SOCS7 (suppressor of cytokine signaling 7) - Rat Genome Database

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Gene: SOCS7 (suppressor of cytokine signaling 7) Homo sapiens
Analyze
Symbol: SOCS7
Name: suppressor of cytokine signaling 7
RGD ID: 1317076
HGNC Page HGNC:29846
Description: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including brain development; fat cell differentiation; and insulin receptor signaling pathway. Located in cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NAP-4; NAP4; Nck, Ash and phospholipase C binding protein; nck, Ash and phospholipase C gamma-binding protein; NCK-associated protein 4; NCKAP4; SOCS-7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381738,351,844 - 38,405,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1738,351,844 - 38,405,593 (+)EnsemblGRCh38hg38GRCh38
GRCh371736,507,727 - 36,561,846 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361733,761,531 - 33,809,545 (+)NCBINCBI36Build 36hg18NCBI36
Celera1733,168,273 - 33,215,998 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1732,304,776 - 32,358,313 (+)NCBIHuRef
CHM1_11736,743,687 - 36,797,156 (+)NCBICHM1_1
T2T-CHM13v2.01739,214,750 - 39,268,637 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Inhibitors of cytokine signal transduction. Wormald S and Hilton DJ, J Biol Chem 2004 Jan 9;279(2):821-4. Epub 2003 Nov 7.
Additional References at PubMed
PMID:9344857   PMID:9419338   PMID:10969179   PMID:11837794   PMID:12052866   PMID:12076535   PMID:12477932   PMID:14644140   PMID:14702039   PMID:15242778   PMID:15489334   PMID:15677474  
PMID:16127460   PMID:16625196   PMID:16751776   PMID:17803907   PMID:18029348   PMID:20357037   PMID:20433750   PMID:20598684   PMID:21145461   PMID:21873635   PMID:22213096   PMID:22397880  
PMID:23392170   PMID:23535730   PMID:23767996   PMID:24046004   PMID:24210661   PMID:25162020   PMID:25286386   PMID:28514442   PMID:31253590   PMID:32268115   PMID:32296183   PMID:32978373  
PMID:33961781   PMID:34345210   PMID:35042950   PMID:35624501   PMID:36169255   PMID:36769102  


Genomics

Comparative Map Data
SOCS7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381738,351,844 - 38,405,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1738,351,844 - 38,405,593 (+)EnsemblGRCh38hg38GRCh38
GRCh371736,507,727 - 36,561,846 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361733,761,531 - 33,809,545 (+)NCBINCBI36Build 36hg18NCBI36
Celera1733,168,273 - 33,215,998 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1732,304,776 - 32,358,313 (+)NCBIHuRef
CHM1_11736,743,687 - 36,797,156 (+)NCBICHM1_1
T2T-CHM13v2.01739,214,750 - 39,268,637 (+)NCBIT2T-CHM13v2.0
Socs7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391197,253,044 - 97,289,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1197,253,261 - 97,289,368 (+)EnsemblGRCm39 Ensembl
GRCm381197,362,292 - 97,398,542 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1197,362,435 - 97,398,542 (+)EnsemblGRCm38mm10GRCm38
MGSCv371197,223,865 - 97,259,856 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361197,178,641 - 97,214,632 (+)NCBIMGSCv36mm8
Celera11106,997,950 - 107,050,631 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1160.96NCBI
Socs7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,848,525 - 82,885,201 (+)NCBIGRCr8
mRatBN7.21082,352,159 - 82,388,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,351,680 - 82,388,830 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01085,301,797 - 85,337,971 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,301,875 - 85,330,397 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,091,496 - 85,126,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,090,339 - 86,134,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11086,104,702 - 86,148,592 (+)NCBI
Celera1081,112,515 - 81,148,028 (+)NCBICelera
Cytogenetic Map10q31NCBI
Socs7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,567,377 - 13,595,685 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545113,567,377 - 13,595,685 (+)NCBIChiLan1.0ChiLan1.0
SOCS7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21926,544,148 - 26,599,077 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11728,427,584 - 28,482,511 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01718,867,241 - 18,921,792 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11719,184,246 - 19,236,423 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1719,193,860 - 19,236,427 (-)Ensemblpanpan1.1panPan2
