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Gene: Large1 (LARGE xylosyl- and glucuronyltransferase 1) Rattus norvegicus
Symbol: Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
RGD ID: 1308895
Description: Predicted to have glucuronosyltransferase activity; manganese ion binding activity; and xylosyltransferase activity. Predicted to be involved in several processes, including muscle cell cellular homeostasis; protein O-linked mannosylation; and skeletal muscle organ development. Predicted to localize to Golgi apparatus. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A6 and muscular dystrophy-dystroglycanopathy type B6. Orthologous to human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1); INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; acetamide.
Type: protein-coding
Also known as: glycosyltransferase-like protein LARGE1; Large; like-glycosyltransferase; LOC361368
Homo sapiens (human) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Canis lupus familiaris (dog) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)
Sus scrofa (pig) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Chlorocebus sabaeus (African green monkey) : LARGE1 (LARGE xylosyl- and glucuronyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Large1 (LARGE xylosyl- and glucuronyltransferase 1)
more info ...
Allele / Splice: LargeTn(sb-T2/Bart3)2.336Mcwi  
Genetic Models: F344-LargeTn(sb-T2/Bart3)2.336Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01912,481,563 - 12,945,320 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1912,481,540 - 12,942,963 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01923,595,328 - 24,054,765 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41912,043,818 - 12,497,663 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11912,049,826 - 12,369,988 (-)NCBI
Celera1911,480,096 - 11,923,685 (-)NCBICelera
Cytogenetic Map19p12-p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Large1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308895
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.