Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | GCA (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GCA mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of GCA mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in increased expression of GCA mRNA | CTD | PMID:30723492 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GCA mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GCA mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Gca (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of GCA mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GCA mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GCA mRNA | CTD | PMID:17101203 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of GCA mRNA | CTD | PMID:30723492 | 4-hydroxyphenyl retinamide | decreases expression | EXP | | 6480464 | Fenretinide results in decreased expression of GCA mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of GCA mRNA | CTD | PMID:24780913 and PMID:25825206 | acetamide | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | acetamide results in increased expression of GCA mRNA | CTD | PMID:31881176 | aflatoxin B1 | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Aflatoxin B1 results in increased expression of GCA mRNA | CTD | PMID:23630614 and PMID:25378103 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of GCA mRNA | CTD | PMID:16788091 | all-trans-retinoic acid | increases expression | ISO | GCA (Homo sapiens) | 6480464 | Tretinoin results in increased expression of GCA mRNA | CTD | PMID:15498508 more ... | antirheumatic drug | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of GCA mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of GCA mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | GCA (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to GCA protein] and arsenite promotes the reaction [G3BP1 protein binds to GCA mRNA] | CTD | PMID:32406909 | azathioprine | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Azathioprine results in decreased expression of GCA mRNA | CTD | PMID:22623647 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of GCA mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of GCA mRNA | CTD | PMID:21632981 | Benzo[ghi]perylene | increases expression | EXP | | 6480464 | 1 and 12-benzoperylene results in increased expression of GCA mRNA | CTD | PMID:26377693 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GCA mRNA | CTD | PMID:21932408 | bisphenol A | increases expression | ISO | GCA (Homo sapiens) | 6480464 | bisphenol A results in increased expression of GCA protein | CTD | PMID:37567409 | bisphenol A | multiple interactions | ISO | Gca (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of GCA gene | CTD | PMID:28505145 | bisphenol A | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of GCA mRNA | CTD | PMID:25181051 | carbamazepine | affects expression | ISO | GCA (Homo sapiens) | 6480464 | Carbamazepine affects the expression of GCA mRNA | CTD | PMID:25979313 | CGP 52608 | multiple interactions | ISO | GCA (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to GCA gene] | CTD | PMID:28238834 | copper(II) sulfate | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of GCA mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of GCA mRNA | CTD | PMID:25562108 | cytarabine | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of GCA mRNA | CTD | PMID:21198554 | dicrotophos | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of GCA mRNA | CTD | PMID:28302478 | diquat | decreases expression | EXP | | 6480464 | Diquat results in decreased expression of GCA protein | CTD | PMID:36851058 | diuron | decreases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of GCA mRNA | CTD | PMID:21551480 | entinostat | increases expression | ISO | GCA (Homo sapiens) | 6480464 | entinostat results in increased expression of GCA mRNA | CTD | PMID:27188386 | ethyl methanesulfonate | increases expression | ISO | GCA (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of GCA mRNA | CTD | PMID:23649840 | furan | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | furan results in increased expression of GCA mRNA | CTD | PMID:27387713 | genistein | multiple interactions | ISO | Gca (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Genistein] results in increased methylation of GCA gene | CTD | PMID:28505145 | gold atom | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Gold results in decreased expression of GCA mRNA | CTD | PMID:25523186 | gold(0) | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Gold results in decreased expression of GCA mRNA | CTD | PMID:25523186 | isoflavones | increases expression | ISO | GCA (Homo sapiens) | 6480464 | Isoflavones results in increased expression of GCA mRNA | CTD | PMID:17374662 | ivermectin | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of GCA protein | CTD | PMID:32959892 | ketamine | decreases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Ketamine results in decreased expression of GCA mRNA | CTD | PMID:20080153 | methapyrilene | decreases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of GCA mRNA | CTD | PMID:30467583 | methotrexate | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of GCA mRNA | CTD | PMID:24449571 | methylmercury chloride | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of GCA mRNA | CTD | PMID:23179753 and PMID:27188386 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GCA mRNA | CTD | PMID:24535843 | nickel atom | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Nickel results in decreased expression of GCA mRNA | CTD | PMID:23195993 | nickel atom | increases expression | ISO | GCA (Homo sapiens) | 6480464 | Nickel results in increased expression of GCA mRNA | CTD | PMID:24768652 and PMID:25583101 | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of GCA mRNA | CTD | PMID:23892564 | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of GCA mRNA | CTD | PMID:37995155 | phenobarbital | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GCA mRNA and NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GCA mRNA] | CTD | PMID:19482888 and PMID:24535843 | phenobarbital | affects expression | ISO | GCA (Homo sapiens) | 6480464 | Phenobarbital affects the expression of GCA mRNA | CTD | PMID:19159669 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of GCA mRNA | CTD | PMID:19482888 | pirinixic acid | multiple interactions | ISO | GCA (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GCA mRNA | CTD | PMID:19710929 | potassium chromate | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of GCA mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | GCA (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GCA mRNA | CTD | PMID:22079256 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of GCA mRNA | CTD | PMID:21278054 | quercetin | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Quercetin results in decreased expression of GCA mRNA | CTD | PMID:21632981 | silicon dioxide | decreases expression | ISO | GCA (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of GCA mRNA | CTD | PMID:25895662 | silver atom | decreases expression | EXP | | 6480464 | Silver results in decreased expression of GCA mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | EXP | | 6480464 | Silver results in decreased expression of GCA mRNA | CTD | PMID:27131904 | sodium arsenite | increases expression | ISO | GCA (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of GCA mRNA | CTD | PMID:22714537 | sodium dichromate | affects expression | ISO | Gca (Rattus norvegicus) | 6480464 | sodium bichromate affects the expression of GCA mRNA | CTD | PMID:22110744 | succimer | multiple interactions | ISO | GCA (Homo sapiens) | 6480464 | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of GCA mRNA | CTD | PMID:26378955 | tamibarotene | increases expression | ISO | GCA (Homo sapiens) | 6480464 | tamibarotene results in increased expression of GCA mRNA | CTD | PMID:15498508 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of GCA mRNA | CTD | PMID:20937368 | thioacetamide | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of GCA mRNA | CTD | PMID:23411599 and PMID:34492290 | topotecan | affects response to substance | ISO | GCA (Homo sapiens) | 6480464 | GCA protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | trichloroethene | decreases expression | ISO | Gca (Rattus norvegicus) | 6480464 | Trichloroethylene results in decreased expression of GCA mRNA | CTD | PMID:33387578 | trichostatin A | affects expression | ISO | GCA (Homo sapiens) | 6480464 | trichostatin A affects the expression of GCA mRNA | CTD | PMID:28542535 | valproic acid | decreases methylation | ISO | GCA (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of GCA gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | GCA (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of GCA mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | GCA (Homo sapiens) | 6480464 | Valproic Acid affects the expression of GCA mRNA | CTD | PMID:25979313 | vinclozolin | increases expression | ISO | Gca (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of GCA mRNA | CTD | PMID:20566332 | vorinostat | increases expression | ISO | GCA (Homo sapiens) | 6480464 | vorinostat results in increased expression of GCA mRNA | CTD | PMID:27188386 | zinc atom | increases expression | ISO | GCA (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of GCA mRNA | CTD | PMID:18356318 | zinc(0) | increases expression | ISO | GCA (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of GCA mRNA | CTD | PMID:18356318 | |