SOCS7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1923,775,349 - 23,809,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl923,776,827 - 23,803,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,237,225 - 23,269,741 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0924,562,862 - 24,595,403 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl924,567,638 - 24,595,660 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,333,880 - 23,366,157 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,594,969 - 23,627,506 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0923,721,544 - 23,754,076 (-)NCBIUU_Cfam_GSD_1.0
Socs7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,200,155 - 23,248,497 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649013,826,636 - 13,874,603 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649013,826,642 - 13,874,984 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,688,722 - 23,723,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11223,687,115 - 23,723,427 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21263,548,726 - 63,584,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11667,784,644 - 67,839,456 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1667,794,258 - 67,839,040 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607738,813,139 - 38,868,989 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,159,402 - 4,186,037 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247954,159,493 - 4,185,677 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOCS7
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
NM_014598.3(SOCS7):c.1026C>T (p.Phe342=) single nucleotide variant Malignant melanoma [RCV000063200] Chr17:38365375 [GRCh38]
Chr17:36521258 [GRCh37]
Chr17:33774784 [NCBI36]
Chr17:17q12		 not provided
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh37/hg19 17q12(chr17:36474601-36552916)x3 copy number gain See cases [RCV000445960] Chr17:36474601..36552916 [GRCh37]
Chr17:17q12		 likely benign
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2		 pathogenic
GRCh37/hg19 17q12(chr17:36353952-36680186)x3 copy number gain not provided [RCV000846603] Chr17:36353952..36680186 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.803C>T (p.Pro268Leu) single nucleotide variant Inborn genetic diseases [RCV003291078] Chr17:38352855 [GRCh38]
Chr17:36508738 [GRCh37]
Chr17:17q12		 uncertain significance
GRCh37/hg19 17q12(chr17:36473175-36567469)x3 copy number gain Short stature [RCV001250262] Chr17:36473175..36567469 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.502G>C (p.Gly168Arg) single nucleotide variant Inborn genetic diseases [RCV002687425] Chr17:38352554 [GRCh38]
Chr17:36508437 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.1780G>A (p.Val594Ile) single nucleotide variant Inborn genetic diseases [RCV002888999] Chr17:38395407 [GRCh38]
Chr17:36551660 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.409G>A (p.Val137Ile) single nucleotide variant Inborn genetic diseases [RCV003006659] Chr17:38352461 [GRCh38]
Chr17:36508344 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.369G>C (p.Gln123His) single nucleotide variant Inborn genetic diseases [RCV002983730] Chr17:38352421 [GRCh38]
Chr17:36508304 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.784C>G (p.Leu262Val) single nucleotide variant Inborn genetic diseases [RCV002831468] Chr17:38352836 [GRCh38]
Chr17:36508719 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.1292C>T (p.Ser431Phe) single nucleotide variant Inborn genetic diseases [RCV002963648] Chr17:38366326 [GRCh38]
Chr17:36522209 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.1261C>T (p.Pro421Ser) single nucleotide variant Inborn genetic diseases [RCV002652376] Chr17:38366295 [GRCh38]
Chr17:36522178 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.653C>G (p.Pro218Arg) single nucleotide variant Inborn genetic diseases [RCV003207936] Chr17:38352705 [GRCh38]
Chr17:36508588 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.236T>C (p.Val79Ala) single nucleotide variant Inborn genetic diseases [RCV003302457] Chr17:38352288 [GRCh38]
Chr17:36508171 [GRCh37]
Chr17:17q12		 likely benign
NM_014598.4(SOCS7):c.252G>T (p.Glu84Asp) single nucleotide variant Inborn genetic diseases [RCV003302458] Chr17:38352304 [GRCh38]
Chr17:36508187 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.391C>A (p.Gln131Lys) single nucleotide variant Inborn genetic diseases [RCV003365136] Chr17:38352443 [GRCh38]
Chr17:36508326 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.1085G>A (p.Arg362Gln) single nucleotide variant Inborn genetic diseases [RCV003370660] Chr17:38364791 [GRCh38]
Chr17:36520674 [GRCh37]
Chr17:17q12		 uncertain significance
NM_014598.4(SOCS7):c.975G>A (p.Ala325=) single nucleotide variant not provided [RCV003413210] Chr17:38353027 [GRCh38]
Chr17:36508910 [GRCh37]
Chr17:17q12		 likely benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR145hsa-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23392170
