Large1 (LARGE xylosyl- and glucuronyltransferase 1) - Rat Genome Database

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Gene: Large1 (LARGE xylosyl- and glucuronyltransferase 1) Mus musculus
Analyze
Symbol: Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
RGD ID: 1318928
MGI Page MGI
Description: Enables glucuronosyltransferase activity and xylosyltransferase activity. Involved in several processes, including muscle cell cellular homeostasis; protein O-linked mannosylation; and skeletal muscle tissue regeneration. Acts upstream of or within several processes, including nervous system development; retina development in camera-type eye; and striated muscle cell differentiation. Located in Golgi membrane. Part of protein-containing complex. Is active in Golgi apparatus; neuromuscular junction; and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and retina. Used to study facioscapulohumeral muscular dystrophy; muscular dystrophy-dystroglycanopathy type B1; and muscular dystrophy-dystroglycanopathy type B6. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A6 and muscular dystrophy-dystroglycanopathy type B6. Orthologous to human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acetylglucosaminyltransferase-like 1A; BPFD#3; BPFD#36; e; enr; fg; frog; froggy; glycosyltransferase-like protein LARGE1; Gyltl1a; Large; like-glycosyltransferase; Mbp-1; Mbp1; mKIAA0609; myd; myodystrophy; xylosyl- and glucuronyltransferase LARGE1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,541,227 - 74,080,164 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl873,541,227 - 74,080,168 (-)EnsemblGRCm39 Ensembl
GRCm38872,814,598 - 73,353,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,814,599 - 73,353,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv37875,338,498 - 75,876,455 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36875,710,671 - 76,248,628 (-)NCBIMGSCv36mm8
Celera877,131,292 - 77,664,765 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map835.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (ISO)
glyphosate  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylphenidate  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
rimonabant  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetylcholine receptor signaling pathway  (IMP)
astrocyte differentiation  (IMP)
basement membrane organization  (IMP)
behavioral fear response  (IMP)
blood vessel development  (IMP)
bone development  (IGI)
brain development  (IDA,IMP)
cardiac muscle cell development  (IMP)
cardiac muscle tissue development  (IMP)
chemical synaptic transmission  (IDA,IMP)
connective tissue development  (IDA,IGI,IMP)
cytoskeleton organization  (IMP)
dentate gyrus development  (IMP)
determination of adult lifespan  (IDA,IGI)
gene expression  (IDA,IGI,IMP)
glycoprotein biosynthetic process  (IDA,IMP,NAS)
glycoprotein metabolic process  (IMP)
heart development  (IMP)
intracellular protein transport  (IDA,IMP)
limb development  (IGI)
localization of cell  (IMP)
long-term synaptic potentiation  (IMP)
macrophage differentiation  (IDA,IMP)
memory  (IMP)
multicellular organism growth  (IDA,IGI,IMP)
muscle cell cellular homeostasis  (IMP)
muscle organ development  (IDA)
myelination  (IMP)
myotube differentiation  (IDA)
nerve development  (IMP)
neuromuscular junction development  (IDA,IMP)
neuromuscular process  (IGI)
neuromuscular process controlling posture  (IDA)
neuromuscular synaptic transmission  (IDA,IMP)
neuron migration  (IMP)
plasma membrane organization  (IMP)
post-embryonic hindlimb morphogenesis  (IDA)
post-translational protein modification  (IMP)
potassium ion transmembrane transport  (IMP)
principal sensory nucleus of trigeminal nerve development  (IMP)
protein deglycosylation  (IMP)
protein glycosylation  (IDA,IGI,IMP,ISO)
protein localization  (IMP)
protein localization to membrane  (IMP)
protein localization to plasma membrane  (IMP)
protein modification process  (IDA,IMP)
protein O-linked glycosylation  (IMP)
protein O-linked mannosylation  (IBA,IDA,ISO)
protein phosphorylation  (IMP)
protein targeting to membrane  (IDA,IMP)
protein-containing complex assembly  (IMP)
reactive gliosis  (IMP)
regulation of kinase activity  (IDA,IMP)
regulation of synaptic plasticity  (IMP)
response to light stimulus  (IMP)
response to mechanical stimulus  (IMP)
retina development in camera-type eye  (IMP)
retina layer formation  (IMP)
retina vasculature development in camera-type eye  (IMP)
sensory perception of sound  (IMP)
skeletal muscle fiber development  (IMP)
skeletal muscle fiber differentiation  (IDA,IMP)
skeletal muscle organ development  (IDA)
skeletal muscle tissue regeneration  (IDA,IMP)
striated muscle cell development  (IDA,IGI,IMP)
striated muscle contraction  (IDA,IGI,IMP)
synapse organization  (IMP)
synaptic assembly at neuromuscular junction  (IMP)
transmembrane transport  (IMP)
walking behavior  (IGI)
water transport  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response waveform shape  (IAGP)
abnormal bone structure  (IEA)
