Clca3a2 (chloride channel accessory 3A2) - Rat Genome Database

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Gene: Clca3a2 (chloride channel accessory 3A2) Mus musculus
Analyze
No known orthologs.
Symbol: Clca3a2
Name: chloride channel accessory 3A2
RGD ID: 1623088
MGI Page MGI
Description: Predicted to enable intracellular calcium activated chloride channel activity. Acts upstream of or within anoikis and extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; heart; and integumental system. Orthologous to human CLCA3P (chloride channel accessory 3, pseudogene).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride channel calcium activated 2; chloride channel calcium activated 3A2; Clc; Clca2
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393144,486,340 - 144,525,385 (-)NCBIGRCm39mm39
GRCm39 Ensembl3144,502,320 - 144,525,255 (-)Ensembl
GRCm383144,780,581 - 144,819,623 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3144,796,559 - 144,819,494 (-)EnsemblGRCm38mm10GRCm38
MGSCv373144,459,523 - 144,482,458 (-)NCBIGRCm37mm9NCBIm37
MGSCv363144,734,469 - 144,756,863 (-)NCBImm8
Celera3151,237,531 - 151,260,462 (-)NCBICelera
Cytogenetic Map3H2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:4309975   PMID:10349636   PMID:10544033   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11483609   PMID:12122442   PMID:12466851   PMID:12477932   PMID:14595844   PMID:16141072  
PMID:16141073   PMID:16569774   PMID:16985003   PMID:17130451   PMID:19210762   PMID:20385786   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24790087   PMID:24952961   PMID:29459677  


Genomics

Position Markers
D3Mit161  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383144,758,867 - 144,758,983UniSTSGRCm38
GRCm383144,817,611 - 144,817,737UniSTSGRCm38
MGSCv373144,421,831 - 144,421,947UniSTSGRCm37
MGSCv373144,480,575 - 144,480,701UniSTSGRCm37
Celera3151,200,552 - 151,200,668UniSTS
Celera3151,258,579 - 151,258,705UniSTS
Cytogenetic Map3H2-H3UniSTS
Cytogenetic Map3H2UniSTS
cM Map372.9UniSTS
cM Map3 UniSTS
Whitehead Genetic351.4UniSTS
Whitehead/MRC_RH31592.35UniSTS
Clca1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383144,805,703 - 144,805,899UniSTSGRCm38
GRCm383144,746,791 - 144,746,987UniSTSGRCm38
MGSCv373144,468,667 - 144,468,863UniSTSGRCm37
MGSCv373144,409,755 - 144,409,951UniSTSGRCm37
Celera3151,246,671 - 151,246,867UniSTS
Celera3151,188,470 - 151,188,666UniSTS
Cytogenetic Map3H2UniSTS
Cytogenetic Map3H2-H3UniSTS
cM Map372.5UniSTS
Clca2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2-H3UniSTS
Cytogenetic Map3H2UniSTS
cM Map3 UniSTS
Clca1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2-H3UniSTS
Cytogenetic Map3H2UniSTS
Clca2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2-H3UniSTS
Cytogenetic Map3H2UniSTS
Clca1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2-H3UniSTS
Cytogenetic Map3H2UniSTS
Clca2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2UniSTS
Clca2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3H2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301528Loco1_mlocomotor activity 1 (mouse)Not determined3133461893159745316Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
1300753Eae10_msusceptibility to experimental allergic encephalomyelitis 10 (mouse)Not determined3131736617148451178Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301221Hrtfm2_mheart failure modifier 2 (mouse)Not determined3143270248147045722Mouse
1301222Scc7_mcolon tumor susceptibility 7 (mouse)Not determined3143352986156364108Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
10412120Ccs3_mcolon cancer susceptibility 3 (mouse)Not determined3131754536146017669Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029929   ⟹   ENSMUSP00000029929
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3144,502,320 - 144,525,255 (-)Ensembl
GRCm38.p6 Ensembl3144,796,559 - 144,819,494 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159643
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3144,522,254 - 144,523,819 (-)Ensembl
GRCm38.p6 Ensembl3144,816,493 - 144,818,058 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197013   ⟹   ENSMUSP00000143332
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3144,507,820 - 144,514,386 (-)Ensembl
GRCm38.p6 Ensembl3144,802,059 - 144,808,625 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199029   ⟹   ENSMUSP00000143543
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3144,507,593 - 144,511,566 (-)Ensembl
GRCm38.p6 Ensembl3144,801,832 - 144,805,805 (-)Ensembl
RefSeq Acc Id: NM_030601   ⟹   NP_085104
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393144,502,320 - 144,525,255 (-)NCBI
GRCm383144,796,559 - 144,819,494 (-)NCBI
MGSCv373144,459,523 - 144,482,458 (-)RGD
Celera3151,237,531 - 151,260,462 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502346   ⟹   XP_006502409
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393144,511,549 - 144,525,381 (-)NCBI
GRCm383144,805,788 - 144,819,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319811   ⟹   XP_017175300
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393144,490,958 - 144,525,385 (-)NCBI
GRCm383144,785,197 - 144,819,623 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017319812   ⟹   XP_017175301
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393144,486,340 - 144,525,382 (-)NCBI
GRCm383144,780,581 - 144,819,621 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_085104   ⟸   NM_030601
- Peptide Label: precursor
- UniProtKB: Q9EQR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502409   ⟸   XM_006502346
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017175301   ⟸   XM_017319812
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017175300   ⟸   XM_017319811
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000143332   ⟸   ENSMUST00000197013
RefSeq Acc Id: ENSMUSP00000029929   ⟸   ENSMUST00000029929
RefSeq Acc Id: ENSMUSP00000143543   ⟸   ENSMUST00000199029
Protein Domains
CLCA   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQR4-F1-model_v2 AlphaFold Q9EQR4 1-902 view protein structure

Promoters
RGD ID:6882556
Promoter ID:EPDNEW_M4729
Type:single initiation site
Name:Clca3a2_1
Description:Mus musculus chloride channel accessory 3A2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383144,819,486 - 144,819,546EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931471 AgrOrtholog
Ensembl Genes ENSMUSG00000028262 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029929 ENTREZGENE
  ENSMUSP00000029929.8 UniProtKB/TrEMBL
  ENSMUSP00000143332.2 UniProtKB/TrEMBL
  ENSMUSP00000143543.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029929 ENTREZGENE
  ENSMUST00000029929.12 UniProtKB/TrEMBL
  ENSMUST00000197013.2 UniProtKB/TrEMBL
  ENSMUST00000199029.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
InterPro CaCC_prot UniProtKB/TrEMBL
  Cl_channel_Ca UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report mmu:80797 UniProtKB/TrEMBL
MGD MGI:1931471 ENTREZGENE
NCBI Gene 80797 ENTREZGENE
Pfam CLCA_N UniProtKB/TrEMBL
  VWA_2 UniProtKB/TrEMBL
PhenoGen Clca3a2 PhenoGen
PROSITE VWFA UniProtKB/TrEMBL
SMART VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
TIGRFAMs hCaCC UniProtKB/TrEMBL
UniProt A0A0G2JFW5_MOUSE UniProtKB/TrEMBL
  A0A0G2JGF3_MOUSE UniProtKB/TrEMBL
  Q3UZ16_MOUSE UniProtKB/TrEMBL
  Q8C9E1_MOUSE UniProtKB/TrEMBL
  Q9EQR4 ENTREZGENE, UniProtKB/TrEMBL
  Q9R070_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-20 Clca3a2  chloride channel accessory 3A2    chloride channel calcium activated 3A2  Symbol and/or name change 5135510 APPROVED
2015-01-20 Clca3a2  chloride channel calcium activated 3A2  Clca2  chloride channel calcium activated 2  Symbol and/or name change 5135510 APPROVED