MIR145hsa-miR-145-5pOncomiRDBexternal_infoNANA23392170

Predicted Target Of
Summary Value
Count of predictions:912
Count of miRNA genes:449
Interacting mature miRNAs:488
Transcripts:ENST00000331159, ENST00000577233, ENST00000580660, ENST00000584132
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G20462  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371736,560,074 - 36,560,185UniSTSGRCh37
Build 361733,813,600 - 33,813,711RGDNCBI36
Celera1733,220,053 - 33,220,164RGD
Cytogenetic Map17q12UniSTS
HuRef1732,356,541 - 32,356,652UniSTS
A005S24  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371736,560,074 - 36,560,185UniSTSGRCh37
Build 361733,813,600 - 33,813,711RGDNCBI36
Celera1733,220,053 - 33,220,164RGD
Cytogenetic Map17q12UniSTS
HuRef1732,356,541 - 32,356,652UniSTS
GeneMap99-GB4 RH Map1704.71UniSTS
NCBI RH Map11894.1UniSTS
D10S2448  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map13q12.3UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map1p22.1UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map13q32.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map1q22UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map1p31UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map1q44UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map4q31.21UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map19qUniSTS
Cytogenetic Map2q32.3UniSTS
RH36905  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map12q24.11UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1p12UniSTS
Cytogenetic Map10p12.33UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map18p11.3-p11.2UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map3q27-q28UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map3q26.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map14q13.2UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map20p11.23UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map3q12.2-q12.3UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map1q21.2-q21.3UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map12q24.2-q24.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map11q12-q13.1UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map18p11.2UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map9q31.1UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map6p24-p22.3UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map10q21UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map4q25-q27UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map1q44UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map10q24.1UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map11q14.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map7q11.21UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map1p21.3UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map3p25.1UniSTS
Cytogenetic Map10q25-q26UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map7p14UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map16q22.1UniSTS
D8S2282  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q32.3UniSTS
Cytogenetic Map4p13UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map9q21.32UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic MapXq25-q26.1UniSTS
Cytogenetic Map2p25-p24UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map5q33.2UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map9q21.11UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4p16.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 459 468 710 22 488 24 1668 390 2026 65 887 794 11 10 1199 3
Low 1892 2390 774 411 1169 251 2650 1795 1638 117 373 669 160 1194 1589 1
Below cutoff 126 118 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_014598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054315892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054315893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001752503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007065295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008484813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008485631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA233668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB005216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC183084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC244092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC244153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI223248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW613025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC121030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC121031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ593634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000612932   ⟹   ENSP00000482229
