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Gene: CLCA1 (chloride channel accessory 1) Homo sapiens
Symbol: CLCA1
Name: chloride channel accessory 1
Description: Predicted to have intracellular calcium activated chloride channel activity. Predicted to be involved in ion transmembrane transport. Predicted to localize to integral component of plasma membrane and secretory granule. Implicated in asthma and chronic obstructive pulmonary disease. Biomarker of chronic obstructive pulmonary disease and cystic fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CACC; CaCC-1; CACC1; calcium-activated chloride channel family member 1; calcium-activated chloride channel protein 1; calcium-activated chloride channel regulator 1; calcium-dependent chloride channel-1; chloride channel regulator 1; chloride channel, calcium activated, family member 1; CLCA family member 1, chloride channel regulator; CLCRG1; FLJ95147; GOB5; hCaCC-1; hCLCA1
Mus musculus (house mouse) : Clca1 (chloride channel accessory 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clca1 (chloride channel accessory 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clca1 (chloride channel accessory 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCA1 (chloride channel accessory 1)
Canis lupus familiaris (dog) : CLCA1 (chloride channel accessory 1)
Sus scrofa (pig) : CLCA1 (chloride channel accessory 1)
Chlorocebus sabaeus (African green monkey) : CLCA1 (chloride channel accessory 1)
Heterocephalus glaber (naked mole-rat) : Clca1 (chloride channel accessory 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl186,468,368 - 86,500,259 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl186,468,368 - 86,500,289 (+)EnsemblGRCh38hg38GRCh38
GRCh38186,468,927 - 86,500,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37186,934,526 - 86,965,977 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36186,707,114 - 86,738,565 (+)NCBINCBI36hg18NCBI36
Build 34186,646,071 - 86,677,963NCBI
Celera185,178,525 - 85,209,980 (+)NCBI
Cytogenetic Map1p22.3NCBI
HuRef185,045,156 - 85,076,624 (+)NCBIHuRef
CHM1_1187,049,378 - 87,080,831 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CLCA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314775
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.