss-Prot),   Q8CG02 (UniProtKB/Swiss-Prot),   P16879 (UniProtKB/Swiss-Prot),   A0A0U1RPM2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000146281   ⟸   ENSMUST00000206744
Ensembl Acc Id: ENSMUSP00000146058   ⟸   ENSMUST00000206735
Ensembl Acc Id: ENSMUSP00000146041   ⟸   ENSMUST00000206728
Ensembl Acc Id: ENSMUSP00000145937   ⟸   ENSMUST00000206698
Ensembl Acc Id: ENSMUSP00000146078   ⟸   ENSMUST00000206539
Ensembl Acc Id: ENSMUSP00000145917   ⟸   ENSMUST00000206479
Ensembl Acc Id: ENSMUSP00000145612   ⟸   ENSMUST00000205617
Ensembl Acc Id: ENSMUSP00000079733   ⟸   ENSMUST00000080932
RefSeq Acc Id: XP_036008562   ⟸   XM_036152669
- Peptide Label: isoform X2
Protein Domains
F-BAR   Protein kinase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16879-F1-model_v2 AlphaFold P16879 1-822 view protein structure

Promoters
RGD ID:8664579
Promoter ID:EPDNEW_M10320
Type:initiation region
Name:Fes_1
Description:Mus musculus feline sarcoma oncogene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38780,387,881 - 80,387,941EPDNEW
RGD ID:6848137
Promoter ID:MM_ACW:45113
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:FES.HSEP07,   FES.ISEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,525,696 - 87,526,196 (-)MPROMDB
RGD ID:6841101
Promoter ID:MM_KWN:51291
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000082267,   NM_010194,   UC009IAS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36787,532,141 - 87,533,692 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95514 AgrOrtholog
Ensembl Genes ENSMUSG00000053158 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000080932 ENTREZGENE
  ENSMUST00000080932.8 UniProtKB/Swiss-Prot
  ENSMUST00000205617.2 UniProtKB/TrEMBL
  ENSMUST00000206479.2 UniProtKB/TrEMBL
  ENSMUST00000206539.2 UniProtKB/TrEMBL
  ENSMUST00000206698.2 UniProtKB/TrEMBL
  ENSMUST00000206728 ENTREZGENE
  ENSMUST00000206728.2 UniProtKB/TrEMBL
  ENSMUST00000206735.2 UniProtKB/TrEMBL
  ENSMUST00000206744 ENTREZGENE
  ENSMUST00000206744.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HR1 repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FCH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fes/Fps/Fer_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr-prot_kinase_Fes/Fps UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95514 ENTREZGENE
NCBI Gene 14159 ENTREZGENE
PANTHER FCH AND DOUBLE SH3 DOMAINS PROTEIN UniProtKB/TrEMBL
  PROTEIN NERVOUS WRECK UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fes PhenoGen
PIRSF TyrPK_fps UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNL3_MOUSE UniProtKB/TrEMBL
  A0A0U1RPB9_MOUSE UniProtKB/TrEMBL
  A0A0U1RPD6_MOUSE UniProtKB/TrEMBL
  A0A0U1RPM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RPN6_MOUSE UniProtKB/TrEMBL
  A0A0U1RPQ5_MOUSE UniProtKB/TrEMBL
  A0A0U1RQ80_MOUSE UniProtKB/TrEMBL
  FES_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TD20 ENTREZGENE
  Q62122 ENTREZGENE
  Q8CG02 ENTREZGENE
  Q8CGG9_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TD20 UniProtKB/Swiss-Prot
  Q62122 UniProtKB/Swiss-Prot
  Q8CG02 UniProtKB/Swiss-Prot