FES (FES proto-oncogene, tyrosine kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: FES (FES proto-oncogene, tyrosine kinase) Chlorocebus sabaeus
Analyze
Symbol: FES
Name: FES proto-oncogene, tyrosine kinase
RGD ID: 18633725
Description: ENCODES a protein that exhibits ATP binding (inferred); immunoglobulin receptor binding (inferred); kinase activity (inferred); INVOLVED IN cardiac muscle cell proliferation (ortholog); centrosome cycle (ortholog); microtubule bundle formation (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); coronary artery disease (ortholog); D-2-hydroxyglutaric aciduria 2 (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred); cytoplasmic vesicle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase Fes/Fps
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,967,542 - 8,979,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,965,997 - 8,979,361 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,746,110 - 37,758,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,967,542 - 8,979,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,965,997 - 8,979,361 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,746,110 - 37,758,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,884,504 - 90,895,776 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,883,695 - 90,895,776 (+)EnsemblGRCh38hg38GRCh38
GRCh371591,427,734 - 91,439,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,228,713 - 89,240,010 (+)NCBINCBI36Build 36hg18NCBI36
Build 341589,228,712 - 89,240,010NCBI
Celera1567,836,636 - 67,847,969 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,539,170 - 67,550,515 (+)NCBIHuRef
CHM1_11591,269,239 - 91,280,594 (+)NCBICHM1_1
T2T-CHM13v2.01588,643,915 - 88,655,365 (+)NCBIT2T-CHM13v2.0
Fes
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,027,506 - 80,037,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,027,504 - 80,037,694 (-)EnsemblGRCm39 Ensembl
GRCm38780,377,758 - 80,387,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,377,756 - 80,387,946 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,522,644 - 87,532,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,251,286 - 80,260,905 (-)NCBIMGSCv36mm8
Celera777,777,722 - 77,787,907 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Fes
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,746,945 - 143,756,181 (-)NCBIGRCr8
mRatBN7.21134,337,698 - 134,346,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,337,698 - 134,346,934 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,246,565 - 142,255,805 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,415,959 - 149,425,199 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,333,966 - 142,343,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,174,648 - 142,183,884 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,174,648 - 142,183,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,127,277 - 143,136,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,199,523 - 136,208,759 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1126,397,304 - 126,406,534 (-)NCBICelera
Cytogenetic Map1q31NCBI
Fes
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,948,123 - 14,960,005 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,948,121 - 14,959,035 (+)NCBIChiLan1.0ChiLan1.0
FES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,437,700 - 80,449,677 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,135,731 - 84,147,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,576,936 - 69,588,834 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,774,967 - 88,786,965 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,774,965 - 88,786,965 (+)Ensemblpanpan1.1panPan2
FES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,346,975 - 53,356,547 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,347,012 - 53,356,516 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,984,668 - 55,994,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,763,060 - 53,772,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,763,067 - 53,772,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,282,201 - 53,291,832 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,493,421 - 53,503,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,833,898 - 53,843,534 (-)NCBIUU_Cfam_GSD_1.0
Fes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,199,476 - 130,210,580 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,123,779 - 16,135,044 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,123,938 - 16,135,044 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,472,947 - 53,485,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,472,947 - 53,485,084 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,504,744 - 58,516,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Fes
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,359,196 - 17,372,712 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,360,602 - 17,372,563 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 18 12 3
Low 18 8 57
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000015145   ⟹   ENSCSAP00000013094
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl298,965,997 - 8,979,361 (-)Ensembl
RefSeq Acc Id: XM_037987660   ⟹   XP_037843588
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605937,746,110 - 37,758,650 (+)NCBI
RefSeq Acc Id: XM_037987661   ⟹   XP_037843589
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605937,746,110 - 37,757,192 (+)NCBI
RefSeq Acc Id: XM_037987662   ⟹   XP_037843590
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605937,746,110 - 37,758,650 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037843588 (Get FASTA)   NCBI Sequence Viewer  
  XP_037843589 (Get FASTA)   NCBI Sequence Viewer  
  XP_037843590 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013094.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000013094   ⟸   ENSCSAT00000015145
RefSeq Acc Id: XP_037843588   ⟸   XM_037987660
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RWV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843590   ⟸   XM_037987662
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RWV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037843589   ⟸   XM_037987661
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RWV5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017051 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015145.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  HR1 repeat UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  Fes/Fps/Fer_SH2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr-prot_kinase_Fes/Fps UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report csab:103231183 UniProtKB/TrEMBL
NCBI Gene FES ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE FES/FPS UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PIRSF TyrPK_fps UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RWV5 ENTREZGENE, UniProtKB/TrEMBL