abnormal diaphragm morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal gait  (IAGP)
abnormal limb posture  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal peripheral nervous system regeneration  (IAGP)
abnormal posture  (IAGP)
abnormal retina ganglion layer morphology  (IAGP)
abnormal retina inner nuclear layer morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal retina outer plexiform layer morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IAGP)
abnormal soleus morphology  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal vitreous body morphology  (IAGP)
absent Schwann cells  (IAGP)
calcified muscle  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased grip strength  (IAGP)
dilated cardiomyopathy  (IAGP)
disorganized retina ganglion layer  (IAGP)
disorganized retina outer plexiform layer  (IAGP)
dystrophic muscle  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased circulating creatinine level  (IAGP)
increased variability of skeletal muscle fiber size  (IAGP)
kyphosis  (IAGP)
limb grasping  (IAGP)
male infertility  (IAGP)
muscle degeneration  (IAGP)
myopathy  (IAGP)
myositis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
sensorineural hearing loss  (IAGP)
skeletal muscle degeneration  (IEA)
skeletal muscle endomysial fibrosis  (IAGP)
skeletal muscle fiber degeneration  (IAGP)
skeletal muscle fiber necrosis  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thin retina outer plexiform layer  (IAGP)
vitreal fibroplasia  (IAGP)
vitreous body deposition  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. Grewal PK, etal., Nat Genet 2001 Jun;28(2):151-4.
2. Skeletal, cardiac and tongue muscle pathology, defective retinal transmission, and neuronal migration defects in the Large(myd) mouse defines a natural model for glycosylation-deficient muscle - eye - brain disorders. Holzfeind PJ, etal., Hum Mol Genet 2002 Oct 1;11(21):2673-87.
3. Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Longman C, etal., Hum Mol Genet 2003 Nov 1;12(21):2853-61. Epub 2003 Sep 9.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:647395   PMID:939913   PMID:1235495   PMID:3155690   PMID:6447833   PMID:7472477   PMID:7506762   PMID:7534359   PMID:7602333   PMID:7613034   PMID:7739634   PMID:8889548  
PMID:9166581   PMID:9570957   PMID:9892679   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12140558   PMID:12354795   PMID:12417403   PMID:12477932  
PMID:12676797   PMID:12925572   PMID:14610273   PMID:14691545   PMID:15184894   PMID:15210115   PMID:15226823   PMID:15389724   PMID:15489334   PMID:15788414   PMID:15797722   PMID:15958417  
PMID:16098969   PMID:16111892   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16819976   PMID:16956587   PMID:17131200   PMID:17452335   PMID:17803675   PMID:17967808   PMID:18077674  
PMID:19017726   PMID:19321787   PMID:19346129   PMID:19494113   PMID:19633189   PMID:19797173   PMID:20044576   PMID:21129441   PMID:21203384   PMID:21267068   PMID:21347376   PMID:21460210  
PMID:21533062   PMID:21628317   PMID:21873635   PMID:21930648   PMID:21970971   PMID:22223806   PMID:22270369   PMID:22728091   PMID:22734004   PMID:22865473   PMID:23125099   PMID:23135544  
PMID:23222475   PMID:23723439   PMID:23798567   PMID:24132234   PMID:24234655   PMID:24256719   PMID:24635668   PMID:24722207   PMID:24753587   PMID:24952961   PMID:25138275   PMID:25198651  
PMID:25279699   PMID:25457550   PMID:25661440   PMID:25710816   PMID:25976249   PMID:26306834   PMID:27467128   PMID:29360985   PMID:29915039   PMID:31413358   PMID:32290105   PMID:32453729  
PMID:32975514   PMID:34142127   PMID:34321999   PMID:35613260   PMID:36723429  


Genomics

Comparative Map Data
Large1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,541,227 - 74,080,164 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl873,541,227 - 74,080,168 (-)EnsemblGRCm39 Ensembl
GRCm38872,814,598 - 73,353,721 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,814,599 - 73,353,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv37875,338,498 - 75,876,455 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36875,710,671 - 76,248,628 (-)NCBIMGSCv36mm8
Celera877,131,292 - 77,664,765 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map835.08NCBI
LARGE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,066,663 - 33,922,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,162,226 - 33,922,841 (-)EnsemblGRCh38hg38GRCh38
GRCh372233,668,495 - 34,318,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362231,999,063 - 32,646,410 (-)NCBINCBI36Build 36hg18NCBI36
Build 342231,993,616 - 32,640,964NCBI
Celera2217,471,158 - 18,118,297 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2216,626,665 - 17,273,268 (-)NCBIHuRef
CHM1_12233,628,484 - 34,276,127 (-)NCBICHM1_1
T2T-CHM13v2.02233,627,091 - 34,380,164 (-)NCBIT2T-CHM13v2.0
Large1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,609,004 - 12,057,174 (-)NCBIGRCr8
