Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Fryl | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | FRYL (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FRYL mRNA | CTD | PMID:22079256 | Fryl | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FRYL mRNA | CTD | PMID:22206623 | Fryl | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of FRYL mRNA | CTD | PMID:29097150 | Fryl | Rat | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | FRYL (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of FRYL mRNA | CTD | PMID:29581250 | Fryl | Rat | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Fryl | Rat | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Fryl | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Fryl (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of FRYL mRNA | CTD | PMID:21570461 | Fryl | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Fryl | Rat | 3-methylcholanthrene | increases expression | ISO | Fryl (Mus musculus) | 6480464 | Methylcholanthrene results in increased expression of FRYL mRNA | CTD | PMID:20713471 | Fryl | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Fryl (Mus musculus) | 6480464 | bisphenol S affects the methylation of FRYL gene | CTD | PMID:31683443 | Fryl | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of FRYL mRNA | CTD | PMID:30047161 | Fryl | Rat | aflatoxin B1 | affects methylation | ISO | FRYL (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of FRYL intron | CTD | PMID:30157460 | Fryl | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of FRYL mRNA | CTD | PMID:30047161 | Fryl | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of FRYL mRNA | CTD | PMID:30779732 | Fryl | Rat | aristolochic acid A | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of FRYL mRNA | CTD | PMID:33212167 | Fryl | Rat | arsenite(3-) | multiple interactions | ISO | FRYL (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to FRYL mRNA] | CTD | PMID:32406909 | Fryl | Rat | atrazine | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | Atrazine results in decreased expression of FRYL mRNA | CTD | PMID:26518232 | Fryl | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of FRYL gene | CTD | PMID:35440735 | Fryl | Rat | benzo[a]pyrene | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of FRYL mRNA | CTD | PMID:20064835 | Fryl | Rat | benzo[a]pyrene | increases methylation | ISO | FRYL (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of FRYL 5' UTR | CTD | PMID:27901495 | Fryl | Rat | benzo[a]pyrene | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of FRYL mRNA] | CTD | PMID:22228805 | Fryl | Rat | benzo[a]pyrene | increases expression | ISO | Fryl (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of FRYL mRNA | CTD | PMID:22228805 | Fryl | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20382639 | Fryl | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of FRYL mRNA | CTD | PMID:25181051 more ... | Fryl | Rat | caffeine | decreases phosphorylation | ISO | FRYL (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of FRYL protein | CTD | PMID:35688186 | Fryl | Rat | cisplatin | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of FRYL mRNA | CTD | PMID:27594783 | Fryl | Rat | cisplatin | multiple interactions | ISO | FRYL (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of FRYL mRNA | CTD | PMID:27392435 | Fryl | Rat | DDT | increases methylation | EXP | | 6480464 | DDT results in increased methylation of FRYL gene | CTD | PMID:30207508 | Fryl | Rat | dibutyl phthalate | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of FRYL mRNA | CTD | PMID:21266533 | Fryl | Rat | dioxygen | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of FRYL mRNA | CTD | PMID:30529165 | Fryl | Rat | doxorubicin | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of FRYL mRNA | CTD | PMID:29803840 | Fryl | Rat | ethanol | increases expression | ISO | Fryl (Mus musculus) | 6480464 | Ethanol results in increased expression of FRYL mRNA | CTD | PMID:30319688 | Fryl | Rat | ethanol | affects expression | ISO | Fryl (Mus musculus) | 6480464 | Ethanol affects the expression of FRYL mRNA | CTD | PMID:30319688 | Fryl | Rat | fenthion | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | Fenthion results in decreased expression of FRYL mRNA | CTD | PMID:34813904 | Fryl | Rat | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of FRYL mRNA | CTD | PMID:30307764 | Fryl | Rat | folic acid | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FRYL mRNA | CTD | PMID:22206623 | Fryl | Rat | FR900359 | increases phosphorylation | ISO | FRYL (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of FRYL protein | CTD | PMID:37730182 | Fryl | Rat | geldanamycin | increases expression | ISO | FRYL (Homo sapiens) | 6480464 | geldanamycin results in increased expression of FRYL mRNA | CTD | PMID:26705709 | Fryl | Rat | glyphosate | increases methylation | EXP | | 6480464 | Glyphosate results in increased methylation of FRYL gene | CTD | PMID:31011160 | Fryl | Rat | ivermectin | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of FRYL protein | CTD | PMID:32959892 | Fryl | Rat | lead(0) | affects expression | ISO | FRYL (Homo sapiens) | 6480464 | Lead affects the expression of FRYL mRNA | CTD | PMID:28903495 | Fryl | Rat | methidathion | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | methidathion results in decreased expression of FRYL mRNA | CTD | PMID:34813904 | Fryl | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of FRYL mRNA | CTD | PMID:30047161 | Fryl | Rat | methotrexate | increases expression | ISO | FRYL (Homo sapiens) | 6480464 | Methotrexate results in increased expression of FRYL mRNA | CTD | PMID:24449571 | Fryl | Rat | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Fryl (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of FRYL mRNA | CTD | PMID:27776689 | Fryl | Rat | nitrofen | decreases expression | EXP | | 6480464 | nitrofen results in decreased expression of FRYL mRNA | CTD | PMID:33484710 | Fryl | Rat | ozone | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of FRYL mRNA | CTD | PMID:34911549 | Fryl | Rat | p-toluidine | decreases expression | EXP | | 6480464 | 4-toluidine results in decreased expression of FRYL mRNA | CTD | PMID:27638505 | Fryl | Rat | paracetamol | increases expression | ISO | FRYL (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of FRYL mRNA | CTD | PMID:22230336 | Fryl | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of FRYL mRNA | CTD | PMID:33387578 | Fryl | Rat | PCB138 | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | Fryl | Rat | pentachlorophenol | increases expression | ISO | Fryl (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of FRYL mRNA | CTD | PMID:23892564 | Fryl | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Fryl (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of FRYL mRNA | CTD | PMID:36331819 | Fryl | Rat | phenobarbital | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of FRYL mRNA | CTD | PMID:23091169 | Fryl | Rat | pirinixic acid | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of FRYL mRNA | CTD | PMID:17426115 and PMID:23811191 | Fryl | Rat | potassium chromate | multiple interactions | ISO | FRYL (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FRYL mRNA | CTD | PMID:22079256 | Fryl | Rat | potassium chromate | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of FRYL mRNA | CTD | PMID:22079256 | Fryl | Rat | sodium arsenate | increases expression | ISO | Fryl (Mus musculus) | 6480464 | sodium arsenate results in increased expression of FRYL mRNA | CTD | PMID:21795629 | Fryl | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of FRYL mRNA | CTD | PMID:30047161 | Fryl | Rat | titanium dioxide | decreases methylation | ISO | Fryl (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of FRYL gene and titanium dioxide results in decreased methylation of FRYL promoter | CTD | PMID:35295148 | Fryl | Rat | triphenyl phosphate | affects expression | ISO | FRYL (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of FRYL mRNA | CTD | PMID:37042841 | Fryl | Rat | triptonide | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | triptonide results in decreased expression of FRYL mRNA | CTD | PMID:33045310 | Fryl | Rat | triptonide | affects expression | ISO | Fryl (Mus musculus) | 6480464 | triptonide affects the expression of FRYL mRNA | CTD | PMID:33045310 | Fryl | Rat | tungsten | decreases expression | ISO | Fryl (Mus musculus) | 6480464 | Tungsten results in decreased expression of FRYL mRNA | CTD | PMID:30912803 | Fryl | Rat | valproic acid | decreases expression | ISO | FRYL (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of FRYL mRNA | CTD | PMID:23179753 | Fryl | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of FRYL mRNA | CTD | PMID:23034163 | |