Gca (grancalcin) - Rat Genome Database

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Gene: Gca (grancalcin) Mus musculus
Analyze
Symbol: Gca
Name: grancalcin
RGD ID: 1315292
MGI Page MGI
Description: Predicted to enable calcium ion binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be located in cytosol and plasma membrane. Is expressed in cerebral cortex ventricular layer and telencephalon ventricular layer. Orthologous to human GCA (grancalcin).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5133401E04Rik; AI573844
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,494,671 - 62,524,453 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,494,629 - 62,524,453 (+)EnsemblGRCm39 Ensembl
GRCm38262,664,327 - 62,694,109 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,664,285 - 62,694,109 (+)EnsemblGRCm38mm10GRCm38
MGSCv37262,502,384 - 62,532,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,465,166 - 62,494,948 (+)NCBIMGSCv36mm8
Celera264,354,587 - 64,386,731 (+)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map236.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO,TAS)
membrane  (IEA)
plasma membrane  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10512203   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12529388   PMID:15118320   PMID:15489334   PMID:15840001   PMID:16141072   PMID:16141073  
PMID:16934789   PMID:16954401   PMID:21267068   PMID:21873635   PMID:34321999   PMID:34614408   PMID:38167327  


Genomics

Comparative Map Data
Gca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,494,671 - 62,524,453 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,494,629 - 62,524,453 (+)EnsemblGRCm39 Ensembl
GRCm38262,664,327 - 62,694,109 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,664,285 - 62,694,109 (+)EnsemblGRCm38mm10GRCm38
MGSCv37262,502,384 - 62,532,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,465,166 - 62,494,948 (+)NCBIMGSCv36mm8
Celera264,354,587 - 64,386,731 (+)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map236.47NCBI
GCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,318,763 - 162,375,396 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2162,318,840 - 162,371,595 (+)EnsemblGRCh38hg38GRCh38
GRCh372163,175,273 - 163,219,633 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,908,896 - 162,925,875 (+)NCBINCBI36Build 36hg18NCBI36
Build 342163,026,156 - 163,043,136NCBI
Celera2156,810,897 - 156,829,481 (+)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2155,082,887 - 155,101,451 (+)NCBIHuRef
CHM1_12163,206,468 - 163,225,034 (+)NCBICHM1_1
T2T-CHM13v2.02162,775,430 - 162,833,885 (+)NCBIT2T-CHM13v2.0
Gca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,705,874 - 67,738,475 (+)NCBIGRCr8
mRatBN7.2347,297,320 - 47,329,913 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,297,383 - 47,328,581 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,652,068 - 50,684,657 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0359,235,600 - 59,268,188 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0357,008,777 - 57,041,316 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,625,965 - 48,661,317 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,626,038 - 48,661,317 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,291,465 - 55,326,008 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,616,037 - 44,648,897 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,512,448 - 44,541,386 (+)NCBI
Celera346,938,285 - 46,969,570 (+)NCBICelera
Cytogenetic Map3q21NCBI
Gca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,504,058 - 11,522,661 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,503,201 - 11,538,809 (-)NCBIChiLan1.0ChiLan1.0
GCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21365,010,804 - 65,054,157 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B65,025,747 - 65,069,132 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,612,156 - 49,657,114 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,980,348 - 167,023,578 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B167,005,108 - 167,023,581 (+)Ensemblpanpan1.1panPan2
GCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,727,578 - 7,780,439 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,749,191 - 7,778,968 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,871,005 - 7,924,587 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,859,231 - 7,913,061 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,880,907 - 7,913,800 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,877,439 - 7,931,219 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,918,593 - 7,972,227 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0368,026,108 - 8,079,928 (+)NCBIUU_Cfam_GSD_1.0
Gca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,914,685 - 124,942,542 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,686,192 - 16,703,109 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,675,897 - 16,703,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,985,328 - 69,054,052 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11569,015,230 - 69,054,057 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,511,222 - 76,544,884 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,732,741 - 47,777,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,757,459 - 47,775,055 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040151,755,186 - 151,800,283 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,160,488 - 3,180,391 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,130,440 - 3,193,853 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gca
736 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:812
Count of miRNA genes:467
Interacting mature miRNAs:568
Transcripts:ENSMUST00000028257, ENSMUST00000148083
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
10449151Hdl8_mhigh density lipoprotein (HDL) level 8 (mouse)23812972567072607Mouse
10449150Pvldlc1_mplasma VLDL-cholesterol 1 (mouse)23812972567072607Mouse
10449145Lanq1_mlanosterol level QTL 1 (mouse)23812972567072607Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
1300645Alcp1_malcohol preference locus 1 (mouse)Not determined24522812867838868Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
4142185Pbwg1.3_mpostnatal body weight growth 1.3 (mouse)Not determined5718712365132495Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
13432185Acdes1_mactivity chamber difference ethanol/saline 1 (mouse)25939228762892287Mouse
13432184Actdes1_mactivity chamber total difference ethanol/saline 1 (mouse)25939228769292287Mouse
13432174Actres5_mactivity response to ethanol/saline 5 (mouse)25989228769792287Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13432178Actres2_mactivity response to ethanol/saline 2 (mouse)26069228774092287Mouse
13432175Actres4_mactivity response to ethanol/saline 4 (mouse)26079228762892287Mouse
13432177Actres3_mactivity response to ethanol/saline 3 (mouse)26079228763092287Mouse
13432180Acq2_mactivity chamber QTL 2 (mouse)26079228764592287Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse

Markers in Region
AI573844  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38262,693,533 - 62,693,640UniSTSGRCm38
MGSCv37262,531,590 - 62,531,697UniSTSGRCm37
Celera264,386,155 - 64,386,262UniSTS
Cytogenetic Map2C1.3UniSTS
Whitehead/MRC_RH21005.39UniSTS
BB403260  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38262,691,589 - 62,691,729UniSTSGRCm38
MGSCv37262,529,646 - 62,529,786UniSTSGRCm37
Celera264,384,223 - 64,384,363UniSTS
Cytogenetic Map2C1.3UniSTS
Whitehead/MRC_RH2993.08UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000028257   ⟹   ENSMUSP00000028257
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl262,494,629 - 62,524,453 (+)Ensembl
GRCm38.p6 Ensembl262,664,285 - 62,694,109 (+)Ensembl
RefSeq Acc Id: ENSMUST00000148083
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl262,516,542 - 62,520,775 (+)Ensembl
GRCm38.p6 Ensembl262,686,198 - 62,690,431 (+)Ensembl
RefSeq Acc Id: NM_145523   ⟹   NP_663498
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39262,494,671 - 62,524,453 (+)NCBI
GRCm38262,664,327 - 62,694,109 (+)ENTREZGENE
MGSCv37262,502,384 - 62,532,166 (+)RGD
Celera264,354,587 - 64,386,731 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_663498   ⟸   NM_145523
- UniProtKB: Q8BL53 (UniProtKB/Swiss-Prot),   Q8K3Z6 (UniProtKB/Swiss-Prot),   Q8VC88 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028257   ⟸   ENSMUST00000028257
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VC88-F1-model_v2 AlphaFold Q8VC88 1-220 view protein structure

Promoters
RGD ID:6831431
Promoter ID:MM_KWN:29419
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000030860
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36262,502,221 - 62,502,721 (+)MPROMDB
RGD ID:6877462
Promoter ID:EPDNEW_M2166
Type:initiation region
Name:Gca_1
Description:Mus musculus grancalcin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38262,664,327 - 62,664,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918521 AgrOrtholog
Ensembl Genes ENSMUSG00000026893 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028257 ENTREZGENE
  ENSMUST00000028257.3 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.900 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
KEGG Report mmu:227960 UniProtKB/Swiss-Prot
MGD MGI:1918521 ENTREZGENE
NCBI Gene 227960 ENTREZGENE
PANTHER CALPAIN, SMALL SUBUNIT 1 A-RELATED UniProtKB/Swiss-Prot
  GRANCALCIN UniProtKB/Swiss-Prot
Pfam EF-hand_8 UniProtKB/Swiss-Prot
PhenoGen Gca PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt GRAN_MOUSE UniProtKB/Swiss-Prot
  Q8BL53 ENTREZGENE
  Q8K3Z6 ENTREZGENE
  Q8VC88 ENTREZGENE
UniProt Secondary Q8BL53 UniProtKB/Swiss-Prot
  Q8K3Z6 UniProtKB/Swiss-Prot