mRatBN7.21911,603,129 - 12,048,930 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,603,129 - 12,048,930 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1911,566,884 - 12,016,406 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01912,332,087 - 12,781,613 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,619,081 - 12,068,592 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01912,481,563 - 12,945,320 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,481,540 - 12,942,963 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01923,595,328 - 24,054,765 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41912,043,818 - 12,497,663 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11912,049,826 - 12,369,988 (-)NCBI
Celera1911,480,096 - 11,923,685 (-)NCBICelera
Cytogenetic Map19p12-p11NCBI
Large1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540541,931,058 - 42,139,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540541,891,430 - 42,225,066 (-)NCBIChiLan1.0ChiLan1.0
LARGE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22343,009,740 - 43,861,899 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12245,708,047 - 46,559,753 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02214,077,463 - 14,929,250 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12232,137,280 - 32,778,639 (-)NCBIpanpan1.1PanPan1.1panPan2
LARGE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11029,875,381 - 30,396,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1029,919,521 - 30,395,787 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1029,820,809 - 30,340,676 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01030,671,995 - 31,198,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1030,669,187 - 31,236,024 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11030,391,521 - 30,940,790 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01030,706,807 - 31,228,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01030,887,220 - 31,413,494 (+)NCBIUU_Cfam_GSD_1.0
Large1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494513,148,086 - 13,647,077 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364926,289,517 - 6,659,465 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364926,160,979 - 6,657,491 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LARGE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.25110,211,538 - 110,349,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LARGE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11916,080,482 - 16,704,968 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1916,080,430 - 16,549,495 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045109,305,163 - 109,923,917 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Large1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247501,286,336 - 1,527,159 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247501,190,712 - 1,524,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Large1
18821 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:961
Count of miRNA genes:355
Interacting mature miRNAs:426
Transcripts:ENSMUST00000004497, ENSMUST00000119826, ENSMUST00000146249
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86872247983326976Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7158942790929226Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse

Markers in Region
Results_ER_8_29_95_1_17.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38873,174,200 - 73,174,370UniSTSGRCm38
MGSCv37875,698,099 - 75,698,269UniSTSGRCm37
Celera877,485,301 - 77,485,471UniSTS
Cytogenetic Map8C1UniSTS
cM Map834.0UniSTS
Whitehead_YAC8 UniSTS
D8Mit303  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,849,157 - 72,849,275UniSTSGRCm38
MGSCv37875,373,056 - 75,373,174UniSTSGRCm37
Celera877,164,697 - 77,164,815UniSTS
Cytogenetic Map8C1UniSTS
cM Map833.0UniSTS
Whitehead Genetic835.0UniSTS
Whitehead_YAC8 UniSTS
D8Mit341  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,952,849 - 72,952,995UniSTSGRCm38
MGSCv37875,476,748 - 75,476,894UniSTSGRCm37
Celera877,267,659 - 77,267,803UniSTS
Cytogenetic Map8C1UniSTS
cM Map833.0UniSTS
Whitehead Genetic835.0UniSTS
Whitehead_YAC8 UniSTS
AJ006278  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,814,739 - 72,814,838UniSTSGRCm38
MGSCv37875,338,638 - 75,338,737UniSTSGRCm37
Celera877,131,432 - 77,131,531UniSTS
Cytogenetic Map8C1UniSTS
cM Map834.0UniSTS
Whitehead/MRC_RH8776.91UniSTS
RH125345  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38873,199,392 - 73,199,476UniSTSGRCm38
MGSCv37875,723,291 - 75,723,375UniSTSGRCm37
Celera877,513,406 - 77,513,490UniSTS
Cytogenetic Map8C1UniSTS
cM Map834.0UniSTS
DXS7708  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,998,432 - 72,998,530UniSTSGRCm38
MGSCv37875,522,331 - 75,522,429UniSTSGRCm37
Celera877,306,547 - 77,306,645UniSTS
Cytogenetic Map8C1UniSTS
