Fhl4 (four and a half LIM domains 4) - Rat Genome Database

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Gene: Fhl4 (four and a half LIM domains 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fhl4
Name: four and a half LIM domains 4
RGD ID: 1308978
Description: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in muscle organ development.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314678; MGC116389
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8720,516,308 - 20,521,111 (+)NCBIGRCr8
mRatBN7.2718,628,608 - 18,633,411 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl718,598,103 - 18,635,184 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx720,589,474 - 20,594,303 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0722,752,172 - 22,756,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0722,529,135 - 22,533,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,138,959 - 26,144,492 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,139,664 - 26,144,466 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0726,271,286 - 26,276,084 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4720,747,012 - 20,748,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1720,767,282 - 20,768,884 (+)NCBI
Celera715,860,029 - 15,861,631 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Fhl4
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:35
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000009162
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009162   ⟹   ENSRNOP00000072571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,627,975 - 18,635,184 (+)Ensembl
Rnor_6.0 Ensembl726,139,664 - 26,144,466 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094639   ⟹   ENSRNOP00000082781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,627,749 - 18,635,184 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110904   ⟹   ENSRNOP00000083294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,628,543 - 18,635,184 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116495   ⟹   ENSRNOP00000079521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,598,103 - 18,635,184 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116698   ⟹   ENSRNOP00000095365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,598,103 - 18,635,184 (+)Ensembl
RefSeq Acc Id: NM_001013172   ⟹   NP_001013190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8720,516,308 - 20,521,111 (+)NCBI
mRatBN7.2718,628,608 - 18,633,411 (+)NCBI
Rnor_6.0726,139,663 - 26,141,265 (-)NCBI
Rnor_5.0726,271,286 - 26,276,084 (-)NCBI
RGSC_v3.4720,747,012 - 20,748,614 (+)RGD
Celera715,860,029 - 15,861,631 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013190 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78961 (Get FASTA)   NCBI Sequence Viewer  
  AAH99213 (Get FASTA)   NCBI Sequence Viewer  
  EDM17102 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072571.1
  ENSRNOP00000079521.1
  ENSRNOP00000082781.1
  ENSRNOP00000083294.1
  ENSRNOP00000095365.1
RefSeq Acc Id: NP_001013190   ⟸   NM_001013172
- UniProtKB: Q4FZR8 (UniProtKB/TrEMBL),   A6IFE6 (UniProtKB/TrEMBL),   A0A0G2K3B5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072571   ⟸   ENSRNOT00000009162
Ensembl Acc Id: ENSRNOP00000095365   ⟸   ENSRNOT00000116698
Ensembl Acc Id: ENSRNOP00000083294   ⟸   ENSRNOT00000110904
Ensembl Acc Id: ENSRNOP00000079521   ⟸   ENSRNOT00000116495
Ensembl Acc Id: ENSRNOP00000082781   ⟸   ENSRNOT00000094639
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZR8-F1-model_v2 AlphaFold Q4FZR8 1-280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695104
Promoter ID:EPDNEW_R5629
Type:initiation region
Name:Fhl4_1
Description:four and a half LIM domains 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0726,144,491 - 26,144,551EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308978 AgrOrtholog
BioCyc Gene G2FUF-34627 BioCyc
Ensembl Genes ENSRNOG00000006998 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009162.8 UniProtKB/TrEMBL
  ENSRNOT00000094639.1 UniProtKB/TrEMBL
  ENSRNOT00000110904.1 UniProtKB/TrEMBL
  ENSRNOT00000116495.1 UniProtKB/TrEMBL
  ENSRNOT00000116698.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111014 IMAGE-MGC_LOAD
  IMAGE:7384591 IMAGE-MGC_LOAD
InterPro Fhl1 UniProtKB/TrEMBL
  Znf_LIM UniProtKB/TrEMBL
KEGG Report rno:314678 UniProtKB/TrEMBL
MGC_CLONE MGC:116389 IMAGE-MGC_LOAD
  MGC:93831 IMAGE-MGC_LOAD
NCBI Gene 314678 ENTREZGENE
PANTHER FOUR AND A HALF LIM DOMAINS 4 UniProtKB/TrEMBL
  PTHR47029 UniProtKB/TrEMBL
Pfam LIM UniProtKB/TrEMBL
PhenoGen Fhl4 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006998 RatGTEx
SMART LIM UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A0G2K3B5 ENTREZGENE, UniProtKB/TrEMBL
  A6IFE6 ENTREZGENE
  Q4FZR8 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYP9_RAT UniProtKB/TrEMBL
UniProt Secondary A6IFE6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Fhl4  four and a half LIM domains 4  Fhl4_predicted  four and a half LIM domains 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fhl4_predicted  four and a half LIM domains 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED