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Gene: FHL1 (four and a half LIM domains 1) Homo sapiens
Symbol: FHL1
Name: four and a half LIM domains 1
Description: Exhibits ion channel binding activity. Involved in several processes, including negative regulation of mitotic cell cycle phase transition; regulation of membrane depolarization; and regulation of potassium ion transport. Localizes to the cytosol; nucleus; and plasma membrane. Implicated in X-linked Emery-Dreifuss muscular dystrophy 6. Biomarker of hypertrophic cardiomyopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FCMSU; FHL-1; FHL1A; FHL1B; FLH1A; four and a half LIM domains protein 1; four-and-a-half Lin11, Isl-1 and Mec-3 domains 1; KYOT; LIM protein SLIMMER; MGC111107; RBMX1A; RBMX1B; skeletal muscle LIM-protein 1; skeletal muscle LIM-protein1; SLIM; SLIM-1; SLIM1; SLIMMER; XMPMA
Mus musculus (house mouse) : Fhl1 (four and a half LIM domains 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fhl1 (four and a half LIM domains 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fhl1 (four and a half LIM domains 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FHL1 (four and a half LIM domains 1)
Canis lupus familiaris (dog) : FHL1 (four and a half LIM domains 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fhl1 (four and a half LIM domains 1)
Sus scrofa (pig) : FHL1 (four and a half LIM domains 1)
Chlorocebus sabaeus (African green monkey) : FHL1 (four and a half LIM domains 1)
Heterocephalus glaber (naked mole-rat) : Fhl1 (four and a half LIM domains 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX136,146,702 - 136,211,359 (+)Ensembl
GRCh38X136,146,702 - 136,211,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X135,228,861 - 135,293,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,057,346 - 135,121,176 (+)NCBINCBI36hg18NCBI36
Build 34X134,955,199 - 135,019,028NCBI
CeleraX135,591,521 - 135,656,168 (+)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX124,502,588 - 124,565,831 (+)NCBIHuRef
CHM1_1X135,139,444 - 135,204,087 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on FHL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1342641
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.