cM Map834.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC157365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC171678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC171917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ006278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW490661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ442282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN699283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM141820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000004497   ⟹   ENSMUSP00000004497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl873,541,227 - 74,079,184 (-)Ensembl
GRCm38.p6 Ensembl872,814,599 - 73,352,556 (-)Ensembl
Ensembl Acc Id: ENSMUST00000119826   ⟹   ENSMUSP00000112617
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl873,541,227 - 74,080,168 (-)Ensembl
GRCm38.p6 Ensembl872,814,599 - 73,353,540 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl873,771,692 - 73,825,541 (-)Ensembl
GRCm38.p6 Ensembl873,045,064 - 73,098,913 (-)Ensembl
Ensembl Acc Id: ENSMUST00000212459   ⟹   ENSMUSP00000148336
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl873,541,227 - 74,080,168 (-)Ensembl
GRCm38.p6 Ensembl872,814,599 - 73,353,540 (-)Ensembl
RefSeq Acc Id: NM_001317391   ⟹   NP_001304320
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,541,227 - 74,080,164 (-)NCBI
GRCm38872,814,598 - 73,353,540 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001414048   ⟹   NP_001400977
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,541,227 - 74,080,164 (-)NCBI
RefSeq Acc Id: NM_001414049   ⟹   NP_001400978
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,743,348 - 74,080,164 (-)NCBI
RefSeq Acc Id: NM_010687   ⟹   NP_034817
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,541,227 - 74,080,164 (-)NCBI
GRCm38872,814,598 - 73,353,540 (-)NCBI
MGSCv37875,338,498 - 75,876,455 (-)RGD
Celera877,131,292 - 77,664,765 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_182234
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,541,227 - 74,080,164 (-)NCBI
RefSeq Acc Id: XM_030243312   ⟹   XP_030099172
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,541,227 - 73,940,864 (-)NCBI
GRCm38872,814,599 - 73,132,269 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034817   ⟸   NM_010687
- Peptide Label: isoform 1
- UniProtKB: Q6P7U2 (UniProtKB/Swiss-Prot),   Q497S9 (UniProtKB/Swiss-Prot),   Q80TW0 (UniProtKB/Swiss-Prot),   Q9Z1M7 (UniProtKB/Swiss-Prot),   Q059X9 (UniProtKB/TrEMBL),   D9IG22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304320   ⟸   NM_001317391
- Peptide Label: isoform 1
- UniProtKB: Q6P7U2 (UniProtKB/Swiss-Prot),   Q497S9 (UniProtKB/Swiss-Prot),   Q80TW0 (UniProtKB/Swiss-Prot),   Q9Z1M7 (UniProtKB/Swiss-Prot),   Q059X9 (UniProtKB/TrEMBL),   D9IG22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099172   ⟸   XM_030243312
- Peptide Label: isoform X1
- UniProtKB: D9IG22 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000112617   ⟸   ENSMUST00000119826
Ensembl Acc Id: ENSMUSP00000148336   ⟸   ENSMUST00000212459
Ensembl Acc Id: ENSMUSP00000004497   ⟸   ENSMUST00000004497
RefSeq Acc Id: NP_001400977   ⟸   NM_001414048
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001400978   ⟸   NM_001414049
- Peptide Label: isoform 3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1M7-F1-model_v2 AlphaFold Q9Z1M7 1-756 view protein structure

Promoters
RGD ID:8667493
Promoter ID:EPDNEW_M11778
Type:initiation region
Name:Large1_1
Description:Mus musculus LARGE xylosyl- and glucuronyltransferase 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38873,353,503 - 73,353,563EPDNEW
RGD ID:6843372
Promoter ID:MM_KWN:54887
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000004497,   ENSMUST00000119826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36875,876,446 - 75,878,417 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1342270 AgrOrtholog
Ensembl Genes ENSMUSG00000004383 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004497 ENTREZGENE
  ENSMUST00000004497.11 UniProtKB/Swiss-Prot
  ENSMUST00000119826.7 UniProtKB/Swiss-Prot
  ENSMUST00000212459 ENTREZGENE
  ENSMUST00000212459.2 UniProtKB/Swiss-Prot
InterPro Glyco_trans_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xyl/GlcA_transferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16795 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1342270 ENTREZGENE
NCBI Gene 16795 ENTREZGENE
PANTHER GLYCOSYLTRANSFERASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LARGE XYLOSYL- AND GLUCURONYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_transf_49 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_transf_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Large1 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D9IG22 ENTREZGENE, UniProtKB/TrEMBL
  LARG1_MOUSE UniProtKB/Swiss-Prot
  Q059X9 ENTREZGENE, UniProtKB/TrEMBL
  Q497S9 ENTREZGENE
  Q6P7U2 ENTREZGENE
  Q80TW0 ENTREZGENE
  Q9Z1M7 ENTREZGENE
UniProt Secondary Q497S9 UniProtKB/Swiss-Prot
  Q6P7U2 UniProtKB/Swiss-Prot
  Q80TW0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-20 Large1  LARGE xylosyl- and glucuronyltransferase 1  Large  like-glycosyltransferase  Symbol and/or name change 5135510 APPROVED