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,351,844 - 38,405,593 (+)Ensembl
RefSeq Acc Id: ENST00000613678   ⟹   ENSP00000484381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,352,228 - 38,399,648 (+)Ensembl
RefSeq Acc Id: ENST00000617360
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,352,551 - 38,399,633 (+)Ensembl
RefSeq Acc Id: ENST00000617765   ⟹   ENSP00000482278
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,352,943 - 38,377,738 (+)Ensembl
RefSeq Acc Id: ENST00000665913   ⟹   ENSP00000499750
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1738,352,124 - 38,405,593 (+)Ensembl
RefSeq Acc Id: NM_014598   ⟹   NP_055413
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,351,844 - 38,405,593 (+)NCBI
GRCh371736,508,007 - 36,561,846 (+)ENTREZGENE
Build 361733,761,531 - 33,809,545 (+)NCBI Archive
HuRef1732,304,776 - 32,358,313 (+)ENTREZGENE
CHM1_11736,743,687 - 36,797,156 (+)NCBI
T2T-CHM13v2.01739,214,750 - 39,268,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017024551   ⟹   XP_016880040
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,351,844 - 38,405,593 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017024552   ⟹   XP_016880041
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,351,844 - 38,405,593 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054315892   ⟹   XP_054171867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01739,214,750 - 39,268,637 (+)NCBI
RefSeq Acc Id: XM_054315893   ⟹   XP_054171868
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01739,214,750 - 39,268,637 (+)NCBI
RefSeq Acc Id: XR_007065295
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,351,844 - 38,366,395 (+)NCBI
RefSeq Acc Id: XR_008484813
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01739,214,750 - 39,229,301 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_055413   ⟸   NM_014598
- UniProtKB: Q0IJ63 (UniProtKB/Swiss-Prot),   O14512 (UniProtKB/Swiss-Prot),   A2VCU2 (UniProtKB/Swiss-Prot),   A0A5F9YLF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016880040   ⟸   XM_017024551
- Peptide Label: isoform X1
- UniProtKB: A0A087X1Q5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016880041   ⟸   XM_017024552
- Peptide Label: isoform X2
- UniProtKB: A0A087X1Q5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000499750   ⟸   ENST00000665913
RefSeq Acc Id: ENSP00000482229   ⟸   ENST00000612932
RefSeq Acc Id: ENSP00000484381   ⟸   ENST00000613678
RefSeq Acc Id: ENSP00000482278   ⟸   ENST00000617765
RefSeq Acc Id: XP_054171867   ⟸   XM_054315892
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054171868   ⟸   XM_054315893
- Peptide Label: isoform X2
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O14512-F1-model_v2 AlphaFold O14512 1-581 view protein structure

Promoters
RGD ID:6794561
Promoter ID:HG_KWN:25935
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_014598,   UC002HQB.1,   UC010CVL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361733,760,884 - 33,761,384 (+)MPROMDB
RGD ID:7234765
Promoter ID:EPDNEW_H23128
Type:initiation region
Name:SOCS7_1
Description:suppressor of cytokine signaling 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381738,352,293 - 38,352,353EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29846 AgrOrtholog
COSMIC SOCS7 COSMIC
Ensembl Genes ENSG00000274211 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000274229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000612932 ENTREZGENE
  ENST00000612932.6 UniProtKB/TrEMBL
  ENST00000613678 ENTREZGENE
  ENST00000613678.5 UniProtKB/TrEMBL
  ENST00000615473.2 UniProtKB/Swiss-Prot
  ENST00000617765.1 UniProtKB/TrEMBL
  ENST00000631692.1 UniProtKB/TrEMBL
  ENST00000632687.1 UniProtKB/TrEMBL
  ENST00000665913.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000274211 GTEx
  ENSG00000274229 GTEx
HGNC ID HGNC:29846 ENTREZGENE
Human Proteome Map SOCS7 Human Proteome Map
InterPro SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS7_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS7_SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:30837 UniProtKB/Swiss-Prot
NCBI Gene 30837 ENTREZGENE
OMIM 608788 OMIM
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUPPRESSOR OF CYTOKINE SIGNALING 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164742488 PharmGKB
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WZ14_HUMAN UniProtKB/TrEMBL
  A0A087X1Q5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0J9YXY1_HUMAN UniProtKB/TrEMBL
  A0A5F9YLF9 ENTREZGENE, UniProtKB/TrEMBL
  A2VCU2 ENTREZGENE
  O14512 ENTREZGENE
  Q0IJ63 ENTREZGENE
  SOCS7_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A2VCU2 UniProtKB/Swiss-Prot
  Q0IJ63 UniProtKB/Swiss-Prot